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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCC2-TSPAN14

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC2-TSPAN14
FusionPDB ID: 247
FusionGDB2.0 ID: 247
HgeneTgene
Gene symbol

ABCC2

TSPAN14

Gene ID

1244

81619

Gene nameATP binding cassette subfamily C member 2tetraspanin 14
SynonymsABC30|CMOAT|DJS|MRP2|cMRPDC-TM4F2|TM4SF14|tspan-14
Cytomap

10q24.2

10q23.1

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 1ATP-binding cassette, sub-family C (CFTR/MRP), member 2canalicular multidrug resistance proteinmultidrug resistance-associated protein 2tetraspanin-14tetraspanin similar to TM4SF9transmembrane 4 superfamily member 14
Modification date2020032920200313
UniProtAcc

Q92887

.
Ensembl transtripts involved in fusion geneENST idsENST00000496621, ENST00000370434, 
ENST00000370449, 		ENST00000429989, 
ENST00000265450, ENST00000341863, 
ENST00000372156, ENST00000372158, 
ENST00000372164, ENST00000481124, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 2=1810 X 10 X 3=300
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCC2 [Title/Abstract] AND TSPAN14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC2(101552116)-TSPAN14(82264484), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC2-TSPAN14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC2-TSPAN14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC2-TSPAN14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC2-TSPAN14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSPAN14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CL-01AABCC2chr10

101552116

+TSPAN14chr10

82264484

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370449ABCC2chr10101552116+ENST00000429989TSPAN14chr1082264484+163254461131177354
ENST00000370434ABCC2chr10101552116+ENST00000429989TSPAN14chr1082264484+16294415821146354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370449ENST00000429989ABCC2chr10101552116+TSPAN14chr1082264484+0.0036472760.9963527
ENST00000370434ENST00000429989ABCC2chr10101552116+TSPAN14chr1082264484+0.0036682880.99633175

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>247_247_1_ABCC2-TSPAN14_ABCC2_chr10_101552116_ENST00000370434_TSPAN14_chr10_82264484_ENST00000429989_length(amino acids)=354AA_BP=111
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTED
SGQATVPAVRYTNPSLYLGTWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCG
TIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSC

--------------------------------------------------------------

>247_247_2_ABCC2-TSPAN14_ABCC2_chr10_101552116_ENST00000370449_TSPAN14_chr10_82264484_ENST00000429989_length(amino acids)=354AA_BP=111
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTED
SGQATVPAVRYTNPSLYLGTWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCG
TIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:101552116/chr10:82264484)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC2

Q92887

.
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321_27111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33249_68111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33290_93111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33228_48111.01546.0TransmembraneHelical%3B Name%3D1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33269_89111.01546.0TransmembraneHelical%3B Name%3D2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33294_114111.01546.0TransmembraneHelical%3B Name%3D3
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372156412254_27027.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641239_6127.0271.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641283_9227.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372158311254_27027.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831139_6127.0271.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831183_9227.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372164081_170254.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037216408254_2700254.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640839_610254.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640883_920254.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000042998919254_27027.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891939_6127.0271.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891983_9227.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000481124061_170148.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000048112406254_2700148.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240639_610148.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240683_920148.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372156412233_25327.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641262_8227.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641293_11327.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372158311233_25327.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831162_8227.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831193_11327.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640818_380254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037216408233_2530254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640862_820254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640893_1130254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000042998919233_25327.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891962_8227.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891993_11327.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240618_380148.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000048112406233_2530148.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240662_820148.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240693_1130148.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321300_1534111.01546.0DomainABC transporter 2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332322_605111.01546.0DomainABC transmembrane type-1 1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332637_861111.01546.0DomainABC transporter 1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332979_1264111.01546.0DomainABC transmembrane type-1 2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321334_1341111.01546.0Nucleotide bindingATP 2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332671_678111.01546.0Nucleotide bindingATP 1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321055_1097111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321119_1119111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321141_1211111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332115_126111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321233_1234111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321256_1545111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332148_165111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332187_313111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332335_360111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332382_437111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332459_461111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332483_544111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332566_587111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332609_971111.01546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332993_1033111.01546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321034_1054111.01546.0TransmembraneHelical%3B Name%3D13
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321098_1118111.01546.0TransmembraneHelical%3B Name%3D14
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321120_1140111.01546.0TransmembraneHelical%3B Name%3D15
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321212_1232111.01546.0TransmembraneHelical%3B Name%3D16
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321235_1255111.01546.0TransmembraneHelical%3B Name%3D17
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332127_147111.01546.0TransmembraneHelical%3B Name%3D4
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332166_186111.01546.0TransmembraneHelical%3B Name%3D5
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332314_334111.01546.0TransmembraneHelical%3B Name%3D6
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332361_381111.01546.0TransmembraneHelical%3B Name%3D7
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332438_458111.01546.0TransmembraneHelical%3B Name%3D8
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332462_482111.01546.0TransmembraneHelical%3B Name%3D9
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332545_565111.01546.0TransmembraneHelical%3B Name%3D10
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332588_608111.01546.0TransmembraneHelical%3B Name%3D11
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332972_992111.01546.0TransmembraneHelical%3B Name%3D12
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721564121_1727.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721583111_1727.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000429989191_1727.0271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641218_3827.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831118_3827.0271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891918_3827.0271.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCC2
TSPAN14


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCC2-TSPAN14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC2-TSPAN14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource