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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UGP2-PLEKHM3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UGP2-PLEKHM3
	FusionPDB ID: 96655
	FusionGDB2.0 ID: 96655
		Hgene	Tgene
	Gene symbol	UGP2	PLEKHM3
	Gene ID	7360	389072
	Gene name	UDP-glucose pyrophosphorylase 2	pleckstrin homology domain containing M3
	Synonyms	EIEE83\|SVUGP2\|UDPG\|UDPGP\|UDPGP2\|UGP1\|UGPP1\|UGPP2\|pHC379	DAPR\|PLEKHM1L
	Cytomap	2p15	2q33.3
	Type of gene	protein-coding	protein-coding
	Description	UTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testi	pleckstrin homology domain-containing family M member 3PH domain-containing family M member 3differentiation associated protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000337130, ENST00000394417, ENST00000445915, ENST00000467648, ENST00000487469,	ENST00000389247, ENST00000427836, ENST00000457206,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 4 X 4=96	7 X 4 X 5=140
	# samples	6	6
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UGP2 [Title/Abstract] AND PLEKHM3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UGP2(64085070)-PLEKHM3(208795843), # samples:3
Anticipated loss of major functional domain due to fusion event.	UGP2-PLEKHM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UGP2-PLEKHM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UGP2-PLEKHM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UGP2-PLEKHM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across UGP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLEKHM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-56-8083-01A	UGP2	chr2	64085070	-	PLEKHM3	chr2	208795843	-
ChimerDB4	LUSC	TCGA-56-8083-01A	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-
ChimerDB4	LUSC	TCGA-56-8083	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394417	UGP2	chr2	64085070	+	ENST00000427836	PLEKHM3	chr2	208795843	-	1139	529	274	1122	282
ENST00000394417	UGP2	chr2	64085070	+	ENST00000389247	PLEKHM3	chr2	208795843	-	991	529	274	990	239
ENST00000394417	UGP2	chr2	64085070	+	ENST00000457206	PLEKHM3	chr2	208795843	-	2098	529	274	855	193
ENST00000467648	UGP2	chr2	64085070	+	ENST00000427836	PLEKHM3	chr2	208795843	-	1171	561	339	1154	271
ENST00000467648	UGP2	chr2	64085070	+	ENST00000389247	PLEKHM3	chr2	208795843	-	1023	561	339	1022	227
ENST00000467648	UGP2	chr2	64085070	+	ENST00000457206	PLEKHM3	chr2	208795843	-	2130	561	339	887	182
ENST00000337130	UGP2	chr2	64085070	+	ENST00000427836	PLEKHM3	chr2	208795843	-	1341	731	476	1324	282
ENST00000337130	UGP2	chr2	64085070	+	ENST00000389247	PLEKHM3	chr2	208795843	-	1193	731	476	1192	239
ENST00000337130	UGP2	chr2	64085070	+	ENST00000457206	PLEKHM3	chr2	208795843	-	2300	731	476	1057	193
ENST00000445915	UGP2	chr2	64085070	+	ENST00000427836	PLEKHM3	chr2	208795843	-	959	349	67	942	291
ENST00000445915	UGP2	chr2	64085070	+	ENST00000389247	PLEKHM3	chr2	208795843	-	811	349	67	810	248
ENST00000445915	UGP2	chr2	64085070	+	ENST00000457206	PLEKHM3	chr2	208795843	-	1918	349	67	675	202

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394417	ENST00000427836	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.007374264	0.9926258
ENST00000394417	ENST00000389247	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.004391861	0.99560815
ENST00000394417	ENST00000457206	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.004718867	0.99528116
ENST00000467648	ENST00000427836	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.008074791	0.9919252
ENST00000467648	ENST00000389247	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.004965312	0.9950347
ENST00000467648	ENST00000457206	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.005089355	0.99491066
ENST00000337130	ENST00000427836	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.004485013	0.9955149
ENST00000337130	ENST00000389247	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.002449977	0.9975501
ENST00000337130	ENST00000457206	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.003348439	0.9966516
ENST00000445915	ENST00000427836	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.009187211	0.9908127
ENST00000445915	ENST00000389247	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.003401227	0.9965988
ENST00000445915	ENST00000457206	UGP2	chr2	64085070	+	PLEKHM3	chr2	208795843	-	0.003556748	0.9964432

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96655_96655_1_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=239AA_BP=85
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF

--------------------------------------------------------------

>96655_96655_2_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=282AA_BP=85
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF
LGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEE

--------------------------------------------------------------

>96655_96655_3_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=193AA_BP=85
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIH

--------------------------------------------------------------

>96655_96655_4_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=239AA_BP=85
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF

--------------------------------------------------------------

>96655_96655_5_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=282AA_BP=85
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF
LGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEE

--------------------------------------------------------------

>96655_96655_6_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=193AA_BP=85
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIH

--------------------------------------------------------------

>96655_96655_7_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=248AA_BP=94
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ

--------------------------------------------------------------

>96655_96655_8_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=291AA_BP=94
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ
VIEGKLAPFLGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQR

--------------------------------------------------------------

>96655_96655_9_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=202AA_BP=94
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENT

--------------------------------------------------------------

>96655_96655_10_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=227AA_BP=74
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSH

--------------------------------------------------------------

>96655_96655_11_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=271AA_BP=74
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSH
VYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEACTMFELSYQN

--------------------------------------------------------------

>96655_96655_12_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=182AA_BP=74
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIHLPTCSRPRHYS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:64085070/chr2:208795843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000389247

669_722

564.0

718.0

Zinc finger

Note=Phorbol-ester/DAG-type

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000427836

669_722

564.0

762.0

Zinc finger

Note=Phorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000337130

113_116

85.0

509.0

Region

UTP binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000337130

115_116

85.0

509.0

Region

Substrate binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000337130

251_253

85.0

509.0

Region

Substrate binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000337130

457_508

85.0

509.0

Region

Note=Oligomerization

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000394417

113_116

74.0

498.0

Region

UTP binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000394417

115_116

74.0

498.0

Region

Substrate binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000394417

251_253

74.0

498.0

Region

Substrate binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000394417

457_508

74.0

498.0

Region

Note=Oligomerization

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000467648

113_116

74.0

498.0

Region

UTP binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000467648

115_116

74.0

498.0

Region

Substrate binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000467648

251_253

74.0

498.0

Region

Substrate binding

Hgene

UGP2

chr2:64085070

chr2:208795843

ENST00000467648

457_508

74.0

498.0

Region

Note=Oligomerization

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000389247

169_175

564.0

718.0

Compositional bias

Note=Poly-Gln

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000427836

169_175

564.0

762.0

Compositional bias

Note=Poly-Gln

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000389247

211_308

564.0

718.0

Domain

PH 1

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000389247

361_456

564.0

718.0

Domain

PH 2

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000427836

211_308

564.0

762.0

Domain

PH 1

Tgene

PLEKHM3

chr2:64085070

chr2:208795843

ENST00000427836

361_456

564.0

762.0

Domain

PH 2

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>513_UGP2_64085070_PLEKHM3_208795843_ranked_0.pdb	UGP2	64085070	64085070	ENST00000457206	PLEKHM3	chr2	208795843	-	MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ VIEGKLAPFLGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQR	291

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

UGP2_pLDDT.png

PLEKHM3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UGP2
PLEKHM3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to UGP2-PLEKHM3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to UGP2-PLEKHM3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source