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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ACO2-PRR5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACO2-PRR5
FusionPDB ID: 1351
FusionGDB2.0 ID: 1351
HgeneTgene
Gene symbol

ACO2

PRR5

Gene ID

50

55615

Gene nameaconitase 2proline rich 5
SynonymsACONM|HEL-S-284|ICRD|OCA8|OPA9FLJ20185k|PP610|PROTOR-1|PROTOR1
Cytomap

22q13.2

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionaconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitaseproline-rich protein 5Rho GTPase activating protein 8proline rich 5 (renal)protein observed with Rictor-1
Modification date2020031320200313
UniProtAcc

Q99798

.
Ensembl transtripts involved in fusion geneENST idsENST00000216254, ENST00000396512, 
ENST00000466237, 		ENST00000477331, 
ENST00000006251, ENST00000336985, 
ENST00000403581, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 8 X 10=13603 X 5 X 3=45
# samples 225
** MAII scorelog2(22/1360*10)=-2.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACO2 [Title/Abstract] AND PRR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACO2(41895866)-PRR5(45098372), # samples:3
Anticipated loss of major functional domain due to fusion event.ACO2-PRR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-PRR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-PRR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-PRR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACO2

GO:0006099

tricarboxylic acid cycle

9630632

HgeneACO2

GO:0006101

citrate metabolic process

9630632


check buttonFusion gene breakpoints across ACO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

-PRR5chr22

45098372

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+PRR5chr22

45098372

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+PRR5chr22

45110471

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+PRR5chr22

45121124

+
ChimerDB4UCECTCGA-AJ-A3EMACO2chr22

41895866

+PRR5chr22

45110470

+
ChimerDB4UCECTCGA-AJ-A3EMACO2chr22

41895866

+PRR5chr22

45121123

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245121123+158019571146379
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245121123+158119571146379
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245121123+158119571146379
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245121123+157519021141379
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245121123+157619021141379
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245121123+157619021141379
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245110470+166119571227406
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245110470+166219571227406
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245110470+166219571227406
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245110470+165619021222406
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245110470+165719021222406
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245110470+165719021222406
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245110471+166119571227406
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245110471+166219571227406
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245110471+166219571227406
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245110471+165619021222406
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245110471+165719021222406
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245110471+165719021222406
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245121124+158019571146379
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245121124+158119571146379
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245121124+158119571146379
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245121124+157519021141379
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245121124+157619021141379
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245121124+157619021141379

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245121123+0.0079030920.9920969
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245121123+0.0078465440.99215347
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245121123+0.0078465440.99215347
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245121123+0.0078574580.99214256
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245121123+0.0078035010.99219656
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245121123+0.0078035010.99219656
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245110470+0.0053808610.99461913
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245110470+0.0053554770.9946445
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245110470+0.0053554770.9946445
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245110470+0.0053394870.99466056
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245110470+0.0053127070.9946873
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245110470+0.0053127070.9946873
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245110471+0.0053808610.99461913
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245110471+0.0053554770.9946445
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245110471+0.0053554770.9946445
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245110471+0.0053394870.99466056
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245110471+0.0053127070.9946873
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245110471+0.0053127070.9946873
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245121124+0.0079030920.9920969
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245121124+0.0078465440.99215347
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245121124+0.0078465440.99215347
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245121124+0.0078574580.99214256
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245121124+0.0078035010.99219656
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245121124+0.0078035010.99219656

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1351_1351_1_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000006251_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_2_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000336985_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_3_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000403581_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_4_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000006251_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_5_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000336985_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_6_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000403581_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_7_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000006251_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_8_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000336985_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_9_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000403581_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_10_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000006251_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_11_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000336985_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_12_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000403581_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_13_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000006251_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_14_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000336985_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_15_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000403581_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_16_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000006251_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_17_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000336985_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_18_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000403581_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------

>1351_1351_19_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000006251_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_20_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000336985_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_21_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000403581_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_22_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000006251_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_23_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000336985_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

>1351_1351_24_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000403581_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41895866/chr22:45098372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACO2

Q99798

.
FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO2chr22:41895866chr22:45110470ENST00000216254+218192_19457.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110470ENST00000216254+218670_67157.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110471ENST00000216254+218192_19457.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110471ENST00000216254+218670_67157.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121123ENST00000216254+218192_19457.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121123ENST00000216254+218670_67157.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121124ENST00000216254+218192_19457.666666666666664781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121124ENST00000216254+218670_67157.666666666666664781.0RegionSubstrate binding
TgenePRR5chr22:41895866chr22:45110470ENST000000062511924_2735.666666666666664380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110470ENST000003369850824_2744.666666666666664389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110470ENST0000040358121024_2767.66666666666667412.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110471ENST000000062511924_2735.666666666666664380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110471ENST000003369850824_2744.666666666666664389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110471ENST0000040358121024_2767.66666666666667412.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121123ENST000000062512924_2762.666666666666664380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121123ENST000003369851824_2771.66666666666667389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121123ENST0000040358131024_2794.66666666666667412.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121124ENST000000062512924_2762.666666666666664380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121124ENST000003369851824_2771.66666666666667389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121124ENST0000040358131024_2794.66666666666667412.0Compositional biasNote=Poly-Ala


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACO2
PRR5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePRR5chr22:41895866chr22:45110470ENST000000062511910_9535.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45110470ENST000003369850810_9544.666666666666664389.0RICTOR
TgenePRR5chr22:41895866chr22:45110470ENST0000040358121010_9567.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST000000062511910_9535.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST000003369850810_9544.666666666666664389.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST0000040358121010_9567.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST000000062512910_9562.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST000003369851810_9571.66666666666667389.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST0000040358131010_9594.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST000000062512910_9562.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST000003369851810_9571.66666666666667389.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST0000040358131010_9594.66666666666667412.0RICTOR


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Related Drugs to ACO2-PRR5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ACO2-PRR5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource