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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATRX-ZNF304

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATRX-ZNF304
FusionPDB ID: 8363
FusionGDB2.0 ID: 8363
HgeneTgene
Gene symbol

ATRX

ZNF304

Gene ID

546

57343

Gene nameATRX chromatin remodelerzinc finger protein 304
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HX-
Cytomap

Xq21.1

19q13.43

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)zinc finger protein 304KRAB-containing zinc finger protein
Modification date2020031320200313
UniProtAcc

P46100

.
Ensembl transtripts involved in fusion geneENST idsENST00000373344, ENST00000395603, 
ENST00000480283, ENST00000373341, 
ENST00000282286, ENST00000391705, 
ENST00000443917, ENST00000598744, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 13 X 9=19891 X 2 X 1=2
# samples 232
** MAII scorelog2(23/1989*10)=-3.11233750988937
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATRX [Title/Abstract] AND ZNF304 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATRX(77041468)-ZNF304(57865093), # samples:3
Anticipated loss of major functional domain due to fusion event.ATRX-ZNF304 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-ZNF304 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-ZNF304 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-ZNF304 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253

TgeneZNF304

GO:0045944

positive regulation of transcription by RNA polymerase II

26081979


check buttonFusion gene breakpoints across ATRX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF304 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-CS-6290-01AATRXchrX

77041468

-ZNF304chr19

57865093

+
ChimerDB4LGGTCGA-CS-6290ATRXchrX

77041468

-ZNF304chr19

57862889

+
ChimerDB4LGGTCGA-CS-6290ATRXchrX

77041468

-ZNF304chr19

57865093

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373344ATRXchrX77041468-ENST00000391705ZNF304chr1957865093+42312353132181622
ENST00000395603ATRXchrX77041468-ENST00000391705ZNF304chr1957865093+42312353132181622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373344ENST00000391705ATRXchrX77041468-ZNF304chr1957865093+0.0041039030.9958961
ENST00000395603ENST00000391705ATRXchrX77041468-ZNF304chr1957865093+0.0041039030.9958961

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8363_8363_1_ATRX-ZNF304_ATRX_chrX_77041468_ENST00000373344_ZNF304_chr19_57865093_ENST00000391705_length(amino acids)=622AA_BP=1
MYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFS
FSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDY
DGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHY
TCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECG
KFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRK
DTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQH

--------------------------------------------------------------

>8363_8363_2_ATRX-ZNF304_ATRX_chrX_77041468_ENST00000395603_ZNF304_chr19_57865093_ENST00000391705_length(amino acids)=622AA_BP=1
MYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFS
FSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDY
DGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHY
TCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECG
KFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRK
DTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:77041468/chr19:57865093)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRX

P46100

.
FUNCTION: Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF304chrX:77041468chr19:57865093ENST000002822860314_8811.0660.0DomainKRAB
TgeneZNF304chrX:77041468chr19:57865093ENST000003917051414_8811.0660.0DomainKRAB
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603115_13911.0660.0Zinc fingerC2H2-type 2
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603251_27311.0660.0Zinc fingerC2H2-type 3
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603279_30111.0660.0Zinc fingerC2H2-type 4
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603307_32911.0660.0Zinc fingerC2H2-type 5
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603335_35711.0660.0Zinc fingerC2H2-type 6
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603363_38511.0660.0Zinc fingerC2H2-type 7
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603391_41311.0660.0Zinc fingerC2H2-type 8
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603419_44111.0660.0Zinc fingerC2H2-type 9
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603447_46911.0660.0Zinc fingerC2H2-type 10
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603475_49711.0660.0Zinc fingerC2H2-type 11
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603503_52511.0660.0Zinc fingerC2H2-type 12
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603531_55311.0660.0Zinc fingerC2H2-type 13
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603559_58111.0660.0Zinc fingerC2H2-type 14
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603587_60911.0660.0Zinc fingerC2H2-type 15
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603615_63711.0660.0Zinc fingerC2H2-type 16
TgeneZNF304chrX:77041468chr19:57865093ENST000002822860389_11111.0660.0Zinc fingerC2H2-type 1
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514115_13911.0660.0Zinc fingerC2H2-type 2
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514251_27311.0660.0Zinc fingerC2H2-type 3
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514279_30111.0660.0Zinc fingerC2H2-type 4
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514307_32911.0660.0Zinc fingerC2H2-type 5
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514335_35711.0660.0Zinc fingerC2H2-type 6
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514363_38511.0660.0Zinc fingerC2H2-type 7
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514391_41311.0660.0Zinc fingerC2H2-type 8
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514419_44111.0660.0Zinc fingerC2H2-type 9
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514447_46911.0660.0Zinc fingerC2H2-type 10
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514475_49711.0660.0Zinc fingerC2H2-type 11
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514503_52511.0660.0Zinc fingerC2H2-type 12
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514531_55311.0660.0Zinc fingerC2H2-type 13
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514559_58111.0660.0Zinc fingerC2H2-type 14
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514587_60911.0660.0Zinc fingerC2H2-type 15
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514615_63711.0660.0Zinc fingerC2H2-type 16
TgeneZNF304chrX:77041468chr19:57865093ENST000003917051489_11111.0660.0Zinc fingerC2H2-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351151_11566.6666666666666672493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351166_11696.6666666666666672493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351202_12066.6666666666666672493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351259_12666.6666666666666672493.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351443_14666.6666666666666672493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351499_15026.6666666666666672493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351929_19396.6666666666666672493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351941_19486.6666666666666672493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352222_22256.6666666666666672493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352262_22656.6666666666666672493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352420_24256.6666666666666672493.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135745_7506.6666666666666672493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341151_11566.6666666666666672455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341166_11696.6666666666666672455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341202_12066.6666666666666672455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341259_12666.6666666666666672455.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341443_14666.6666666666666672455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341499_15026.6666666666666672455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341929_19396.6666666666666672455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341941_19486.6666666666666672455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342222_22256.6666666666666672455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342262_22656.6666666666666672455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342420_24256.6666666666666672455.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134745_7506.6666666666666672455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351581_17686.6666666666666672493.0DomainHelicase ATP-binding
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135159_2966.6666666666666672493.0DomainADD
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352025_22056.6666666666666672493.0DomainHelicase C-terminal
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341581_17686.6666666666666672455.0DomainHelicase ATP-binding
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134159_2966.6666666666666672455.0DomainADD
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342025_22056.6666666666666672455.0DomainHelicase C-terminal
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351719_17226.6666666666666672493.0MotifNote=DEGH box
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135581_5946.6666666666666672493.0MotifNote=PxVxL motif
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341719_17226.6666666666666672455.0MotifNote=DEGH box
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134581_5946.6666666666666672455.0MotifNote=PxVxL motif
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351594_16016.6666666666666672493.0Nucleotide bindingATP
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341594_16016.6666666666666672455.0Nucleotide bindingATP
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135170_2066.6666666666666672493.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135217_2726.6666666666666672493.0Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134170_2066.6666666666666672455.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134217_2726.6666666666666672455.0Zinc fingerPHD-type%3B atypical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1308_ATRX_77041468_ZNF304_57865093_1308_ATRX_77041468_ZNF304_57865093_ranked_0.pdbATRX7704146877041468ENST00000391705ZNF304chr1957865093+
MYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFS
FSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDY
DGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHY
TCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECG
KFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRK
DTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQH
622


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ATRX_pLDDT.png
all structure
all structure
ZNF304_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATRX
ZNF304


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351189_13266.6666666666666672493.0DAXX
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341189_13266.6666666666666672455.0DAXX
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352010_22806.6666666666666672493.0MECP2
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342010_22806.6666666666666672455.0MECP2


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Related Drugs to ATRX-ZNF304


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATRX-ZNF304


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource