UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:CSGALNACT1-TMEM150A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CSGALNACT1-TMEM150A
FusionPDB ID: 19699
FusionGDB2.0 ID: 19699
HgeneTgene
Gene symbol

CSGALNACT1

TMEM150A

Gene ID

55790

129303

Gene namechondroitin sulfate N-acetylgalactosaminyltransferase 1transmembrane protein 150A
SynonymsCSGalNAcT-1|ChGn|ChGn-1|beta4GalNAcTTM6P1|TMEM150|TTN1
Cytomap

8p21.3

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionchondroitin sulfate N-acetylgalactosaminyltransferase 1beta4GalNAcT-1chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1chondroitin beta1,4 N-acetylgalactosaminyltransferaseglucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferastransmembrane protein 150Afasting-inducible integral membrane protein TM6P1tentonin 1transmembrane protein 150
Modification date2020031320200320
UniProtAcc

Q8TDX6

.
Ensembl transtripts involved in fusion geneENST idsENST00000518542, ENST00000311540, 
ENST00000332246, ENST00000454498, 
ENST00000522854, ENST00000544602, 
ENST00000306353, ENST00000334462, 
ENST00000409668, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 10 X 4=3202 X 2 X 2=8
# samples 103
** MAII scorelog2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context (manual curation of fusion genes in FusionPDB)

PubMed: CSGALNACT1 [Title/Abstract] AND TMEM150A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CSGALNACT1(19315937)-TMEM150A(85826825), # samples:3
Anticipated loss of major functional domain due to fusion event.CSGALNACT1-TMEM150A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CSGALNACT1-TMEM150A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSGALNACT1

GO:0019276

UDP-N-acetylgalactosamine metabolic process

11514575

HgeneCSGALNACT1

GO:0030206

chondroitin sulfate biosynthetic process

11514575|12163485

HgeneCSGALNACT1

GO:0046398

UDP-glucuronate metabolic process

11514575

HgeneCSGALNACT1

GO:0050653

chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

12163485

TgeneTMEM150A

GO:0072659

protein localization to plasma membrane

25608530


check buttonFusion gene breakpoints across CSGALNACT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM150A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A46F-01ACSGALNACT1chr8

19315937

-TMEM150Achr2

85826825

-
ChimerDB4PRADTCGA-EJ-A46FCSGALNACT1chr8

19315936

-TMEM150Achr2

85826825

-
ChimerDB4PRADTCGA-EJ-A46FCSGALNACT1chr8

19315937

-TMEM150Achr2

85826825

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000544602CSGALNACT1chr819315937-ENST00000306353TMEM150Achr285826825-221212644131678421
ENST00000544602CSGALNACT1chr819315937-ENST00000334462TMEM150Achr285826825-219812644131678421
ENST00000544602CSGALNACT1chr819315937-ENST00000409668TMEM150Achr285826825-217612644131678421
ENST00000544602CSGALNACT1chr819315936-ENST00000306353TMEM150Achr285826825-221212644131678421
ENST00000544602CSGALNACT1chr819315936-ENST00000334462TMEM150Achr285826825-219812644131678421
ENST00000544602CSGALNACT1chr819315936-ENST00000409668TMEM150Achr285826825-217612644131678421

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544602ENST00000306353CSGALNACT1chr819315937-TMEM150Achr285826825-0.0612119030.9387881
ENST00000544602ENST00000334462CSGALNACT1chr819315937-TMEM150Achr285826825-0.060830120.9391699
ENST00000544602ENST00000409668CSGALNACT1chr819315937-TMEM150Achr285826825-0.069958210.93004185
ENST00000544602ENST00000306353CSGALNACT1chr819315936-TMEM150Achr285826825-0.0612119030.9387881
ENST00000544602ENST00000334462CSGALNACT1chr819315936-TMEM150Achr285826825-0.060830120.9391699
ENST00000544602ENST00000409668CSGALNACT1chr819315936-TMEM150Achr285826825-0.069958210.93004185

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19699_19699_1_CSGALNACT1-TMEM150A_CSGALNACT1_chr8_19315936_ENST00000544602_TMEM150A_chr2_85826825_ENST00000306353_length(amino acids)=421AA_BP=283
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP

--------------------------------------------------------------

>19699_19699_2_CSGALNACT1-TMEM150A_CSGALNACT1_chr8_19315936_ENST00000544602_TMEM150A_chr2_85826825_ENST00000334462_length(amino acids)=421AA_BP=283
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP

--------------------------------------------------------------

>19699_19699_3_CSGALNACT1-TMEM150A_CSGALNACT1_chr8_19315936_ENST00000544602_TMEM150A_chr2_85826825_ENST00000409668_length(amino acids)=421AA_BP=283
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP

--------------------------------------------------------------

>19699_19699_4_CSGALNACT1-TMEM150A_CSGALNACT1_chr8_19315937_ENST00000544602_TMEM150A_chr2_85826825_ENST00000306353_length(amino acids)=421AA_BP=283
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP

--------------------------------------------------------------

>19699_19699_5_CSGALNACT1-TMEM150A_CSGALNACT1_chr8_19315937_ENST00000544602_TMEM150A_chr2_85826825_ENST00000334462_length(amino acids)=421AA_BP=283
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP

--------------------------------------------------------------

>19699_19699_6_CSGALNACT1-TMEM150A_CSGALNACT1_chr8_19315937_ENST00000544602_TMEM150A_chr2_85826825_ENST00000409668_length(amino acids)=421AA_BP=283
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:19315937/chr2:85826825)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSGALNACT1

Q8TDX6

.
FUNCTION: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). {ECO:0000250|UniProtKB:Q8BJQ9, ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758, ECO:0000269|PubMed:21160489, ECO:0000269|PubMed:27599773, ECO:0000269|PubMed:31705726}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000311540-4957_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000332246-51057_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000454498-51057_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000522854-3857_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000544602-4957_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000311540-4957_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000332246-51057_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000454498-51057_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000522854-3857_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000544602-4957_100283.6666666666667533.0Coiled coilOntology_term=ECO:0000255
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000311540-491_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000332246-5101_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000454498-5101_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000522854-381_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000544602-491_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000311540-491_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000332246-5101_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000454498-5101_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000522854-381_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000544602-491_14283.6666666666667533.0Topological domainCytoplasmic
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000311540-4915_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000332246-51015_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000454498-51015_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000522854-3815_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000544602-4915_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000311540-4915_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000332246-51015_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000454498-51015_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000522854-3815_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000544602-4915_35283.6666666666667533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347130_14079.0219.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347162_17879.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347200_21179.0219.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347233_27179.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST000003063534797_10879.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258130_140132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258162_178132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258200_211132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258233_271132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847130_140132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847162_178132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847200_211132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847233_271132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347130_14079.0219.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347162_17879.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347200_21179.0219.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347233_27179.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST000003063534797_10879.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258130_140132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258162_178132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258200_211132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258233_271132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847130_140132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847162_178132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847200_211132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847233_271132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347109_12979.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347141_16179.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347179_19979.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000030635347212_23279.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST000003063534776_9679.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258141_161132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258179_199132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258212_232132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847141_161132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847179_199132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847212_232132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347109_12979.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347141_16179.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347179_19979.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000030635347212_23279.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST000003063534776_9679.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258141_161132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258179_199132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258212_232132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847141_161132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847179_199132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847212_232132.0272.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000311540-4936_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000332246-51036_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000454498-51036_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000522854-3836_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315936chr2:85826825ENST00000544602-4936_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000311540-4936_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000332246-51036_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000454498-51036_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000522854-3836_532283.6666666666667533.0Topological domainLumenal
HgeneCSGALNACT1chr8:19315937chr2:85826825ENST00000544602-4936_532283.6666666666667533.0Topological domainLumenal
TgeneTMEM150Achr8:19315936chr2:85826825ENST00000306353471_279.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST000003063534724_7579.0219.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST00000334462581_2132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST000003344625824_75132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST000003344625897_108132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST00000409668471_2132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST000004096684724_75132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315936chr2:85826825ENST000004096684797_108132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST00000306353471_279.0219.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST000003063534724_7579.0219.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST00000334462581_2132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST000003344625824_75132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST000003344625897_108132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST00000409668471_2132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315937chr2:85826825ENST000004096684724_75132.0272.0Topological domainExtracellular
TgeneTMEM150Achr8:19315937chr2:85826825ENST000004096684797_108132.0272.0Topological domainCytoplasmic
TgeneTMEM150Achr8:19315936chr2:85826825ENST00000306353473_2379.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000033446258109_129132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST00000334462583_23132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST000003344625876_96132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST0000040966847109_129132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST00000409668473_23132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315936chr2:85826825ENST000004096684776_96132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST00000306353473_2379.0219.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000033446258109_129132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST00000334462583_23132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST000003344625876_96132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST0000040966847109_129132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST00000409668473_23132.0272.0TransmembraneHelical
TgeneTMEM150Achr8:19315937chr2:85826825ENST000004096684776_96132.0272.0TransmembraneHelical


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>872_CSGALNACT1_19315937_TMEM150A_85826825_872_CSGALNACT1_19315937_TMEM150A_85826825_ranked_0.pdbCSGALNACT11931593619315937ENST00000409668TMEM150Achr285826825-
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERS
EQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLA
KRVDKFRQFMQNFRWIMPGLCTTLELAWPSLRGCSLFACTVLSPTKGPPPRWTWLWPICEVCWLSSPLSPWSSVESSLSMRVLSCNMGQP
421


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CSGALNACT1_pLDDT.png
all structure
all structure
TMEM150A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CSGALNACT1
TMEM150A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to CSGALNACT1-TMEM150A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CSGALNACT1-TMEM150A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource