UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CLDN18-ARHGAP6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CLDN18-ARHGAP6
	FusionPDB ID: 17035
	FusionGDB2.0 ID: 17035
		Hgene	Tgene
	Gene symbol	CLDN18	ARHGAP6
	Gene ID	51208	395
	Gene name	claudin 18	Rho GTPase activating protein 6
	Synonyms	SFTA5\|SFTPJ	RHOGAP6\|RHOGAPX-1
	Cytomap	3q22.3	Xp22.2
	Type of gene	protein-coding	protein-coding
	Description	claudin-18surfactant associated 5surfactant associated protein Jsurfactant, pulmonary associated protein J	rho GTPase-activating protein 6Rho-type GTPase-activating protein RhoGAPX-1rho-type GTPase-activating protein 6
	Modification date	20200313	20200313
	UniProtAcc	P56856	O43182
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000183605, ENST00000343735,	ENST00000303025, ENST00000380736, ENST00000413512, ENST00000491514, ENST00000337414, ENST00000380718, ENST00000380732, ENST00000534860,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 11 X 5=440	8 X 5 X 6=240
	# samples	13	9
	** MAII score	log2(13/440*10)=-1.7589919004962 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CLDN18 [Title/Abstract] AND ARHGAP6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CLDN18(137749947)-ARHGAP6(11272827), # samples:2
Anticipated loss of major functional domain due to fusion event.	CLDN18-ARHGAP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLDN18-ARHGAP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CLDN18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-A4Z0-01A	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000343735	CLDN18	chr3	137749947	+	ENST00000337414	ARHGAP6	chrX	11272827	-	6951	3295	3316	5631	771
ENST00000343735	CLDN18	chr3	137749947	+	ENST00000380718	ARHGAP6	chrX	11272827	-	5466	3295	3316	5004	562
ENST00000343735	CLDN18	chr3	137749947	+	ENST00000380732	ARHGAP6	chrX	11272827	-	4684	3295	3316	4683	456
ENST00000343735	CLDN18	chr3	137749947	+	ENST00000534860	ARHGAP6	chrX	11272827	-	5256	3295	3316	5046	576
ENST00000183605	CLDN18	chr3	137749947	+	ENST00000337414	ARHGAP6	chrX	11272827	-	7040	3384	3405	5720	771
ENST00000183605	CLDN18	chr3	137749947	+	ENST00000380718	ARHGAP6	chrX	11272827	-	5555	3384	3405	5093	562
ENST00000183605	CLDN18	chr3	137749947	+	ENST00000380732	ARHGAP6	chrX	11272827	-	4773	3384	3405	4772	455
ENST00000183605	CLDN18	chr3	137749947	+	ENST00000534860	ARHGAP6	chrX	11272827	-	5345	3384	3405	5135	576

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000343735	ENST00000337414	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.001707504	0.9982925
ENST00000343735	ENST00000380718	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.000843627	0.99915636
ENST00000343735	ENST00000380732	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.000686805	0.99931324
ENST00000343735	ENST00000534860	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.000572215	0.99942774
ENST00000183605	ENST00000337414	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.00230795	0.9976921
ENST00000183605	ENST00000380718	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.00116366	0.99883634
ENST00000183605	ENST00000380732	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.000948213	0.99905175
ENST00000183605	ENST00000534860	CLDN18	chr3	137749947	+	ARHGAP6	chrX	11272827	-	0.000780733	0.9992193

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17035_17035_1_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000183605_ARHGAP6_chrX_11272827_ENST00000337414_length(amino acids)=771AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLK
SGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERP
TARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTDQGGQAAEREQQVTQ

--------------------------------------------------------------

>17035_17035_2_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000183605_ARHGAP6_chrX_11272827_ENST00000380718_length(amino acids)=562AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKGNWSLASRRWPKQATLLL

--------------------------------------------------------------

>17035_17035_3_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000183605_ARHGAP6_chrX_11272827_ENST00000380732_length(amino acids)=455AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSTSSVLPAAVQACPQYPA

--------------------------------------------------------------

>17035_17035_4_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000183605_ARHGAP6_chrX_11272827_ENST00000534860_length(amino acids)=576AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLK

--------------------------------------------------------------

>17035_17035_5_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000343735_ARHGAP6_chrX_11272827_ENST00000337414_length(amino acids)=771AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLK
SGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERP
TARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTDQGGQAAEREQQVTQ

--------------------------------------------------------------

>17035_17035_6_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000343735_ARHGAP6_chrX_11272827_ENST00000380718_length(amino acids)=562AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKGNWSLASRRWPKQATLLL

--------------------------------------------------------------

>17035_17035_7_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000343735_ARHGAP6_chrX_11272827_ENST00000380732_length(amino acids)=456AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSTSSVLPAAVQACPQYPA

--------------------------------------------------------------

>17035_17035_8_CLDN18-ARHGAP6_CLDN18_chr3_137749947_ENST00000343735_ARHGAP6_chrX_11272827_ENST00000534860_length(amino acids)=576AA_BP=
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRA
YKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQL
SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFL
RDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLL
HKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:137749947/chrX:11272827)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLDN18 P56856	ARHGAP6 O43182
FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269\|PubMed:10699171}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000303025

401_602

772.0

Domain

Rho-GAP

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000337414

401_602

196.0

975.0

Domain

Rho-GAP

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000380718

401_602

196.0

766.0

Domain

Rho-GAP

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000380732

401_602

228.0

691.0

Domain

Rho-GAP

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000380736

401_602

772.0

Domain

Rho-GAP

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000303025

342_352

772.0

Motif

Note=SH3-binding

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000337414

342_352

196.0

975.0

Motif

Note=SH3-binding

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000380718

342_352

196.0

766.0

Motif

Note=SH3-binding

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000380732

342_352

228.0

691.0

Motif

Note=SH3-binding

Tgene

ARHGAP6

chr3:137749947

chrX:11272827

ENST00000380736

342_352

772.0

Motif

Note=SH3-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

102_122

262.0

Topological domain

Cytoplasmic

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

144_174

262.0

Topological domain

Extracellular

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

196_261

262.0

Topological domain

Cytoplasmic

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

1_6

262.0

Topological domain

Cytoplasmic

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

28_80

262.0

Topological domain

Extracellular

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

102_122

262.0

Topological domain

Cytoplasmic

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

144_174

262.0

Topological domain

Extracellular

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

196_261

262.0

Topological domain

Cytoplasmic

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

1_6

262.0

Topological domain

Cytoplasmic

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

28_80

262.0

Topological domain

Extracellular

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

123_143

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

175_195

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

7_27

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000183605

81_101

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

123_143

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

175_195

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

7_27

262.0

Transmembrane

Helical

Hgene

CLDN18

chr3:137749947

chrX:11272827

ENST00000343735

81_101

262.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CLDN18
ARHGAP6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CLDN18-ARHGAP6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CLDN18-ARHGAP6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source