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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CTNND2-NRBP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CTNND2-NRBP1
	FusionPDB ID: 20396
	FusionGDB2.0 ID: 20396
		Hgene	Tgene
	Gene symbol	CTNND2	NRBP1
	Gene ID	1501	29959
	Gene name	catenin delta 2	nuclear receptor binding protein 1
	Synonyms	GT24\|NPRAP	BCON3\|MADM\|MUDPNP\|NRBP
	Cytomap	5p15.2	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	catenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungin	nuclear receptor-binding proteinmultiple domain putative nuclear proteinmyeloid leukemia factor 1 adaptor molecule
	Modification date	20200320	20200329
	UniProtAcc	Q9UQB3	Q9UHY1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000458100, ENST00000304623, ENST00000359640, ENST00000495388, ENST00000503622, ENST00000511377,	ENST00000233557, ENST00000379852, ENST00000379863,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 13 X 7=1274	6 X 8 X 4=192
	# samples	15	8
	** MAII score	log2(15/1274*10)=-3.08633087176042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CTNND2 [Title/Abstract] AND NRBP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CTNND2(11732248)-NRBP1(27656540), # samples:3
Anticipated loss of major functional domain due to fusion event.	CTNND2-NRBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CTNND2-NRBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CTNND2-NRBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CTNND2-NRBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NRBP1	GO:0006888	ER to Golgi vesicle-mediated transport	11956649

Fusion gene breakpoints across CTNND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-QH-A6XC-01A	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+
ChimerDB4	LGG	TCGA-QH-A6XC	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+
ChimerDB4	LGG	TCGA-QH-A6XC	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304623	CTNND2	chr5	11732248	-	ENST00000233557	NRBP1	chr2	27656540	+	2209	364	190	1761	523
ENST00000304623	CTNND2	chr5	11732248	-	ENST00000379852	NRBP1	chr2	27656540	+	2205	364	190	1761	523
ENST00000304623	CTNND2	chr5	11732248	-	ENST00000379863	NRBP1	chr2	27656540	+	2229	364	190	1785	531
ENST00000359640	CTNND2	chr5	11732248	-	ENST00000233557	NRBP1	chr2	27656540	+	2164	319	145	1716	523
ENST00000359640	CTNND2	chr5	11732248	-	ENST00000379852	NRBP1	chr2	27656540	+	2160	319	145	1716	523
ENST00000359640	CTNND2	chr5	11732248	-	ENST00000379863	NRBP1	chr2	27656540	+	2184	319	145	1740	531
ENST00000304623	CTNND2	chr5	11732247	-	ENST00000233557	NRBP1	chr2	27656539	+	2209	364	190	1761	523
ENST00000304623	CTNND2	chr5	11732247	-	ENST00000379852	NRBP1	chr2	27656539	+	2205	364	190	1761	523
ENST00000304623	CTNND2	chr5	11732247	-	ENST00000379863	NRBP1	chr2	27656539	+	2229	364	190	1785	531
ENST00000359640	CTNND2	chr5	11732247	-	ENST00000233557	NRBP1	chr2	27656539	+	2164	319	145	1716	523
ENST00000359640	CTNND2	chr5	11732247	-	ENST00000379852	NRBP1	chr2	27656539	+	2160	319	145	1716	523
ENST00000359640	CTNND2	chr5	11732247	-	ENST00000379863	NRBP1	chr2	27656539	+	2184	319	145	1740	531

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304623	ENST00000233557	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+	0.007816052	0.992184
ENST00000304623	ENST00000379852	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+	0.007894124	0.99210584
ENST00000304623	ENST00000379863	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+	0.007337264	0.9926628
ENST00000359640	ENST00000233557	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+	0.006910818	0.99308914
ENST00000359640	ENST00000379852	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+	0.006970047	0.99303
ENST00000359640	ENST00000379863	CTNND2	chr5	11732248	-	NRBP1	chr2	27656540	+	0.006465006	0.99353504
ENST00000304623	ENST00000233557	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+	0.007816052	0.992184
ENST00000304623	ENST00000379852	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+	0.007894124	0.99210584
ENST00000304623	ENST00000379863	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+	0.007337264	0.9926628
ENST00000359640	ENST00000233557	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+	0.006910818	0.99308914
ENST00000359640	ENST00000379852	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+	0.006970047	0.99303
ENST00000359640	ENST00000379863	CTNND2	chr5	11732247	-	NRBP1	chr2	27656539	+	0.006465006	0.99353504

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20396_20396_1_CTNND2-NRBP1_CTNND2_chr5_11732247_ENST00000304623_NRBP1_chr2_27656539_ENST00000233557_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_2_CTNND2-NRBP1_CTNND2_chr5_11732247_ENST00000304623_NRBP1_chr2_27656539_ENST00000379852_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_3_CTNND2-NRBP1_CTNND2_chr5_11732247_ENST00000304623_NRBP1_chr2_27656539_ENST00000379863_length(amino acids)=531AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEI
QGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSA
VLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESV

--------------------------------------------------------------

>20396_20396_4_CTNND2-NRBP1_CTNND2_chr5_11732247_ENST00000359640_NRBP1_chr2_27656539_ENST00000233557_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_5_CTNND2-NRBP1_CTNND2_chr5_11732247_ENST00000359640_NRBP1_chr2_27656539_ENST00000379852_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_6_CTNND2-NRBP1_CTNND2_chr5_11732247_ENST00000359640_NRBP1_chr2_27656539_ENST00000379863_length(amino acids)=531AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEI
QGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSA
VLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESV

--------------------------------------------------------------

>20396_20396_7_CTNND2-NRBP1_CTNND2_chr5_11732248_ENST00000304623_NRBP1_chr2_27656540_ENST00000233557_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_8_CTNND2-NRBP1_CTNND2_chr5_11732248_ENST00000304623_NRBP1_chr2_27656540_ENST00000379852_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_9_CTNND2-NRBP1_CTNND2_chr5_11732248_ENST00000304623_NRBP1_chr2_27656540_ENST00000379863_length(amino acids)=531AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEI
QGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSA
VLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESV

--------------------------------------------------------------

>20396_20396_10_CTNND2-NRBP1_CTNND2_chr5_11732248_ENST00000359640_NRBP1_chr2_27656540_ENST00000233557_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_11_CTNND2-NRBP1_CTNND2_chr5_11732248_ENST00000359640_NRBP1_chr2_27656540_ENST00000379852_length(amino acids)=523AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSY
VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAG
PGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHL

--------------------------------------------------------------

>20396_20396_12_CTNND2-NRBP1_CTNND2_chr5_11732248_ENST00000359640_NRBP1_chr2_27656540_ENST00000379863_length(amino acids)=531AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH
SCDPPIIHGNLTCDTIFIQHNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEI
QGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSA
VLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:11732248/chr2:27656540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTNND2 Q9UQB3	NRBP1 Q9UHY1
FUNCTION: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250\|UniProtKB:O35927, ECO:0000269\|PubMed:25807484, ECO:0000269\|PubMed:9971746}.	FUNCTION: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269\|PubMed:11956649, ECO:0000269\|PubMed:15084397, ECO:0000303\|PubMed:11956649}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NRBP1

chr5:11732247

chr2:27656539

ENST00000233557

68_327

70.0

536.0

Domain

Protein kinase

Tgene

NRBP1

chr5:11732247

chr2:27656539

ENST00000379852

68_327

70.0

536.0

Domain

Protein kinase

Tgene

NRBP1

chr5:11732248

chr2:27656540

ENST00000233557

68_327

70.0

536.0

Domain

Protein kinase

Tgene

NRBP1

chr5:11732248

chr2:27656540

ENST00000379852

68_327

70.0

536.0

Domain

Protein kinase

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

49_84

58.0

1226.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

49_84

58.0

1168.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

49_84

58.0

1226.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

49_84

58.0

1168.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

216_226

58.0

1226.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

811_817

58.0

1226.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

216_226

58.0

1168.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

811_817

58.0

1168.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

216_226

58.0

1226.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

811_817

58.0

1226.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

216_226

58.0

1168.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

811_817

58.0

1168.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

394_438

58.0

1226.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

540_579

58.0

1226.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

582_621

58.0

1226.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

626_666

58.0

1226.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

682_724

58.0

1226.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

728_773

58.0

1226.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

835_875

58.0

1226.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

882_921

58.0

1226.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000304623

975_1018

58.0

1226.0

Repeat

Note=ARM 9

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

394_438

58.0

1168.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

540_579

58.0

1168.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

582_621

58.0

1168.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

626_666

58.0

1168.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

682_724

58.0

1168.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

728_773

58.0

1168.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

835_875

58.0

1168.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

882_921

58.0

1168.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11732247

chr2:27656539

ENST00000359640

975_1018

58.0

1168.0

Repeat

Note=ARM 9

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

394_438

58.0

1226.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

540_579

58.0

1226.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

582_621

58.0

1226.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

626_666

58.0

1226.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

682_724

58.0

1226.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

728_773

58.0

1226.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

835_875

58.0

1226.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

882_921

58.0

1226.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000304623

975_1018

58.0

1226.0

Repeat

Note=ARM 9

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

394_438

58.0

1168.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

540_579

58.0

1168.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

582_621

58.0

1168.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

626_666

58.0

1168.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

682_724

58.0

1168.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

728_773

58.0

1168.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

835_875

58.0

1168.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

882_921

58.0

1168.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11732248

chr2:27656540

ENST00000359640

975_1018

58.0

1168.0

Repeat

Note=ARM 9

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1138_CTNND2_11732248_NRBP1_27656540_1138_CTNND2_11732248_NRBP1_27656540_ranked_0.pdb	CTNND2	11732247	11732248	ENST00000379863	NRBP1	chr2	27656540	+	MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLH SCDPPIIHGNLTCDTIFIQHNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEI QGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSA VLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESV	531

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CTNND2_pLDDT.png

NRBP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CTNND2
NRBP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CTNND2-NRBP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CTNND2-NRBP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source