UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
![]() |
|||||||
|
Fusion Protein:BRAF-CIITA |
Fusion Protein Summary |
![]() |
Fusion partner gene information | Fusion gene name: BRAF-CIITA | FusionPDB ID: 10118 | FusionGDB2.0 ID: 10118 | Hgene | Tgene | Gene symbol | BRAF | CIITA | Gene ID | 673 | 4261 |
Gene name | B-Raf proto-oncogene, serine/threonine kinase | class II major histocompatibility complex transactivator | |
Synonyms | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | C2TA|CIITAIV|MHC2TA|NLRA | |
Cytomap | 7q34 | 16p13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | MHC class II transactivatorMHC class II transactivator type IMHC class II transactivator type IIINLR family, acid domain containingnucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing | |
Modification date | 20200329 | 20200320 | |
UniProtAcc | P15056 | P33076 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000288602, | ENST00000537380, ENST00000324288, ENST00000381835, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 28 X 21 X 11=6468 | 7 X 7 X 6=294 |
# samples | 32 | 7 | |
** MAII score | log2(32/6468*10)=-4.3371758685863 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: BRAF [Title/Abstract] AND CIITA [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BRAF(140487348)-CIITA(10995371), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | BRAF-CIITA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-CIITA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-CIITA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-CIITA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BRAF | GO:0000186 | activation of MAPKK activity | 29433126 |
Hgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
Hgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
Hgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
Hgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
Hgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
Hgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
Hgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
Tgene | CIITA | GO:0034341 | response to interferon-gamma | 19041327 |
Tgene | CIITA | GO:0045345 | positive regulation of MHC class I biosynthetic process | 20639463 |
Tgene | CIITA | GO:0045892 | negative regulation of transcription, DNA-templated | 19041327 |
Tgene | CIITA | GO:0045893 | positive regulation of transcription, DNA-templated | 19041327 |
Tgene | CIITA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20639463 |
Tgene | CIITA | GO:0046677 | response to antibiotic | 107465 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
Top |
Fusion Gene Sample Information |
![]() |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | THCA | TCGA-EM-A3AQ-01A | BRAF | chr7 | 140487348 | - | CIITA | chr16 | 10995371 | + |
Top |
Fusion ORF Analysis |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000288602 | BRAF | chr7 | 140487348 | - | ENST00000324288 | CIITA | chr16 | 10995371 | + | 10107 | 1238 | 61 | 4194 | 1377 |
ENST00000288602 | BRAF | chr7 | 140487348 | - | ENST00000381835 | CIITA | chr16 | 10995371 | + | 3025 | 1238 | 61 | 2442 | 793 |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000288602 | ENST00000324288 | BRAF | chr7 | 140487348 | - | CIITA | chr16 | 10995371 | + | 0.001094813 | 0.9989052 |
ENST00000288602 | ENST00000381835 | BRAF | chr7 | 140487348 | - | CIITA | chr16 | 10995371 | + | 0.006972153 | 0.99302787 |
Top |
Fusion Amino Acid Sequences |
![]() |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >10118_10118_1_BRAF-CIITA_BRAF_chr7_140487348_ENST00000288602_CIITA_chr16_10995371_ENST00000324288_length(amino acids)=1377AA_BP=392 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGAFPEELPADLKHWKPAEPPTVVTGSLLVRPVSDCSTLPCLPLPALFNQEPASGQMRLE KTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPS ATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELA TPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADAL FELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSP PGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRK KRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRL SFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAK SLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQ LKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVE -------------------------------------------------------------- >10118_10118_2_BRAF-CIITA_BRAF_chr7_140487348_ENST00000288602_CIITA_chr16_10995371_ENST00000381835_length(amino acids)=793AA_BP=392 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGAFPEELPADLKHWKPVPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSS IFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPGLAWSPC LGLRPSLHRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPV SGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCIC -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140487348/chr16:10995371) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
BRAF | CIITA |
FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}. | FUNCTION: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215}. |
![]() |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 122_129 | 392.3333333333333 | 767.0 | Compositional bias | Note=Poly-Ser |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 6_11 | 392.3333333333333 | 767.0 | Compositional bias | Note=Poly-Gly |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 155_227 | 392.3333333333333 | 767.0 | Domain | RBD |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 234_280 | 392.3333333333333 | 767.0 | Zinc finger | Phorbol-ester/DAG-type |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 414_724 | 145.33333333333334 | 3032.6666666666665 | Domain | NACHT | |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 420_427 | 145.33333333333334 | 3032.6666666666665 | Nucleotide binding | Note=GTP | |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 1016_1037 | 145.33333333333334 | 3032.6666666666665 | Repeat | Note=LRR 2 | |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 1045_1066 | 145.33333333333334 | 3032.6666666666665 | Repeat | Note=LRR 3 | |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 1073_1093 | 145.33333333333334 | 3032.6666666666665 | Repeat | Note=LRR 4 | |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 985_1008 | 145.33333333333334 | 3032.6666666666665 | Repeat | Note=LRR 1 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 428_432 | 392.3333333333333 | 767.0 | Compositional bias | Note=Poly-Ser |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 457_717 | 392.3333333333333 | 767.0 | Domain | Protein kinase |
Hgene | BRAF | chr7:140487348 | chr16:10995371 | ENST00000288602 | - | 9 | 18 | 463_471 | 392.3333333333333 | 767.0 | Nucleotide binding | ATP |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 52_137 | 145.33333333333334 | 3032.6666666666665 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
Tgene | CIITA | chr7:140487348 | chr16:10995371 | ENST00000324288 | 4 | 20 | 94_132 | 145.33333333333334 | 3032.6666666666665 | Region | Note=Required for acetyltransferase activity |
Top |
Fusion Protein-Protein Interaction |
![]() |
![]() |
Gene | PPI interactors |
BRAF | YWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, Nedd4, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, Vps4b, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS, HSPA4, DNAJB6, PDCD11, PIP5K1A, DNAJC15, VANGL1, DNAJC11, FKBP5, HSPA4L, HSP90B1, GNAI2, DNAJC13, GNAS, PPP2CB, HSD11B2, DNAJB11, PLD2, RAP1B, WDR6, CPNE3, MYOF, COPA, UBLCP1, PPP1CA, RAD50, PIP4K2C, PHB, VIM, PGAM1, DNAJA1, MAP2K7, SPRY2, ALDOA, AP2B1, ATP5A1, SSB, IGF1R, JUP, PPP6C, PARP1, HSPB1, NME2, PRDX2, CCT7, RAB1A, FARSA, FASN, EPRS, TRAF2, REST, KIAA1429, NANOG, ITCH, SMURF2, WWP1, WWP2, PPP2CA, PPP2R2A, AURKA, LATS2, MAP2K3, MAP2K6, RASSF1, STK11, TERT, PEBP1, CRBN, FAR1, PSMC4, UBA52, UBB, UBC, RPS27A, HSPA6, HSP90AB3P, DSP, ATAD3A, ATAD3B, P4HB, SDF2L1, SLC25A22, SPTBN4, TMEM33, CTSB, NCL, HPX, TXNDC12, SLC25A11, NDUFA4, CTSV, FBP1, HSD17B3, ZNF189, ZNF510, KIF14, SRC, TRAP1, JTB, S100P, USP28, |
![]() |
Gene | STRING network |
BRAF | ![]() |
CIITA |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to BRAF-CIITA |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to BRAF-CIITA |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BRAF | C0025202 | melanoma | 24 | CGI;CTD_human;UNIPROT |
Hgene | BRAF | C1275081 | Cardio-facio-cutaneous syndrome | 14 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | BRAF | C0009402 | Colorectal Carcinoma | 8 | CTD_human;UNIPROT |
Hgene | BRAF | C0028326 | Noonan Syndrome | 8 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | BRAF | C0238463 | Papillary thyroid carcinoma | 8 | CTD_human;ORPHANET |
Hgene | BRAF | C0040136 | Thyroid Neoplasm | 6 | CGI;CTD_human |
Hgene | BRAF | C0151468 | Thyroid Gland Follicular Adenoma | 6 | CTD_human |
Hgene | BRAF | C0175704 | LEOPARD Syndrome | 6 | CLINGEN;GENOMICS_ENGLAND |
Hgene | BRAF | C0549473 | Thyroid carcinoma | 6 | CGI;CTD_human |
Hgene | BRAF | C3150970 | NOONAN SYNDROME 7 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | BRAF | C0009404 | Colorectal Neoplasms | 4 | CTD_human |
Hgene | BRAF | C3150971 | LEOPARD SYNDROME 3 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | BRAF | C1519086 | Pilomyxoid astrocytoma | 3 | ORPHANET |
Hgene | BRAF | C0004565 | Melanoma, B16 | 2 | CTD_human |
Hgene | BRAF | C0009075 | Melanoma, Cloudman S91 | 2 | CTD_human |
Hgene | BRAF | C0018598 | Melanoma, Harding-Passey | 2 | CTD_human |
Hgene | BRAF | C0023443 | Hairy Cell Leukemia | 2 | CGI;ORPHANET |
Hgene | BRAF | C0025205 | Melanoma, Experimental | 2 | CTD_human |
Hgene | BRAF | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | BRAF | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CGI;CTD_human |
Hgene | BRAF | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
Hgene | BRAF | C0587248 | Costello syndrome (disorder) | 2 | CLINGEN;CTD_human |
Hgene | BRAF | C3501843 | Nonmedullary Thyroid Carcinoma | 2 | CTD_human |
Hgene | BRAF | C3501844 | Familial Nonmedullary Thyroid Cancer | 2 | CTD_human |
Hgene | BRAF | C0002448 | Ameloblastoma | 1 | CTD_human |
Hgene | BRAF | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET |
Hgene | BRAF | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | BRAF | C0017638 | Glioma | 1 | CGI;CTD_human |
Hgene | BRAF | C0019621 | Histiocytosis, Langerhans-Cell | 1 | CGI;ORPHANET |
Hgene | BRAF | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Hgene | BRAF | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | BRAF | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
Hgene | BRAF | C0024694 | Mandibular Neoplasms | 1 | CTD_human |
Hgene | BRAF | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | BRAF | C0027962 | Melanocytic nevus | 1 | GENOMICS_ENGLAND |
Hgene | BRAF | C0036920 | Sezary Syndrome | 1 | CTD_human |
Hgene | BRAF | C0041409 | Turner Syndrome, Male | 1 | CTD_human |
Hgene | BRAF | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
Hgene | BRAF | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Hgene | BRAF | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
Hgene | BRAF | C0259783 | mixed gliomas | 1 | CTD_human |
Hgene | BRAF | C0278875 | Adult Craniopharyngioma | 1 | CTD_human |
Hgene | BRAF | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0334579 | Anaplastic astrocytoma | 1 | CGI;CTD_human |
Hgene | BRAF | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0334583 | Pilocytic Astrocytoma | 1 | CGI;CTD_human |
Hgene | BRAF | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
Hgene | BRAF | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
Hgene | BRAF | C0406803 | Syringocystadenoma Papilliferum | 1 | GENOMICS_ENGLAND |
Hgene | BRAF | C0431128 | Papillary craniopharyngioma | 1 | CTD_human |
Hgene | BRAF | C0431129 | Adamantinous Craniopharyngioma | 1 | CTD_human |
Hgene | BRAF | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
Hgene | BRAF | C0555198 | Malignant Glioma | 1 | CTD_human |
Hgene | BRAF | C0596263 | Carcinogenesis | 1 | CTD_human |
Hgene | BRAF | C0684249 | Carcinoma of lung | 1 | CGI;UNIPROT |
Hgene | BRAF | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
Hgene | BRAF | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0751061 | Craniopharyngioma, Child | 1 | CTD_human |
Hgene | BRAF | C0920269 | Microsatellite Instability | 1 | CTD_human |
Hgene | BRAF | C1527404 | Female Pseudo-Turner Syndrome | 1 | CTD_human |
Hgene | BRAF | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C1721098 | Replication Error Phenotype | 1 | CTD_human |
Hgene | BRAF | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | BRAF | C4551484 | Leopard Syndrome 1 | 1 | GENOMICS_ENGLAND |
Hgene | BRAF | C4551602 | Noonan Syndrome 1 | 1 | CTD_human |
Hgene | BRAF | C4721532 | Lymphoma, Non-Hodgkin, Familial | 1 | UNIPROT |
Hgene | BRAF | C4733333 | familial non-medullary thyroid cancer | 1 | GENOMICS_ENGLAND |