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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNAJB1-EPS15L1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNAJB1-EPS15L1
FusionPDB ID: 23419
FusionGDB2.0 ID: 23419
HgeneTgene
Gene symbol

DNAJB1

EPS15L1

Gene ID

3337

58513

Gene nameDnaJ heat shock protein family (Hsp40) member B1epidermal growth factor receptor pathway substrate 15 like 1
SynonymsHSPF1|Hdj1|Hsp40|RSPH16B|Sis1EPS15R
Cytomap

19p13.12

19p13.11

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog Bepidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related protein
Modification date2020031320200313
UniProtAcc

Q8TBM8

Q9UBC2

Ensembl transtripts involved in fusion geneENST idsENST00000254322, ENST00000396969, 
ENST00000248070, ENST00000535753, 
ENST00000594975, ENST00000597937, 
ENST00000602009, ENST00000455140, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 8 X 5=20012 X 10 X 6=720
# samples 1013
** MAII scorelog2(10/200*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNAJB1 [Title/Abstract] AND EPS15L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNAJB1(14628951)-EPS15L1(16472795), # samples:2
DNAJB1(14628950)-EPS15L1(16472795), # samples:2
Anticipated loss of major functional domain due to fusion event.DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJB1

GO:0032781

positive regulation of ATPase activity

23921388

HgeneDNAJB1

GO:0051085

chaperone cofactor-dependent protein refolding

18620420

HgeneDNAJB1

GO:0090084

negative regulation of inclusion body assembly

21231916

HgeneDNAJB1

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401


check buttonFusion gene breakpoints across DNAJB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPS15L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1519-01ADNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
ChimerDB4OVTCGA-04-1519-01ADNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
ChimerDB4OVTCGA-04-1519DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254322DNAJB1chr1914628951-ENST00000248070EPS15L1chr1916472795-6862825802193
ENST00000254322DNAJB1chr1914628951-ENST00000535753EPS15L1chr1916472795-67028211496161
ENST00000254322DNAJB1chr1914628950-ENST00000248070EPS15L1chr1916472795-6862825802193
ENST00000254322DNAJB1chr1914628950-ENST00000535753EPS15L1chr1916472795-67028211496161

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254322ENST00000248070DNAJB1chr1914628951-EPS15L1chr1916472795-0.0103753220.9896247
ENST00000254322ENST00000535753DNAJB1chr1914628951-EPS15L1chr1916472795-0.0106167290.9893833
ENST00000254322ENST00000248070DNAJB1chr1914628950-EPS15L1chr1916472795-0.0103753220.9896247
ENST00000254322ENST00000535753DNAJB1chr1914628950-EPS15L1chr1916472795-0.0106167290.9893833

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23419_23419_1_DNAJB1-EPS15L1_DNAJB1_chr19_14628950_ENST00000254322_EPS15L1_chr19_16472795_ENST00000248070_length(amino acids)=193AA_BP=1
MGGLPLKGDKNPREAASGREWGGPEAEDSTYRGEVCKARGRGLRRFSCRGGDKWVFSTKRVPKPLFTLERVAAVSPEWLEWIGGLGKVCG
TKLAYRCTFTFLPVAVEDLALARVAEHVVGLSDLLELLLGAGLLVLVRVVAQRLAAVGPLDLLVRRAAGQAQRLVVVFTHDPLLRPADPL

--------------------------------------------------------------

>23419_23419_2_DNAJB1-EPS15L1_DNAJB1_chr19_14628950_ENST00000254322_EPS15L1_chr19_16472795_ENST00000535753_length(amino acids)=161AA_BP=90
MVGGGAGGRRQRVGGPQEGVMGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEE

--------------------------------------------------------------

>23419_23419_3_DNAJB1-EPS15L1_DNAJB1_chr19_14628951_ENST00000254322_EPS15L1_chr19_16472795_ENST00000248070_length(amino acids)=193AA_BP=1
MGGLPLKGDKNPREAASGREWGGPEAEDSTYRGEVCKARGRGLRRFSCRGGDKWVFSTKRVPKPLFTLERVAAVSPEWLEWIGGLGKVCG
TKLAYRCTFTFLPVAVEDLALARVAEHVVGLSDLLELLLGAGLLVLVRVVAQRLAAVGPLDLLVRRAAGQAQRLVVVFTHDPLLRPADPL

--------------------------------------------------------------

>23419_23419_4_DNAJB1-EPS15L1_DNAJB1_chr19_14628951_ENST00000254322_EPS15L1_chr19_16472795_ENST00000535753_length(amino acids)=161AA_BP=90
MVGGGAGGRRQRVGGPQEGVMGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14628951/chr19:16472795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJB1

Q8TBM8

EPS15L1

Q9UBC2

FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJB1chr19:14628950chr19:16472795ENST00000254322-132_7070.33333333333333341.0DomainJ
HgeneDNAJB1chr19:14628951chr19:16472795ENST00000254322-132_7070.33333333333333341.0DomainJ
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016172_1840602.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016172_1840602.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016386_5530602.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016386_5530602.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022750_816749.0755.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016750_8160602.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022750_816749.0755.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016750_8160602.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016127_2150602.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016159_1940602.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST0000059793701615_1040602.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016275_3650602.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016127_2150602.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016159_1940602.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST0000059793701615_1040602.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016275_3650602.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016618_8350602.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016618_8350602.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123806_808793.3333333333334865.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123812_814793.3333333333334865.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123833_835793.3333333333334865.0RepeatNote=15
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124806_808793.3333333333334911.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124812_814793.3333333333334911.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124833_835793.3333333333334911.0RepeatNote=15
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022754_756749.0755.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022806_808749.0755.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022812_814749.0755.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022833_835749.0755.0RepeatNote=15
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016618_6200602.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016640_6420602.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016645_6470602.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016650_6520602.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016656_6580602.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016661_6630602.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016667_6690602.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016685_6870602.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016690_6920602.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016709_7110602.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016728_7300602.0RepeatNote=11
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016754_7560602.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016806_8080602.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016812_8140602.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016833_8350602.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123806_808793.3333333333334865.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123812_814793.3333333333334865.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123833_835793.3333333333334865.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124806_808793.3333333333334911.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124812_814793.3333333333334911.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124833_835793.3333333333334911.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022754_756749.0755.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022806_808749.0755.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022812_814749.0755.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022833_835749.0755.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016618_6200602.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016640_6420602.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016645_6470602.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016650_6520602.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016656_6580602.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016661_6630602.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016667_6690602.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016685_6870602.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016690_6920602.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016709_7110602.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016728_7300602.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016754_7560602.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016806_8080602.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016812_8140602.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016833_8350602.0RepeatNote=15

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123172_184793.3333333333334865.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124172_184793.3333333333334911.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022172_184749.0755.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123172_184793.3333333333334865.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124172_184793.3333333333334911.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022172_184749.0755.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123386_553793.3333333333334865.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124386_553793.3333333333334911.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022386_553749.0755.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123386_553793.3333333333334865.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124386_553793.3333333333334911.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022386_553749.0755.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123750_816793.3333333333334865.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124750_816793.3333333333334911.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123750_816793.3333333333334865.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124750_816793.3333333333334911.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123127_215793.3333333333334865.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123159_194793.3333333333334865.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000248070212315_104793.3333333333334865.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123275_365793.3333333333334865.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124127_215793.3333333333334911.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124159_194793.3333333333334911.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000455140212415_104793.3333333333334911.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124275_365793.3333333333334911.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022127_215749.0755.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022159_194749.0755.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000535753202215_104749.0755.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022275_365749.0755.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123127_215793.3333333333334865.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123159_194793.3333333333334865.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000248070212315_104793.3333333333334865.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123275_365793.3333333333334865.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124127_215793.3333333333334911.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124159_194793.3333333333334911.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000455140212415_104793.3333333333334911.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124275_365793.3333333333334911.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022127_215749.0755.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022159_194749.0755.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000535753202215_104749.0755.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022275_365749.0755.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123618_835793.3333333333334865.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124618_835793.3333333333334911.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022618_835749.0755.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123618_835793.3333333333334865.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124618_835793.3333333333334911.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022618_835749.0755.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123618_620793.3333333333334865.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123640_642793.3333333333334865.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123645_647793.3333333333334865.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123650_652793.3333333333334865.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123656_658793.3333333333334865.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123661_663793.3333333333334865.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123667_669793.3333333333334865.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123685_687793.3333333333334865.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123690_692793.3333333333334865.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123709_711793.3333333333334865.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123728_730793.3333333333334865.0RepeatNote=11
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123754_756793.3333333333334865.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124618_620793.3333333333334911.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124640_642793.3333333333334911.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124645_647793.3333333333334911.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124650_652793.3333333333334911.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124656_658793.3333333333334911.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124661_663793.3333333333334911.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124667_669793.3333333333334911.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124685_687793.3333333333334911.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124690_692793.3333333333334911.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124709_711793.3333333333334911.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124728_730793.3333333333334911.0RepeatNote=11
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124754_756793.3333333333334911.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022618_620749.0755.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022640_642749.0755.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022645_647749.0755.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022650_652749.0755.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022656_658749.0755.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022661_663749.0755.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022667_669749.0755.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022685_687749.0755.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022690_692749.0755.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022709_711749.0755.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022728_730749.0755.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123618_620793.3333333333334865.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123640_642793.3333333333334865.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123645_647793.3333333333334865.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123650_652793.3333333333334865.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123656_658793.3333333333334865.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123661_663793.3333333333334865.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123667_669793.3333333333334865.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123685_687793.3333333333334865.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123690_692793.3333333333334865.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123709_711793.3333333333334865.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123728_730793.3333333333334865.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123754_756793.3333333333334865.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124618_620793.3333333333334911.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124640_642793.3333333333334911.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124645_647793.3333333333334911.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124650_652793.3333333333334911.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124656_658793.3333333333334911.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124661_663793.3333333333334911.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124667_669793.3333333333334911.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124685_687793.3333333333334911.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124690_692793.3333333333334911.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124709_711793.3333333333334911.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124728_730793.3333333333334911.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124754_756793.3333333333334911.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022618_620749.0755.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022640_642749.0755.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022645_647749.0755.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022650_652749.0755.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022656_658749.0755.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022661_663749.0755.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022667_669749.0755.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022685_687749.0755.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022690_692749.0755.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022709_711749.0755.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022728_730749.0755.0RepeatNote=11


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNAJB1
EPS15L1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000248070212315_368793.3333333333334865.0DAB2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000455140212415_368793.3333333333334911.0DAB2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000535753202215_368749.0755.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000248070212315_368793.3333333333334865.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000455140212415_368793.3333333333334911.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000535753202215_368749.0755.0DAB2


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Related Drugs to DNAJB1-EPS15L1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNAJB1-EPS15L1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource