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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ETHE1-CEACAM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ETHE1-CEACAM1
FusionPDB ID: 27646
FusionGDB2.0 ID: 27646
HgeneTgene
Gene symbol

ETHE1

CEACAM1

Gene ID

23474

634

Gene nameETHE1 persulfide dioxygenaseCEA cell adhesion molecule 1
SynonymsHSCO|YF13H12BGP|BGP1|BGPI
Cytomap

19q13.31

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionpersulfide dioxygenase ETHE1, mitochondrialethylmalonic encephalopathy 1hepatoma subtracted clone one proteinprotein ETHE1, mitochondrialsulfur dioxygenase ETHE1carcinoembryonic antigen-related cell adhesion molecule 1CD66a antigenantigen CD66carcinoembryonic antigen related cell adhesion molecule 1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Modification date2020031320200313
UniProtAcc

O95571

P13688

Ensembl transtripts involved in fusion geneENST idsENST00000292147, ENST00000600651, 
ENST00000308072, ENST00000403444, 
ENST00000403461, ENST00000599389, 
ENST00000358394, ENST00000488639, 
ENST00000351134, ENST00000161559, 
ENST00000352591, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 7 X 8=5603 X 2 X 3=18
# samples 113
** MAII scorelog2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ETHE1 [Title/Abstract] AND CEACAM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ETHE1(44030353)-CEACAM1(43013380), # samples:1
Anticipated loss of major functional domain due to fusion event.ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ETHE1-CEACAM1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETHE1

GO:0006749

glutathione metabolic process

23144459

HgeneETHE1

GO:0070813

hydrogen sulfide metabolic process

23144459

TgeneCEACAM1

GO:0001915

negative regulation of T cell mediated cytotoxicity

18424730

TgeneCEACAM1

GO:0030334

regulation of cell migration

16291724

TgeneCEACAM1

GO:0043318

negative regulation of cytotoxic T cell degranulation

18424730

TgeneCEACAM1

GO:0044319

wound healing, spreading of cells

16291724

TgeneCEACAM1

GO:0050860

negative regulation of T cell receptor signaling pathway

18424730


check buttonFusion gene breakpoints across ETHE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEACAM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5734-11AETHE1chr19

44030353

-CEACAM1chr19

43013380

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000292147ETHE1chr1944030353-ENST00000352591CEACAM1chr1943013380-236744267561164
ENST00000292147ETHE1chr1944030353-ENST00000161559CEACAM1chr1943013380-236544267561164
ENST00000600651ETHE1chr1944030353-ENST00000352591CEACAM1chr1943013380-232439924518164
ENST00000600651ETHE1chr1944030353-ENST00000161559CEACAM1chr1943013380-232239924518164

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000292147ENST00000352591ETHE1chr1944030353-CEACAM1chr1943013380-0.025554880.9744451
ENST00000292147ENST00000161559ETHE1chr1944030353-CEACAM1chr1943013380-0.0260057240.9739943
ENST00000600651ENST00000352591ETHE1chr1944030353-CEACAM1chr1943013380-0.0161392220.98386085
ENST00000600651ENST00000161559ETHE1chr1944030353-CEACAM1chr1943013380-0.0164889490.9835111

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27646_27646_1_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000292147_CEACAM1_chr19_43013380_ENST00000161559_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------

>27646_27646_2_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000292147_CEACAM1_chr19_43013380_ENST00000352591_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------

>27646_27646_3_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000600651_CEACAM1_chr19_43013380_ENST00000161559_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------

>27646_27646_4_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000600651_CEACAM1_chr19_43013380_ENST00000352591_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44030353/chr19:43013380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETHE1

O95571

CEACAM1

P13688

FUNCTION: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897, ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963, ECO:0000269|PubMed:23144459}.FUNCTION: [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035113446237_317213.0253.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035113446323_413213.0253.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035113446453_526213.0253.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035259168453_526391.0431.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035839479453_526422.0462.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040346157453_526373.3333333333333282.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000059938968453_526404.3333333333333241.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035113446429_452213.0253.0TransmembraneHelical
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035259168429_452391.0431.0TransmembraneHelical
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035839479429_452422.0462.0TransmembraneHelical
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040346157429_452373.3333333333333282.0TransmembraneHelical
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000059938968429_452404.3333333333333241.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979145_232487.0527.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979237_317487.0527.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979323_413487.0527.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST000001615597935_142487.0527.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035113446145_232213.0253.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003511344635_142213.0253.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035259168145_232391.0431.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035259168237_317391.0431.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035259168323_413391.0431.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003525916835_142391.0431.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035839479145_232422.0462.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035839479237_317422.0462.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000035839479323_413422.0462.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003583947935_142422.0462.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468145_232469.3333333333333938.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468237_317469.3333333333333938.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468323_413469.3333333333333938.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST000004034446835_142469.3333333333333938.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040346157145_232373.3333333333333282.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040346157237_317373.3333333333333282.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040346157323_413373.3333333333333282.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST000004034615735_142373.3333333333333282.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000059938968145_232404.3333333333333241.0DomainIg-like C2-type 1
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000059938968237_317404.3333333333333241.0DomainIg-like C2-type 2
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000059938968323_413404.3333333333333241.0DomainIg-like C2-type 3
TgeneCEACAM1chr19:44030353chr19:43013380ENST000005993896835_142404.3333333333333241.0DomainIg-like V-type
TgeneCEACAM1chr19:44030353chr19:43013380ENST000001615597939_142487.0527.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003511344639_142213.0253.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003525916839_142391.0431.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003583947939_142422.0462.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000004034446839_142469.3333333333333938.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000004034615739_142373.3333333333333282.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000005993896839_142404.3333333333333241.0RegionRequired for homophilic binding
TgeneCEACAM1chr19:44030353chr19:43013380ENST000001615597935_428487.0527.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979453_526487.0527.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003511344635_428213.0253.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003525916835_428391.0431.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST000003583947935_428422.0462.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST000004034446835_428469.3333333333333938.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468453_526469.3333333333333938.0Topological domainCytoplasmic
TgeneCEACAM1chr19:44030353chr19:43013380ENST000004034615735_428373.3333333333333282.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST000005993896835_428404.3333333333333241.0Topological domainExtracellular
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979429_452487.0527.0TransmembraneHelical
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468429_452469.3333333333333938.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ETHE1
CEACAM1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979450_462487.0527.0calmodulin
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468450_462469.3333333333333938.0calmodulin
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000016155979452_526487.0527.0FLNA
TgeneCEACAM1chr19:44030353chr19:43013380ENST0000040344468452_526469.3333333333333938.0FLNA


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Related Drugs to ETHE1-CEACAM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ETHE1-CEACAM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource