UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ZC3H3-SCRIB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZC3H3-SCRIB
FusionPDB ID: 100561
FusionGDB2.0 ID: 100561
HgeneTgene
Gene symbol

ZC3H3

SCRIB

Gene ID

23144

23513

Gene namezinc finger CCCH-type containing 3scribble planar cell polarity protein
SynonymsSMICL|ZC3HDC3CRIB1|SCRB1|SCRIB1|Vartul
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3protein scribble homologscribbled homologscribbled planar cell polarity protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000262577, ENST00000546337, 
ENST00000320476, ENST00000356994, 
ENST00000377533, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 8 X 9=10083 X 3 X 3=27
# samples 173
** MAII scorelog2(17/1008*10)=-2.56788898736222
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZC3H3 [Title/Abstract] AND SCRIB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZC3H3(144547887)-SCRIB(144889183), # samples:1
Anticipated loss of major functional domain due to fusion event.ZC3H3-SCRIB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZC3H3-SCRIB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZC3H3-SCRIB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZC3H3-SCRIB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSCRIB

GO:0008283

cell proliferation

16965391

TgeneSCRIB

GO:0045930

negative regulation of mitotic cell cycle

16965391


check buttonFusion gene breakpoints across ZC3H3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SCRIB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8580-01AZC3H3chr8

144547887

-SCRIBchr8

144889183

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262577ZC3H3chr8144547887-ENST00000320476SCRIBchr8144889183-529723393250531673
ENST00000262577ZC3H3chr8144547887-ENST00000356994SCRIBchr8144889183-537223393251281698
ENST00000262577ZC3H3chr8144547887-ENST00000377533SCRIBchr8144889183-529123393250531673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262577ENST00000320476ZC3H3chr8144547887-SCRIBchr8144889183-0.0104561810.9895438
ENST00000262577ENST00000356994ZC3H3chr8144547887-SCRIBchr8144889183-0.0132566230.98674333
ENST00000262577ENST00000377533ZC3H3chr8144547887-SCRIBchr8144889183-0.0105999930.98939997

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100561_100561_1_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000320476_length(amino acids)=1673AA_BP=769
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH
AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT
DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP
LLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKLTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG
PAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPL
RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE
REAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVF
ISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR
DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGH
RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSP
PSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSP
AELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLE

--------------------------------------------------------------

>100561_100561_2_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000356994_length(amino acids)=1698AA_BP=769
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH
AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT
DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP
LLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKLTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG
PAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPL
RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE
REAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVF
ISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR
DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGH
RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSP
PSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSP
AELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAF

--------------------------------------------------------------

>100561_100561_3_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000377533_length(amino acids)=1673AA_BP=769
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH
AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT
DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP
LLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKLTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG
PAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPL
RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE
REAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVF
ISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR
DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGH
RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSP
PSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSP
AELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLE

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:144547887/chr8:144889183)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912382_391769.0949.0Compositional biasNote=Poly-Ser
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912667_695769.0949.0Zinc fingerC3H1-type 1
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912699_722769.0949.0Zinc fingerC3H1-type 2
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912723_749769.0949.0Zinc fingerC3H1-type 3
TgeneSCRIBchr8:144547887chr8:144889183ENST0000032047615361379_1419726.01631.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST0000035699415371379_1419726.01656.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST0000037753315361379_1419645.01550.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536656_701645.01550.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST0000032047615361296_1349726.01631.0Compositional biasNote=Pro-rich
TgeneSCRIBchr8:144547887chr8:144889183ENST0000035699415371296_1349726.01656.0Compositional biasNote=Pro-rich
TgeneSCRIBchr8:144547887chr8:144889183ENST0000037753315361296_1349645.01550.0Compositional biasNote=Pro-rich
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536660_695645.01550.0Compositional biasNote=Glu-rich
TgeneSCRIBchr8:144547887chr8:144889183ENST0000032047615361004_1093726.01631.0DomainPDZ 3
TgeneSCRIBchr8:144547887chr8:144889183ENST0000032047615361100_1194726.01631.0DomainPDZ 4
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536728_815726.01631.0DomainPDZ 1
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536862_950726.01631.0DomainPDZ 2
TgeneSCRIBchr8:144547887chr8:144889183ENST0000035699415371004_1093726.01656.0DomainPDZ 3
TgeneSCRIBchr8:144547887chr8:144889183ENST0000035699415371100_1194726.01656.0DomainPDZ 4
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537728_815726.01656.0DomainPDZ 1
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537862_950726.01656.0DomainPDZ 2
TgeneSCRIBchr8:144547887chr8:144889183ENST0000037753315361004_1093645.01550.0DomainPDZ 3
TgeneSCRIBchr8:144547887chr8:144889183ENST0000037753315361100_1194645.01550.0DomainPDZ 4
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536728_815645.01550.0DomainPDZ 1
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536862_950645.01550.0DomainPDZ 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912873_881769.0949.0Compositional biasNote=Poly-Ser
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912750_777769.0949.0Zinc fingerC3H1-type 4
HgeneZC3H3chr8:144547887chr8:144889183ENST00000262577-912778_800769.0949.0Zinc fingerC3H1-type 5
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536458_474726.01631.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536656_701726.01631.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537458_474726.01656.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537656_701726.01656.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536458_474645.01550.0Coiled coilOntology_term=ECO:0000255
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536660_695726.01631.0Compositional biasNote=Glu-rich
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537660_695726.01656.0Compositional biasNote=Glu-rich
TgeneSCRIBchr8:144547887chr8:144889183ENST0000032047615361_818726.01631.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
TgeneSCRIBchr8:144547887chr8:144889183ENST0000035699415371_818726.01656.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
TgeneSCRIBchr8:144547887chr8:144889183ENST0000037753315361_818645.01550.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536106_127726.01631.0RepeatNote=LRR 4
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536129_150726.01631.0RepeatNote=LRR 5
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536152_174726.01631.0RepeatNote=LRR 6
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536175_197726.01631.0RepeatNote=LRR 7
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536198_219726.01631.0RepeatNote=LRR 8
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536221_243726.01631.0RepeatNote=LRR 9
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536244_265726.01631.0RepeatNote=LRR 10
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536267_288726.01631.0RepeatNote=LRR 11
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536290_312726.01631.0RepeatNote=LRR 12
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536313_334726.01631.0RepeatNote=LRR 13
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536336_357726.01631.0RepeatNote=LRR 14
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536359_381726.01631.0RepeatNote=LRR 15
TgeneSCRIBchr8:144547887chr8:144889183ENST00000320476153637_58726.01631.0RepeatNote=LRR 1
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536382_402726.01631.0RepeatNote=LRR 16
TgeneSCRIBchr8:144547887chr8:144889183ENST00000320476153660_81726.01631.0RepeatNote=LRR 2
TgeneSCRIBchr8:144547887chr8:144889183ENST00000320476153683_104726.01631.0RepeatNote=LRR 3
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537106_127726.01656.0RepeatNote=LRR 4
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537129_150726.01656.0RepeatNote=LRR 5
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537152_174726.01656.0RepeatNote=LRR 6
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537175_197726.01656.0RepeatNote=LRR 7
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537198_219726.01656.0RepeatNote=LRR 8
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537221_243726.01656.0RepeatNote=LRR 9
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537244_265726.01656.0RepeatNote=LRR 10
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537267_288726.01656.0RepeatNote=LRR 11
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537290_312726.01656.0RepeatNote=LRR 12
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537313_334726.01656.0RepeatNote=LRR 13
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537336_357726.01656.0RepeatNote=LRR 14
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537359_381726.01656.0RepeatNote=LRR 15
TgeneSCRIBchr8:144547887chr8:144889183ENST00000356994153737_58726.01656.0RepeatNote=LRR 1
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537382_402726.01656.0RepeatNote=LRR 16
TgeneSCRIBchr8:144547887chr8:144889183ENST00000356994153760_81726.01656.0RepeatNote=LRR 2
TgeneSCRIBchr8:144547887chr8:144889183ENST00000356994153783_104726.01656.0RepeatNote=LRR 3
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536106_127645.01550.0RepeatNote=LRR 4
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536129_150645.01550.0RepeatNote=LRR 5
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536152_174645.01550.0RepeatNote=LRR 6
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536175_197645.01550.0RepeatNote=LRR 7
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536198_219645.01550.0RepeatNote=LRR 8
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536221_243645.01550.0RepeatNote=LRR 9
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536244_265645.01550.0RepeatNote=LRR 10
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536267_288645.01550.0RepeatNote=LRR 11
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536290_312645.01550.0RepeatNote=LRR 12
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536313_334645.01550.0RepeatNote=LRR 13
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536336_357645.01550.0RepeatNote=LRR 14
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536359_381645.01550.0RepeatNote=LRR 15
TgeneSCRIBchr8:144547887chr8:144889183ENST00000377533153637_58645.01550.0RepeatNote=LRR 1
TgeneSCRIBchr8:144547887chr8:144889183ENST000003775331536382_402645.01550.0RepeatNote=LRR 16
TgeneSCRIBchr8:144547887chr8:144889183ENST00000377533153660_81645.01550.0RepeatNote=LRR 2
TgeneSCRIBchr8:144547887chr8:144889183ENST00000377533153683_104645.01550.0RepeatNote=LRR 3


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZC3H3
SCRIB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSCRIBchr8:144547887chr8:144889183ENST000003204761536717_1229726.01631.0ARHGEF7
TgeneSCRIBchr8:144547887chr8:144889183ENST000003569941537717_1229726.01656.0ARHGEF7


Top

Related Drugs to ZC3H3-SCRIB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ZC3H3-SCRIB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource