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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DDX5-SKAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DDX5-SKAP1
	FusionPDB ID: 22099
	FusionGDB2.0 ID: 22099
		Hgene	Tgene
	Gene symbol	DDX5	SKAP1
	Gene ID	1655	8631
	Gene name	DEAD-box helicase 5	src kinase associated phosphoprotein 1
	Synonyms	G17P1\|HLR1\|HUMP68\|p68	HEL-S-81p\|SCAP1\|SKAP55
	Cytomap	17q23.3	17q21.32
	Type of gene	protein-coding	protein-coding
	Description	probable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA h	src kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDa
	Modification date	20200313	20200313
	UniProtAcc	Q5T1V6	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000580026, ENST00000225792, ENST00000450599, ENST00000578804,	ENST00000336915, ENST00000584924,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	33 X 25 X 10=8250	24 X 12 X 10=2880
	# samples	27	29
	** MAII score	log2(27/8250*10)=-4.93336280696971 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/2880*10)=-3.31194400631474 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DDX5 [Title/Abstract] AND SKAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DDX5(62496667)-SKAP1(46474147), # samples:2
Anticipated loss of major functional domain due to fusion event.	DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DDX5-SKAP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DDX5	GO:0000122	negative regulation of transcription by RNA polymerase II	15298701
Hgene	DDX5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21343338
Hgene	DDX5	GO:0000956	nuclear-transcribed mRNA catabolic process	23788676
Tgene	SKAP1	GO:0002821	positive regulation of adaptive immune response	12652296
Tgene	SKAP1	GO:0033625	positive regulation of integrin activation	12652296
Tgene	SKAP1	GO:0034116	positive regulation of heterotypic cell-cell adhesion	12652296
Tgene	SKAP1	GO:0045944	positive regulation of transcription by RNA polymerase II	11909961
Tgene	SKAP1	GO:1903039	positive regulation of leukocyte cell-cell adhesion	12652296

Fusion gene breakpoints across DDX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SKAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A8PJ-01A	DDX5	chr17	62496667	-	SKAP1	chr17	46474147	-
ChimerDB4	STAD	TCGA-VQ-A8PJ	DDX5	chr17	62496666	-	SKAP1	chr17	46474147	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000225792	DDX5	chr17	62496667	-	ENST00000584924	SKAP1	chr17	46474147	-	3175	1843	213	2876	887
ENST00000450599	DDX5	chr17	62496667	-	ENST00000584924	SKAP1	chr17	46474147	-	2704	1372	39	2405	788
ENST00000578804	DDX5	chr17	62496667	-	ENST00000584924	SKAP1	chr17	46474147	-	2940	1608	80	2641	853
ENST00000225792	DDX5	chr17	62496666	-	ENST00000584924	SKAP1	chr17	46474147	-	3175	1843	213	2876	887
ENST00000450599	DDX5	chr17	62496666	-	ENST00000584924	SKAP1	chr17	46474147	-	2704	1372	39	2405	788
ENST00000578804	DDX5	chr17	62496666	-	ENST00000584924	SKAP1	chr17	46474147	-	2940	1608	80	2641	853

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000225792	ENST00000584924	DDX5	chr17	62496667	-	SKAP1	chr17	46474147	-	0.002898781	0.99710125
ENST00000450599	ENST00000584924	DDX5	chr17	62496667	-	SKAP1	chr17	46474147	-	0.002330217	0.99766976
ENST00000578804	ENST00000584924	DDX5	chr17	62496667	-	SKAP1	chr17	46474147	-	0.002640422	0.9973596
ENST00000225792	ENST00000584924	DDX5	chr17	62496666	-	SKAP1	chr17	46474147	-	0.002898781	0.99710125
ENST00000450599	ENST00000584924	DDX5	chr17	62496666	-	SKAP1	chr17	46474147	-	0.002330217	0.99766976
ENST00000578804	ENST00000584924	DDX5	chr17	62496666	-	SKAP1	chr17	46474147	-	0.002640422	0.9973596

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22099_22099_1_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000225792_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=887AA_BP=543
MPESGRHLIHFYRSLVVQLRLVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAG
PLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEP
TAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPK
GPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDY
IHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEF
KHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVED
RGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGA
QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTA
TSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLE

--------------------------------------------------------------

>22099_22099_2_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000450599_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=788AA_BP=444
MVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWN
LDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLER
GVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALE
LSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILI
ATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFL
AEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQ
GYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDW
VDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRK

--------------------------------------------------------------

>22099_22099_3_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000578804_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=853AA_BP=509
MLFVWGLGSCRGGCHLVAVEGVERERIVRMKAGRFEADEGTSVRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQE
HPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP
AIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRR
TTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIR
LMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNS
SEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQ
QIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVS
RGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEE
EKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQ

--------------------------------------------------------------

>22099_22099_4_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000225792_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=887AA_BP=543
MPESGRHLIHFYRSLVVQLRLVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAG
PLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEP
TAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPK
GPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDY
IHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEF
KHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVED
RGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGA
QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTA
TSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLE

--------------------------------------------------------------

>22099_22099_5_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000450599_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=788AA_BP=444
MVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWN
LDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLER
GVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALE
LSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILI
ATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFL
AEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQ
GYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDW
VDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRK

--------------------------------------------------------------

>22099_22099_6_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000578804_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=853AA_BP=509
MLFVWGLGSCRGGCHLVAVEGVERERIVRMKAGRFEADEGTSVRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQE
HPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP
AIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRR
TTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIR
LMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNS
SEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQ
QIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVS
RGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEE
EKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:62496667/chr17:46474147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DDX5 Q5T1V6	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

125_300

480.3333333333333

615.0

Domain

Helicase ATP-binding

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

328_475

480.3333333333333

615.0

Domain

Helicase C-terminal

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

125_300

480.3333333333333

615.0

Domain

Helicase ATP-binding

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

328_475

480.3333333333333

615.0

Domain

Helicase C-terminal

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

248_251

480.3333333333333

615.0

Motif

Note=DEAD box

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

94_122

480.3333333333333

615.0

Motif

Note=Q motif

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

248_251

480.3333333333333

615.0

Motif

Note=DEAD box

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

94_122

480.3333333333333

615.0

Motif

Note=Q motif

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

114_116

480.3333333333333

615.0

Nucleotide binding

Note=ATP

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

138_145

480.3333333333333

615.0

Nucleotide binding

Note=ATP

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

114_116

480.3333333333333

615.0

Nucleotide binding

Note=ATP

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

138_145

480.3333333333333

615.0

Nucleotide binding

Note=ATP

Tgene

SKAP1

chr17:62496666

chr17:46474147

ENST00000336915

220_230

15.333333333333334

448.0

Compositional bias

Note=Poly-Glu

Tgene

SKAP1

chr17:62496666

chr17:46474147

ENST00000584924

220_230

15.333333333333334

360.0

Compositional bias

Note=Poly-Glu

Tgene

SKAP1

chr17:62496667

chr17:46474147

ENST00000336915

220_230

15.333333333333334

448.0

Compositional bias

Note=Poly-Glu

Tgene

SKAP1

chr17:62496667

chr17:46474147

ENST00000584924

220_230

15.333333333333334

360.0

Compositional bias

Note=Poly-Glu

Tgene

SKAP1

chr17:62496666

chr17:46474147

ENST00000336915

107_210

15.333333333333334

448.0

Domain

Tgene

SKAP1

chr17:62496666

chr17:46474147

ENST00000336915

294_355

15.333333333333334

448.0

Domain

SH3

Tgene

SKAP1

chr17:62496666

chr17:46474147

ENST00000584924

107_210

15.333333333333334

360.0

Domain

Tgene

SKAP1

chr17:62496666

chr17:46474147

ENST00000584924

294_355

15.333333333333334

360.0

Domain

SH3

Tgene

SKAP1

chr17:62496667

chr17:46474147

ENST00000336915

107_210

15.333333333333334

448.0

Domain

Tgene

SKAP1

chr17:62496667

chr17:46474147

ENST00000336915

294_355

15.333333333333334

448.0

Domain

SH3

Tgene

SKAP1

chr17:62496667

chr17:46474147

ENST00000584924

107_210

15.333333333333334

360.0

Domain

Tgene

SKAP1

chr17:62496667

chr17:46474147

ENST00000584924

294_355

15.333333333333334

360.0

Domain

SH3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DDX5

chr17:62496666

chr17:46474147

ENST00000225792

477_614

480.3333333333333

615.0

Region

Note=Transactivation domain

Hgene

DDX5

chr17:62496667

chr17:46474147

ENST00000225792

477_614

480.3333333333333

615.0

Region

Note=Transactivation domain

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

DDX5

STK24, HDAC1, CREBBP, EP300, AKAP8, FBL, OTUB1, MEPCE, CDK9, HNRNPA1, HNRNPH1, KHDRBS2, IPO11, TCEA1, AIRE, MYOD1, SMARCA4, TBP, POLR2A, MGMT, SRRM1, SRRM2, tat, PIAS1, MBD3, CHD3, ESR1, TADA2A, SMN1, CD4, DGCR8, ZWINT, Cdk1, AI837181, Ybx1, CALM1, EBNA-LP, PIK3CA, PSMA3, TNNT1, VHL, SMARCAD1, YY1, NDRG1, HDGF, CENPA, MBNL1, SF3A2, ARRB2, ERG, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDX5, DDX17, HDAC2, HDAC3, BBLF2-BBLF3, INPPL1, SHC1, CRK, AKT1, DHX15, SRSF1, SF3B3, U2AF2, DHX38, SNRPA1, EIF4A3, PRKDC, SF3A1, HNRNPM, HNRNPF, SNRPD1, RBMX, SYNCRIP, U2AF1, SART1, PRPF40A, IGF2BP3, SNW1, PRPF19, SNRPD2, VTN, MCM7, SYN1, RPS20, XRCC4, RPS16, HNRNPA0, EEF2, PRSS1, THRAP3, GOLIM4, EPRS, RPL19, SRP14, SMURF1, FN1, VCAM1, RBM10, WBP11, HNRNPK, DHX9, RBM4, HNRNPH2, HNRNPH3, KHDRBS1, RBFOX2, IL7R, MAP1LC3A, ITGA4, CTNNB1, CD81, IGSF8, FBXW4, FBXO46, SP1, MAPK10, FBXO6, TARDBP, PARK2, PIN1, DBNL, ERO1L, FKBP10, LRSAM1, PABPC4, PRPSAP1, WDR4, rev, RPA1, RPA2, RPA3, STAU1, MDM2, SPRTN, AURKA, AURKB, CEP250, TP53, TUBGCP3, FUS, MAPKAPK2, DROSHA, NXF1, CUL7, OBSL1, CCDC8, UBE2I, EZH2, SUZ12, EED, RNF2, SMAD3, ABL1, ARAF, CDK2, DAPK1, ILK, MAST3, SGK2, SRPK1, TNK1, TYK2, LUZP4, RPS6KB2, UNK, NTRK1, ATXN2, ATXN2L, C14orf166, CPSF6, DDX18, DNAJC2, ELAC2, GTPBP4, HNRNPR, IMPDH1, SBDS, SKIV2L2, TRMT6, DHX36, EDC4, EIF2A, GMPS, LUC7L2, NACA, UPF1, SFN, SCARNA22, FRS3, gag, XPO1, HNRNPU, RPL10, MATR3, Bcas2, Bag2, Fus, SKI, MCM2, MCM5, Ksr1, CDC5L, CDC37, CRBN, CBX7, RYBP, WWP2, DERL1, EGFR, YPEL5, RMND5A, MAEA, RANBP9, ARMC8, NR2E1, CYLD, CD2BP2, INO80B, TRIM25, HOTAIR, HEY1, BRCA1, LMNA, MTF1, FBXO7, IQGAP1, TMPO, WDR77, MTCH2, PCBP1, PPIE, CCNT1, GSK3A, MAP2K3, MED12, POLD1, TGFB1, TRIP4, ZNF217, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD4, LARP7, RNF4, TNF, RIOK1, SQSTM1, HEXIM1, RUNX1, DPF2, RNF123, NBN, SNAI1, AGR2, RECQL4, ZFP36L2, CNTNAP1, MYC, Prkaa1, Prkab1, CDK5RAP2, METTL3, METTL14, WTAP, KIAA1429, PSME3, PHF1, PHB, FAF1, RBX1, KIN, USP14, NR2C2, UCHL3, PPP1CC, SETD1A, ZFYVE21, XRCC6, CTCF, AGRN, VRK1, HIST1H4A, PSMD14, APEX1, SNRNP70, EWSR1, TAF15, SNRPC, ITFG1, GSK3B, CDC6, BIRC3, BRD7, ERCC6, SOX2, TRIM28, CMTR1, PLEKHA4, MAGEA3, KCTD10, PINK1, YAP1, TFCP2, FANCD2, ORF50, ZC3H18, PTK6, STAG2, MAU2, HSCB, CELF1, ELAVL1, DUX4L9, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, ACACA, C12orf49, INS, SUMO2, NDN, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, nsp13ab, LGALS9, IFI16, EIF3F, DDX58, OGT, SPOP, UFL1, DDRGK1, NR4A1, DDX23, NIFK, RPL31, SLC26A4-AS1, E2F1, FZR1, WDR5, PAGE4, NAA40, BTF3, AGO2, AGO1, RCHY1, NBR1, nsp14, RB1CC1, DDX3X, ZEB1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DDX5
SKAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DDX5-SKAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DDX5-SKAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DDX5	C0014175	Endometriosis	1	CTD_human
Hgene	DDX5	C0269102	Endometrioma	1	CTD_human