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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CASK-FHL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CASK-FHL2
FusionPDB ID: 13193
FusionGDB2.0 ID: 13193
HgeneTgene
Gene symbol

CASK

FHL2

Gene ID

8573

2274

Gene namecalcium/calmodulin dependent serine protein kinasefour and a half LIM domains 2
SynonymsCAGH39|CAMGUK|CMG|FGS4|LIN2|MICPCH|MRXSNA|TNRC8|hCASKAAG11|DRAL|FHL-2|SLIM-3|SLIM3
Cytomap

Xp11.4

2q12.2

Type of geneprotein-codingprotein-coding
Descriptionperipheral plasma membrane protein CASKcalcium/calmodulin-dependent serin protein kinasecalcium/calmodulin-dependent serine protein kinase (MAGUK family)calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinaseprotein linfour and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 3
Modification date2020032720200327
UniProtAcc

Q8WXE0

Q14192

Ensembl transtripts involved in fusion geneENST idsENST00000318588, ENST00000361962, 
ENST00000378154, ENST00000378158, 
ENST00000378163, ENST00000378166, 
ENST00000421587, ENST00000442742, 
ENST00000472704, 		ENST00000322142, 
ENST00000336660, ENST00000344213, 
ENST00000358129, ENST00000393353, 
ENST00000408995, ENST00000409177, 
ENST00000409807, ENST00000607522, 
ENST00000393352, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 5=7807 X 3 X 5=105
# samples 149
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/105*10)=-0.222392421336448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CASK [Title/Abstract] AND FHL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CASK(41598636)-FHL2(105990190), # samples:1
Anticipated loss of major functional domain due to fusion event.CASK-FHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASK-FHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASK-FHL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASK-FHL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASK

GO:0010839

negative regulation of keratinocyte proliferation

18664494

TgeneFHL2

GO:0000122

negative regulation of transcription by RNA polymerase II

15692560

TgeneFHL2

GO:0043066

negative regulation of apoptotic process

15692560


check buttonFusion gene breakpoints across CASK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FHL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8532CASKchrX

41598636

-FHL2chr2

105990190

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000421587CASKchrX41598636-ENST00000393352FHL2chr2105990190-1594453241136370
ENST00000318588CASKchrX41598636-ENST00000393352FHL2chr2105990190-1616475461158370
ENST00000361962CASKchrX41598636-ENST00000393352FHL2chr2105990190-1616475461158370
ENST00000378163CASKchrX41598636-ENST00000393352FHL2chr2105990190-20459044751587370
ENST00000378158CASKchrX41598636-ENST00000393352FHL2chr2105990190-19217803511463370
ENST00000378166CASKchrX41598636-ENST00000393352FHL2chr2105990190-1597456271139370
ENST00000442742CASKchrX41598636-ENST00000393352FHL2chr2105990190-1589448191131370
ENST00000378154CASKchrX41598636-ENST00000393352FHL2chr2105990190-20459044751587370

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000421587ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010360170.99896395
ENST00000318588ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010568980.99894315
ENST00000361962ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010568980.99894315
ENST00000378163ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0034282970.99657166
ENST00000378158ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0025443330.99745566
ENST00000378166ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010582410.9989417
ENST00000442742ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010210320.998979
ENST00000378154ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0034282970.99657166

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13193_13193_1_CASK-FHL2_CASK_chrX_41598636_ENST00000318588_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_2_CASK-FHL2_CASK_chrX_41598636_ENST00000361962_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_3_CASK-FHL2_CASK_chrX_41598636_ENST00000378154_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_4_CASK-FHL2_CASK_chrX_41598636_ENST00000378158_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_5_CASK-FHL2_CASK_chrX_41598636_ENST00000378163_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_6_CASK-FHL2_CASK_chrX_41598636_ENST00000378166_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_7_CASK-FHL2_CASK_chrX_41598636_ENST00000421587_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

>13193_13193_8_CASK-FHL2_CASK_chrX_41598636_ENST00000442742_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:41598636/chr2:105990190)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASK

Q8WXE0

FHL2

Q14192

FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-52618_26143.0910.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-52718_26143.0927.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-52718_26143.0922.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-52518_26143.0898.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-52618_26143.0899.0Nucleotide bindingATP
TgeneFHL2chrX:41598636chr2:105990190ENST0000032214227101_15352.0280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000032214227162_21252.0280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000032214227221_27552.0280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000035812938101_15352.0280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000035812938162_21252.0280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000035812938221_27552.0280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335216101_15352.0280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335216162_21252.0280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335216221_27552.0280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335316101_15352.0280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335316162_21252.0280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335316221_27552.0280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000040899516101_15352.0280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000040899516162_21252.0280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000040899516221_27552.0280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000040980716101_15352.0280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000040980716162_21252.0280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000040980716221_27552.0280.0DomainLIM zinc-binding 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-52612_276143.0910.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526343_398143.0910.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526402_455143.0910.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526489_564143.0910.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526612_682143.0910.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526739_911143.0910.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-52712_276143.0927.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527343_398143.0927.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527402_455143.0927.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527489_564143.0927.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527612_682143.0927.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527739_911143.0927.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-52712_276143.0922.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527343_398143.0922.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527402_455143.0922.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527489_564143.0922.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527612_682143.0922.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527739_911143.0922.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-52512_276143.0898.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525343_398143.0898.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525402_455143.0898.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525489_564143.0898.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525612_682143.0898.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525739_911143.0898.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-52612_276143.0899.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526343_398143.0899.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526402_455143.0899.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526489_564143.0899.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526612_682143.0899.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526739_911143.0899.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526305_315143.0910.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527305_315143.0927.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527305_315143.0922.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525305_315143.0898.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526305_315143.0899.0RegionNote=Calmodulin-binding
TgeneFHL2chrX:41598636chr2:105990190ENST000003221422740_9252.0280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000003581293840_9252.0280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000003933521640_9252.0280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000003933531640_9252.0280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000004089951640_9252.0280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000004098071640_9252.0280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST00000322142277_3152.0280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000358129387_3152.0280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000393352167_3152.0280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000393353167_3152.0280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000408995167_3152.0280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000409807167_3152.0280.0Zinc fingerC4-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CASK
FHL2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CASK-FHL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CASK-FHL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource