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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DUSP7-PBRM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DUSP7-PBRM1
FusionPDB ID: 24509
FusionGDB2.0 ID: 24509
HgeneTgene
Gene symbol

DUSP7

PBRM1

Gene ID

1849

55193

Gene namedual specificity phosphatase 7polybromo 1
SynonymsMKPX|PYST2BAF180|PB1
Cytomap

3p21.2

3p21.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 7dual specificity protein phosphatase PYST2protein polybromo-1BRG1-associated factor 180polybromo-1D
Modification date2020031320200313
UniProtAcc

Q16829

.
Ensembl transtripts involved in fusion geneENST idsENST00000296483, ENST00000495880, 
ENST00000337303, ENST00000409057, 
ENST00000409114, ENST00000409767, 
ENST00000410007, ENST00000296302, 
ENST00000356770, ENST00000394830, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=110 X 10 X 7=700
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/700*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DUSP7 [Title/Abstract] AND PBRM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DUSP7(52087956)-PBRM1(52588895), # samples:2
Anticipated loss of major functional domain due to fusion event.DUSP7-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP7-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP7-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP7-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUSP7

GO:0035335

peptidyl-tyrosine dephosphorylation

9788880

HgeneDUSP7

GO:0043407

negative regulation of MAP kinase activity

9788880


check buttonFusion gene breakpoints across DUSP7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PBRM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A140-01ADUSP7chr3

52087956

-PBRM1chr3

52588895

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000495880DUSP7chr352087956-ENST00000356770PBRM1chr352588895-446411361091752547
ENST00000495880DUSP7chr352087956-ENST00000394830PBRM1chr352588895-197511361091752547
ENST00000495880DUSP7chr352087956-ENST00000296302PBRM1chr352588895-182611361091752547
ENST00000296483DUSP7chr352087956-ENST00000356770PBRM1chr352588895-4359103141647547
ENST00000296483DUSP7chr352087956-ENST00000394830PBRM1chr352588895-1870103141647547
ENST00000296483DUSP7chr352087956-ENST00000296302PBRM1chr352588895-1721103141647547

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000495880ENST00000356770DUSP7chr352087956-PBRM1chr352588895-0.0023370370.997663
ENST00000495880ENST00000394830DUSP7chr352087956-PBRM1chr352588895-0.0517346040.94826543
ENST00000495880ENST00000296302DUSP7chr352087956-PBRM1chr352588895-0.0599051340.94009495
ENST00000296483ENST00000356770DUSP7chr352087956-PBRM1chr352588895-0.0023923910.9976076
ENST00000296483ENST00000394830DUSP7chr352087956-PBRM1chr352588895-0.053370870.9466291
ENST00000296483ENST00000296302DUSP7chr352087956-PBRM1chr352588895-0.0606105140.93938947

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24509_24509_1_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000296302_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

>24509_24509_2_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000356770_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

>24509_24509_3_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000394830_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

>24509_24509_4_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000296302_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

>24509_24509_5_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000356770_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

>24509_24509_6_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000394830_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52087956/chr3:52588895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP7

Q16829

.
FUNCTION: Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). {ECO:0000250|UniProtKB:Q91Z46, ECO:0000269|PubMed:9788880}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-23192_240266.3333333333333369.0Compositional biasSer-rich
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-23192_240317.3333333333333420.0Compositional biasSer-rich
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-2368_187266.3333333333333369.0DomainRhodanese
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-2368_187317.3333333333333420.0DomainRhodanese
TgenePBRM1chr3:52087956chr3:52588895ENST000003373030281468_159901583.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028630_63301583.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST0000035677023281468_15991397.33333333333331603.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST0000039483025301468_15991377.33333333333331583.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST0000040905724291468_15991429.33333333333331635.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST000004091140301468_159901653.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030630_63301653.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST000004097670291468_159901598.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029630_63301598.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST0000041000724291468_15991404.33333333333331610.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST000003373030281379_144701583.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST0000039483025301379_14471377.33333333333331583.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST000004091140301379_144701653.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST000004097670291379_144701598.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST000003373030281156_127201583.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028200_27001583.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028400_47001583.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028538_60801583.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST0000033730302864_13401583.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028676_74601583.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028792_86201583.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303028956_107401583.0DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST000004091140301156_127201653.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030200_27001653.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030400_47001653.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030538_60801653.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST0000040911403064_13401653.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030676_74601653.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030792_86201653.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114030956_107401653.0DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST000004097670291156_127201598.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029200_27001598.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029400_47001598.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029538_60801598.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST0000040976702964_13401598.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029676_74601598.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029792_86201598.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767029956_107401598.0DomainBAH 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-23244_387266.3333333333333369.0DomainTyrosine-protein phosphatase
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-23244_387317.3333333333333420.0DomainTyrosine-protein phosphatase
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-23331_337266.3333333333333369.0RegionSubstrate binding
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-23331_337317.3333333333333420.0RegionSubstrate binding
TgenePBRM1chr3:52087956chr3:52588895ENST0000029630225301468_15991484.33333333333331690.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530630_6331484.33333333333331690.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328630_6331397.33333333333331603.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530630_6331377.33333333333331583.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429630_6331429.33333333333331635.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429630_6331404.33333333333331610.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST0000029630225301379_14471484.33333333333331690.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST0000035677023281379_14471397.33333333333331603.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST0000040905724291379_14471429.33333333333331635.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST0000041000724291379_14471404.33333333333331610.0DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST0000029630225301156_12721484.33333333333331690.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530200_2701484.33333333333331690.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530400_4701484.33333333333331690.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530538_6081484.33333333333331690.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302253064_1341484.33333333333331690.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530676_7461484.33333333333331690.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530792_8621484.33333333333331690.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST000002963022530956_10741484.33333333333331690.0DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST0000035677023281156_12721397.33333333333331603.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328200_2701397.33333333333331603.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328400_4701397.33333333333331603.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328538_6081397.33333333333331603.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770232864_1341397.33333333333331603.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328676_7461397.33333333333331603.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328792_8621397.33333333333331603.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST000003567702328956_10741397.33333333333331603.0DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST0000039483025301156_12721377.33333333333331583.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530200_2701377.33333333333331583.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530400_4701377.33333333333331583.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530538_6081377.33333333333331583.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830253064_1341377.33333333333331583.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530676_7461377.33333333333331583.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530792_8621377.33333333333331583.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST000003948302530956_10741377.33333333333331583.0DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST0000040905724291156_12721429.33333333333331635.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429200_2701429.33333333333331635.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429400_4701429.33333333333331635.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429538_6081429.33333333333331635.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057242964_1341429.33333333333331635.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429676_7461429.33333333333331635.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429792_8621429.33333333333331635.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST000004090572429956_10741429.33333333333331635.0DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST0000041000724291156_12721404.33333333333331610.0DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429200_2701404.33333333333331610.0DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429400_4701404.33333333333331610.0DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429538_6081404.33333333333331610.0DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007242964_1341404.33333333333331610.0DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429676_7461404.33333333333331610.0DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429792_8621404.33333333333331610.0DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST000004100072429956_10741404.33333333333331610.0DomainBAH 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DUSP7
PBRM1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DUSP7-PBRM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DUSP7-PBRM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource