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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CSNK2B-CCT5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CSNK2B-CCT5
	FusionPDB ID: 19888
	FusionGDB2.0 ID: 19888
		Hgene	Tgene
	Gene symbol	CSNK2B	CCT5
	Gene ID	1460	22948
	Gene name	casein kinase 2 beta	chaperonin containing TCP1 subunit 5
	Synonyms	CK2B\|CK2N\|CSK2B\|Ckb1\|Ckb2\|G5A\|POBINDS	CCT-epsilon\|CCTE\|HEL-S-69\|PNAS-102\|TCP-1-epsilon
	Cytomap	6p21.33	5p15.2
	Type of gene	protein-coding	protein-coding
	Description	casein kinase II subunit betaCK II betaCSNK2B-LY6G5B-1072CSNK2B-LY6G5B-1103CSNK2B-LY6G5B-532CSNK2B-LY6G5B-560CSNK2B-LY6G5B-562Casein kinase II beta subunitalternative name: G5a, phosvitincasein kinase 2, beta polypeptidecasein kinase II b subuni	T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
	Modification date	20200327	20200313
	UniProtAcc	P67870	P48643
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000375865, ENST00000375866, ENST00000375882, ENST00000375885, ENST00000383427, ENST00000383431, ENST00000383433, ENST00000400110, ENST00000400116, ENST00000412802, ENST00000413083, ENST00000416194, ENST00000418230, ENST00000422261, ENST00000422567, ENST00000424502, ENST00000428483, ENST00000429633, ENST00000431476, ENST00000432290, ENST00000436169, ENST00000437010, ENST00000439572, ENST00000443673, ENST00000448596, ENST00000451917, ENST00000452985, ENST00000453234, ENST00000454382, ENST00000454511, ENST00000455161, ENST00000458330, ENST00000464220, ENST00000468132, ENST00000476022, ENST00000480866, ENST00000485003, ENST00000488020,	ENST00000503026, ENST00000506600, ENST00000515390, ENST00000515676, ENST00000280326,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 4=144	58 X 14 X 17=13804
	# samples	6	61
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(61/13804*10)=-4.50013332598527 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CSNK2B [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CSNK2B(31637847)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.	CSNK2B-CCT5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CSNK2B-CCT5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CSNK2B-CCT5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CSNK2B-CCT5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CSNK2B	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	19592636
Hgene	CSNK2B	GO:0018107	peptidyl-threonine phosphorylation	15723517
Hgene	CSNK2B	GO:0033211	adiponectin-activated signaling pathway	19233263
Hgene	CSNK2B	GO:0043537	negative regulation of blood vessel endothelial cell migration	19592636

Fusion gene breakpoints across CSNK2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-ND-A4W6-01A	CSNK2B	chr6	31637847	-	CCT5	chr5	10250033	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375885	CSNK2B	chr6	31637847	-	ENST00000280326	CCT5	chr5	10250033	+	4736	1061	1451	3106	551
ENST00000375882	CSNK2B	chr6	31637847	-	ENST00000280326	CCT5	chr5	10250033	+	4623	948	1338	2993	551
ENST00000375865	CSNK2B	chr6	31637847	-	ENST00000280326	CCT5	chr5	10250033	+	4583	908	1298	2953	551
ENST00000375866	CSNK2B	chr6	31637847	-	ENST00000280326	CCT5	chr5	10250033	+	4611	936	1326	2981	551

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375885	ENST00000280326	CSNK2B	chr6	31637847	-	CCT5	chr5	10250033	+	0.000936709	0.9990633
ENST00000375882	ENST00000280326	CSNK2B	chr6	31637847	-	CCT5	chr5	10250033	+	0.000862135	0.9991379
ENST00000375865	ENST00000280326	CSNK2B	chr6	31637847	-	CCT5	chr5	10250033	+	0.000854239	0.99914575
ENST00000375866	ENST00000280326	CSNK2B	chr6	31637847	-	CCT5	chr5	10250033	+	0.000830525	0.99916947

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19888_19888_1_CSNK2B-CCT5_CSNK2B_chr6_31637847_ENST00000375865_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

>19888_19888_2_CSNK2B-CCT5_CSNK2B_chr6_31637847_ENST00000375866_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

>19888_19888_3_CSNK2B-CCT5_CSNK2B_chr6_31637847_ENST00000375882_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

>19888_19888_4_CSNK2B-CCT5_CSNK2B_chr6_31637847_ENST00000375885_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31637847/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CSNK2B P67870	CCT5 P48643
FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250\|UniProtKB:P67871, ECO:0000269\|PubMed:11239457, ECO:0000269\|PubMed:16818610}.	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000375865

55_64

264.0

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000375866

55_64

264.0

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000375882

55_64

264.0

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000383427

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000383433

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000400110

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000412802

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000418230

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000422567

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000429633

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000431476

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000436169

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000443673

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000448596

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000451917

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000452985

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000453234

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000454382

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000454511

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000455161

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

CSNK2B

chr6:31637847

chr5:10250033

ENST00000458330

55_64

216.0

Compositional bias

Note=Asp/Glu-rich (acidic)

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CSNK2B
CCT5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000383427	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000383433	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000400110	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000412802	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000418230	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000422567	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000429633	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000431476	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000436169	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000443673	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000448596	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000451917	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000452985	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000453234	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000454382	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000454511	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000455161	-	1	7	188_193	0	216.0	alpha subunit
Hgene	CSNK2B	chr6:31637847	chr5:10250033	ENST00000458330	-	1	7	188_193	0	216.0	alpha subunit

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Related Drugs to CSNK2B-CCT5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CSNK2B-CCT5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source