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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TBC1D2-GABBR2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TBC1D2-GABBR2
	FusionPDB ID: 89350
	FusionGDB2.0 ID: 89350
		Hgene	Tgene
	Gene symbol	TBC1D2	GABBR2
	Gene ID	55357	9568
	Gene name	TBC1 domain family member 2	gamma-aminobutyric acid type B receptor subunit 2
	Synonyms	PARIS-1\|PARIS1\|TBC1D2A	EIEE59\|GABABR2\|GPR51\|GPRC3B\|HG20\|HRIHFB2099\|NDPLHS
	Cytomap	9q22.33	9q22.33
	Type of gene	protein-coding	protein-coding
	Description	TBC1 domain family member 2ATBC1 domain family, member 2Aarmusprostate antigen recognized and identified by SEREX 1	gamma-aminobutyric acid type B receptor subunit 2G-protein coupled receptor 51GABA-B receptor 2GABA-B receptor, R2 subunitGABA-B-R2GABA-BR2gamma-aminobutyric acid (GABA) B receptor, 2gamma-aminobutyric acid B receptor 2gb2
	Modification date	20200313	20200313
	UniProtAcc	.	O75899
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000342112, ENST00000375064, ENST00000375066, ENST00000493589, ENST00000375063,	ENST00000477471, ENST00000259455,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 2=18	8 X 8 X 5=320
	# samples	3	8
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TBC1D2 [Title/Abstract] AND GABBR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TBC1D2(100991234)-GABBR2(101258796), # samples:2
Anticipated loss of major functional domain due to fusion event.	TBC1D2-GABBR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TBC1D2-GABBR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TBC1D2	GO:0043547	positive regulation of GTPase activity	20116244
Tgene	GABBR2	GO:0007214	gamma-aminobutyric acid signaling pathway	9872316

Fusion gene breakpoints across TBC1D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GABBR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CN-4739-01A	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-
ChimerDB4	HNSC	TCGA-CN-4739	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375064	TBC1D2	chr9	100991234	-	ENST00000259455	GABBR2	chr9	101258796	-	5688	1017	30	3212	1060
ENST00000375066	TBC1D2	chr9	100991234	-	ENST00000259455	GABBR2	chr9	101258796	-	5741	1070	14	3265	1083

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375064	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-	0.001445734	0.9985543
ENST00000375066	ENST00000259455	TBC1D2	chr9	100991234	-	GABBR2	chr9	101258796	-	0.001458124	0.99854195

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89350_89350_1_TBC1D2-GABBR2_TBC1D2_chr9_100991234_ENST00000375064_GABBR2_chr9_101258796_ENST00000259455_length(amino acids)=1060AA_BP=329
MAAMEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDA
NPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAEL
EEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDS
PKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKVRNDLTGVLYGEDIEISDTESFSNDPCTSVK
KLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTIS
GKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGE
RMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKL
IKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIV
GGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKY
IGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVN
QASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEP

--------------------------------------------------------------

>89350_89350_2_TBC1D2-GABBR2_TBC1D2_chr9_100991234_ENST00000375066_GABBR2_chr9_101258796_ENST00000259455_length(amino acids)=1083AA_BP=352
MPAESPRFVPGGPADPSSLRSLRLAAMEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGW
KSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPAT
PDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSG
EPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKVRNDLTGV
LYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLL
AAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRI
ILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSAL
TILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRV
HAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLM
LFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR
RFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTD
GGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:100991234/chr9:101258796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GABBR2 O75899
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269\|PubMed:10075644, ECO:0000269\|PubMed:10328880, ECO:0000269\|PubMed:15617512, ECO:0000269\|PubMed:18165688, ECO:0000269\|PubMed:22660477, ECO:0000269\|PubMed:24305054, ECO:0000269\|PubMed:9872316, ECO:0000269\|PubMed:9872744, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

11_14

108.0

711.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

11_14

326.0

861.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

11_14

326.0

918.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

45_142

326.0

861.0

Domain

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

45_142

326.0

918.0

Domain

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

781_819

210.0

942.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

505_522

210.0

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

544_551

210.0

942.0

Topological domain

Extracellular

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

573_597

210.0

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

619_654

210.0

942.0

Topological domain

Extracellular

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

676_691

210.0

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

713_720

210.0

942.0

Topological domain

Extracellular

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

742_941

210.0

942.0

Topological domain

Cytoplasmic

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

484_504

210.0

942.0

Transmembrane

Helical%3B Name%3D1

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

523_543

210.0

942.0

Transmembrane

Helical%3B Name%3D2

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

552_572

210.0

942.0

Transmembrane

Helical%3B Name%3D3

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

598_618

210.0

942.0

Transmembrane

Helical%3B Name%3D4

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

655_675

210.0

942.0

Transmembrane

Helical%3B Name%3D5

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

692_712

210.0

942.0

Transmembrane

Helical%3B Name%3D6

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

721_741

210.0

942.0

Transmembrane

Helical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

298_416

108.0

711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

875_913

108.0

711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

298_416

469.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

875_913

469.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

298_416

326.0

861.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

875_913

326.0

861.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

298_416

326.0

918.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

875_913

326.0

918.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

11_14

469.0

Compositional bias

Note=Poly-Ser

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

45_142

108.0

711.0

Domain

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000342112

625_817

108.0

711.0

Domain

Rab-GAP TBC

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

45_142

469.0

Domain

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375063

625_817

469.0

Domain

Rab-GAP TBC

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375064

625_817

326.0

861.0

Domain

Rab-GAP TBC

Hgene

TBC1D2

chr9:100991234

chr9:101258796

ENST00000375066

625_817

326.0

918.0

Domain

Rab-GAP TBC

Tgene

GABBR2

chr9:100991234

chr9:101258796

ENST00000259455

42_483

210.0

942.0

Topological domain

Extracellular

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1853_TBC1D2_100991234_GABBR2_101258796_ranked_0.pdb	TBC1D2	100991234	100991234	ENST00000259455	GABBR2	chr9	101258796	-	MPAESPRFVPGGPADPSSLRSLRLAAMEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGW KSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPAT PDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSG EPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKVRNDLTGV LYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLL AAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRI ILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSAL TILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRV HAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLM LFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR RFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTD GGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMV	1083

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TBC1D2_pLDDT.png

GABBR2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TBC1D2
GABBR2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000342112	-	4	12	1_169	108.0	711.0	CADH1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375063	-	1	7	1_169	0	469.0	CADH1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000342112	-	4	12	295_433	108.0	711.0	RAC1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375063	-	1	7	295_433	0	469.0	RAC1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375064	-	5	13	295_433	326.0	861.0	RAC1
Hgene	TBC1D2	chr9:100991234	chr9:101258796	ENST00000375066	-	5	13	295_433	326.0	918.0	RAC1

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Related Drugs to TBC1D2-GABBR2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TBC1D2-GABBR2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source