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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DSC3-RPS6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DSC3-RPS6
	FusionPDB ID: 24188
	FusionGDB2.0 ID: 24188
		Hgene	Tgene
	Gene symbol	DSC3	RPS6
	Gene ID	1825	6194
	Gene name	desmocollin 3	ribosomal protein S6
	Synonyms	CDHF3\|DSC\|DSC1\|DSC2\|DSC4\|HT-CP	S6
	Cytomap	18q12.1	9p22.1
	Type of gene	protein-coding	protein-coding
	Description	desmocollin-3cadherin family member 3desmocollin-4	40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
	Modification date	20200313	20200313
	UniProtAcc	Q14574	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000360428, ENST00000434452,	ENST00000380381, ENST00000315377, ENST00000380384, ENST00000498815, ENST00000380394,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 7 X 4=168	15 X 15 X 4=900
	# samples	6	17
	** MAII score	log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/900*10)=-2.40439025507934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DSC3 [Title/Abstract] AND RPS6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DSC3(28576756)-RPS6(19378916), # samples:1 DSC3(28576757)-RPS6(19378916), # samples:1
Anticipated loss of major functional domain due to fusion event.	DSC3-RPS6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSC3-RPS6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RPS6	GO:0031929	TOR signaling	16428328
Tgene	RPS6	GO:0043065	positive regulation of apoptotic process	18362888

Fusion gene breakpoints across DSC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-IP-7968-11A	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
ChimerDB4	Non-Cancer	TCGA-IP-7968-11A	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360428	DSC3	chr18	28576756	-	ENST00000380394	RPS6	chr9	19378916	-	3764	2574	9	3185	1058
ENST00000434452	DSC3	chr18	28576756	-	ENST00000380394	RPS6	chr9	19378916	-	3838	2648	83	3259	1058
ENST00000360428	DSC3	chr18	28576757	-	ENST00000380394	RPS6	chr9	19378916	-	3764	2574	9	3185	1058
ENST00000434452	DSC3	chr18	28576757	-	ENST00000380394	RPS6	chr9	19378916	-	3838	2648	83	3259	1058

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360428	ENST00000380394	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-	0.00031629	0.99968374
ENST00000434452	ENST00000380394	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-	0.000378398	0.9996216
ENST00000360428	ENST00000380394	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-	0.00031629	0.99968374
ENST00000434452	ENST00000380394	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-	0.000378398	0.9996216

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24188_24188_1_DSC3-RPS6_DSC3_chr18_28576756_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------

>24188_24188_2_DSC3-RPS6_DSC3_chr18_28576756_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------

>24188_24188_3_DSC3-RPS6_DSC3_chr18_28576757_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------

>24188_24188_4_DSC3-RPS6_DSC3_chr18_28576757_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28576756/chr9:19378916)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSC3 Q14574	.
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

136_243

831.0

897.0

Domain

Cadherin 1

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

244_355

831.0

897.0

Domain

Cadherin 2

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

356_471

831.0

897.0

Domain

Cadherin 3

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

472_579

831.0

897.0

Domain

Cadherin 4

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

580_690

831.0

897.0

Domain

Cadherin 5

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

136_243

831.0

2180.3333333333335

Domain

Cadherin 1

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

244_355

831.0

2180.3333333333335

Domain

Cadherin 2

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

356_471

831.0

2180.3333333333335

Domain

Cadherin 3

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

472_579

831.0

2180.3333333333335

Domain

Cadherin 4

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

580_690

831.0

2180.3333333333335

Domain

Cadherin 5

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

136_243

831.0

897.0

Domain

Cadherin 1

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

244_355

831.0

897.0

Domain

Cadherin 2

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

356_471

831.0

897.0

Domain

Cadherin 3

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

472_579

831.0

897.0

Domain

Cadherin 4

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

580_690

831.0

897.0

Domain

Cadherin 5

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

136_243

831.0

2180.3333333333335

Domain

Cadherin 1

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

244_355

831.0

2180.3333333333335

Domain

Cadherin 2

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

356_471

831.0

2180.3333333333335

Domain

Cadherin 3

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

472_579

831.0

2180.3333333333335

Domain

Cadherin 4

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

580_690

831.0

2180.3333333333335

Domain

Cadherin 5

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

136_690

831.0

897.0

Topological domain

Extracellular

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

136_690

831.0

2180.3333333333335

Topological domain

Extracellular

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

136_690

831.0

897.0

Topological domain

Extracellular

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

136_690

831.0

2180.3333333333335

Topological domain

Extracellular

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

691_711

831.0

897.0

Transmembrane

Helical

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

691_711

831.0

2180.3333333333335

Transmembrane

Helical

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

691_711

831.0

897.0

Transmembrane

Helical

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

691_711

831.0

2180.3333333333335

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

712_896

831.0

897.0

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

712_896

831.0

2180.3333333333335

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

712_896

831.0

897.0

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

712_896

831.0

2180.3333333333335

Topological domain

Cytoplasmic

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DSC3
RPS6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DSC3-RPS6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DSC3-RPS6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source