UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SOS1-MAP4K3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SOS1-MAP4K3
FusionPDB ID: 85262
FusionGDB2.0 ID: 85262
HgeneTgene
Gene symbol

SOS1

MAP4K3

Gene ID

6654

8491

Gene nameSOS Ras/Rac guanine nucleotide exchange factor 1mitogen-activated protein kinase kinase kinase kinase 3
SynonymsGF1|GGF1|GINGF|HGF|NS4|SOS-1GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1
Cytomap

2p22.1

2p22.1

Type of geneprotein-codingprotein-coding
Descriptionson of sevenless homolog 1gingival fibromatosis, hereditary, 1guanine nucleotide exchange factormitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase
Modification date2020032720200313
UniProtAcc.

Q8IVH8

Ensembl transtripts involved in fusion geneENST idsENST00000395038, ENST00000402219, 
ENST00000426016, ENST00000428721, 
ENST00000472480, 		ENST00000341681, 
ENST00000437545, ENST00000484274, 
ENST00000536018, ENST00000474502, 
ENST00000263881, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 12 X 9=9728 X 8 X 7=448
# samples 1411
** MAII scorelog2(14/972*10)=-2.79552948666081
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/448*10)=-2.02599520853294
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SOS1 [Title/Abstract] AND MAP4K3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SOS1(39278285)-MAP4K3(39605264), # samples:3
SOS1(39283843)-MAP4K3(39605264), # samples:3
Anticipated loss of major functional domain due to fusion event.SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP4K3

GO:0006468

protein phosphorylation

9275185

TgeneMAP4K3

GO:0009411

response to UV

9275185

TgeneMAP4K3

GO:0034612

response to tumor necrosis factor

9275185

TgeneMAP4K3

GO:0035556

intracellular signal transduction

9275185


check buttonFusion gene breakpoints across SOS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP4K3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8238-01ASOS1chr2

39347477

-MAP4K3chr2

39542529

-
ChimerDB4TGCTTCGA-XE-AANR-01ASOS1chr2

39278285

-MAP4K3chr2

39605264

-
ChimerDB4TGCTTCGA-XE-AANRSOS1chr2

39278285

-MAP4K3chr2

39605264

-
ChimerDB4THCATCGA-EL-A3H8-01ASOS1chr2

39283843

-MAP4K3chr2

39605264

-
ChimerDB4THCATCGA-EL-A3H8SOS1chr2

39283842

-MAP4K3chr2

39605264

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402219SOS1chr239278285-ENST00000263881MAP4K3chr239605264-48469054134931150
ENST00000395038SOS1chr239278285-ENST00000263881MAP4K3chr239605264-48338922834801150
ENST00000402219SOS1chr239283843-ENST00000263881MAP4K3chr239605264-44925514131391032
ENST00000395038SOS1chr239283843-ENST00000263881MAP4K3chr239605264-44795382831261032
ENST00000402219SOS1chr239283842-ENST00000263881MAP4K3chr239605264-44925514131391032
ENST00000395038SOS1chr239283842-ENST00000263881MAP4K3chr239605264-44795382831261032
ENST00000402219SOS1chr239347477-ENST00000263881MAP4K3chr239542529-3247128411894617
ENST00000402219SOS1chr239347477-ENST00000437545MAP4K3chr239542529-3172128411831596
ENST00000402219SOS1chr239347477-ENST00000341681MAP4K3chr239542529-3167128411831596
ENST00000395038SOS1chr239347477-ENST00000263881MAP4K3chr239542529-3234115281881617
ENST00000395038SOS1chr239347477-ENST00000437545MAP4K3chr239542529-3159115281818596
ENST00000395038SOS1chr239347477-ENST00000341681MAP4K3chr239542529-3154115281818596

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402219ENST00000263881SOS1chr239278285-MAP4K3chr239605264-4.73E-050.9999528
ENST00000395038ENST00000263881SOS1chr239278285-MAP4K3chr239605264-4.66E-050.9999534
ENST00000402219ENST00000263881SOS1chr239283843-MAP4K3chr239605264-7.14E-050.9999286
ENST00000395038ENST00000263881SOS1chr239283843-MAP4K3chr239605264-7.05E-050.9999294
ENST00000402219ENST00000263881SOS1chr239283842-MAP4K3chr239605264-7.14E-050.9999286
ENST00000395038ENST00000263881SOS1chr239283842-MAP4K3chr239605264-7.05E-050.9999294
ENST00000402219ENST00000263881SOS1chr239347477-MAP4K3chr239542529-0.000354160.9996458
ENST00000402219ENST00000437545SOS1chr239347477-MAP4K3chr239542529-0.0004630590.999537
ENST00000402219ENST00000341681SOS1chr239347477-MAP4K3chr239542529-0.0004505490.99954945
ENST00000395038ENST00000263881SOS1chr239347477-MAP4K3chr239542529-0.0003490580.99965096
ENST00000395038ENST00000437545SOS1chr239347477-MAP4K3chr239542529-0.0004588560.99954116
ENST00000395038ENST00000341681SOS1chr239347477-MAP4K3chr239542529-0.0004474410.99955255

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85262_85262_1_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1150AA_BP=288
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT
DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV
TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL
CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE
LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD
LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM
SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG
CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV
AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE
YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV

--------------------------------------------------------------

>85262_85262_2_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1150AA_BP=288
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT
DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV
TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL
CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE
LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD
LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM
SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG
CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV
AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE
YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV

--------------------------------------------------------------

>85262_85262_3_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------

>85262_85262_4_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------

>85262_85262_5_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------

>85262_85262_6_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------

>85262_85262_7_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=617AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYY
TARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQG
TIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGAC
FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR
QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEM
LVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFD

--------------------------------------------------------------

>85262_85262_8_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------

>85262_85262_9_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------

>85262_85262_10_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=617AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYY
TARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQG
TIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGAC
FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR
QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEM
LVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFD

--------------------------------------------------------------

>85262_85262_11_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------

>85262_85262_12_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39278285/chr2:39605264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP4K3

Q8IVH8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP4K3chr2:39278285chr2:39605264ENST00000263881034556_86732.0895.0DomainCNH
TgeneMAP4K3chr2:39278285chr2:39605264ENST00000341681033556_86732.0874.0DomainCNH
TgeneMAP4K3chr2:39283842chr2:39605264ENST00000263881034556_86732.0895.0DomainCNH
TgeneMAP4K3chr2:39283842chr2:39605264ENST00000341681033556_86732.0874.0DomainCNH
TgeneMAP4K3chr2:39283843chr2:39605264ENST00000263881034556_86732.0895.0DomainCNH
TgeneMAP4K3chr2:39283843chr2:39605264ENST00000341681033556_86732.0874.0DomainCNH
TgeneMAP4K3chr2:39347477chr2:39542529ENST000002638811134556_867306.0895.0DomainCNH
TgeneMAP4K3chr2:39347477chr2:39542529ENST000003416811133556_867306.0874.0DomainCNH

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-6231258_1261288.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-7241258_1261288.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-4231258_1261170.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-5241258_1261170.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-4231258_1261170.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-5241258_1261170.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-1231258_126129.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-2241258_126129.01334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623200_390288.01334.0DomainDH
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623444_548288.01334.0DomainPH
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623597_741288.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623780_1019288.01334.0DomainRas-GEF
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724200_390288.01334.0DomainDH
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724444_548288.01334.0DomainPH
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724597_741288.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724780_1019288.01334.0DomainRas-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423200_390170.01334.0DomainDH
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423444_548170.01334.0DomainPH
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423597_741170.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423780_1019170.01334.0DomainRas-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524200_390170.01334.0DomainDH
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524444_548170.01334.0DomainPH
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524597_741170.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524780_1019170.01334.0DomainRas-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423200_390170.01334.0DomainDH
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423444_548170.01334.0DomainPH
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423597_741170.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423780_1019170.01334.0DomainRas-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524200_390170.01334.0DomainDH
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524444_548170.01334.0DomainPH
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524597_741170.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524780_1019170.01334.0DomainRas-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123200_39029.01334.0DomainDH
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123444_54829.01334.0DomainPH
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123597_74129.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123780_101929.01334.0DomainRas-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224200_39029.01334.0DomainDH
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224444_54829.01334.0DomainPH
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224597_74129.01334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224780_101929.01334.0DomainRas-GEF
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000026388103416_27332.0895.0DomainProtein kinase
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000034168103316_27332.0874.0DomainProtein kinase
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000026388103416_27332.0895.0DomainProtein kinase
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000034168103316_27332.0874.0DomainProtein kinase
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000026388103416_27332.0895.0DomainProtein kinase
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000034168103316_27332.0874.0DomainProtein kinase
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000263881113416_273306.0895.0DomainProtein kinase
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000341681113316_273306.0874.0DomainProtein kinase
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000026388103422_3032.0895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000034168103322_3032.0874.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000026388103422_3032.0895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000034168103322_3032.0874.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000026388103422_3032.0895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000034168103322_3032.0874.0Nucleotide bindingATP
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000263881113422_30306.0895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000341681113322_30306.0874.0Nucleotide bindingATP


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1889_SOS1_39278285_MAP4K3_39605264_ranked_0.pdbSOS13934747739278285ENST00000341681MAP4K3chr239605264-
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT
DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV
TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL
CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE
LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD
LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM
SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG
CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV
AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE
YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV
1150


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SOS1_pLDDT.png
all structure
all structure
MAP4K3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SOS1
MAP4K3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to SOS1-MAP4K3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SOS1-MAP4K3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource