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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CASC3-ACLY

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CASC3-ACLY
	FusionPDB ID: 13141
	FusionGDB2.0 ID: 13141
		Hgene	Tgene
	Gene symbol	CASC3	ACLY
	Gene ID	22794	47
	Gene name	CASC3 exon junction complex subunit	ATP citrate lyase
	Synonyms	BTZ\|MLN51	ACL\|ATPCL\|CLATP
	Cytomap	17q21.1	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	protein CASC3MLN 51barentszcancer susceptibility 3cancer susceptibility candidate 3cancer susceptibility candidate gene 3 proteinmetastatic lymph node 51metastatic lymph node gene 51 proteinprotein barentsz	ATP-citrate synthaseATP-citrate (pro-S-)-lyasecitrate cleavage enzyme
	Modification date	20200313	20200313
	UniProtAcc	O15234	P53396
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264645,	ENST00000588779, ENST00000352035, ENST00000353196, ENST00000393896, ENST00000537919, ENST00000590151,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 10 X 10=2100	13 X 13 X 6=1014
	# samples	28	15
	** MAII score	log2(28/2100*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1014*10)=-2.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CASC3 [Title/Abstract] AND ACLY [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CASC3(38324670)-ACLY(40024157), # samples:3
Anticipated loss of major functional domain due to fusion event.	CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CASC3-ACLY seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CASC3	GO:0000398	mRNA splicing, via spliceosome	29301961
Tgene	ACLY	GO:0006085	acetyl-CoA biosynthetic process	1371749
Tgene	ACLY	GO:0006101	citrate metabolic process	1371749
Tgene	ACLY	GO:0006107	oxaloacetate metabolic process	1371749
Tgene	ACLY	GO:0008610	lipid biosynthetic process	23932781

Fusion gene breakpoints across CASC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACLY (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-R5-A7ZE-01B	CASC3	chr17	38324670	+	ACLY	chr17	40024157	-
ChimerDB4	STAD	TCGA-R5-A7ZE	CASC3	chr17	38324670	+	ACLY	chr17	40024157	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264645	CASC3	chr17	38324670	+	ENST00000590151	ACLY	chr17	40024157	-	3179	2191	172	2217	681
ENST00000264645	CASC3	chr17	38324670	+	ENST00000353196	ACLY	chr17	40024157	-	3165	2191	172	2217	681
ENST00000264645	CASC3	chr17	38324670	+	ENST00000537919	ACLY	chr17	40024157	-	2640	2191	172	2217	681
ENST00000264645	CASC3	chr17	38324670	+	ENST00000393896	ACLY	chr17	40024157	-	2522	2191	172	2217	681

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264645	ENST00000590151	CASC3	chr17	38324670	+	ACLY	chr17	40024157	-	0.001680343	0.9983197
ENST00000264645	ENST00000353196	CASC3	chr17	38324670	+	ACLY	chr17	40024157	-	0.001610357	0.9983897
ENST00000264645	ENST00000537919	CASC3	chr17	38324670	+	ACLY	chr17	40024157	-	0.006746597	0.9932534
ENST00000264645	ENST00000393896	CASC3	chr17	38324670	+	ACLY	chr17	40024157	-	0.008144006	0.991856

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13141_13141_1_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000353196_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------

>13141_13141_2_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000393896_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------

>13141_13141_3_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000537919_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------

>13141_13141_4_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000590151_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38324670/chr17:40024157)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CASC3 O15234	ACLY P53396
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. {ECO:0000269\|PubMed:17375189, ECO:0000269\|PubMed:17652158, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961}.	FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000269\|PubMed:10653665, ECO:0000269\|PubMed:1371749, ECO:0000269\|PubMed:19286649, ECO:0000269\|PubMed:23932781, ECO:0000269\|PubMed:9116495}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

95_131

655.0

1130.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

392_395

655.0

1130.6666666666667

Compositional bias

Note=Poly-Pro

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

41_46

655.0

1130.6666666666667

Compositional bias

Note=Poly-Gly

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

425_428

655.0

1130.6666666666667

Compositional bias

Note=Poly-Pro

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

643_648

655.0

1130.6666666666667

Compositional bias

Note=Poly-Pro

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

204_210

655.0

1130.6666666666667

Motif

Nuclear localization signal 1

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

254_262

655.0

1130.6666666666667

Motif

Nuclear localization signal 2

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

462_466

655.0

1130.6666666666667

Motif

Note=Nuclear export signal

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

137_283

655.0

1130.6666666666667

Region

Note=Sufficient to form the EJC

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

692_695

655.0

1130.6666666666667

Compositional bias

Note=Poly-Pro

Hgene

CASC3

chr17:38324670

chr17:40024157

ENST00000264645

377_703

655.0

1130.6666666666667

Region

Note=Necessary for localization in cytoplasmic stress granules

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000352035

4_265

1070.3333333333333

1102.0

Domain

Note=ATP-grasp

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000353196

4_265

1060.3333333333333

1092.0

Domain

Note=ATP-grasp

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000393896

4_265

1060.3333333333333

1092.0

Domain

Note=ATP-grasp

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000590151

4_265

1070.3333333333333

1102.0

Domain

Note=ATP-grasp

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000352035

109_111

1070.3333333333333

1102.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000352035

66_67

1070.3333333333333

1102.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000352035

701_721

1070.3333333333333

1102.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000352035

752_778

1070.3333333333333

1102.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000353196

109_111

1060.3333333333333

1092.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000353196

66_67

1060.3333333333333

1092.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000353196

701_721

1060.3333333333333

1092.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000353196

752_778

1060.3333333333333

1092.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000393896

109_111

1060.3333333333333

1092.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000393896

66_67

1060.3333333333333

1092.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000393896

701_721

1060.3333333333333

1092.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000393896

752_778

1060.3333333333333

1092.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000590151

109_111

1070.3333333333333

1102.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000590151

66_67

1070.3333333333333

1102.0

Nucleotide binding

Note=ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000590151

701_721

1070.3333333333333

1102.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000590151

752_778

1070.3333333333333

1102.0

Nucleotide binding

ATP

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000352035

779_789

1070.3333333333333

1102.0

Region

CoA-binding

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000353196

779_789

1060.3333333333333

1092.0

Region

CoA-binding

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000393896

779_789

1060.3333333333333

1092.0

Region

CoA-binding

Tgene

ACLY

chr17:38324670

chr17:40024157

ENST00000590151

779_789

1070.3333333333333

1102.0

Region

CoA-binding

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1402_CASC3_38324670_ACLY_40024157_ranked_0.pdb	CASC3	38324670	38324670	ENST00000393896	ACLY	chr17	40024157	-	MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP	681

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CASC3_pLDDT.png

ACLY_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CASC3
ACLY

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CASC3-ACLY

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CASC3-ACLY

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source