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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CUL3-SPAG16

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CUL3-SPAG16
FusionPDB ID: 20673
FusionGDB2.0 ID: 20673
HgeneTgene
Gene symbol

CUL3

SPAG16

Gene ID

8452

79582

Gene namecullin 3sperm associated antigen 16
SynonymsCUL-3|PHA2EPF20|WDR29
Cytomap

2q36.2

2q34

Type of geneprotein-codingprotein-coding
Descriptioncullin-3sperm-associated antigen 16 proteinWD repeat domain 29pf20 protein homologsperm-associated WD repeat protein
Modification date2020032720200313
UniProtAcc

Q13618

.
Ensembl transtripts involved in fusion geneENST idsENST00000264414, ENST00000344951, 
ENST00000409096, ENST00000409777, 
ENST00000432260, 		ENST00000414961, 
ENST00000272898, ENST00000374309, 
ENST00000413312, ENST00000432529, 
ENST00000447990, ENST00000331683, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 12 X 7=100816 X 16 X 8=2048
# samples 1418
** MAII scorelog2(14/1008*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2048*10)=-3.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CUL3 [Title/Abstract] AND SPAG16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CUL3(225360549)-SPAG16(214174783), # samples:3
SPAG16(214162081)-CUL3(225346795), # samples:3
Anticipated loss of major functional domain due to fusion event.CUL3-SPAG16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CUL3-SPAG16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG16-CUL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG16-CUL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CUL3-SPAG16 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CUL3-SPAG16 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SPAG16-CUL3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SPAG16-CUL3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCUL3

GO:0000209

protein polyubiquitination

19261606

HgeneCUL3

GO:0006511

ubiquitin-dependent protein catabolic process

25401743|27561354

HgeneCUL3

GO:0006513

protein monoubiquitination

22358839

HgeneCUL3

GO:0006888

ER to Golgi vesicle-mediated transport

22358839

HgeneCUL3

GO:0016567

protein ubiquitination

17543862|19782033|19995937|20389280|23213400

HgeneCUL3

GO:0031145

anaphase-promoting complex-dependent catabolic process

10500095

HgeneCUL3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

19261606|19782033|20389280

HgeneCUL3

GO:0071630

nuclear protein quality control by the ubiquitin-proteasome system

27561354


check buttonFusion gene breakpoints across CUL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPAG16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-O2-A52V-01ACUL3chr2

225360549

-SPAG16chr2

214174783

+
ChimerDB4LUSCTCGA-O2-A52VCUL3chr2

225360549

-SPAG16chr2

214174783

+
ChimerDB4LUSCTCGA-O2-A52VCUL3chr2

225360549

-SPAG16chr2

214181943

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264414CUL3chr2225360549-ENST00000331683SPAG16chr2214174783+3984218133937971152
ENST00000344951CUL3chr2225360549-ENST00000331683SPAG16chr2214174783+3831202838436441086
ENST00000409096CUL3chr2225360549-ENST00000331683SPAG16chr2214174783+371619135335291158
ENST00000264414CUL3chr2225360549-ENST00000432529SPAG16chr2214181943+294121813392186615
ENST00000344951CUL3chr2225360549-ENST00000432529SPAG16chr2214181943+278820283842033549
ENST00000409096CUL3chr2225360549-ENST00000432529SPAG16chr2214181943+26731913531918621
ENST00000409777CUL3chr2225360549-ENST00000331683SPAG16chr2214181943+406023766002381593
ENST00000409777CUL3chr2225360549-ENST00000374309SPAG16chr2214181943+387423766002381593
ENST00000409777CUL3chr2225360549-ENST00000413312SPAG16chr2214181943+408123766002381593
ENST00000409777CUL3chr2225360549-ENST00000272898SPAG16chr2214181943+302223766002381593
ENST00000409777CUL3chr2225360549-ENST00000447990SPAG16chr2214181943+330523766002381593

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264414ENST00000331683CUL3chr2225360549-SPAG16chr2214174783+0.0003569050.9996431
ENST00000344951ENST00000331683CUL3chr2225360549-SPAG16chr2214174783+0.000428270.99957174
ENST00000409096ENST00000331683CUL3chr2225360549-SPAG16chr2214174783+0.0002065910.99979347
ENST00000264414ENST00000432529CUL3chr2225360549-SPAG16chr2214181943+0.0005867170.99941325
ENST00000344951ENST00000432529CUL3chr2225360549-SPAG16chr2214181943+0.0008114170.9991886
ENST00000409096ENST00000432529CUL3chr2225360549-SPAG16chr2214181943+0.0003249460.99967504
ENST00000409777ENST00000331683CUL3chr2225360549-SPAG16chr2214181943+0.0002627630.9997372
ENST00000409777ENST00000374309CUL3chr2225360549-SPAG16chr2214181943+0.0002704840.99972945
ENST00000409777ENST00000413312CUL3chr2225360549-SPAG16chr2214181943+0.0002545820.9997454
ENST00000409777ENST00000272898CUL3chr2225360549-SPAG16chr2214181943+0.0003848680.9996151
ENST00000409777ENST00000447990CUL3chr2225360549-SPAG16chr2214181943+0.0003865440.99961346

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20673_20673_1_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000264414_SPAG16_chr2_214174783_ENST00000331683_length(amino acids)=1152AA_BP=612
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELIS
KHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDS
EKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL
AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEERKTVLPSKHAVPEVI
EDFLCNFLIKMGMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADKAREDLLKIQKERDFHRMHH
KRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKEKMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPE
GPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVL
GLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER
CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSID

--------------------------------------------------------------

>20673_20673_2_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000264414_SPAG16_chr2_214181943_ENST00000432529_length(amino acids)=615AA_BP=
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELIS
KHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDS
EKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL

--------------------------------------------------------------

>20673_20673_3_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000344951_SPAG16_chr2_214174783_ENST00000331683_length(amino acids)=1086AA_BP=546
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGC
IRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIE
RVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGK
NPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKD
VFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQ
SATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN
NREKYTFEERKTVLPSKHAVPEVIEDFLCNFLIKMGMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYK
QAADKAREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKEKMLTSLERDKVVGQISGLQETLKKL
QRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPV
SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWH
SCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI
ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDG

--------------------------------------------------------------

>20673_20673_4_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000344951_SPAG16_chr2_214181943_ENST00000432529_length(amino acids)=549AA_BP=
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGC
IRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIE
RVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGK
NPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKD
VFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQ
SATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN

--------------------------------------------------------------

>20673_20673_5_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409096_SPAG16_chr2_214174783_ENST00000331683_length(amino acids)=1158AA_BP=618
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERK
GEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVV
ERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDR
FLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNK
SVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEI
FRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEERKTVLPSKH
AVPEVIEDFLCNFLIKMGMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADKAREDLLKIQKERD
FHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKEKMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSRE
KENAPEGPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGED
RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW
DVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLL

--------------------------------------------------------------

>20673_20673_6_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409096_SPAG16_chr2_214181943_ENST00000432529_length(amino acids)=621AA_BP=
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERK
GEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVV
ERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDR
FLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNK
SVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEI

--------------------------------------------------------------

>20673_20673_7_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409777_SPAG16_chr2_214181943_ENST00000272898_length(amino acids)=593AA_BP=
MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDH
QTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYE
EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGK
TEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS
RSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG
MFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT

--------------------------------------------------------------

>20673_20673_8_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409777_SPAG16_chr2_214181943_ENST00000331683_length(amino acids)=593AA_BP=
MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDH
QTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYE
EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGK
TEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS
RSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG
MFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT

--------------------------------------------------------------

>20673_20673_9_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409777_SPAG16_chr2_214181943_ENST00000374309_length(amino acids)=593AA_BP=
MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDH
QTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYE
EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGK
TEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS
RSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG
MFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT

--------------------------------------------------------------

>20673_20673_10_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409777_SPAG16_chr2_214181943_ENST00000413312_length(amino acids)=593AA_BP=
MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDH
QTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYE
EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGK
TEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS
RSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG
MFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT

--------------------------------------------------------------

>20673_20673_11_CUL3-SPAG16_CUL3_chr2_225360549_ENST00000409777_SPAG16_chr2_214181943_ENST00000447990_length(amino acids)=593AA_BP=
MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDH
QTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYE
EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGK
TEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS
RSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG
MFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:225360549/chr2:214174783)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUL3

Q13618

.
FUNCTION: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). {ECO:0000269|PubMed:10500095, ECO:0000269|PubMed:11311237, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:20389280, ECO:0000269|PubMed:21670212, ECO:0000269|PubMed:21840486, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:23213400, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:24768539, ECO:0000269|PubMed:25270598, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:29769719}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210152_26793.0348.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216152_26793.0632.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217152_26762.0252.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925152_26793.0184.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310152_267132.66666666666666348.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316152_267132.66666666666666632.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227152_267101.66666666666667252.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935152_267132.66666666666666184.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210350_38993.0348.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210392_43193.0348.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210434_47393.0348.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210476_51593.0348.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210518_55793.0348.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210560_60093.0348.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214174783ENST00000272898210601_63093.0348.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216350_38993.0632.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216392_43193.0632.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216434_47393.0632.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216476_51593.0632.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216518_55793.0632.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216560_60093.0632.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214174783ENST00000331683216601_63093.0632.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217350_38962.0252.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217392_43162.0252.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217434_47362.0252.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217476_51562.0252.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217518_55762.0252.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217560_60062.0252.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214174783ENST0000041331217601_63062.0252.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925350_38993.0184.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925392_43193.0184.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925434_47393.0184.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925476_51593.0184.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925518_55793.0184.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925560_60093.0184.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214174783ENST0000043252925601_63093.0184.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310350_389132.66666666666666348.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310392_431132.66666666666666348.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310434_473132.66666666666666348.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310476_515132.66666666666666348.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310518_557132.66666666666666348.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310560_600132.66666666666666348.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214181943ENST00000272898310601_630132.66666666666666348.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316350_389132.66666666666666632.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316392_431132.66666666666666632.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316434_473132.66666666666666632.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316476_515132.66666666666666632.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316518_557132.66666666666666632.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316560_600132.66666666666666632.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214181943ENST00000331683316601_630132.66666666666666632.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227350_389101.66666666666667252.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227392_431101.66666666666667252.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227434_473101.66666666666667252.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227476_515101.66666666666667252.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227518_557101.66666666666667252.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227560_600101.66666666666667252.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214181943ENST0000041331227601_630101.66666666666667252.0RepeatNote=WD 7
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935350_389132.66666666666666184.0RepeatNote=WD 1
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935392_431132.66666666666666184.0RepeatNote=WD 2
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935434_473132.66666666666666184.0RepeatNote=WD 3
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935476_515132.66666666666666184.0RepeatNote=WD 4
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935518_557132.66666666666666184.0RepeatNote=WD 5
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935560_600132.66666666666666184.0RepeatNote=WD 6
TgeneSPAG16chr2:225360549chr2:214181943ENST0000043252935601_630132.66666666666666184.0RepeatNote=WD 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1895_CUL3_225360549_SPAG16_214174783_ranked_0.pdbCUL3225360549225360549ENST00000447990SPAG16chr2214174783+
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERK
GEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVV
ERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDR
FLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNK
SVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEI
FRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEERKTVLPSKH
AVPEVIEDFLCNFLIKMGMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADKAREDLLKIQKERD
FHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKEKMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSRE
KENAPEGPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGED
RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW
DVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLL
1158


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CUL3_pLDDT.png
all structure
all structure
SPAG16_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CUL3
SPAG16


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CUL3-SPAG16


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CUL3-SPAG16


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource