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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CAP1-KCNQ4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CAP1-KCNQ4
FusionPDB ID: 12813
FusionGDB2.0 ID: 12813
HgeneTgene
Gene symbol

CAP1

KCNQ4

Gene ID

10487

9132

Gene namecyclase associated actin cytoskeleton regulatory protein 1potassium voltage-gated channel subfamily Q member 4
SynonymsCAP|CAP1-PENDFNA2|DFNA2A|KV7.4
Cytomap

1p34.2

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionadenylyl cyclase-associated protein 1CAP, adenylate cyclase-associated protein 1adenylate cyclase associated protein 1testis secretory sperm-binding protein Li 218ppotassium voltage-gated channel subfamily KQT member 4potassium channel KQT-like 4potassium channel subunit alpha KvLQT4potassium channel, voltage gated KQT-like subfamily Q, member 4potassium voltage-gated channel, KQT-like subfamily, member 4
Modification date2020031320200329
UniProtAcc

Q01518

P56696

Ensembl transtripts involved in fusion geneENST idsENST00000340450, ENST00000372792, 
ENST00000372797, ENST00000372798, 
ENST00000372802, ENST00000372805, 
ENST00000479759, 		ENST00000506017, 
ENST00000347132, ENST00000509682, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 13 X 7=14563 X 3 X 3=27
# samples 193
** MAII scorelog2(19/1456*10)=-2.93793903186775
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CAP1 [Title/Abstract] AND KCNQ4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAP1(40527484)-KCNQ4(41285547), # samples:1
Anticipated loss of major functional domain due to fusion event.CAP1-KCNQ4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAP1-KCNQ4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAP1-KCNQ4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAP1-KCNQ4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNQ4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7235-01ACAP1chr1

40527484

+KCNQ4chr1

41285547

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372797CAP1chr140527484+ENST00000347132KCNQ4chr141285547+40388555342108524
ENST00000372797CAP1chr140527484+ENST00000509682KCNQ4chr141285547+19478555341946470
ENST00000372802CAP1chr140527484+ENST00000347132KCNQ4chr141285547+40318485272101524
ENST00000372802CAP1chr140527484+ENST00000509682KCNQ4chr141285547+19408485271939471
ENST00000372792CAP1chr140527484+ENST00000347132KCNQ4chr141285547+3543360481613521
ENST00000372792CAP1chr140527484+ENST00000509682KCNQ4chr141285547+1452360481451467
ENST00000372798CAP1chr140527484+ENST00000347132KCNQ4chr141285547+3537354451607520
ENST00000372798CAP1chr140527484+ENST00000509682KCNQ4chr141285547+1446354451445466
ENST00000340450CAP1chr140527484+ENST00000347132KCNQ4chr141285547+3533350441603519
ENST00000340450CAP1chr140527484+ENST00000509682KCNQ4chr141285547+1442350441441466
ENST00000372805CAP1chr140527484+ENST00000347132KCNQ4chr141285547+3528345361598520
ENST00000372805CAP1chr140527484+ENST00000509682KCNQ4chr141285547+1437345361436466

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372797ENST00000347132CAP1chr140527484+KCNQ4chr141285547+0.0138524860.9861476
ENST00000372797ENST00000509682CAP1chr140527484+KCNQ4chr141285547+0.0145618860.9854381
ENST00000372802ENST00000347132CAP1chr140527484+KCNQ4chr141285547+0.0176767670.9823232
ENST00000372802ENST00000509682CAP1chr140527484+KCNQ4chr141285547+0.0221846350.9778154
ENST00000372792ENST00000347132CAP1chr140527484+KCNQ4chr141285547+0.017541610.9824584
ENST00000372792ENST00000509682CAP1chr140527484+KCNQ4chr141285547+0.0071174280.9928826
ENST00000372798ENST00000347132CAP1chr140527484+KCNQ4chr141285547+0.0217623640.9782376
ENST00000372798ENST00000509682CAP1chr140527484+KCNQ4chr141285547+0.0108865890.98911345
ENST00000340450ENST00000347132CAP1chr140527484+KCNQ4chr141285547+0.021246420.97875357
ENST00000340450ENST00000509682CAP1chr140527484+KCNQ4chr141285547+0.0113705450.98862946
ENST00000372805ENST00000347132CAP1chr140527484+KCNQ4chr141285547+0.0170405540.9829594
ENST00000372805ENST00000509682CAP1chr140527484+KCNQ4chr141285547+0.0074954330.9925046

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12813_12813_1_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000340450_KCNQ4_chr1_41285547_ENST00000347132_length(amino acids)=519AA_BP=1
MRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERAL
LVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTD
MSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQ
RRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRS
IRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQV

--------------------------------------------------------------

>12813_12813_2_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000340450_KCNQ4_chr1_41285547_ENST00000509682_length(amino acids)=466AA_BP=1
MRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERAL
LVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTD
MSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPR
TSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRG
PGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVS

--------------------------------------------------------------

>12813_12813_3_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372792_KCNQ4_chr1_41285547_ENST00000347132_length(amino acids)=521AA_BP=1
MSRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLER
ALLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYS
TDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGS
SQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVI
RSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEK

--------------------------------------------------------------

>12813_12813_4_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372792_KCNQ4_chr1_41285547_ENST00000509682_length(amino acids)=467AA_BP=1
MSRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLER
ALLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYS
TDMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLK
PRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVG
RGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDIS

--------------------------------------------------------------

>12813_12813_5_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372797_KCNQ4_chr1_41285547_ENST00000347132_length(amino acids)=524AA_BP=5
MIAVRRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLK
LERALLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWR
LYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIR
MGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVK
TVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVK

--------------------------------------------------------------

>12813_12813_6_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372797_KCNQ4_chr1_41285547_ENST00000509682_length(amino acids)=470AA_BP=5
MIAVRRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLK
LERALLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWR
LYSTDMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASL
RLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQ
IVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHE

--------------------------------------------------------------

>12813_12813_7_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372798_KCNQ4_chr1_41285547_ENST00000347132_length(amino acids)=520AA_BP=1
MSRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERA
LLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYST
DMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSS
QRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIR
SIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQ

--------------------------------------------------------------

>12813_12813_8_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372798_KCNQ4_chr1_41285547_ENST00000509682_length(amino acids)=466AA_BP=1
MSRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERA
LLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYST
DMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKP
RTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGR
GPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISV

--------------------------------------------------------------

>12813_12813_9_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372802_KCNQ4_chr1_41285547_ENST00000347132_length(amino acids)=524AA_BP=5
MIAVRSRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLK
LERALLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWR
LYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIR
MGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVK
TVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVK

--------------------------------------------------------------

>12813_12813_10_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372802_KCNQ4_chr1_41285547_ENST00000509682_length(amino acids)=471AA_BP=5
MIAVRSRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLK
LERALLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWR
LYSTDMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASL
RLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQ
IVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHE

--------------------------------------------------------------

>12813_12813_11_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372805_KCNQ4_chr1_41285547_ENST00000347132_length(amino acids)=520AA_BP=1
MRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERA
LLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYST
DMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSS
QRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIR
SIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQ

--------------------------------------------------------------

>12813_12813_12_CAP1-KCNQ4_CAP1_chr1_40527484_ENST00000372805_KCNQ4_chr1_41285547_ENST00000509682_length(amino acids)=466AA_BP=1
MRWSIMADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERA
LLVTASQCQQPAEITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYST
DMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKP
RTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGR
GPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:40527484/chr1:41285547)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAP1

Q01518

KCNQ4

P56696

FUNCTION: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.FUNCTION: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414610_645278.0696.0Coiled coil.
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413610_645278.0642.0Coiled coil.
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414283_288278.0696.0MotifSelectivity filter
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413283_288278.0642.0MotifSelectivity filter
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414546_650278.0696.0RegionNote=A-domain (Tetramerization)
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413546_650278.0642.0RegionNote=A-domain (Tetramerization)
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414293_296278.0696.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414318_695278.0696.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413293_296278.0642.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413318_695278.0642.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414297_317278.0696.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413297_317278.0642.0TransmembraneHelical%3B Name%3DSegment S6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAP1chr1:40527484chr1:41285547ENST00000340450+413218_25697.0475.0Compositional biasNote=Ala/Pro/Ser-rich
HgeneCAP1chr1:40527484chr1:41285547ENST00000340450+413230_24197.0475.0Compositional biasNote=Poly-Pro
HgeneCAP1chr1:40527484chr1:41285547ENST00000372792+413218_25698.0476.0Compositional biasNote=Ala/Pro/Ser-rich
HgeneCAP1chr1:40527484chr1:41285547ENST00000372792+413230_24198.0476.0Compositional biasNote=Poly-Pro
HgeneCAP1chr1:40527484chr1:41285547ENST00000372797+413218_25698.0476.0Compositional biasNote=Ala/Pro/Ser-rich
HgeneCAP1chr1:40527484chr1:41285547ENST00000372797+413230_24198.0476.0Compositional biasNote=Poly-Pro
HgeneCAP1chr1:40527484chr1:41285547ENST00000372798+413218_25697.0475.0Compositional biasNote=Ala/Pro/Ser-rich
HgeneCAP1chr1:40527484chr1:41285547ENST00000372798+413230_24197.0475.0Compositional biasNote=Poly-Pro
HgeneCAP1chr1:40527484chr1:41285547ENST00000372802+413218_25697.0475.0Compositional biasNote=Ala/Pro/Ser-rich
HgeneCAP1chr1:40527484chr1:41285547ENST00000372802+413230_24197.0475.0Compositional biasNote=Poly-Pro
HgeneCAP1chr1:40527484chr1:41285547ENST00000372805+413218_25698.0476.0Compositional biasNote=Ala/Pro/Ser-rich
HgeneCAP1chr1:40527484chr1:41285547ENST00000372805+413230_24198.0476.0Compositional biasNote=Poly-Pro
HgeneCAP1chr1:40527484chr1:41285547ENST00000340450+413319_45397.0475.0DomainC-CAP/cofactor C-like
HgeneCAP1chr1:40527484chr1:41285547ENST00000372792+413319_45398.0476.0DomainC-CAP/cofactor C-like
HgeneCAP1chr1:40527484chr1:41285547ENST00000372797+413319_45398.0476.0DomainC-CAP/cofactor C-like
HgeneCAP1chr1:40527484chr1:41285547ENST00000372798+413319_45397.0475.0DomainC-CAP/cofactor C-like
HgeneCAP1chr1:40527484chr1:41285547ENST00000372802+413319_45397.0475.0DomainC-CAP/cofactor C-like
HgeneCAP1chr1:40527484chr1:41285547ENST00000372805+413319_45398.0476.0DomainC-CAP/cofactor C-like
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414271_292278.0696.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413271_292278.0642.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414119_131278.0696.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414153_172278.0696.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414194_201278.0696.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST000003471324141_97278.0696.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414225_237278.0696.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414259_270278.0696.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413119_131278.0642.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413153_172278.0642.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413194_201278.0642.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST000005096824131_97278.0642.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413225_237278.0642.0Topological domainCytoplasmic
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413259_270278.0642.0Topological domainExtracellular
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414132_152278.0696.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414173_193278.0696.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414202_224278.0696.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000347132414238_258278.0696.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ4chr1:40527484chr1:41285547ENST0000034713241498_118278.0696.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413132_152278.0642.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413173_193278.0642.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413202_224278.0642.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ4chr1:40527484chr1:41285547ENST00000509682413238_258278.0642.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ4chr1:40527484chr1:41285547ENST0000050968241398_118278.0642.0TransmembraneHelical%3B Name%3DSegment S1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CAP1
KCNQ4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CAP1-KCNQ4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CAP1-KCNQ4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource