UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:DLK1-CCT5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DLK1-CCT5
FusionPDB ID: 23190
FusionGDB2.0 ID: 23190
HgeneTgene
Gene symbol

DLK1

CCT5

Gene ID

8788

22948

Gene namedelta like non-canonical Notch ligand 1chaperonin containing TCP1 subunit 5
SynonymsDLK|DLK-1|Delta1|FA1|PREF1|Pref-1|ZOG|pG2CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

14q32.2

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionprotein delta homolog 1delta-like 1 homologfetal antigen 1preadipocyte factor 1secredeltinT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020032920200313
UniProtAcc

P80370

P48643

Ensembl transtripts involved in fusion geneENST idsENST00000341267, ENST00000331224, 
ENST00000556051, 
ENST00000280326, 
ENST00000503026, ENST00000506600, 
ENST00000515390, ENST00000515676, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 4=22458 X 14 X 17=13804
# samples 961
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DLK1 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DLK1(101201464)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.DLK1-CCT5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLK1-CCT5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLK1-CCT5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLK1-CCT5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLK1

GO:0045746

negative regulation of Notch signaling pathway

25093684


check buttonFusion gene breakpoints across DLK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NG-A4VU-01ADLK1chr14

101201464

-CCT5chr5

10250033

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000331224DLK1chr14101201464-ENST00000280326CCT5chr510250033+4999132417143369551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331224ENST00000280326DLK1chr14101201464-CCT5chr510250033+0.0013972030.9986028

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23190_23190_1_DLK1-CCT5_DLK1_chr14_101201464_ENST00000331224_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:101201464/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLK1

P80370

CCT5

P48643

FUNCTION: May have a role in neuroendocrine differentiation.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-66127_168388.0311.0DomainEGF-like 4
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-66170_206388.0311.0DomainEGF-like 5
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-66208_245388.0311.0DomainEGF-like 6
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-6624_55388.0311.0DomainEGF-like 1
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-6653_86388.0311.0DomainEGF-like 2
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-6688_125388.0311.0DomainEGF-like 3
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-6624_303388.0311.0Topological domainExtracellular
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-66328_383388.0311.0Topological domainCytoplasmic
HgeneDLK1chr14:101201464chr5:10250033ENST00000331224-66304_327388.0311.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-15127_1680384.0DomainEGF-like 4
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-15170_2060384.0DomainEGF-like 5
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-15208_2450384.0DomainEGF-like 6
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-1524_550384.0DomainEGF-like 1
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-1553_860384.0DomainEGF-like 2
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-1588_1250384.0DomainEGF-like 3
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-1524_3030384.0Topological domainExtracellular
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-15328_3830384.0Topological domainCytoplasmic
HgeneDLK1chr14:101201464chr5:10250033ENST00000341267-15304_3270384.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DLK1
CCT5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to DLK1-CCT5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to DLK1-CCT5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource