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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ECE1-SRSF10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ECE1-SRSF10
FusionPDB ID: 24862
FusionGDB2.0 ID: 24862
HgeneTgene
Gene symbol

ECE1

SRSF10

Gene ID

1889

10772

Gene nameendothelin converting enzyme 1serine and arginine rich splicing factor 10
SynonymsECEFUSIP1|FUSIP2|NSSR|PPP1R149|SFRS13|SFRS13A|SRp38|SRrp40|TASR|TASR1|TASR2
Cytomap

1p36.12

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionendothelin-converting enzyme 1ECE-1serine/arginine-rich splicing factor 1040 kDa SR-repressor proteinFUS interacting protein (serine-arginine rich) 1FUS-interacting protein (serine-arginine rich) 2SR splicing factor 10TLS-associated SR proteinTLS-associated protein TASRTLS-associate
Modification date2020031320200313
UniProtAcc

P42892

.
Ensembl transtripts involved in fusion geneENST idsENST00000264205, ENST00000357071, 
ENST00000374893, ENST00000415912, 
ENST00000436918, ENST00000528294, 
ENST00000341154, ENST00000343255, 
ENST00000374452, ENST00000374453, 
ENST00000484146, ENST00000492112, 
ENST00000374449, ENST00000374457, 
ENST00000433682, ENST00000344989, 
ENST00000453840, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 15 X 9=21604 X 4 X 2=32
# samples 184
** MAII scorelog2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ECE1 [Title/Abstract] AND SRSF10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ECE1(21573714)-SRSF10(24305307), # samples:2
Anticipated loss of major functional domain due to fusion event.ECE1-SRSF10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECE1-SRSF10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECE1-SRSF10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ECE1-SRSF10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneECE1

GO:0010814

substance P catabolic process

18039931

HgeneECE1

GO:0010815

bradykinin catabolic process

18039931

HgeneECE1

GO:0010816

calcitonin catabolic process

18039931

HgeneECE1

GO:0016485

protein processing

7805846

HgeneECE1

GO:0016486

peptide hormone processing

7864876

HgeneECE1

GO:0034959

endothelin maturation

7805846

HgeneECE1

GO:0042447

hormone catabolic process

7864876

TgeneSRSF10

GO:0000375

RNA splicing, via transesterification reactions

9774382

TgeneSRSF10

GO:0000398

mRNA splicing, via spliceosome

9774382

TgeneSRSF10

GO:0006376

mRNA splice site selection

9774382

TgeneSRSF10

GO:0048024

regulation of mRNA splicing, via spliceosome

26876937

TgeneSRSF10

GO:0048025

negative regulation of mRNA splicing, via spliceosome

11684676


check buttonFusion gene breakpoints across ECE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRSF10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-1673-01AECE1chr1

21573714

-SRSF10chr1

24305307

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415912ECE1chr121573714-ENST00000344989SRSF10chr124305307-458712411261727533
ENST00000415912ECE1chr121573714-ENST00000453840SRSF10chr124305307-294312411261724532
ENST00000357071ECE1chr121573714-ENST00000344989SRSF10chr124305307-45881242461728560
ENST00000357071ECE1chr121573714-ENST00000453840SRSF10chr124305307-29441242461725559
ENST00000374893ECE1chr121573714-ENST00000344989SRSF10chr124305307-45841238631724553
ENST00000374893ECE1chr121573714-ENST00000453840SRSF10chr124305307-29401238631721552
ENST00000436918ECE1chr121573714-ENST00000344989SRSF10chr124305307-45591213381699553
ENST00000436918ECE1chr121573714-ENST00000453840SRSF10chr124305307-29151213381696552
ENST00000264205ECE1chr121573714-ENST00000344989SRSF10chr124305307-45591213591699546
ENST00000264205ECE1chr121573714-ENST00000453840SRSF10chr124305307-29151213591696545

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415912ENST00000344989ECE1chr121573714-SRSF10chr124305307-0.0004520030.999548
ENST00000415912ENST00000453840ECE1chr121573714-SRSF10chr124305307-0.0010602980.9989397
ENST00000357071ENST00000344989ECE1chr121573714-SRSF10chr124305307-0.0002146720.99978536
ENST00000357071ENST00000453840ECE1chr121573714-SRSF10chr124305307-0.0005122780.99948764
ENST00000374893ENST00000344989ECE1chr121573714-SRSF10chr124305307-0.0001473220.99985266
ENST00000374893ENST00000453840ECE1chr121573714-SRSF10chr124305307-0.0003475840.9996524
ENST00000436918ENST00000344989ECE1chr121573714-SRSF10chr124305307-0.0001474340.99985254
ENST00000436918ENST00000453840ECE1chr121573714-SRSF10chr124305307-0.0003446880.99965537
ENST00000264205ENST00000344989ECE1chr121573714-SRSF10chr124305307-0.0001792350.99982077
ENST00000264205ENST00000453840ECE1chr121573714-SRSF10chr124305307-0.0003976880.9996024

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24862_24862_1_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000264205_SRSF10_chr1_24305307_ENST00000344989_length(amino acids)=546AA_BP=385
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE
SEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQ
GDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRPNCSWNTQYSSAY

--------------------------------------------------------------

>24862_24862_2_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000264205_SRSF10_chr1_24305307_ENST00000453840_length(amino acids)=545AA_BP=385
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE
SEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQ
GDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNRPTGRPRRSRSHSDNDRPNCSWNTQYSSAYY

--------------------------------------------------------------

>24862_24862_3_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000357071_SRSF10_chr1_24305307_ENST00000344989_length(amino acids)=560AA_BP=399
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWL
PFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDR
KWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDND

--------------------------------------------------------------

>24862_24862_4_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000357071_SRSF10_chr1_24305307_ENST00000453840_length(amino acids)=559AA_BP=399
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWL
PFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDR
KWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNRPTGRPRRSRSHSDNDR

--------------------------------------------------------------

>24862_24862_5_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000374893_SRSF10_chr1_24305307_ENST00000344989_length(amino acids)=553AA_BP=392
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIF
YPVEINESEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQ
IEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRPNCSWN

--------------------------------------------------------------

>24862_24862_6_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000374893_SRSF10_chr1_24305307_ENST00000453840_length(amino acids)=552AA_BP=392
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIF
YPVEINESEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQ
IEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNRPTGRPRRSRSHSDNDRPNCSWNT

--------------------------------------------------------------

>24862_24862_7_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000415912_SRSF10_chr1_24305307_ENST00000344989_length(amino acids)=533AA_BP=372
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
QISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKE

--------------------------------------------------------------

>24862_24862_8_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000415912_SRSF10_chr1_24305307_ENST00000453840_length(amino acids)=532AA_BP=372
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
QISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKE

--------------------------------------------------------------

>24862_24862_9_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000436918_SRSF10_chr1_24305307_ENST00000344989_length(amino acids)=553AA_BP=392
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIF
YPVEINESEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQ
IEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRPNCSWN

--------------------------------------------------------------

>24862_24862_10_ECE1-SRSF10_ECE1_chr1_21573714_ENST00000436918_SRSF10_chr1_24305307_ENST00000453840_length(amino acids)=552AA_BP=392
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIF
YPVEINESEPIVVYDKEYLEQISTLINTTDRWSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQ
IEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNRPTGRPRRSRSHSDNDRPNCSWNT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21573714/chr1:24305307)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECE1

P42892

.
FUNCTION: Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:9396733}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneECE1chr1:21573714chr1:24305307ENST00000264205-8181_68384.6666666666667768.0Topological domainCytoplasmic
HgeneECE1chr1:21573714chr1:24305307ENST00000357071-7171_68375.6666666666667759.0Topological domainCytoplasmic
HgeneECE1chr1:21573714chr1:24305307ENST00000374893-9191_68387.6666666666667771.0Topological domainCytoplasmic
HgeneECE1chr1:21573714chr1:24305307ENST00000415912-9191_68371.6666666666667755.0Topological domainCytoplasmic
HgeneECE1chr1:21573714chr1:24305307ENST00000264205-81869_89384.6666666666667768.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21573714chr1:24305307ENST00000357071-71769_89375.6666666666667759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21573714chr1:24305307ENST00000374893-91969_89387.6666666666667771.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21573714chr1:24305307ENST00000415912-91969_89371.6666666666667755.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSRSF10chr1:21573714chr1:24305307ENST0000034325506106_26021.666666666666668262.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF10chr1:21573714chr1:24305307ENST0000034498906106_26021.666666666666668184.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF10chr1:21573714chr1:24305307ENST0000037445206106_26021.666666666666668174.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF10chr1:21573714chr1:24305307ENST0000045384006106_26021.666666666666668183.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF10chr1:21573714chr1:24305307ENST0000048414605106_26021.666666666666668166.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF10chr1:21573714chr1:24305307ENST0000049211206106_26021.666666666666668263.0Compositional biasNote=Arg/Ser-rich (RS domain)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneECE1chr1:21573714chr1:24305307ENST00000264205-81898_770384.6666666666667768.0DomainPeptidase M13
HgeneECE1chr1:21573714chr1:24305307ENST00000357071-71798_770375.6666666666667759.0DomainPeptidase M13
HgeneECE1chr1:21573714chr1:24305307ENST00000374893-91998_770387.6666666666667771.0DomainPeptidase M13
HgeneECE1chr1:21573714chr1:24305307ENST00000415912-91998_770371.6666666666667755.0DomainPeptidase M13
HgeneECE1chr1:21573714chr1:24305307ENST00000264205-81890_770384.6666666666667768.0Topological domainExtracellular
HgeneECE1chr1:21573714chr1:24305307ENST00000357071-71790_770375.6666666666667759.0Topological domainExtracellular
HgeneECE1chr1:21573714chr1:24305307ENST00000374893-91990_770387.6666666666667771.0Topological domainExtracellular
HgeneECE1chr1:21573714chr1:24305307ENST00000415912-91990_770371.6666666666667755.0Topological domainExtracellular
TgeneSRSF10chr1:21573714chr1:24305307ENST000003432550610_8821.666666666666668262.0DomainRRM
TgeneSRSF10chr1:21573714chr1:24305307ENST000003449890610_8821.666666666666668184.0DomainRRM
TgeneSRSF10chr1:21573714chr1:24305307ENST000003744520610_8821.666666666666668174.0DomainRRM
TgeneSRSF10chr1:21573714chr1:24305307ENST000004538400610_8821.666666666666668183.0DomainRRM
TgeneSRSF10chr1:21573714chr1:24305307ENST000004841460510_8821.666666666666668166.0DomainRRM
TgeneSRSF10chr1:21573714chr1:24305307ENST000004921120610_8821.666666666666668263.0DomainRRM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ECE1
SRSF10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ECE1-SRSF10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ECE1-SRSF10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource