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Fusion Protein:CERS2-GOLPH3L |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: CERS2-GOLPH3L | FusionPDB ID: 15973 | FusionGDB2.0 ID: 15973 | Hgene | Tgene | Gene symbol | CERS2 | GOLPH3L | Gene ID | 29956 | 55204 |
Gene name | ceramide synthase 2 | golgi phosphoprotein 3 like | |
Synonyms | L3|LASS2|SP260|TMSG1 | GPP34R | |
Cytomap | 1q21.3 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ceramide synthase 2LAG1 homolog, ceramide synthase 2LAG1 longevity assurance 2longevity assurance (LAG1, S. cerevisiae) homolog 2sphingosine N-acyltransferase CERS2tumor metastasis-suppressor gene 1 protein | Golgi phosphoprotein 3-likeGPP34-related protein | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q96G23 | Q9H4A5 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000271688, ENST00000368954, ENST00000561294, ENST00000345896, | ENST00000479757, ENST00000271732, ENST00000540514, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 4 X 6 X 5=120 | 8 X 5 X 7=280 |
# samples | 6 | 10 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: CERS2 [Title/Abstract] AND GOLPH3L [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CERS2(150941394)-GOLPH3L(150621224), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CERS2 | GO:0046513 | ceramide biosynthetic process | 17977534|18165233|29632068 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-09-1667-01C | CERS2 | chr1 | 150941394 | - | GOLPH3L | chr1 | 150621224 | - |
ChimerDB4 | OV | TCGA-09-1667-01C | CERS2 | chr1 | 150947095 | - | GOLPH3L | chr1 | 150621224 | - |
ChimerDB4 | OV | TCGA-09-1667 | CERS2 | chr1 | 150941393 | - | GOLPH3L | chr1 | 150621224 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000561294 | CERS2 | chr1 | 150941394 | - | ENST00000540514 | GOLPH3L | chr1 | 150621224 | - | 733 | 195 | 107 | 622 | 171 |
ENST00000368954 | CERS2 | chr1 | 150941394 | - | ENST00000271732 | GOLPH3L | chr1 | 150621224 | - | 3083 | 559 | 471 | 986 | 171 |
ENST00000561294 | CERS2 | chr1 | 150941393 | - | ENST00000540514 | GOLPH3L | chr1 | 150621224 | - | 733 | 195 | 107 | 622 | 171 |
ENST00000368954 | CERS2 | chr1 | 150941393 | - | ENST00000271732 | GOLPH3L | chr1 | 150621224 | - | 3083 | 559 | 471 | 986 | 171 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000561294 | ENST00000540514 | CERS2 | chr1 | 150941394 | - | GOLPH3L | chr1 | 150621224 | - | 0.007874545 | 0.99212545 |
ENST00000368954 | ENST00000271732 | CERS2 | chr1 | 150941394 | - | GOLPH3L | chr1 | 150621224 | - | 0.004185129 | 0.99581486 |
ENST00000561294 | ENST00000540514 | CERS2 | chr1 | 150941393 | - | GOLPH3L | chr1 | 150621224 | - | 0.007874545 | 0.99212545 |
ENST00000368954 | ENST00000271732 | CERS2 | chr1 | 150941393 | - | GOLPH3L | chr1 | 150621224 | - | 0.004185129 | 0.99581486 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >15973_15973_1_CERS2-GOLPH3L_CERS2_chr1_150941393_ENST00000368954_GOLPH3L_chr1_150621224_ENST00000271732_length(amino acids)=171AA_BP=0 MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ -------------------------------------------------------------- >15973_15973_2_CERS2-GOLPH3L_CERS2_chr1_150941393_ENST00000561294_GOLPH3L_chr1_150621224_ENST00000540514_length(amino acids)=171AA_BP=0 MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ -------------------------------------------------------------- >15973_15973_3_CERS2-GOLPH3L_CERS2_chr1_150941394_ENST00000368954_GOLPH3L_chr1_150621224_ENST00000271732_length(amino acids)=171AA_BP=0 MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ -------------------------------------------------------------- >15973_15973_4_CERS2-GOLPH3L_CERS2_chr1_150941394_ENST00000561294_GOLPH3L_chr1_150621224_ENST00000540514_length(amino acids)=171AA_BP=0 MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150941394/chr1:150621224) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CERS2 | GOLPH3L |
FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor. May regulate lipid metabolism in hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q924Z4, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:19728861, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}. | FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 1_40 | 57.666666666666664 | 381.0 | Topological domain | Lumenal |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 1_40 | 57.666666666666664 | 381.0 | Topological domain | Lumenal |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 1_40 | 57.666666666666664 | 381.0 | Topological domain | Lumenal |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 1_40 | 57.666666666666664 | 381.0 | Topological domain | Lumenal |
Tgene | GOLPH3L | chr1:150941393 | chr1:150621224 | ENST00000271732 | 3 | 5 | 176_187 | 143.33333333333334 | 286.0 | Region | Beta-hairpin required for oligomerization | |
Tgene | GOLPH3L | chr1:150941394 | chr1:150621224 | ENST00000271732 | 3 | 5 | 176_187 | 143.33333333333334 | 286.0 | Region | Beta-hairpin required for oligomerization |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 131_332 | 57.666666666666664 | 381.0 | Domain | TLC |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 131_332 | 57.666666666666664 | 381.0 | Domain | TLC |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 131_332 | 57.666666666666664 | 381.0 | Domain | TLC |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 131_332 | 57.666666666666664 | 381.0 | Domain | TLC |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 291_300 | 57.666666666666664 | 381.0 | Motif | Last loop motif |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 291_300 | 57.666666666666664 | 381.0 | Motif | Last loop motif |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 291_300 | 57.666666666666664 | 381.0 | Motif | Last loop motif |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 291_300 | 57.666666666666664 | 381.0 | Motif | Last loop motif |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 67_128 | 57.666666666666664 | 381.0 | Region | Homeobox-like |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 67_128 | 57.666666666666664 | 381.0 | Region | Homeobox-like |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 67_128 | 57.666666666666664 | 381.0 | Region | Homeobox-like |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 67_128 | 57.666666666666664 | 381.0 | Region | Homeobox-like |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 325_380 | 57.666666666666664 | 381.0 | Topological domain | Cytoplasmic |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 325_380 | 57.666666666666664 | 381.0 | Topological domain | Cytoplasmic |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 325_380 | 57.666666666666664 | 381.0 | Topological domain | Cytoplasmic |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 325_380 | 57.666666666666664 | 381.0 | Topological domain | Cytoplasmic |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 140_160 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 181_201 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 209_229 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 264_284 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 304_324 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 41_61 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 140_160 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 181_201 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 209_229 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 264_284 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 304_324 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941393 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 41_61 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 140_160 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 181_201 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 209_229 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 264_284 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 304_324 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000271688 | - | 2 | 11 | 41_61 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 140_160 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 181_201 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 209_229 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 264_284 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 304_324 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
Hgene | CERS2 | chr1:150941394 | chr1:150621224 | ENST00000368954 | - | 2 | 11 | 41_61 | 57.666666666666664 | 381.0 | Transmembrane | Helical |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
CERS2 | |
GOLPH3L |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CERS2-GOLPH3L |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CERS2-GOLPH3L |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |