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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERMP1-RBBP8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERMP1-RBBP8
FusionPDB ID: 27437
FusionGDB2.0 ID: 27437
HgeneTgene
Gene symbol

ERMP1

RBBP8

Gene ID

79956

5932

Gene nameendoplasmic reticulum metallopeptidase 1RB binding protein 8, endonuclease
SynonymsFXNA|KIAA1815|bA207C16.3COM1|CTIP|JWDS|RIM|SAE2|SCKL2
Cytomap

9p24.1

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionendoplasmic reticulum metallopeptidase 1Felix-inaaminopeptidase FxnabA207C16.3 (novel protein similar to predicted yeast, plant and worm proteins)DNA endonuclease RBBP8CTBP-interacting proteinRBBP-8retinoblastoma binding protein 8sporulation in the absence of SPO11 protein 2 homolog
Modification date2020032020200328
UniProtAcc

Q7Z2K6

RBBP8NL,C20orf151

Ensembl transtripts involved in fusion geneENST idsENST00000339450, ENST00000214893, 
ENST00000381506, ENST00000543230, 
ENST00000581687, ENST00000327155, 
ENST00000360790, ENST00000399722, 
ENST00000399725, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 5=15012 X 12 X 6=864
# samples 615
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/864*10)=-2.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERMP1 [Title/Abstract] AND RBBP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERMP1(5830727)-RBBP8(20555116), # samples:1
Anticipated loss of major functional domain due to fusion event.ERMP1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERMP1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERMP1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERMP1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ERMP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBBP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-6A-AB49-01AERMP1chr9

5830727

-RBBP8chr18

20555116

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000339450ERMP1chr95830727-ENST00000327155RBBP8chr1820555116+33097305430621002
ENST00000339450ERMP1chr95830727-ENST00000399722RBBP8chr1820555116+33117305430621002
ENST00000339450ERMP1chr95830727-ENST00000399725RBBP8chr1820555116+3212730542972972
ENST00000339450ERMP1chr95830727-ENST00000360790RBBP8chr1820555116+32087305430771007

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339450ENST00000327155ERMP1chr95830727-RBBP8chr1820555116+0.0002532090.99974674
ENST00000339450ENST00000399722ERMP1chr95830727-RBBP8chr1820555116+0.0002497120.9997503
ENST00000339450ENST00000399725ERMP1chr95830727-RBBP8chr1820555116+0.0003219830.999678
ENST00000339450ENST00000360790ERMP1chr95830727-RBBP8chr1820555116+0.0003315870.9996685

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27437_27437_1_ERMP1-RBBP8_ERMP1_chr9_5830727_ENST00000339450_RBBP8_chr18_20555116_ENST00000327155_length(amino acids)=1002AA_BP=225
MGRLGWQLRLVAMEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLA
LYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSF
SIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPVNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPI
TAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLAT
VVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTS
LSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLE
PLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEAL
KTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQ
TRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKK
QEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPH
IEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYN

--------------------------------------------------------------

>27437_27437_2_ERMP1-RBBP8_ERMP1_chr9_5830727_ENST00000339450_RBBP8_chr18_20555116_ENST00000360790_length(amino acids)=1007AA_BP=225
MGRLGWQLRLVAMEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLA
LYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSF
SIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPVNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPI
TAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLAT
VVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTS
LSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLE
PLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEAL
KTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQ
TRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKK
QEQKGEKSSMLFYIDEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSL
QNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKR

--------------------------------------------------------------

>27437_27437_3_ERMP1-RBBP8_ERMP1_chr9_5830727_ENST00000339450_RBBP8_chr18_20555116_ENST00000399722_length(amino acids)=1002AA_BP=225
MGRLGWQLRLVAMEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLA
LYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSF
SIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPVNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPI
TAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLAT
VVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTS
LSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLE
PLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEAL
KTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQ
TRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKK
QEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPH
IEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYN

--------------------------------------------------------------

>27437_27437_4_ERMP1-RBBP8_ERMP1_chr9_5830727_ENST00000339450_RBBP8_chr18_20555116_ENST00000399725_length(amino acids)=972AA_BP=225
MGRLGWQLRLVAMEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLA
LYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSF
SIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPVNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPI
TAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLAT
VVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTS
LSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLE
PLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEAL
KTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQ
TRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKK
QEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDESIMQICQQKK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:5830727/chr18:20555116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERMP1

Q7Z2K6

RBBP8

RBBP8NL,C20orf151

FUNCTION: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. {ECO:0000250|UniProtKB:Q6UPR8}.664

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-2151_63213.33333333333334905.0Topological domainCytoplasmic
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-21564_84213.33333333333334905.0TransmembraneHelical%3B Name%3D1
TgeneRBBP8chr9:5830727chr18:20555116ENST00000327155419490_494120.33333333333333898.0MotifNote=PXDLS motif
TgeneRBBP8chr9:5830727chr18:20555116ENST00000327155419840_842120.33333333333333898.0MotifKLHL15-binding
TgeneRBBP8chr9:5830727chr18:20555116ENST00000399722419490_494120.33333333333333898.0MotifNote=PXDLS motif
TgeneRBBP8chr9:5830727chr18:20555116ENST00000399722419840_842120.33333333333333898.0MotifKLHL15-binding
TgeneRBBP8chr9:5830727chr18:20555116ENST00000399725418490_494120.33333333333333868.0MotifNote=PXDLS motif
TgeneRBBP8chr9:5830727chr18:20555116ENST00000399725418840_842120.33333333333333868.0MotifKLHL15-binding
TgeneRBBP8chr9:5830727chr18:20555116ENST00000327155419509_557120.33333333333333898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr9:5830727chr18:20555116ENST00000399722419509_557120.33333333333333898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr9:5830727chr18:20555116ENST00000399725418509_557120.33333333333333868.0RegionNote=Damage-recruitment motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215421_457213.33333333333334905.0Topological domainCytoplasmic
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215479_489213.33333333333334905.0Topological domainLumenal
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215511_519213.33333333333334905.0Topological domainCytoplasmic
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215541_541213.33333333333334905.0Topological domainLumenal
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215563_579213.33333333333334905.0Topological domainCytoplasmic
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215601_621213.33333333333334905.0Topological domainLumenal
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215643_651213.33333333333334905.0Topological domainCytoplasmic
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215673_904213.33333333333334905.0Topological domainLumenal
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-21585_399213.33333333333334905.0Topological domainLumenal
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215400_420213.33333333333334905.0TransmembraneHelical%3B Name%3D2
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215458_478213.33333333333334905.0TransmembraneHelical%3B Name%3D3
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215490_510213.33333333333334905.0TransmembraneHelical%3B Name%3D4
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215520_540213.33333333333334905.0TransmembraneHelical%3B Name%3D5
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215542_562213.33333333333334905.0TransmembraneHelical%3B Name%3D6
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215580_600213.33333333333334905.0TransmembraneHelical%3B Name%3D7
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215622_642213.33333333333334905.0TransmembraneHelical%3B Name%3D8
HgeneERMP1chr9:5830727chr18:20555116ENST00000339450-215652_672213.33333333333334905.0TransmembraneHelical%3B Name%3D9
TgeneRBBP8chr9:5830727chr18:20555116ENST0000032715541928_157120.33333333333333898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr9:5830727chr18:20555116ENST0000039972241928_157120.33333333333333898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr9:5830727chr18:20555116ENST0000039972541828_157120.33333333333333868.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr9:5830727chr18:20555116ENST0000032715541922_45120.33333333333333898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr9:5830727chr18:20555116ENST0000039972241922_45120.33333333333333898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr9:5830727chr18:20555116ENST0000039972541822_45120.33333333333333868.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERMP1
RBBP8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ERMP1-RBBP8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERMP1-RBBP8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource