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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNMT1-ZNF563

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNMT1-ZNF563
FusionPDB ID: 23705
FusionGDB2.0 ID: 23705
HgeneTgene
Gene symbol

DNMT1

ZNF563

Gene ID

1786

147837

Gene nameDNA methyltransferase 1zinc finger protein 563
SynonymsADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaI-
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 1CXXC-type zinc finger protein 9DNA (cytosine-5-)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaIzinc finger protein 563
Modification date2020031320200313
UniProtAcc

P26358

.
Ensembl transtripts involved in fusion geneENST idsENST00000340748, ENST00000359526, 
ENST00000540357, ENST00000589538, 
ENST00000293725, ENST00000595977, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 11=18481 X 1 X 1=1
# samples 171
** MAII scorelog2(17/1848*10)=-3.44235810527836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNMT1 [Title/Abstract] AND ZNF563 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNMT1(10273343)-ZNF563(12433525), # samples:2
Anticipated loss of major functional domain due to fusion event.DNMT1-ZNF563 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT1-ZNF563 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT1-ZNF563 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT1-ZNF563 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT1

GO:0010216

maintenance of DNA methylation

18754681|21745816


check buttonFusion gene breakpoints across DNMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF563 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HF-7134-01ADNMT1chr19

10273343

-ZNF563chr19

12433525

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340748DNMT1chr1910273343-ENST00000293725ZNF563chr1912433525-37411196442623859
ENST00000340748DNMT1chr1910273343-ENST00000595977ZNF563chr1912433525-19131196441882612
ENST00000540357DNMT1chr1910273343-ENST00000293725ZNF563chr1912433525-368511401802567795
ENST00000540357DNMT1chr1910273343-ENST00000595977ZNF563chr1912433525-185711401801826548
ENST00000359526DNMT1chr1910273343-ENST00000293725ZNF563chr1912433525-373311881802615811
ENST00000359526DNMT1chr1910273343-ENST00000595977ZNF563chr1912433525-190511881801874564

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340748ENST00000293725DNMT1chr1910273343-ZNF563chr1912433525-0.0015441350.9984559
ENST00000340748ENST00000595977DNMT1chr1910273343-ZNF563chr1912433525-0.0079258340.99207413
ENST00000540357ENST00000293725DNMT1chr1910273343-ZNF563chr1912433525-0.0014951340.9985049
ENST00000540357ENST00000595977DNMT1chr1910273343-ZNF563chr1912433525-0.0083906590.9916093
ENST00000359526ENST00000293725DNMT1chr1910273343-ZNF563chr1912433525-0.0015643010.9984357
ENST00000359526ENST00000595977DNMT1chr1910273343-ZNF563chr1912433525-0.0068345530.99316543

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23705_23705_1_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000340748_ZNF563_chr19_12433525_ENST00000293725_length(amino acids)=859AA_BP=386
MGMAGSVPSFCTGYRLSPFGTSPPPPRPDWGGRRRLRSSPLPIGFRAKSRGACAAAAASAEASEMPARTAPARVPTLAVPAISLPDDVRR
RLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSE
ARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRR
VTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAK
RRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHM
VERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQ
SRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMH
TGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPH
KCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCG

--------------------------------------------------------------

>23705_23705_2_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000340748_ZNF563_chr19_12433525_ENST00000595977_length(amino acids)=612AA_BP=389
MGMAGSVPSFCTGYRLSPFGTSPPPPRPDWGGRRRLRSSPLPIGFRAKSRGACAAAAASAEASEMPARTAPARVPTLAVPAISLPDDVRR
RLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSE
ARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRR
VTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAK
RRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHM
VERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQ

--------------------------------------------------------------

>23705_23705_3_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000359526_ZNF563_chr19_12433525_ENST00000293725_length(amino acids)=811AA_BP=338
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTP
KQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQ
KNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGH
LSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKA
FFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSS
LRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMI
MHTGGGPHKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNKCKVCGKAFVYPSVCQRHEKTHWRET

--------------------------------------------------------------

>23705_23705_4_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000359526_ZNF563_chr19_12433525_ENST00000595977_length(amino acids)=564AA_BP=149
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTP
KQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQ
KNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGH
LSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKFPIEDMR

--------------------------------------------------------------

>23705_23705_5_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000540357_ZNF563_chr19_12433525_ENST00000293725_length(amino acids)=795AA_BP=322
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGV
QADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLD
CIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPH
EYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTG
EKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYEC
KQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKA

--------------------------------------------------------------

>23705_23705_6_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000540357_ZNF563_chr19_12433525_ENST00000595977_length(amino acids)=548AA_BP=325
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGV
QADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLD
CIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPH
EYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKFPIEDMRECTLGRNRMNVSSVLK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10273343/chr19:12433525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT1

P26358

.
FUNCTION: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-124016_109320.01617.0DomainDMAP1-binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-134116_109336.01633.0DomainDMAP1-binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240177_205320.01617.0MotifNuclear localization signal
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341177_205336.01633.0MotifNuclear localization signal
TgeneZNF563chr19:10273343chr19:12433525ENST00000293725044_961.0477.0DomainKRAB
TgeneZNF563chr19:10273343chr19:12433525ENST00000595977054_961.0230.0DomainKRAB
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504101_1251.0477.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504169_1911.0477.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504197_2191.0477.0Zinc fingerC2H2-type 3
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504225_2471.0477.0Zinc fingerC2H2-type 4
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504253_2751.0477.0Zinc fingerC2H2-type 5
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504281_3031.0477.0Zinc fingerC2H2-type 6
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504309_3311.0477.0Zinc fingerC2H2-type 7
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504337_3591.0477.0Zinc fingerC2H2-type 8
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504365_3871.0477.0Zinc fingerC2H2-type 9
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504393_4151.0477.0Zinc fingerC2H2-type 10
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504421_4431.0477.0Zinc fingerC2H2-type 11
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504449_4711.0477.0Zinc fingerC2H2-type 12
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705101_1251.0230.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705169_1911.0230.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705197_2191.0230.0Zinc fingerC2H2-type 3
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705225_2471.0230.0Zinc fingerC2H2-type 4
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705253_2751.0230.0Zinc fingerC2H2-type 5
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705281_3031.0230.0Zinc fingerC2H2-type 6
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705309_3311.0230.0Zinc fingerC2H2-type 7
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705337_3591.0230.0Zinc fingerC2H2-type 8
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705365_3871.0230.0Zinc fingerC2H2-type 9
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705393_4151.0230.0Zinc fingerC2H2-type 10
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705421_4431.0230.0Zinc fingerC2H2-type 11
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705449_4711.0230.0Zinc fingerC2H2-type 12

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401139_1599320.01617.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240755_880320.01617.0DomainBAH 1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240972_1100320.01617.0DomainBAH 2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411139_1599336.01633.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341755_880336.01633.0DomainBAH 1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341972_1100336.01633.0DomainBAH 2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401109_1120320.01617.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401139_1616320.01617.0RegionNote=Catalytic
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401150_1151320.01617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401168_1169320.01617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401190_1191320.01617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240310_502320.01617.0RegionNote=Homodimerization
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240331_550320.01617.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240651_697320.01617.0RegionNote=Required for activity
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240693_754320.01617.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411109_1120336.01633.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411139_1616336.01633.0RegionNote=Catalytic
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411150_1151336.01633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411168_1169336.01633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411190_1191336.01633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341310_502336.01633.0RegionNote=Homodimerization
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341331_550336.01633.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341651_697336.01633.0RegionNote=Required for activity
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341693_754336.01633.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401109_1110320.01617.0RepeatNote=1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401111_1112320.01617.0RepeatNote=2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401113_1114320.01617.0RepeatNote=3
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401115_1116320.01617.0RepeatNote=4
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401117_1118320.01617.0RepeatNote=5
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401119_1120320.01617.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411109_1110336.01633.0RepeatNote=1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411111_1112336.01633.0RepeatNote=2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411113_1114336.01633.0RepeatNote=3
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411115_1116336.01633.0RepeatNote=4
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411117_1118336.01633.0RepeatNote=5
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411119_1120336.01633.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240646_692320.01617.0Zinc fingerCXXC-type
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341646_692336.01633.0Zinc fingerCXXC-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNMT1
ZNF563


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401121_1616320.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240308_606320.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411121_1616336.01633.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341308_606336.01633.0the PRC2/EED-EZH2 complex


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Related Drugs to DNMT1-ZNF563


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNMT1-ZNF563


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource