UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:DGCR2-CLTCL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DGCR2-CLTCL1
FusionPDB ID: 22400
FusionGDB2.0 ID: 22400
HgeneTgene
Gene symbol

DGCR2

CLTCL1

Gene ID

9993

8218

Gene nameDiGeorge syndrome critical region gene 2clathrin heavy chain like 1
SynonymsDGS-C|IDD|LAN|SEZ-12CHC22|CLH22|CLTCL|CLTD
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionintegral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndromeclathrin heavy chain 2CLH-22Clathrin, heavy polypeptide Dclathrin heavy chain on chromosome 22clathrin, heavy polypeptide-like 1
Modification date2020031320200313
UniProtAcc

P98153

P53675

Ensembl transtripts involved in fusion geneENST idsENST00000545799, ENST00000263196, 
ENST00000537045, ENST00000473832, 
ENST00000263200, ENST00000353891, 
ENST00000427926, ENST00000442042, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 15 X 8=19209 X 7 X 7=441
# samples 2112
** MAII scorelog2(21/1920*10)=-3.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/441*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DGCR2 [Title/Abstract] AND CLTCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DGCR2(19076881)-CLTCL1(19263353), # samples:3
Anticipated loss of major functional domain due to fusion event.DGCR2-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DGCR2-CLTCL1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DGCR2-CLTCL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLTCL1

GO:0000278

mitotic cell cycle

19509056

TgeneCLTCL1

GO:0000278

mitotic cell cycle

20065094

TgeneCLTCL1

GO:0006898

receptor-mediated endocytosis

19509056


check buttonFusion gene breakpoints across DGCR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLTCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01ADGCR2chr22

19076881

-CLTCL1chr22

19263353

-
ChimerDB4BRCATCGA-A7-A4SC-01ADGCR2chr22

19076881

-CLTCL1chr22

19178947

-
ChimerDB4STADTCGA-CD-A489-01ADGCR2chr22

19044499

-CLTCL1chr22

19263353

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545799DGCR2chr2219076881-ENST00000353891CLTCL1chr2219263353-563040325651121618
ENST00000545799DGCR2chr2219076881-ENST00000263200CLTCL1chr2219263353-580140325652831675
ENST00000545799DGCR2chr2219076881-ENST00000427926CLTCL1chr2219263353-579840325652831675
ENST00000545799DGCR2chr2219076881-ENST00000353891CLTCL1chr2219178947-1481403256963235
ENST00000545799DGCR2chr2219076881-ENST00000263200CLTCL1chr2219178947-16524032561134292
ENST00000545799DGCR2chr2219076881-ENST00000427926CLTCL1chr2219178947-16494032561134292

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545799ENST00000353891DGCR2chr2219076881-CLTCL1chr2219263353-0.0038447860.9961552
ENST00000545799ENST00000263200DGCR2chr2219076881-CLTCL1chr2219263353-0.0038226580.9961773
ENST00000545799ENST00000427926DGCR2chr2219076881-CLTCL1chr2219263353-0.0038319810.99616796
ENST00000545799ENST00000353891DGCR2chr2219076881-CLTCL1chr2219178947-0.0054508980.9945491
ENST00000545799ENST00000263200DGCR2chr2219076881-CLTCL1chr2219178947-0.0057757430.99422425
ENST00000545799ENST00000427926DGCR2chr2219076881-CLTCL1chr2219178947-0.0057367810.99426323

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22400_22400_1_DGCR2-CLTCL1_DGCR2_chr22_19076881_ENST00000545799_CLTCL1_chr22_19178947_ENST00000263200_length(amino acids)=292AA_BP=3
MSPSRCGQSCGATLGSLRVAAAPSSASPSPGSVTAGRLARMRATKPTVQVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSF
FSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELC
KKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALES

--------------------------------------------------------------

>22400_22400_2_DGCR2-CLTCL1_DGCR2_chr22_19076881_ENST00000545799_CLTCL1_chr22_19178947_ENST00000353891_length(amino acids)=235AA_BP=3
MSPSRCGQSCGATLGSLRVAAAPSSASPSPGSVTAGRLARMRATKPTVQVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSF
FSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLEL

--------------------------------------------------------------

>22400_22400_3_DGCR2-CLTCL1_DGCR2_chr22_19076881_ENST00000545799_CLTCL1_chr22_19178947_ENST00000427926_length(amino acids)=292AA_BP=3
MSPSRCGQSCGATLGSLRVAAAPSSASPSPGSVTAGRLARMRATKPTVQVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSF
FSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELC
KKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALES

--------------------------------------------------------------

>22400_22400_4_DGCR2-CLTCL1_DGCR2_chr22_19076881_ENST00000545799_CLTCL1_chr22_19263353_ENST00000263200_length(amino acids)=1675AA_BP=3
MSPSRCGQSCGATLGSLRVAAAPSSASPSPGSVTAGRLARMRATKPTVQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDM
SDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRH
TSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQ
PAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVL
SVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLL
QYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYA
KKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQV
ADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQV
ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLI
IVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQ
IQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPEL
WAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYIS
RLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPS
SYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFA
RLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMG
MFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCY
RALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISL
AQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLEL

--------------------------------------------------------------

>22400_22400_5_DGCR2-CLTCL1_DGCR2_chr22_19076881_ENST00000545799_CLTCL1_chr22_19263353_ENST00000353891_length(amino acids)=1618AA_BP=3
MSPSRCGQSCGATLGSLRVAAAPSSASPSPGSVTAGRLARMRATKPTVQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDM
SDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRH
TSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQ
PAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVL
SVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLL
QYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYA
KKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQV
ADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQV
ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLI
IVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQ
IQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPEL
WAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYIS
RLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPS
SYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFA
RLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMG
MFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCY
RALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQDAMQHAAESRDAELAQK

--------------------------------------------------------------

>22400_22400_6_DGCR2-CLTCL1_DGCR2_chr22_19076881_ENST00000545799_CLTCL1_chr22_19263353_ENST00000427926_length(amino acids)=1675AA_BP=3
MSPSRCGQSCGATLGSLRVAAAPSSASPSPGSVTAGRLARMRATKPTVQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDM
SDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRH
TSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQ
PAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVL
SVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLL
QYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYA
KKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQV
ADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQV
ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLI
IVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQ
IQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPEL
WAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYIS
RLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPS
SYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFA
RLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMG
MFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCY
RALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISL
AQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLEL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19076881/chr22:19263353)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGCR2

P98153

CLTCL1

P53675

FUNCTION: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGCR2chr22:19076881chr22:19178947ENST00000263196-21028_6867.33333333333333551.0DomainLDL-receptor class A
HgeneDGCR2chr22:19076881chr22:19263353ENST00000263196-21028_6867.33333333333333551.0DomainLDL-receptor class A
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000026320025331551_16401397.01712.3333333333333RegionTrimerization
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000035389125321551_16401397.01665.0RegionTrimerization
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000042792626341551_16401397.01710.6666666666667RegionTrimerization
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033108_14914.01712.3333333333333RegionNote=WD40-like repeat 3
TgeneCLTCL1chr22:19076881chr22:19263353ENST000002632000331213_152214.01712.3333333333333RegionInvolved in binding clathrin light chain
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033150_19514.01712.3333333333333RegionNote=WD40-like repeat 4
TgeneCLTCL1chr22:19076881chr22:19263353ENST000002632000331551_164014.01712.3333333333333RegionTrimerization
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033196_25714.01712.3333333333333RegionNote=WD40-like repeat 5
TgeneCLTCL1chr22:19076881chr22:19263353ENST0000026320003324_6714.01712.3333333333333RegionNote=WD40-like repeat 1
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033258_30114.01712.3333333333333RegionNote=WD40-like repeat 6
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033302_33014.01712.3333333333333RegionNote=WD40-like repeat 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033449_46514.01712.3333333333333RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033480_52314.01712.3333333333333RegionNote=Flexible linker
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033524_164014.01712.3333333333333RegionNote=Heavy chain arm
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033524_63414.01712.3333333333333RegionNote=Distal segment
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033639_164014.01712.3333333333333RegionNote=Proximal segment
TgeneCLTCL1chr22:19076881chr22:19263353ENST0000026320003368_10714.01712.3333333333333RegionNote=WD40-like repeat 2
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032108_14914.01665.0RegionNote=WD40-like repeat 3
TgeneCLTCL1chr22:19076881chr22:19263353ENST000003538910321213_152214.01665.0RegionInvolved in binding clathrin light chain
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032150_19514.01665.0RegionNote=WD40-like repeat 4
TgeneCLTCL1chr22:19076881chr22:19263353ENST000003538910321551_164014.01665.0RegionTrimerization
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032196_25714.01665.0RegionNote=WD40-like repeat 5
TgeneCLTCL1chr22:19076881chr22:19263353ENST0000035389103224_6714.01665.0RegionNote=WD40-like repeat 1
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032258_30114.01665.0RegionNote=WD40-like repeat 6
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032302_33014.01665.0RegionNote=WD40-like repeat 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032449_46514.01665.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032480_52314.01665.0RegionNote=Flexible linker
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032524_164014.01665.0RegionNote=Heavy chain arm
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032524_63414.01665.0RegionNote=Distal segment
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032639_164014.01665.0RegionNote=Proximal segment
TgeneCLTCL1chr22:19076881chr22:19263353ENST0000035389103268_10714.01665.0RegionNote=WD40-like repeat 2
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034108_14914.01710.6666666666667RegionNote=WD40-like repeat 3
TgeneCLTCL1chr22:19076881chr22:19263353ENST000004279260341213_152214.01710.6666666666667RegionInvolved in binding clathrin light chain
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034150_19514.01710.6666666666667RegionNote=WD40-like repeat 4
TgeneCLTCL1chr22:19076881chr22:19263353ENST000004279260341551_164014.01710.6666666666667RegionTrimerization
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034196_25714.01710.6666666666667RegionNote=WD40-like repeat 5
TgeneCLTCL1chr22:19076881chr22:19263353ENST0000042792603424_6714.01710.6666666666667RegionNote=WD40-like repeat 1
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034258_30114.01710.6666666666667RegionNote=WD40-like repeat 6
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034302_33014.01710.6666666666667RegionNote=WD40-like repeat 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034449_46514.01710.6666666666667RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034480_52314.01710.6666666666667RegionNote=Flexible linker
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034524_164014.01710.6666666666667RegionNote=Heavy chain arm
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034524_63414.01710.6666666666667RegionNote=Distal segment
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034639_164014.01710.6666666666667RegionNote=Proximal segment
TgeneCLTCL1chr22:19076881chr22:19263353ENST0000042792603468_10714.01710.6666666666667RegionNote=WD40-like repeat 2
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000026320025331423_15661397.01712.3333333333333RepeatNote=CHCR 7
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000035389125321423_15661397.01665.0RepeatNote=CHCR 7
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000042792626341423_15661397.01710.6666666666667RepeatNote=CHCR 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST000002632000331128_126914.01712.3333333333333RepeatNote=CHCR 5
TgeneCLTCL1chr22:19076881chr22:19263353ENST000002632000331274_142014.01712.3333333333333RepeatNote=CHCR 6
TgeneCLTCL1chr22:19076881chr22:19263353ENST000002632000331423_156614.01712.3333333333333RepeatNote=CHCR 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033537_68314.01712.3333333333333RepeatNote=CHCR 1
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033686_82814.01712.3333333333333RepeatNote=CHCR 2
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033833_97214.01712.3333333333333RepeatNote=CHCR 3
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000263200033979_112414.01712.3333333333333RepeatNote=CHCR 4
TgeneCLTCL1chr22:19076881chr22:19263353ENST000003538910321128_126914.01665.0RepeatNote=CHCR 5
TgeneCLTCL1chr22:19076881chr22:19263353ENST000003538910321274_142014.01665.0RepeatNote=CHCR 6
TgeneCLTCL1chr22:19076881chr22:19263353ENST000003538910321423_156614.01665.0RepeatNote=CHCR 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032537_68314.01665.0RepeatNote=CHCR 1
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032686_82814.01665.0RepeatNote=CHCR 2
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032833_97214.01665.0RepeatNote=CHCR 3
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000353891032979_112414.01665.0RepeatNote=CHCR 4
TgeneCLTCL1chr22:19076881chr22:19263353ENST000004279260341128_126914.01710.6666666666667RepeatNote=CHCR 5
TgeneCLTCL1chr22:19076881chr22:19263353ENST000004279260341274_142014.01710.6666666666667RepeatNote=CHCR 6
TgeneCLTCL1chr22:19076881chr22:19263353ENST000004279260341423_156614.01710.6666666666667RepeatNote=CHCR 7
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034537_68314.01710.6666666666667RepeatNote=CHCR 1
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034686_82814.01710.6666666666667RepeatNote=CHCR 2
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034833_97214.01710.6666666666667RepeatNote=CHCR 3
TgeneCLTCL1chr22:19076881chr22:19263353ENST00000427926034979_112414.01710.6666666666667RepeatNote=CHCR 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGCR2chr22:19076881chr22:19178947ENST00000263196-210115_24167.33333333333333551.0DomainC-type lectin
HgeneDGCR2chr22:19076881chr22:19178947ENST00000263196-210270_33367.33333333333333551.0DomainNote=VWFC
HgeneDGCR2chr22:19076881chr22:19178947ENST00000537045-19115_2410510.0DomainC-type lectin
HgeneDGCR2chr22:19076881chr22:19178947ENST00000537045-19270_3330510.0DomainNote=VWFC
HgeneDGCR2chr22:19076881chr22:19178947ENST00000537045-1928_680510.0DomainLDL-receptor class A
HgeneDGCR2chr22:19076881chr22:19263353ENST00000263196-210115_24167.33333333333333551.0DomainC-type lectin
HgeneDGCR2chr22:19076881chr22:19263353ENST00000263196-210270_33367.33333333333333551.0DomainNote=VWFC
HgeneDGCR2chr22:19076881chr22:19263353ENST00000537045-19115_2410510.0DomainC-type lectin
HgeneDGCR2chr22:19076881chr22:19263353ENST00000537045-19270_3330510.0DomainNote=VWFC
HgeneDGCR2chr22:19076881chr22:19263353ENST00000537045-1928_680510.0DomainLDL-receptor class A
HgeneDGCR2chr22:19076881chr22:19178947ENST00000263196-21021_34967.33333333333333551.0Topological domainExtracellular
HgeneDGCR2chr22:19076881chr22:19178947ENST00000263196-210369_55067.33333333333333551.0Topological domainCytoplasmic
HgeneDGCR2chr22:19076881chr22:19178947ENST00000537045-1921_3490510.0Topological domainExtracellular
HgeneDGCR2chr22:19076881chr22:19178947ENST00000537045-19369_5500510.0Topological domainCytoplasmic
HgeneDGCR2chr22:19076881chr22:19263353ENST00000263196-21021_34967.33333333333333551.0Topological domainExtracellular
HgeneDGCR2chr22:19076881chr22:19263353ENST00000263196-210369_55067.33333333333333551.0Topological domainCytoplasmic
HgeneDGCR2chr22:19076881chr22:19263353ENST00000537045-1921_3490510.0Topological domainExtracellular
HgeneDGCR2chr22:19076881chr22:19263353ENST00000537045-19369_5500510.0Topological domainCytoplasmic
HgeneDGCR2chr22:19076881chr22:19178947ENST00000263196-210350_36867.33333333333333551.0TransmembraneHelical
HgeneDGCR2chr22:19076881chr22:19178947ENST00000537045-19350_3680510.0TransmembraneHelical
HgeneDGCR2chr22:19076881chr22:19263353ENST00000263196-210350_36867.33333333333333551.0TransmembraneHelical
HgeneDGCR2chr22:19076881chr22:19263353ENST00000537045-19350_3680510.0TransmembraneHelical
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533108_1491397.01712.3333333333333RegionNote=WD40-like repeat 3
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000026320025331213_15221397.01712.3333333333333RegionInvolved in binding clathrin light chain
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533150_1951397.01712.3333333333333RegionNote=WD40-like repeat 4
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533196_2571397.01712.3333333333333RegionNote=WD40-like repeat 5
TgeneCLTCL1chr22:19076881chr22:19178947ENST00000263200253324_671397.01712.3333333333333RegionNote=WD40-like repeat 1
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533258_3011397.01712.3333333333333RegionNote=WD40-like repeat 6
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000026320025332_4791397.01712.3333333333333RegionNote=Globular terminal domain
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533302_3301397.01712.3333333333333RegionNote=WD40-like repeat 7
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533449_4651397.01712.3333333333333RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533480_5231397.01712.3333333333333RegionNote=Flexible linker
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533524_16401397.01712.3333333333333RegionNote=Heavy chain arm
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533524_6341397.01712.3333333333333RegionNote=Distal segment
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533639_16401397.01712.3333333333333RegionNote=Proximal segment
TgeneCLTCL1chr22:19076881chr22:19178947ENST00000263200253368_1071397.01712.3333333333333RegionNote=WD40-like repeat 2
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532108_1491397.01665.0RegionNote=WD40-like repeat 3
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000035389125321213_15221397.01665.0RegionInvolved in binding clathrin light chain
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532150_1951397.01665.0RegionNote=WD40-like repeat 4
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532196_2571397.01665.0RegionNote=WD40-like repeat 5
TgeneCLTCL1chr22:19076881chr22:19178947ENST00000353891253224_671397.01665.0RegionNote=WD40-like repeat 1
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532258_3011397.01665.0RegionNote=WD40-like repeat 6
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000035389125322_4791397.01665.0RegionNote=Globular terminal domain
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532302_3301397.01665.0RegionNote=WD40-like repeat 7
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532449_4651397.01665.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532480_5231397.01665.0RegionNote=Flexible linker
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532524_16401397.01665.0RegionNote=Heavy chain arm
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532524_6341397.01665.0RegionNote=Distal segment
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532639_16401397.01665.0RegionNote=Proximal segment
TgeneCLTCL1chr22:19076881chr22:19178947ENST00000353891253268_1071397.01665.0RegionNote=WD40-like repeat 2
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634108_1491397.01710.6666666666667RegionNote=WD40-like repeat 3
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000042792626341213_15221397.01710.6666666666667RegionInvolved in binding clathrin light chain
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634150_1951397.01710.6666666666667RegionNote=WD40-like repeat 4
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634196_2571397.01710.6666666666667RegionNote=WD40-like repeat 5
TgeneCLTCL1chr22:19076881chr22:19178947ENST00000427926263424_671397.01710.6666666666667RegionNote=WD40-like repeat 1
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634258_3011397.01710.6666666666667RegionNote=WD40-like repeat 6
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000042792626342_4791397.01710.6666666666667RegionNote=Globular terminal domain
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634302_3301397.01710.6666666666667RegionNote=WD40-like repeat 7
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634449_4651397.01710.6666666666667RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634480_5231397.01710.6666666666667RegionNote=Flexible linker
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634524_16401397.01710.6666666666667RegionNote=Heavy chain arm
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634524_6341397.01710.6666666666667RegionNote=Distal segment
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634639_16401397.01710.6666666666667RegionNote=Proximal segment
TgeneCLTCL1chr22:19076881chr22:19178947ENST00000427926263468_1071397.01710.6666666666667RegionNote=WD40-like repeat 2
TgeneCLTCL1chr22:19076881chr22:19263353ENST000002632000332_47914.01712.3333333333333RegionNote=Globular terminal domain
TgeneCLTCL1chr22:19076881chr22:19263353ENST000003538910322_47914.01665.0RegionNote=Globular terminal domain
TgeneCLTCL1chr22:19076881chr22:19263353ENST000004279260342_47914.01710.6666666666667RegionNote=Globular terminal domain
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000026320025331128_12691397.01712.3333333333333RepeatNote=CHCR 5
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000026320025331274_14201397.01712.3333333333333RepeatNote=CHCR 6
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533537_6831397.01712.3333333333333RepeatNote=CHCR 1
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533686_8281397.01712.3333333333333RepeatNote=CHCR 2
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533833_9721397.01712.3333333333333RepeatNote=CHCR 3
TgeneCLTCL1chr22:19076881chr22:19178947ENST000002632002533979_11241397.01712.3333333333333RepeatNote=CHCR 4
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000035389125321128_12691397.01665.0RepeatNote=CHCR 5
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000035389125321274_14201397.01665.0RepeatNote=CHCR 6
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532537_6831397.01665.0RepeatNote=CHCR 1
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532686_8281397.01665.0RepeatNote=CHCR 2
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532833_9721397.01665.0RepeatNote=CHCR 3
TgeneCLTCL1chr22:19076881chr22:19178947ENST000003538912532979_11241397.01665.0RepeatNote=CHCR 4
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000042792626341128_12691397.01710.6666666666667RepeatNote=CHCR 5
TgeneCLTCL1chr22:19076881chr22:19178947ENST0000042792626341274_14201397.01710.6666666666667RepeatNote=CHCR 6
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634537_6831397.01710.6666666666667RepeatNote=CHCR 1
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634686_8281397.01710.6666666666667RepeatNote=CHCR 2
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634833_9721397.01710.6666666666667RepeatNote=CHCR 3
TgeneCLTCL1chr22:19076881chr22:19178947ENST000004279262634979_11241397.01710.6666666666667RepeatNote=CHCR 4


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DGCR2
CLTCL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to DGCR2-CLTCL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to DGCR2-CLTCL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource