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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ETV4-TCAP

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ETV4-TCAP
	FusionPDB ID: 27694
	FusionGDB2.0 ID: 27694
		Hgene	Tgene
	Gene symbol	ETV4	TCAP
	Gene ID	2118	8557
	Gene name	ETS variant transcription factor 4	titin-cap
	Synonyms	E1A-F\|E1AF\|PEA3\|PEAS3	CMD1N\|CMH25\|LGMD2G\|LGMDR7\|T-cap\|TELE\|telethonin
	Cytomap	17q21.31	17q12
	Type of gene	protein-coding	protein-coding
	Description	ETS translocation variant 4ETS variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homolog	telethonin19 kDa sarcomeric proteinlimb girdle muscular dystrophy 2G (autosomal recessive)teneurin C-terminal associated peptidetitin cap protein
	Modification date	20200313	20200327
	UniProtAcc	P43268	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000319349, ENST00000393664, ENST00000538265, ENST00000545089, ENST00000545954, ENST00000591713, ENST00000586826,	ENST00000578283, ENST00000309889,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 3=48	6 X 6 X 6=216
	# samples	7	8
	** MAII score	log2(7/48*10)=0.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ETV4 [Title/Abstract] AND TCAP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ETV4(41610042)-TCAP(37821969), # samples:3
Anticipated loss of major functional domain due to fusion event.	ETV4-TCAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ETV4-TCAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ETV4-TCAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ETV4-TCAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ETV4-TCAP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ETV4-TCAP seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETV4	GO:0045944	positive regulation of transcription by RNA polymerase II	24983502

Fusion gene breakpoints across ETV4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TCAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OW-01A	ETV4	chr17	41610042	-	TCAP	chr17	37821969	+
ChimerDB4	ESCA	TCGA-L5-A4OW	ETV4	chr17	41610041	-	TCAP	chr17	37821968	+
ChimerDB4	ESCA	TCGA-L5-A4OW	ETV4	chr17	41610042	-	TCAP	chr17	37821969	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000319349	ETV4	chr17	41610042	-	ENST00000309889	TCAP	chr17	37821969	+	1950	1110	80	1201	373
ENST00000393664	ETV4	chr17	41610042	-	ENST00000309889	TCAP	chr17	37821969	+	1705	865	54	956	300
ENST00000545089	ETV4	chr17	41610042	-	ENST00000309889	TCAP	chr17	37821969	+	1585	745	96	836	246
ENST00000591713	ETV4	chr17	41610042	-	ENST00000309889	TCAP	chr17	37821969	+	1741	901	90	992	300
ENST00000319349	ETV4	chr17	41610041	-	ENST00000309889	TCAP	chr17	37821968	+	1950	1110	80	1201	373
ENST00000393664	ETV4	chr17	41610041	-	ENST00000309889	TCAP	chr17	37821968	+	1705	865	54	956	300
ENST00000545089	ETV4	chr17	41610041	-	ENST00000309889	TCAP	chr17	37821968	+	1585	745	96	836	246
ENST00000591713	ETV4	chr17	41610041	-	ENST00000309889	TCAP	chr17	37821968	+	1741	901	90	992	300

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000319349	ENST00000309889	ETV4	chr17	41610042	-	TCAP	chr17	37821969	+	0.065747164	0.93425286
ENST00000393664	ENST00000309889	ETV4	chr17	41610042	-	TCAP	chr17	37821969	+	0.06270897	0.93729097
ENST00000545089	ENST00000309889	ETV4	chr17	41610042	-	TCAP	chr17	37821969	+	0.028582735	0.9714173
ENST00000591713	ENST00000309889	ETV4	chr17	41610042	-	TCAP	chr17	37821969	+	0.06529459	0.9347054
ENST00000319349	ENST00000309889	ETV4	chr17	41610041	-	TCAP	chr17	37821968	+	0.065747164	0.93425286
ENST00000393664	ENST00000309889	ETV4	chr17	41610041	-	TCAP	chr17	37821968	+	0.06270897	0.93729097
ENST00000545089	ENST00000309889	ETV4	chr17	41610041	-	TCAP	chr17	37821968	+	0.028582735	0.9714173
ENST00000591713	ENST00000309889	ETV4	chr17	41610041	-	TCAP	chr17	37821968	+	0.06529459	0.9347054

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27694_27694_1_ETV4-TCAP_ETV4_chr17_41610041_ENST00000319349_TCAP_chr17_37821968_ENST00000309889_length(amino acids)=373AA_BP=343
MLPRAHNCLLRPKNKSVRWGPGAGAALLRPSPAALGAGSRACSGPPAAPAQTPRPQVSAPAWGPGRAAGGSGRMERRMKAGYLDQQVPYT
FSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPA
LSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTS
QGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSAAPCMRRTPRDMRPTTS

--------------------------------------------------------------

>27694_27694_2_ETV4-TCAP_ETV4_chr17_41610041_ENST00000393664_TCAP_chr17_37821968_ENST00000309889_length(amino acids)=300AA_BP=270
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE
HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDS

--------------------------------------------------------------

>27694_27694_3_ETV4-TCAP_ETV4_chr17_41610041_ENST00000545089_TCAP_chr17_37821968_ENST00000309889_length(amino acids)=246AA_BP=216
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLY

--------------------------------------------------------------

>27694_27694_4_ETV4-TCAP_ETV4_chr17_41610041_ENST00000591713_TCAP_chr17_37821968_ENST00000309889_length(amino acids)=300AA_BP=270
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE
HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDS

--------------------------------------------------------------

>27694_27694_5_ETV4-TCAP_ETV4_chr17_41610042_ENST00000319349_TCAP_chr17_37821969_ENST00000309889_length(amino acids)=373AA_BP=343
MLPRAHNCLLRPKNKSVRWGPGAGAALLRPSPAALGAGSRACSGPPAAPAQTPRPQVSAPAWGPGRAAGGSGRMERRMKAGYLDQQVPYT
FSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPA
LSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTS
QGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSAAPCMRRTPRDMRPTTS

--------------------------------------------------------------

>27694_27694_6_ETV4-TCAP_ETV4_chr17_41610042_ENST00000393664_TCAP_chr17_37821969_ENST00000309889_length(amino acids)=300AA_BP=270
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE
HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDS

--------------------------------------------------------------

>27694_27694_7_ETV4-TCAP_ETV4_chr17_41610042_ENST00000545089_TCAP_chr17_37821969_ENST00000309889_length(amino acids)=246AA_BP=216
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLY

--------------------------------------------------------------

>27694_27694_8_ETV4-TCAP_ETV4_chr17_41610042_ENST00000591713_TCAP_chr17_37821969_ENST00000309889_length(amino acids)=300AA_BP=270
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE
HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41610042/chr17:37821969)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ETV4 P43268	.
FUNCTION: Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269\|PubMed:19307308, ECO:0000269\|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269\|PubMed:8441666}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000319349

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000319349

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000393664

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000393664

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000538265

49_75

231.33333333333334

446.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000545954

49_75

231.33333333333334

446.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000591713

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000591713

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000319349

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000319349

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000393664

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000393664

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000538265

49_75

231.33333333333334

446.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000545954

49_75

231.33333333333334

446.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000591713

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000591713

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000538265

148_244

231.33333333333334

446.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000545954

148_244

231.33333333333334

446.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000538265

148_244

231.33333333333334

446.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000545954

148_244

231.33333333333334

446.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000319349

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000393664

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000538265

341_421

231.33333333333334

446.0

DNA binding

ETS

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000545954

341_421

231.33333333333334

446.0

DNA binding

ETS

Hgene

ETV4

chr17:41610041

chr17:37821968

ENST00000591713

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000319349

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000393664

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000538265

341_421

231.33333333333334

446.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000545954

341_421

231.33333333333334

446.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:37821969

ENST00000591713

341_421

270.3333333333333

485.0

DNA binding

ETS

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>734_ETV4_41610042_TCAP_37821969_ranked_0.pdb	ETV4	41610041	41610042	ENST00000309889	TCAP	chr17	37821969	+	MLPRAHNCLLRPKNKSVRWGPGAGAALLRPSPAALGAGSRACSGPPAAPAQTPRPQVSAPAWGPGRAAGGSGRMERRMKAGYLDQQVPYT FSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPA LSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTS QGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSAAPCMRRTPRDMRPTTS	373

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ETV4_pLDDT.png

TCAP_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ETV4
TCAP

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ETV4-TCAP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ETV4-TCAP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ETV4	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	ETV4	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	ETV4	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	ETV4	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	ETV4	C0678222	Breast Carcinoma	1	CTD_human
Hgene	ETV4	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	ETV4	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	ETV4	C4704874	Mammary Carcinoma, Human	1	CTD_human