UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
![]() |
|||||||
|
Fusion Protein:CCT8-LHX4 |
Fusion Protein Summary |
![]() |
Fusion partner gene information | Fusion gene name: CCT8-LHX4 | FusionPDB ID: 14358 | FusionGDB2.0 ID: 14358 | Hgene | Tgene | Gene symbol | CCT8 | LHX4 | Gene ID | 10694 | 89884 |
Gene name | chaperonin containing TCP1 subunit 8 | LIM homeobox 4 | |
Synonyms | C21orf112|Cctq|D21S246|PRED71 | CPHD4 | |
Cytomap | 21q21.3 | 1q25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | T-complex protein 1 subunit thetaCCT-thetaTCP-1-thetachaperonin containing T-complex polypeptide 1 subunit 8chaperonin containing TCP1, subunit 8 (theta)renal carcinoma antigen NY-REN-15 | LIM/homeobox protein Lhx4LIM homeobox protein 4 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | P50990 | Q969G2 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000470450, ENST00000286788, ENST00000540844, ENST00000542732, | ENST00000263726, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 2=72 | 3 X 3 X 5=45 |
# samples | 6 | 7 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/45*10)=0.637429920615292 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: CCT8 [Title/Abstract] AND LHX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CCT8(30432862)-LHX4(180217420), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | CCT8-LHX4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CCT8-LHX4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CCT8-LHX4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CCT8-LHX4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CCT8-LHX4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. CCT8-LHX4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LHX4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15998782 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
Top |
Fusion Gene Sample Information |
![]() |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-EW-A6SA-01A | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
ChimerDB4 | BRCA | TCGA-EW-A6SA | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + |
Top |
Fusion ORF Analysis |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000542732 | CCT8 | chr21 | 30432862 | - | ENST00000263726 | LHX4 | chr1 | 180217420 | + | 8401 | 1638 | 126 | 1691 | 521 |
ENST00000542732 | CCT8 | chr21 | 30432861 | - | ENST00000263726 | LHX4 | chr1 | 180217419 | + | 8401 | 1638 | 126 | 1691 | 521 |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + | 0.002162237 | 0.99783784 |
ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + | 0.002162237 | 0.99783784 |
Top |
Fusion Amino Acid Sequences |
![]() |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >14358_14358_1_CCT8-LHX4_CCT8_chr21_30432861_ENST00000542732_LHX4_chr1_180217419_ENST00000263726_length(amino acids)=521AA_BP=503 MHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAG ALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNV DNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGAN VVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRG STDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYA -------------------------------------------------------------- >14358_14358_2_CCT8-LHX4_CCT8_chr21_30432862_ENST00000542732_LHX4_chr1_180217420_ENST00000263726_length(amino acids)=521AA_BP=503 MHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAG ALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNV DNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGAN VVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRG STDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYA -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:30432862/chr1:180217420) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
CCT8 | LHX4 |
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}. | FUNCTION: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250, ECO:0000269|PubMed:28473536}. |
![]() |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 157_216 | 25.333333333333332 | 391.0 | DNA binding | Homeobox | |
Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 157_216 | 25.333333333333332 | 391.0 | DNA binding | Homeobox | |
Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 28_87 | 25.333333333333332 | 391.0 | Domain | LIM zinc-binding 1 | |
Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 88_150 | 25.333333333333332 | 391.0 | Domain | LIM zinc-binding 2 | |
Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 28_87 | 25.333333333333332 | 391.0 | Domain | LIM zinc-binding 1 | |
Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 88_150 | 25.333333333333332 | 391.0 | Domain | LIM zinc-binding 2 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Protein-Protein Interaction |
![]() |
![]() |
Gene | PPI interactors |
![]() |
Gene | STRING network |
CCT8 | |
LHX4 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to CCT8-LHX4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to CCT8-LHX4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |