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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLIT3-ITPR2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLIT3-ITPR2
FusionPDB ID: 83673
FusionGDB2.0 ID: 83673
HgeneTgene
Gene symbol

SLIT3

ITPR2

Gene ID

6586

3709

Gene nameslit guidance ligand 3inositol 1,4,5-trisphosphate receptor type 2
SynonymsMEGF5|SLIL2|SLIT1|Slit-3|slit2ANHD|CFAP48|INSP3R2|IP3R2
Cytomap

5q34-q35.1

12p11.23

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3inositol 1,4,5-trisphosphate receptor type 2IP3 receptorIP3R 2cilia and flagella associated protein 48type 2 InsP3 receptor
Modification date2020031320200313
UniProtAcc.

Q14571

Ensembl transtripts involved in fusion geneENST idsENST00000332966, ENST00000404867, 
ENST00000519560, ENST00000521130, 
ENST00000242737, ENST00000545902, 
ENST00000381340, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 5=27027 X 21 X 12=6804
# samples 827
** MAII scorelog2(8/270*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/6804*10)=-4.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLIT3 [Title/Abstract] AND ITPR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLIT3(168620483)-ITPR2(26943160), # samples:3
Anticipated loss of major functional domain due to fusion event.SLIT3-ITPR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT3-ITPR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT3-ITPR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT3-ITPR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT3

GO:0007411

axon guidance

11748139

HgeneSLIT3

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT3

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT3

GO:0050919

negative chemotaxis

11748139

TgeneITPR2

GO:0001666

response to hypoxia

19120137


check buttonFusion gene breakpoints across SLIT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITPR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KZ-01ASLIT3chr5

168620483

-ITPR2chr12

26943160

-
ChimerDB4SARCTCGA-RN-AAAQ-01ASLIT3chr5

168620483

-ITPR2chr12

26943160

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000519560SLIT3chr5168620483-ENST00000381340ITPR2chr1226943160-1083583341188462811
ENST00000332966SLIT3chr5168620483-ENST00000381340ITPR2chr1226943160-104884866484992811
ENST00000404867SLIT3chr5168620483-ENST00000381340ITPR2chr1226943160-10415413084262808

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000519560ENST00000381340SLIT3chr5168620483-ITPR2chr1226943160-0.0006976620.9993024
ENST00000332966ENST00000381340SLIT3chr5168620483-ITPR2chr1226943160-0.0004437890.99955624
ENST00000404867ENST00000381340SLIT3chr5168620483-ITPR2chr1226943160-0.0003936890.9996063

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83673_83673_1_SLIT3-ITPR2_SLIT3_chr5_168620483_ENST00000332966_ITPR2_chr12_26943160_ENST00000381340_length(amino acids)=2811AA_BP=141
MHTMAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNL
RVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQK
QYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSW
FYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKF
LTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTS
KKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFA
IVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFG
ILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHI
TAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDS
NKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRD
PQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFS
ELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTK
LKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRV
LIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGE
EPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHT
FLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDM
VMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVK
IAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFI
QLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYR
NIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVE
EGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIA
LLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEA
SSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLD
CICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLA
IMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALK
YYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWG
SISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKI
VFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFS
IIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGV
GDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMW
HYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKN

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>83673_83673_2_SLIT3-ITPR2_SLIT3_chr5_168620483_ENST00000404867_ITPR2_chr12_26943160_ENST00000381340_length(amino acids)=2808AA_BP=138
MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVL
HLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYW
KAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYI
HPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTC
DEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKK
RQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVS
VPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILK
APFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAK
EIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKE
PHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQE
SVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELL
RLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKI
IEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIH
LIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPI
EESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQ
NFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMT
ELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAY
VNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLL
QSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNII
EKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGN
TLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLE
GGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSA
TSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCIC
GSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIME
SRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYA
NHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSIS
FNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFL
VSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIG
FLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDV
LRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYL
YFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQR

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>83673_83673_3_SLIT3-ITPR2_SLIT3_chr5_168620483_ENST00000519560_ITPR2_chr12_26943160_ENST00000381340_length(amino acids)=2811AA_BP=141
MHTMAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNL
RVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQK
QYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSW
FYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKF
LTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTS
KKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFA
IVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFG
ILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHI
TAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDS
NKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRD
PQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFS
ELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTK
LKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRV
LIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGE
EPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHT
FLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDM
VMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVK
IAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFI
QLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYR
NIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVE
EGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIA
LLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEA
SSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLD
CICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLA
IMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALK
YYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWG
SISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKI
VFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFS
IIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGV
GDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMW
HYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:168620483/chr12:26943160)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITPR2

Q14571

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250|UniProtKB:Q9Z329}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-43634_61137.666666666666661473.0DomainNote=LRRNT
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-43634_61137.666666666666661524.0DomainNote=LRRNT
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436110_131137.666666666666661473.0RepeatNote=LRR 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-43662_83137.666666666666661473.0RepeatNote=LRR 1
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-43686_107137.666666666666661473.0RepeatNote=LRR 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436110_131137.666666666666661524.0RepeatNote=LRR 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-43662_83137.666666666666661524.0RepeatNote=LRR 1
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-43686_107137.666666666666661524.0RepeatNote=LRR 2
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706112_16630.666666666666668182.0DomainMIR 1
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706173_22330.666666666666668182.0DomainMIR 2
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706231_28730.666666666666668182.0DomainMIR 3
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706294_37230.666666666666668182.0DomainMIR 4
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706378_43430.666666666666668182.0DomainMIR 5
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057112_16630.6666666666666682702.0DomainMIR 1
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057173_22330.6666666666666682702.0DomainMIR 2
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057231_28730.6666666666666682702.0DomainMIR 3
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057294_37230.6666666666666682702.0DomainMIR 4
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057378_43430.6666666666666682702.0DomainMIR 5
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706265_26930.666666666666668182.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706507_51030.666666666666668182.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneITPR2chr5:168620483chr12:26943160ENST0000024273706567_56930.666666666666668182.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057265_26930.6666666666666682702.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057507_51030.6666666666666682702.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneITPR2chr5:168620483chr12:26943160ENST00000381340057567_56930.6666666666666682702.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062249_226030.666666666666668182.0Topological domainExtracellular
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062282_230730.666666666666668182.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062329_235130.666666666666668182.0Topological domainExtracellular
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062373_239430.666666666666668182.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062416_252130.666666666666668182.0Topological domainExtracellular
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062543_270130.666666666666668182.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572249_226030.6666666666666682702.0Topological domainExtracellular
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572282_230730.6666666666666682702.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572329_235130.6666666666666682702.0Topological domainExtracellular
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572373_239430.6666666666666682702.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572416_252130.6666666666666682702.0Topological domainExtracellular
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572543_270130.6666666666666682702.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062228_224830.666666666666668182.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062261_228130.666666666666668182.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062308_232830.666666666666668182.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062352_237230.666666666666668182.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062395_241530.666666666666668182.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737062522_254230.666666666666668182.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572228_224830.6666666666666682702.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572261_228130.6666666666666682702.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572308_232830.6666666666666682702.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572352_237230.6666666666666682702.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572395_241530.6666666666666682702.0TransmembraneHelical
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400572522_254230.6666666666666682702.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361034_1072137.666666666666661473.0DomainEGF-like 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361074_1110137.666666666666661473.0DomainEGF-like 5
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361119_1155137.666666666666661473.0DomainEGF-like 6
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361158_1332137.666666666666661473.0DomainLaminin G-like
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361340_1365137.666666666666661473.0DomainEGF-like 7
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361368_1403137.666666666666661473.0DomainEGF-like 8
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361408_1444137.666666666666661473.0DomainEGF-like 9
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-4361449_1523137.666666666666661473.0DomainCTCK
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436215_265137.666666666666661473.0DomainNote=LRRCT 1
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436271_307137.666666666666661473.0DomainNote=LRRNT 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436437_487137.666666666666661473.0DomainNote=LRRCT 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436496_532137.666666666666661473.0DomainNote=LRRNT 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436663_713137.666666666666661473.0DomainNote=LRRCT 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436716_752137.666666666666661473.0DomainNote=LRRNT 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436857_907137.666666666666661473.0DomainNote=LRRCT 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436918_953137.666666666666661473.0DomainEGF-like 1
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436955_994137.666666666666661473.0DomainEGF-like 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436996_1032137.666666666666661473.0DomainEGF-like 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361034_1072137.666666666666661524.0DomainEGF-like 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361074_1110137.666666666666661524.0DomainEGF-like 5
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361119_1155137.666666666666661524.0DomainEGF-like 6
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361158_1332137.666666666666661524.0DomainLaminin G-like
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361340_1365137.666666666666661524.0DomainEGF-like 7
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361368_1403137.666666666666661524.0DomainEGF-like 8
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361408_1444137.666666666666661524.0DomainEGF-like 9
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-4361449_1523137.666666666666661524.0DomainCTCK
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436215_265137.666666666666661524.0DomainNote=LRRCT 1
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436271_307137.666666666666661524.0DomainNote=LRRNT 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436437_487137.666666666666661524.0DomainNote=LRRCT 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436496_532137.666666666666661524.0DomainNote=LRRNT 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436663_713137.666666666666661524.0DomainNote=LRRCT 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436716_752137.666666666666661524.0DomainNote=LRRNT 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436857_907137.666666666666661524.0DomainNote=LRRCT 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436918_953137.666666666666661524.0DomainEGF-like 1
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436955_994137.666666666666661524.0DomainEGF-like 2
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436996_1032137.666666666666661524.0DomainEGF-like 3
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436134_155137.666666666666661473.0RepeatNote=LRR 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436158_179137.666666666666661473.0RepeatNote=LRR 5
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436182_203137.666666666666661473.0RepeatNote=LRR 6
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436308_329137.666666666666661473.0RepeatNote=LRR 7
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436332_353137.666666666666661473.0RepeatNote=LRR 8
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436356_377137.666666666666661473.0RepeatNote=LRR 9
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436380_401137.666666666666661473.0RepeatNote=LRR 10
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436404_425137.666666666666661473.0RepeatNote=LRR 11
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436533_554137.666666666666661473.0RepeatNote=LRR 12
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436558_579137.666666666666661473.0RepeatNote=LRR 13
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436582_603137.666666666666661473.0RepeatNote=LRR 14
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436606_627137.666666666666661473.0RepeatNote=LRR 15
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436630_651137.666666666666661473.0RepeatNote=LRR 16
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436753_775137.666666666666661473.0RepeatNote=LRR 17
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436776_797137.666666666666661473.0RepeatNote=LRR 18
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436800_821137.666666666666661473.0RepeatNote=LRR 19
HgeneSLIT3chr5:168620483chr12:26943160ENST00000404867-436824_845137.666666666666661473.0RepeatNote=LRR 20
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436134_155137.666666666666661524.0RepeatNote=LRR 4
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436158_179137.666666666666661524.0RepeatNote=LRR 5
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436182_203137.666666666666661524.0RepeatNote=LRR 6
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436308_329137.666666666666661524.0RepeatNote=LRR 7
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436332_353137.666666666666661524.0RepeatNote=LRR 8
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436356_377137.666666666666661524.0RepeatNote=LRR 9
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436380_401137.666666666666661524.0RepeatNote=LRR 10
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436404_425137.666666666666661524.0RepeatNote=LRR 11
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436533_554137.666666666666661524.0RepeatNote=LRR 12
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436558_579137.666666666666661524.0RepeatNote=LRR 13
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436582_603137.666666666666661524.0RepeatNote=LRR 14
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436606_627137.666666666666661524.0RepeatNote=LRR 15
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436630_651137.666666666666661524.0RepeatNote=LRR 16
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436753_775137.666666666666661524.0RepeatNote=LRR 17
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436776_797137.666666666666661524.0RepeatNote=LRR 18
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436800_821137.666666666666661524.0RepeatNote=LRR 19
HgeneSLIT3chr5:168620483chr12:26943160ENST00000519560-436824_845137.666666666666661524.0RepeatNote=LRR 20
TgeneITPR2chr5:168620483chr12:26943160ENST00000242737061_222730.666666666666668182.0Topological domainCytoplasmic
TgeneITPR2chr5:168620483chr12:26943160ENST000003813400571_222730.6666666666666682702.0Topological domainCytoplasmic


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLIT3_pLDDT.png
all structure
all structure
ITPR2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLIT3
ITPR2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLIT3-ITPR2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLIT3-ITPR2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneITPR2C0003132Anoxic Encephalopathy1CTD_human
TgeneITPR2C0018800Cardiomegaly1CTD_human
TgeneITPR2C0995195Anoxia of brain1CTD_human
TgeneITPR2C1140716Hypoxic Brain Damage1CTD_human
TgeneITPR2C1383860Cardiac Hypertrophy1CTD_human
TgeneITPR2C1527348Brain Hypoxia1CTD_human
TgeneITPR2C1862871ANHIDROSIS, ISOLATED, WITH NORMAL SWEAT GLANDS1CTD_human;ORPHANET;UNIPROT