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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ENSA-FBP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ENSA-FBP1
	FusionPDB ID: 26664
	FusionGDB2.0 ID: 26664
		Hgene	Tgene
	Gene symbol	ENSA	FBP1
	Gene ID	2029	2203
	Gene name	endosulfine alpha	fructose-bisphosphatase 1
	Synonyms	ARPP-19e	FBP
	Cytomap	1q21.3	9q22.32
	Type of gene	protein-coding	protein-coding
	Description	alpha-endosulfine	fructose-1,6-bisphosphatase 1D-fructose-1,6-bisphosphate 1-phosphohydrolase 1FBPase 1growth-inhibiting protein 17liver FBPase
	Modification date	20200313	20200313
	UniProtAcc	O43768	P09467
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000339643, ENST00000361532, ENST00000361631, ENST00000369009, ENST00000369014, ENST00000369016, ENST00000271690, ENST00000354702, ENST00000356527, ENST00000362052, ENST00000503241, ENST00000503345, ENST00000513281,	ENST00000375326, ENST00000415431,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 11 X 6=858	3 X 1 X 2=6
	# samples	17	4
	** MAII score	log2(17/858*10)=-2.33544290136184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/6*10)=2.73696559416621
Context (manual curation of fusion genes in FusionPDB)	PubMed: ENSA [Title/Abstract] AND FBP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ENSA(150598117)-FBP1(97382773), # samples:1
Anticipated loss of major functional domain due to fusion event.	ENSA-FBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ENSA-FBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ENSA	GO:0050796	regulation of insulin secretion	9653196
Tgene	FBP1	GO:0006002	fructose 6-phosphate metabolic process	8387495\|16442285
Tgene	FBP1	GO:0016311	dephosphorylation	8387495\|18650089
Tgene	FBP1	GO:0030308	negative regulation of cell growth	19881551
Tgene	FBP1	GO:0035690	cellular response to drug	16442285\|18650089
Tgene	FBP1	GO:0045820	negative regulation of glycolytic process	19881551
Tgene	FBP1	GO:0046580	negative regulation of Ras protein signal transduction	19881551
Tgene	FBP1	GO:0071286	cellular response to magnesium ion	10222032

Fusion gene breakpoints across ENSA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A1-A0SF	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369016	ENSA	chr1	150598117	-	ENST00000375326	FBP1	chr9	97382773	-	1589	494	18	1340	440
ENST00000369016	ENSA	chr1	150598117	-	ENST00000415431	FBP1	chr9	97382773	-	1581	494	18	1340	440
ENST00000369014	ENSA	chr1	150598117	-	ENST00000375326	FBP1	chr9	97382773	-	1571	476	48	1322	424
ENST00000369014	ENSA	chr1	150598117	-	ENST00000415431	FBP1	chr9	97382773	-	1563	476	48	1322	424
ENST00000369009	ENSA	chr1	150598117	-	ENST00000375326	FBP1	chr9	97382773	-	1640	545	48	1391	447
ENST00000369009	ENSA	chr1	150598117	-	ENST00000415431	FBP1	chr9	97382773	-	1632	545	48	1391	447
ENST00000339643	ENSA	chr1	150598117	-	ENST00000375326	FBP1	chr9	97382773	-	1599	504	28	1350	440
ENST00000339643	ENSA	chr1	150598117	-	ENST00000415431	FBP1	chr9	97382773	-	1591	504	28	1350	440
ENST00000361532	ENSA	chr1	150598117	-	ENST00000375326	FBP1	chr9	97382773	-	1468	373	35	1219	394
ENST00000361532	ENSA	chr1	150598117	-	ENST00000415431	FBP1	chr9	97382773	-	1460	373	35	1219	394
ENST00000361631	ENSA	chr1	150598117	-	ENST00000375326	FBP1	chr9	97382773	-	1504	409	23	1255	410
ENST00000361631	ENSA	chr1	150598117	-	ENST00000415431	FBP1	chr9	97382773	-	1496	409	23	1255	410

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369016	ENST00000375326	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.001230558	0.99876946
ENST00000369016	ENST00000415431	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.001317902	0.9986821
ENST00000369014	ENST00000375326	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.00133341	0.99866664
ENST00000369014	ENST00000415431	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.001431753	0.9985682
ENST00000369009	ENST00000375326	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.000786576	0.99921346
ENST00000369009	ENST00000415431	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.000859727	0.99914026
ENST00000339643	ENST00000375326	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.00119686	0.99880314
ENST00000339643	ENST00000415431	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.001291379	0.9987086
ENST00000361532	ENST00000375326	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.000746256	0.9992537
ENST00000361532	ENST00000415431	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.000814577	0.9991854
ENST00000361631	ENST00000375326	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.000819487	0.9991805
ENST00000361631	ENST00000415431	ENSA	chr1	150598117	-	FBP1	chr9	97382773	-	0.000900955	0.999099

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26664_26664_1_ENSA-FBP1_ENSA_chr1_150598117_ENST00000339643_FBP1_chr9_97382773_ENST00000375326_length(amino acids)=440AA_BP=149
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGDYK
SLHWSVLLCADEMQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLS
NDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALY
GSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV

--------------------------------------------------------------

>26664_26664_2_ENSA-FBP1_ENSA_chr1_150598117_ENST00000339643_FBP1_chr9_97382773_ENST00000415431_length(amino acids)=440AA_BP=149
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGDYK
SLHWSVLLCADEMQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLS
NDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALY
GSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV

--------------------------------------------------------------

>26664_26664_3_ENSA-FBP1_ENSA_chr1_150598117_ENST00000361532_FBP1_chr9_97382773_ENST00000375326_length(amino acids)=394AA_BP=103
MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTG
DHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGS
SNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNE
GYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVL

--------------------------------------------------------------

>26664_26664_4_ENSA-FBP1_ENSA_chr1_150598117_ENST00000361532_FBP1_chr9_97382773_ENST00000415431_length(amino acids)=394AA_BP=103
MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTG
DHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGS
SNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNE
GYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVL

--------------------------------------------------------------

>26664_26664_5_ENSA-FBP1_ENSA_chr1_150598117_ENST00000361631_FBP1_chr9_97382773_ENST00000375326_length(amino acids)=410AA_BP=119
MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGDYKSLHWSVLLCADEMQKYFDSGDYNMAKAKMK
NKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEP
EKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVD
KDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYV

--------------------------------------------------------------

>26664_26664_6_ENSA-FBP1_ENSA_chr1_150598117_ENST00000361631_FBP1_chr9_97382773_ENST00000415431_length(amino acids)=410AA_BP=119
MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGDYKSLHWSVLLCADEMQKYFDSGDYNMAKAKMK
NKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEP
EKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVD
KDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYV

--------------------------------------------------------------

>26664_26664_7_ENSA-FBP1_ENSA_chr1_150598117_ENST00000369009_FBP1_chr9_97382773_ENST00000375326_length(amino acids)=447AA_BP=156
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGVWG
IVSYPLSLELKEVLRMKSVEQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQV
KKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLV
AAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVA

--------------------------------------------------------------

>26664_26664_8_ENSA-FBP1_ENSA_chr1_150598117_ENST00000369009_FBP1_chr9_97382773_ENST00000415431_length(amino acids)=447AA_BP=156
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGVWG
IVSYPLSLELKEVLRMKSVEQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQV
KKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLV
AAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVA

--------------------------------------------------------------

>26664_26664_9_ENSA-FBP1_ENSA_chr1_150598117_ENST00000369014_FBP1_chr9_97382773_ENST00000375326_length(amino acids)=424AA_BP=133
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKY
FDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCV
LVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNC
FMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNG

--------------------------------------------------------------

>26664_26664_10_ENSA-FBP1_ENSA_chr1_150598117_ENST00000369014_FBP1_chr9_97382773_ENST00000415431_length(amino acids)=424AA_BP=133
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKY
FDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCV
LVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNC
FMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNG

--------------------------------------------------------------

>26664_26664_11_ENSA-FBP1_ENSA_chr1_150598117_ENST00000369016_FBP1_chr9_97382773_ENST00000375326_length(amino acids)=440AA_BP=149
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGDYK
SLHWSVLLCADEMQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLS
NDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALY
GSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV

--------------------------------------------------------------

>26664_26664_12_ENSA-FBP1_ENSA_chr1_150598117_ENST00000369016_FBP1_chr9_97382773_ENST00000415431_length(amino acids)=440AA_BP=149
MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGDYK
SLHWSVLLCADEMQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGYGIAGSTNVTGDQVKKLDVLS
NDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALY
GSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150598117/chr9:97382773)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ENSA O43768	FBP1 P09467
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269\|PubMed:9653196}.	FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269\|PubMed:16497803, ECO:0000269\|PubMed:18375435, ECO:0000269\|PubMed:22517657}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000375326

113_114

56.666666666666664

339.0

Nucleotide binding

AMP

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000415431

113_114

56.666666666666664

339.0

Nucleotide binding

AMP

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000375326

122_125

56.666666666666664

339.0

Region

Substrate binding

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000375326

213_216

56.666666666666664

339.0

Region

Substrate binding

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000375326

244_249

56.666666666666664

339.0

Region

Substrate binding

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000415431

122_125

56.666666666666664

339.0

Region

Substrate binding

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000415431

213_216

56.666666666666664

339.0

Region

Substrate binding

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000415431

244_249

56.666666666666664

339.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000375326

18_22

56.666666666666664

339.0

Nucleotide binding

AMP

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000375326

28_32

56.666666666666664

339.0

Nucleotide binding

AMP

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000415431

18_22

56.666666666666664

339.0

Nucleotide binding

AMP

Tgene

FBP1

chr1:150598117

chr9:97382773

ENST00000415431

28_32

56.666666666666664

339.0

Nucleotide binding

AMP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ENSA
FBP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ENSA-FBP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ENSA-FBP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source