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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNAJC3-CLDN10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNAJC3-CLDN10
FusionPDB ID: 23537
FusionGDB2.0 ID: 23537
HgeneTgene
Gene symbol

DNAJC3

CLDN10

Gene ID

5611

9071

Gene nameDnaJ heat shock protein family (Hsp40) member C3claudin 10
SynonymsACPHD|ERdj6|HP58|P58|P58IPK|PRKRI|p58(IPK)CPETRL3|HELIX|OSP-L|OSPL
Cytomap

13q32.1

13q32.1

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 3DnaJ (Hsp40) homolog, subfamily C, member 3ER-resident protein ERdj6endoplasmic reticulum DNA J domain-containing protein 6interferon-induced, double-stranded RNA-activated protein kinase inhibitorprotein kinase inhibclaudin-10OSP-like proteinoligodendrocyte-specific protein-like
Modification date2020032920200329
UniProtAcc

Q13217

P78369

Ensembl transtripts involved in fusion geneENST idsENST00000376795, ENST00000602402, 
ENST00000376855, ENST00000299339, 
ENST00000376873, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 14 X 8=16806 X 4 X 5=120
# samples 187
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNAJC3 [Title/Abstract] AND CLDN10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNAJC3(96329591)-CLDN10(96212386), # samples:4
Anticipated loss of major functional domain due to fusion event.DNAJC3-CLDN10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJC3-CLDN10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DNAJC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLDN10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0787-01ADNAJC3chr13

96416207

+CLDN10chr13

96212386

+
ChimerDB4LUADTCGA-44-4112-01ADNAJC3chr13

96329591

-CLDN10chr13

96212386

+
ChimerDB4LUADTCGA-44-4112-01ADNAJC3chr13

96329591

+CLDN10chr13

96212386

+
ChimerDB4STADTCGA-BR-8289-01ADNAJC3chr13

96329591

-CLDN10chr13

96212386

+
ChimerDB4STADTCGA-BR-8289-01ADNAJC3chr13

96329591

+CLDN10chr13

96212386

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000602402DNAJC3chr1396416207+ENST00000376873CLDN10chr1396212386+34041192451658537
ENST00000602402DNAJC3chr1396416207+ENST00000299339CLDN10chr1396212386+18921192451658537
ENST00000376795DNAJC3chr1396416207+ENST00000376873CLDN10chr1396212386+32321020261486486
ENST00000376795DNAJC3chr1396416207+ENST00000299339CLDN10chr1396212386+17201020261486486
ENST00000602402DNAJC3chr1396329591+ENST00000376873CLDN10chr1396212386+241119945665206
ENST00000602402DNAJC3chr1396329591+ENST00000299339CLDN10chr1396212386+89919945665206
ENST00000376795DNAJC3chr1396329591+ENST00000376873CLDN10chr1396212386+239218026646206
ENST00000376795DNAJC3chr1396329591+ENST00000299339CLDN10chr1396212386+88018026646206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000602402ENST00000376873DNAJC3chr1396416207+CLDN10chr1396212386+0.0004183720.99958163
ENST00000602402ENST00000299339DNAJC3chr1396416207+CLDN10chr1396212386+0.000637640.9993624
ENST00000376795ENST00000376873DNAJC3chr1396416207+CLDN10chr1396212386+0.000513040.9994869
ENST00000376795ENST00000299339DNAJC3chr1396416207+CLDN10chr1396212386+0.0007295580.9992705
ENST00000602402ENST00000376873DNAJC3chr1396329591+CLDN10chr1396212386+0.0006628550.99933714
ENST00000602402ENST00000299339DNAJC3chr1396329591+CLDN10chr1396212386+0.0009489470.99905103
ENST00000376795ENST00000376873DNAJC3chr1396329591+CLDN10chr1396212386+0.0005947710.99940526
ENST00000376795ENST00000299339DNAJC3chr1396329591+CLDN10chr1396212386+0.0008210990.9991788

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23537_23537_1_DNAJC3-CLDN10_DNAJC3_chr13_96329591_ENST00000376795_CLDN10_chr13_96212386_ENST00000299339_length(amino acids)=206AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA
KAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMS

--------------------------------------------------------------

>23537_23537_2_DNAJC3-CLDN10_DNAJC3_chr13_96329591_ENST00000376795_CLDN10_chr13_96212386_ENST00000376873_length(amino acids)=206AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA
KAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMS

--------------------------------------------------------------

>23537_23537_3_DNAJC3-CLDN10_DNAJC3_chr13_96329591_ENST00000602402_CLDN10_chr13_96212386_ENST00000299339_length(amino acids)=206AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA
KAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMS

--------------------------------------------------------------

>23537_23537_4_DNAJC3-CLDN10_DNAJC3_chr13_96329591_ENST00000602402_CLDN10_chr13_96212386_ENST00000376873_length(amino acids)=206AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA
KAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMS

--------------------------------------------------------------

>23537_23537_5_DNAJC3-CLDN10_DNAJC3_chr13_96416207_ENST00000376795_CLDN10_chr13_96212386_ENST00000299339_length(amino acids)=486AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVVCVWDAELRELRAECFIKEGEPRKA
ISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKT
EPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEGYIQACRGLMIAAVSLGFFGSIFALFGMK
CTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRY

--------------------------------------------------------------

>23537_23537_6_DNAJC3-CLDN10_DNAJC3_chr13_96416207_ENST00000376795_CLDN10_chr13_96212386_ENST00000376873_length(amino acids)=486AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVVCVWDAELRELRAECFIKEGEPRKA
ISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKT
EPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEGYIQACRGLMIAAVSLGFFGSIFALFGMK
CTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRY

--------------------------------------------------------------

>23537_23537_7_DNAJC3-CLDN10_DNAJC3_chr13_96416207_ENST00000602402_CLDN10_chr13_96212386_ENST00000299339_length(amino acids)=537AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQR
LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVR
ECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQME
PDNVNALKDRAEAYLIEEMYDEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANK

--------------------------------------------------------------

>23537_23537_8_DNAJC3-CLDN10_DNAJC3_chr13_96416207_ENST00000602402_CLDN10_chr13_96212386_ENST00000376873_length(amino acids)=537AA_BP=25
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQR
LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVR
ECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQME
PDNVNALKDRAEAYLIEEMYDEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:96329591/chr13:96212386)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC3

Q13217

CLDN10

P78369

FUNCTION: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}.FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597). {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912105_138358.3333333333333505.0RepeatNote=TPR 3
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912154_187358.3333333333333505.0RepeatNote=TPR 4
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912189_221358.3333333333333505.0RepeatNote=TPR 5
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912222_255358.3333333333333505.0RepeatNote=TPR 6
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912268_301358.3333333333333505.0RepeatNote=TPR 7
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912306_339358.3333333333333505.0RepeatNote=TPR 8
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+91237_70358.3333333333333505.0RepeatNote=TPR 1
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+91272_104358.3333333333333505.0RepeatNote=TPR 2
TgeneCLDN10chr13:96329591chr13:96212386ENST0000029933905102_11573.33333333333333229.0Topological domainCytoplasmic
TgeneCLDN10chr13:96329591chr13:96212386ENST0000029933905137_16073.33333333333333229.0Topological domainExtracellular
TgeneCLDN10chr13:96329591chr13:96212386ENST0000029933905182_22873.33333333333333229.0Topological domainCytoplasmic
TgeneCLDN10chr13:96329591chr13:96212386ENST0000037687305102_11571.33333333333333227.0Topological domainCytoplasmic
TgeneCLDN10chr13:96329591chr13:96212386ENST0000037687305137_16071.33333333333333227.0Topological domainExtracellular
TgeneCLDN10chr13:96329591chr13:96212386ENST0000037687305182_22871.33333333333333227.0Topological domainCytoplasmic
TgeneCLDN10chr13:96416207chr13:96212386ENST0000029933905102_11573.33333333333333229.0Topological domainCytoplasmic
TgeneCLDN10chr13:96416207chr13:96212386ENST0000029933905137_16073.33333333333333229.0Topological domainExtracellular
TgeneCLDN10chr13:96416207chr13:96212386ENST0000029933905182_22873.33333333333333229.0Topological domainCytoplasmic
TgeneCLDN10chr13:96416207chr13:96212386ENST0000037687305102_11571.33333333333333227.0Topological domainCytoplasmic
TgeneCLDN10chr13:96416207chr13:96212386ENST0000037687305137_16071.33333333333333227.0Topological domainExtracellular
TgeneCLDN10chr13:96416207chr13:96212386ENST0000037687305182_22871.33333333333333227.0Topological domainCytoplasmic
TgeneCLDN10chr13:96329591chr13:96212386ENST0000029933905116_13673.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96329591chr13:96212386ENST0000029933905161_18173.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96329591chr13:96212386ENST000002993390581_10173.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96329591chr13:96212386ENST0000037687305116_13671.33333333333333227.0TransmembraneHelical
TgeneCLDN10chr13:96329591chr13:96212386ENST0000037687305161_18171.33333333333333227.0TransmembraneHelical
TgeneCLDN10chr13:96329591chr13:96212386ENST000003768730581_10171.33333333333333227.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST0000029933905116_13673.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST0000029933905161_18173.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST000002993390581_10173.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST0000037687305116_13671.33333333333333227.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST0000037687305161_18171.33333333333333227.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST000003768730581_10171.33333333333333227.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112394_46227.333333333333332505.0DomainJ
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912394_462358.3333333333333505.0DomainJ
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112375_39327.333333333333332505.0RegionNote=Flexible linker
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912375_393358.3333333333333505.0RegionNote=Flexible linker
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112105_13827.333333333333332505.0RepeatNote=TPR 3
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112154_18727.333333333333332505.0RepeatNote=TPR 4
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112189_22127.333333333333332505.0RepeatNote=TPR 5
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112222_25527.333333333333332505.0RepeatNote=TPR 6
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112268_30127.333333333333332505.0RepeatNote=TPR 7
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112306_33927.333333333333332505.0RepeatNote=TPR 8
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+112340_37327.333333333333332505.0RepeatNote=TPR 9
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+11237_7027.333333333333332505.0RepeatNote=TPR 1
HgeneDNAJC3chr13:96329591chr13:96212386ENST00000602402+11272_10427.333333333333332505.0RepeatNote=TPR 2
HgeneDNAJC3chr13:96416207chr13:96212386ENST00000602402+912340_373358.3333333333333505.0RepeatNote=TPR 9
TgeneCLDN10chr13:96329591chr13:96212386ENST000002993390522_8073.33333333333333229.0Topological domainExtracellular
TgeneCLDN10chr13:96329591chr13:96212386ENST000003768730522_8071.33333333333333227.0Topological domainExtracellular
TgeneCLDN10chr13:96416207chr13:96212386ENST000002993390522_8073.33333333333333229.0Topological domainExtracellular
TgeneCLDN10chr13:96416207chr13:96212386ENST000003768730522_8071.33333333333333227.0Topological domainExtracellular
TgeneCLDN10chr13:96329591chr13:96212386ENST00000299339051_2173.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96329591chr13:96212386ENST00000376873051_2171.33333333333333227.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST00000299339051_2173.33333333333333229.0TransmembraneHelical
TgeneCLDN10chr13:96416207chr13:96212386ENST00000376873051_2171.33333333333333227.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>290_DNAJC3_96329591_CLDN10_96212386_ranked_0.pdbDNAJC39632959196329591ENST00000299339CLDN10chr1396212386+
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA
KAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMS
206


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DNAJC3_pLDDT.png
all structure
all structure
CLDN10_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNAJC3
CLDN10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DNAJC3-CLDN10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNAJC3-CLDN10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource