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Fusion Protein:TRPC4AP-KCNB1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: TRPC4AP-KCNB1 | FusionPDB ID: 94346 | FusionGDB2.0 ID: 94346 | Hgene | Tgene | Gene symbol | TRPC4AP | KCNB1 | Gene ID | 26133 | 3745 |
| Gene name | transient receptor potential cation channel subfamily C member 4 associated protein | potassium voltage-gated channel subfamily B member 1 | |
| Synonyms | C20orf188|PPP1R158|TRRP4AP|TRUSS | DRK1|Kv2.1 | |
| Cytomap | 20q11.22 | 20q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | short transient receptor potential channel 4-associated proteinTNF-receptor ubiquitous scaffolding/signaling proteinTRP4-associated proteinprotein phosphatase 1, regulatory subunit 158trpc4-associated proteintumor necrosis factor receptor-associated | potassium voltage-gated channel subfamily B member 1delayed rectifier potassium channel 1potassium voltage-gated channel, Shab-related subfamily, member 1voltage-gated potassium channel subunit Kv2.1 | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | . | Q14721 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000252015, ENST00000451813, ENST00000432634, ENST00000539834, | ENST00000371741, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 30 X 25 X 10=7500 | 7 X 4 X 6=168 |
| # samples | 33 | 7 | |
| ** MAII score | log2(33/7500*10)=-4.50635266602479 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: TRPC4AP [Title/Abstract] AND KCNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TRPC4AP(33657099)-KCNB1(47991529), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | TRPC4AP-KCNB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRPC4AP-KCNB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRPC4AP-KCNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRPC4AP-KCNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRPC4AP | GO:0006511 | ubiquitin-dependent protein catabolic process | 20551172 |
| Hgene | TRPC4AP | GO:0016567 | protein ubiquitination | 20551172 |
| Tgene | KCNB1 | GO:0001508 | action potential | 19223394 |
| Tgene | KCNB1 | GO:0071805 | potassium ion transmembrane transport | 19074135|19223394 |
| Tgene | KCNB1 | GO:0090314 | positive regulation of protein targeting to membrane | 19074135 |
| Fusion gene breakpoints across TRPC4AP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KCNB1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LGG | TCGA-TM-A84H-01A | TRPC4AP | chr20 | 33657099 | - | KCNB1 | chr20 | 47991529 | - |
| ChimerDB4 | LGG | TCGA-TM-A84H | TRPC4AP | chr20 | 33657099 | - | KCNB1 | chr20 | 47991529 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000451813 | TRPC4AP | chr20 | 33657099 | - | ENST00000371741 | KCNB1 | chr20 | 47991529 | - | 11556 | 440 | 5 | 2449 | 814 |
| ENST00000252015 | TRPC4AP | chr20 | 33657099 | - | ENST00000371741 | KCNB1 | chr20 | 47991529 | - | 11620 | 504 | 69 | 2513 | 814 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000451813 | ENST00000371741 | TRPC4AP | chr20 | 33657099 | - | KCNB1 | chr20 | 47991529 | - | 0.000813226 | 0.9991868 |
| ENST00000252015 | ENST00000371741 | TRPC4AP | chr20 | 33657099 | - | KCNB1 | chr20 | 47991529 | - | 0.000828288 | 0.99917173 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >94346_94346_1_TRPC4AP-KCNB1_TRPC4AP_chr20_33657099_ENST00000252015_KCNB1_chr20_47991529_ENST00000371741_length(amino acids)=814AA_BP=145 MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST DNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHS TGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV IALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRT LSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRS MSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKV NFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEG QLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTR -------------------------------------------------------------- >94346_94346_2_TRPC4AP-KCNB1_TRPC4AP_chr20_33657099_ENST00000451813_KCNB1_chr20_47991529_ENST00000371741_length(amino acids)=814AA_BP=145 MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST DNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHS TGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV IALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRT LSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRS MSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKV NFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEG QLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33657099/chr20:47991529) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | KCNB1 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 517_520 | 189.0 | 859.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 701_706 | 189.0 | 859.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 365_376 | 189.0 | 859.0 | Intramembrane | Helical%3B Name%3DPore helix | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 377_384 | 189.0 | 859.0 | Intramembrane | Ontology_term=ECO:0000250 | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 377_382 | 189.0 | 859.0 | Motif | Selectivity filter | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 448_481 | 189.0 | 859.0 | Region | Self-association | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 209_228 | 189.0 | 859.0 | Topological domain | Extracellular | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 251_259 | 189.0 | 859.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 281_294 | 189.0 | 859.0 | Topological domain | Extracellular | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 317_330 | 189.0 | 859.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 352_364 | 189.0 | 859.0 | Topological domain | Extracellular | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 385_391 | 189.0 | 859.0 | Topological domain | Extracellular | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 421_858 | 189.0 | 859.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 187_208 | 189.0 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 229_250 | 189.0 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 260_280 | 189.0 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 295_316 | 189.0 | 859.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 331_351 | 189.0 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 392_420 | 189.0 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 59_75 | 189.0 | 859.0 | Region | Self-association | |
| Tgene | KCNB1 | chr20:33657099 | chr20:47991529 | ENST00000371741 | 0 | 2 | 1_186 | 189.0 | 859.0 | Topological domain | Cytoplasmic |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1591_TRPC4AP_33657099_KCNB1_47991529_ranked_0.pdb | TRPC4AP | 33657099 | 33657099 | ENST00000371741 | KCNB1 | chr20 | 47991529 | - | MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST DNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHS TGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV IALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRT LSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRS MSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKV NFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEG QLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTR | 814 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
TRPC4AP_pLDDT.png  |
KCNB1_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| TRPC4AP | |
| KCNB1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TRPC4AP | chr20:33657099 | chr20:47991529 | ENST00000252015 | - | 3 | 19 | 2_400 | 138.0 | 798.0 | TNFRSF1A |
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Related Drugs to TRPC4AP-KCNB1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TRPC4AP-KCNB1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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