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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ETV6-ABL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ETV6-ABL2
FusionPDB ID: 27698
FusionGDB2.0 ID: 27698
HgeneTgene
Gene symbol

ETV6

ABL2

Gene ID

2120

27

Gene nameETS variant transcription factor 6ABL proto-oncogene 2, non-receptor tyrosine kinase
SynonymsTEL|TEL/ABL|THC5ABLL|ARG
Cytomap

12p13.2

1q25.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2
Modification date2020031320200327
UniProtAcc

P41212

P42684

Ensembl transtripts involved in fusion geneENST idsENST00000396373, ENST00000544715, 
ENST00000344730, ENST00000367623, 
ENST00000392043, ENST00000408940, 
ENST00000504405, ENST00000507173, 
ENST00000511413, ENST00000512653, 
ENST00000502732, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score59 X 37 X 25=5457512 X 13 X 3=468
# samples 5813
** MAII scorelog2(58/54575*10)=-6.55604351475058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ETV6 [Title/Abstract] AND ABL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502

TgeneABL2

GO:0018108

peptidyl-tyrosine phosphorylation

15886098

TgeneABL2

GO:0051353

positive regulation of oxidoreductase activity

12893824


check buttonFusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..ETV6chr12

12022903

+ABL2chr1

179102509

-
ChimerKB4..ETV6chr12

12022903

+ABL2chr1

179102509

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396373ETV6chr1212022903+ENST00000502732ABL2chr1179102509-13066128327446741466

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27698_27698_1_ETV6-ABL2_ETV6_chr12_12022903_ENST00000396373_ABL2_chr1_179102509_ENST00000502732_length(amino acids)=1466AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADHFASCVEDGFEGDKTGGSSPEAL
HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLV
TTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG
DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP
ADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQA
SSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPA
QQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDR
MAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAA
APKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPR
RVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTK
VALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr1:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

ABL2

P42684

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (935)CIF file (935) >>>935.cifETV6chr1212022903+ABL2chr1179102509-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADHFASCVEDGFEGD
KTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALY
DFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGR
VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC
NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV
KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPY
GNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL
VGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE
LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVV
PYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQA
SSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPP
KRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPK
CYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAG
KPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTV
STSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPS
GDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSP
AKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQV
TSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTS
ETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTK
VALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQL
LDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVL
1466
3D view using mol* of 935 (AA BP:)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ETV6_pLDDT.png
all structure
all structure
ABL2_pLDDT.png
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ETV6_ABL2_935_pLDDT_and_active_sites.png (AA BP:)
all structure
ETV6_ABL2_935_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
9351.081971.125194.4810.4920.7671.0712.8940.7993.6220.995Chain A: 662,666,667,670,671,674,759,762,763,764,7
65,767,791,792,793,794,795,798,823,832,833,836,840


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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
935ZINC000005844788DB04861Nebivolol-9.23094-9.25074
935ZINC000000000850DB00744Zileuton-8.98931-9.00791
935ZINC000043206370DB11793Niraparib-8.85208-8.85208
935ZINC000004213946DB04861Nebivolol-8.64132-8.66112
935ZINC000035342789DB00323Tolcapone-7.06468-8.60168
935ZINC000001999441DB04861Nebivolol-8.42557-8.44537
935ZINC000053084692DB06654Safinamide-7.65969-8.43779
935ZINC000005844792DB04861Nebivolol-8.40519-8.42499
935InfigratinibDB04861-7.85022-8.41702
935ZINC000043207238DB08907Canagliflozin-8.31459-8.31459
935ZINC000034220093DB15058Flutemetamol-8.24466-8.25876
935ZINC000000000323DB00712Flurbiprofen-8.25155-8.25205
935ZINC000000008667DB00712Flurbiprofen-8.22911-8.22961
935ZINC000006467621DB11115Ensulizole-7.80972-8.22062
935ZINC000000643143DB01026Ketoconazole-7.80084-8.12554
935ZINC000000020243DB00861Diflunisal-8.06762-8.06762
935ZINC000000004319DB00598Labetalol-8.02603-8.05363
935ZINC000003872605DB00176Fluvoxamine-8.04084-8.04444
935ZINC000252678020DB00176Fluvoxamine-8.04084-8.04444
935ZINC000002568036DB01219Dantrolene-7.92536-7.99776

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000043206370DB11793NiraparibSmall moleculeNC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1Approved|Investigational
ZINC000035342789DB00323TolcaponeSmall moleculeCC1=CC=C(C=C1)C(=O)C1=CC(=C(O)C(O)=C1)[N+]([O-])=OApproved|Withdrawn
ZINC000053084692DB06654SafinamideSmall moleculeC[C@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C(N)=OApproved|Investigational
ZINC000043207238DB08907CanagliflozinSmall molecule[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C1=CC=C(C)C(CC2=CC=C(S2)C2=CC=C(F)C=C2)=C1Approved
ZINC000034220093DB15058FlutemetamolSmall moleculeCNC1=C(F)C=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2Investigational
ZINC000000008667DB00712FlurbiprofenSmall moleculeCC(C(O)=O)C1=CC(F)=C(C=C1)C1=CC=CC=C1Approved|Investigational
ZINC000006467621DB11115EnsulizoleSmall moleculeOS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C1=CC=CC=C1Approved
ZINC000000020243DB00861DiflunisalSmall moleculeOC(=O)C1=C(O)C=CC(=C1)C1=C(F)C=C(F)C=C1Approved|Investigational
ZINC000252678020DB00176FluvoxamineSmall moleculeCOCCCCC(=N/OCCN)C1=CC=C(C=C1)C(F)(F)FApproved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000005844788405.4411.102724.6273.70387.795269.33993.7621272.25736.49.305394.99500
ZINC000005844788405.4413.204688.14293.00460.761240.61593.761244.95936.49.151310000
ZINC000000000850236.2885.297457.64285.783137.035198.52336.3755.01533.78.91375.35100
ZINC000000000850236.2885.297450.83785.532135.419201.89327.994746.83933.78.57376.55500
ZINC000043206370320.3933.754607.688185.794143.417278.47601055.805358.546376.7200
ZINC000004213946405.4415.213712.775270.54687.695260.77393.7611260.0136.49.251394.55500
ZINC000004213946405.4413.313660.255261.06875.583229.84493.761216.09336.49.124395.53300
ZINC000035342789273.2453.817507.14288.195223.7195.2470847.54824.59.508367.93400
ZINC000035342789273.2455.603506.16988.195222.204195.7690846.89124.59.828368.23300
ZINC000035342789273.2453.5506.84288.2223.976194.6650847.73424.59.758367.88100
ZINC000001999441405.4414.722712.226273.48884.211260.77493.7531256.14736.49.229395.14300
ZINC000001999441405.4410.513723.645269.65591.189269.03293.7681265.84436.49.27394.03900
ZINC000053084692302.3486.36612.581156.033105.388304.28646.8741036.21834.759.083376.96100
ZINC000053084692302.3483.053603.233143.432120.534292.3746.8971022.59734.759.137372.68300
ZINC000005844792405.4412.88705.095278.73976.814255.78193.7611255.09936.49.355396.66500
ZINC000005844792405.4412.543700.215280.74373.672252.03693.7641255.10136.49.361310000
ZINC000043207238444.5174.415747.287209.678166.727291.44679.4361342.61848.58.906388.9902
ZINC000034220093274.3121.949511.17789.83386.339254.7680.245847.32223.258.207310000
ZINC000034220093274.3121.174509.60989.8384.419255.17680.184844.62323.258.146310000
ZINC000000000323244.2652.669490.20987.74392.913277.08932.464818.983129.231396.35400
ZINC000000008667244.2652.669490.20987.74392.913277.08932.464818.983129.231396.35400
ZINC000006467621274.2949.514495.1790165.642327.0772.46816.85725.59.09370.24100
ZINC000006467621274.2945.937496.1670165.586328.1242.456817.80525.59.121370.28800
ZINC000006467621274.2949.57496.8940166.022328.3772.495819.64625.58.954370.26400
ZINC000000643143531.4389.855856.851327.71380.224331.811117.1031560.89508.258.211392.47110
ZINC000000643143531.4386.997824.307333.32681.685289.695119.6011537.56608.258.204392.42710
ZINC000000643143531.4386.356853.952332.54878.446320.618122.3411564.06108.259.22392.92210
ZINC000000643143531.4386.331852.73332.66278.89318.374122.8041561.36608.259.213392.80710
ZINC000000020243250.2018.261459.0810144.436231.00583.64751.87911.759.879386.60100
ZINC000000004319328.415.655664.549169.051199.646295.85201140.61545.459.067270.58900
ZINC000000004319328.413.937652.909170.739198.631283.53901134.88245.459.364270.66200
ZINC000003872605318.3383.821606.238306.60765.012116.869117.751044.62125.49.599393.67200
ZINC000252678020318.3383.821606.238306.60765.012116.869117.751044.62125.49.599393.67200
ZINC000252678020318.3383.426598.781317.35553.672110.076117.6781044.79625.49.44396.42500
ZINC000002568036314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000002568036314.2574.186547.354.729241.127251.4440922.097159.191367.40800


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000005844788O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000000000850C[C@@H](c1cc2ccccc2s1)N(O)C(N)=O0.1363358820.223511692
ZINC000043206370NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc120.158103060.243905197
ZINC000004213946O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000035342789Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc10.3597350140.498165074
ZINC000001999441O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000053084692C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O0.2799554790.265373208
ZINC000005844792O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000043207238Cc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc(-c2ccc(F)cc2)s10.0682111610.161061761
ZINC000034220093CNc1ccc(-c2nc3ccc(O)cc3s2)cc1F0.3011586210.239116152
ZINC000000000323C[C@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c10.313804640.287418039
ZINC000000008667C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c10.313804640.287418039
ZINC000006467621O=S(=O)(O)c1ccc2[nH]c(-c3ccccc3)nc2c10.385041040.405031793
ZINC000000643143CC(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC10.0873932720.387082142
ZINC000000020243O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O0.4404093730.371648269
ZINC000000004319C[C@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000003872605COCCCC/C(=NOCCN)c1ccc(C(F)(F)F)cc10.2322523760.356848479
ZINC000252678020COCCCCC(=NOCCN)c1ccc(C(F)(F)F)cc10.2322523760.356848479
ZINC000002568036O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N10.2040708230.461176527


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2, EGLN3, NKX2-1, TRAF2, AXIN1, ESR2, LMNA, TP53BP1, BRCA1, MDC1, KIAA1429, WWP2, ESR1, BRD4, NFE2L2, MAD2L1, B4GALT2, KLHL9, KLHL13, SUMO2, ARHGAP32, SEC16A, XPOT, PIAS2, CEP152, NUP214, NUP62, NUP98, SEC13, RBM11, ECH1, ZNF146, TRIP6, CEP85, NUP54, TAB3, ALMS1, CEP192, PPIL4, RQCD1, SDCCAG3, NUP88, TBL1Y, KIAA1671, C2orf44, GRPEL1, TNRC6C, MID1IP1, CYLD, ZMYM2, LIMD1, SPATA2, TNRC6B, TIMM13, FLOT1, LGALS3BP, FLOT2, HNRNPUL1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ETV6all structure
ABL2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ETV6-ABL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ETV6-ABL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ETV6ABL2Breast Invasive Ductal CarcinomaMyCancerGenome
ETV6ABL2Invasive Breast CarcinomaMyCancerGenome
ETV6ABL2Lung AdenocarcinomaMyCancerGenome
ETV6ABL2Appendix AdenocarcinomaMyCancerGenome
ETV6ABL2Colon AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
HgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
HgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET
HgeneETV6C0006413Burkitt Lymphoma1ORPHANET
HgeneETV6C0013146Drug abuse1CTD_human
HgeneETV6C0013170Drug habituation1CTD_human
HgeneETV6C0013222Drug Use Disorders1CTD_human
HgeneETV6C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneETV6C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneETV6C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;GENOMICS_ENGLAND
HgeneETV6C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneETV6C0038580Substance Dependence1CTD_human
HgeneETV6C0038586Substance Use Disorders1CTD_human
HgeneETV6C0087031Juvenile-Onset Still Disease1CTD_human
HgeneETV6C0236969Substance-Related Disorders1CTD_human
HgeneETV6C0238463Papillary thyroid carcinoma1ORPHANET
HgeneETV6C0376544Hematopoietic Neoplasms1CTD_human
HgeneETV6C0376545Hematologic Neoplasms1CTD_human
HgeneETV6C0740858Substance abuse problem1CTD_human
HgeneETV6C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
HgeneETV6C1510472Drug Dependence1CTD_human
HgeneETV6C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1ORPHANET
HgeneETV6C1838656Macrocytosis, Familial1CTD_human
HgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneETV6C3495559Juvenile arthritis1CTD_human
HgeneETV6C3714758Juvenile psoriatic arthritis1CTD_human
HgeneETV6C4316881Prescription Drug Abuse1CTD_human
HgeneETV6C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneETV6C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human