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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EEF2-SMARCA4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EEF2-SMARCA4
FusionPDB ID: 25260
FusionGDB2.0 ID: 25260
HgeneTgene
Gene symbol

EEF2

SMARCA4

Gene ID

1938

6597

Gene nameeukaryotic translation elongation factor 2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SynonymsEEF-2|EF-2|EF2|SCA26BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2b
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 2epididymis secretory sperm binding proteinpolypeptidyl-tRNA translocasetranscription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription a
Modification date2020031320200315
UniProtAcc

Q96G04

.
Ensembl transtripts involved in fusion geneENST idsENST00000309311, ENST00000600720, 
ENST00000538456, ENST00000344626, 
ENST00000358026, ENST00000413806, 
ENST00000429416, ENST00000444061, 
ENST00000450717, ENST00000541122, 
ENST00000589677, ENST00000590574, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 37 X 16=2604820 X 28 X 15=8400
# samples 5632
** MAII scorelog2(56/26048*10)=-5.53960196732128
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/8400*10)=-4.71424551766612
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EEF2 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EEF2(3982805)-SMARCA4(11151983), # samples:1
Anticipated loss of major functional domain due to fusion event.EEF2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EEF2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EEF2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EEF2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

TgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

TgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

TgeneSMARCA4

GO:0051091

positive regulation of DNA-binding transcription factor activity

11950834|17938176

TgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283


check buttonFusion gene breakpoints across EEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMARCA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-K1-A3PO-11AEEF2chr19

3982805

-SMARCA4chr19

11151983

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309311EEF2chr193982805-ENST00000358026SMARCA4chr1911151983+1941701891474461
ENST00000309311EEF2chr193982805-ENST00000344626SMARCA4chr1911151983+1718701891474461
ENST00000309311EEF2chr193982805-ENST00000429416SMARCA4chr1911151983+1941701891474461
ENST00000309311EEF2chr193982805-ENST00000541122SMARCA4chr1911151983+14747014781473332
ENST00000309311EEF2chr193982805-ENST00000589677SMARCA4chr1911151983+14717014781470331
ENST00000309311EEF2chr193982805-ENST00000444061SMARCA4chr1911151983+1472701891471461
ENST00000309311EEF2chr193982805-ENST00000590574SMARCA4chr1911151983+1475701891474462
ENST00000309311EEF2chr193982805-ENST00000413806SMARCA4chr1911151983+19407014781473331
ENST00000309311EEF2chr193982805-ENST00000450717SMARCA4chr1911151983+19377014781470330

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309311ENST00000358026EEF2chr193982805-SMARCA4chr1911151983+0.0043411850.9956589
ENST00000309311ENST00000344626EEF2chr193982805-SMARCA4chr1911151983+0.0050868620.9949131
ENST00000309311ENST00000429416EEF2chr193982805-SMARCA4chr1911151983+0.0043411850.9956589
ENST00000309311ENST00000541122EEF2chr193982805-SMARCA4chr1911151983+0.0144194580.9855805
ENST00000309311ENST00000589677EEF2chr193982805-SMARCA4chr1911151983+0.0160319280.983968
ENST00000309311ENST00000444061EEF2chr193982805-SMARCA4chr1911151983+0.0040272610.9959727
ENST00000309311ENST00000590574EEF2chr193982805-SMARCA4chr1911151983+0.0037268990.99627316
ENST00000309311ENST00000413806EEF2chr193982805-SMARCA4chr1911151983+0.0258279850.97417206
ENST00000309311ENST00000450717EEF2chr193982805-SMARCA4chr1911151983+0.0275610650.9724389

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25260_25260_1_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000344626_length(amino acids)=461AA_BP=204
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIK
QSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR
IVENVNVIISTYGEGESGPMGNIMAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPP
NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLI
YEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQE

--------------------------------------------------------------

>25260_25260_2_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000358026_length(amino acids)=461AA_BP=204
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIK
QSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR
IVENVNVIISTYGEGESGPMGNIMAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPP
NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLI
YEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQE

--------------------------------------------------------------

>25260_25260_3_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000413806_length(amino acids)=331AA_BP=74
MRVRRVRADGDSAAAGHCRAHQACADDEQDGPRPAGAAAGARGALPDFPAHRGERERHHLHLRRGRERPHGQHHAIEEGTLEEIEEEVRQ
KKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPE
YYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGS

--------------------------------------------------------------

>25260_25260_4_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000429416_length(amino acids)=461AA_BP=204
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIK
QSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR
IVENVNVIISTYGEGESGPMGNIMAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPP
NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLI
YEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQE

--------------------------------------------------------------

>25260_25260_5_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000444061_length(amino acids)=461AA_BP=204
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIK
QSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR
IVENVNVIISTYGEGESGPMGNIMAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPP
NLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIY
EDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEE

--------------------------------------------------------------

>25260_25260_6_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000450717_length(amino acids)=330AA_BP=74
MRVRRVRADGDSAAAGHCRAHQACADDEQDGPRPAGAAAGARGALPDFPAHRGERERHHLHLRRGRERPHGQHHAIEEGTLEEIEEEVRQ
KKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEY
YELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSE

--------------------------------------------------------------

>25260_25260_7_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000541122_length(amino acids)=332AA_BP=74
MRVRRVRADGDSAAAGHCRAHQACADDEQDGPRPAGAAAGARGALPDFPAHRGERERHHLHLRRGRERPHGQHHAIEEGTLEEIEEEVRQ
KKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPE
YYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGS

--------------------------------------------------------------

>25260_25260_8_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000589677_length(amino acids)=331AA_BP=74
MRVRRVRADGDSAAAGHCRAHQACADDEQDGPRPAGAAAGARGALPDFPAHRGERERHHLHLRRGRERPHGQHHAIEEGTLEEIEEEVRQ
KKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEY
YELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSE

--------------------------------------------------------------

>25260_25260_9_EEF2-SMARCA4_EEF2_chr19_3982805_ENST00000309311_SMARCA4_chr19_11151983_ENST00000590574_length(amino acids)=462AA_BP=204
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIK
QSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR
IVENVNVIISTYGEGESGPMGNIMAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPP
NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLI
YEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3982805/chr19:11151983)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF2

Q96G04

.
FUNCTION: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. {ECO:0000269|PubMed:25231979}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEEF2chr19:3982805chr19:11151983ENST00000309311-415104_108204.0859.0Nucleotide bindingGTP
HgeneEEF2chr19:3982805chr19:11151983ENST00000309311-415158_161204.0859.0Nucleotide bindingGTP
HgeneEEF2chr19:3982805chr19:11151983ENST00000309311-41526_33204.0859.0Nucleotide bindingGTP
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000034462628351571_15841390.01648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004138060331360_13640.01618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004138060331571_15840.01618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033578_5880.01618.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033663_6720.01618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000042941629361571_15841390.01648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000044406128351360_13641357.01614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000044406128351571_15841357.01614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004507170331360_13640.01617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004507170331571_15840.01617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033578_5880.01617.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033663_6720.01617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005411220351360_136401618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005411220351571_158401618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035578_58801618.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035663_67201618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005896770351360_136401617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005896770351571_158401617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035578_58801617.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035663_67201617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000059057427341360_13641357.01615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000059057427341571_15841357.01615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000034462628351477_15471390.01648.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004138060331084_12460.01618.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004138060331477_15470.01618.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033171_2060.01618.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033460_5320.01618.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033766_9310.01618.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000042941629361477_15471390.01648.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000044406128351477_15471357.01614.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004507170331084_12460.01617.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004507170331477_15470.01617.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033171_2060.01617.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033460_5320.01617.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033766_9310.01617.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005411220351084_124601618.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005411220351477_154701618.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035171_20601618.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035460_53201618.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035766_93101618.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005896770351084_124601617.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005896770351477_154701617.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035171_20601617.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035460_53201617.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035766_93101617.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000059057427341477_15471357.01615.0DomainBromo
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033881_8840.01618.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033881_8840.01617.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035881_88401618.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035881_88401617.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033779_7860.01618.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033779_7860.01617.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035779_78601618.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035779_78601617.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000413806033462_7280.01618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000450717033462_7280.01617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000541122035462_72801618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr19:3982805chr19:11151983ENST00000589677035462_72801617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEEF2chr19:3982805chr19:11151983ENST00000309311-41517_362204.0859.0Domaintr-type G
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000034462628351360_13641390.01648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835578_5881390.01648.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835663_6721390.01648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000042941629361360_13641390.01648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936578_5881390.01648.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936663_6721390.01648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835578_5881357.01614.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835663_6721357.01614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734578_5881357.01615.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734663_6721357.01615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000034462628351084_12461390.01648.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835171_2061390.01648.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835460_5321390.01648.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835766_9311390.01648.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000042941629361084_12461390.01648.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936171_2061390.01648.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936460_5321390.01648.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936766_9311390.01648.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000044406128351084_12461357.01614.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835171_2061357.01614.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835460_5321357.01614.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835766_9311357.01614.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST0000059057427341084_12461357.01615.0DomainHelicase C-terminal
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734171_2061357.01615.0DomainQLQ
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734460_5321357.01615.0DomainHSA
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734766_9311357.01615.0DomainHelicase ATP-binding
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835881_8841390.01648.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936881_8841390.01648.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835881_8841357.01614.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734881_8841357.01615.0MotifNote=DEGH box
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835779_7861390.01648.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936779_7861390.01648.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835779_7861357.01614.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734779_7861357.01615.0Nucleotide bindingATP
TgeneSMARCA4chr19:3982805chr19:11151983ENST000003446262835462_7281390.01648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004294162936462_7281390.01648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr19:3982805chr19:11151983ENST000004440612835462_7281357.01614.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr19:3982805chr19:11151983ENST000005905742734462_7281357.01615.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EEF2
SMARCA4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EEF2-SMARCA4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EEF2-SMARCA4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource