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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EZH2-ZNF746

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EZH2-ZNF746
	FusionPDB ID: 28107
	FusionGDB2.0 ID: 28107
		Hgene	Tgene
	Gene symbol	EZH2	ZNF746
	Gene ID	2146	155061
	Gene name	enhancer of zeste 2 polycomb repressive complex 2 subunit	zinc finger protein 746
	Synonyms	ENX-1\|ENX1\|EZH2b\|KMT6\|KMT6A\|WVS\|WVS2	PARIS
	Cytomap	7q36.1	7q36.1
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase EZH2enhancer of zeste homolog 2lysine N-methyltransferase 6	zinc finger protein 746parkin-interacting substrateparkin-interacting sustrate
	Modification date	20200329	20200313
	UniProtAcc	Q15910	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000536783, ENST00000320356, ENST00000350995, ENST00000460911, ENST00000476773, ENST00000478654, ENST00000483967, ENST00000541220,	ENST00000340622, ENST00000458143, ENST00000461958,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 9 X 5=405	1 X 1 X 1=1
	# samples	9	1
	** MAII score	log2(9/405*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: EZH2 [Title/Abstract] AND ZNF746 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EZH2(148543561)-ZNF746(149191594), # samples:1
Anticipated loss of major functional domain due to fusion event.	EZH2-ZNF746 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EZH2-ZNF746 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EZH2-ZNF746 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EZH2-ZNF746 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EZH2	GO:0000122	negative regulation of transcription by RNA polymerase II	20154697
Hgene	EZH2	GO:0010718	positive regulation of epithelial to mesenchymal transition	20154697
Hgene	EZH2	GO:0043406	positive regulation of MAP kinase activity	20154697
Hgene	EZH2	GO:0043547	positive regulation of GTPase activity	20154697
Hgene	EZH2	GO:0045814	negative regulation of gene expression, epigenetic	20154697
Hgene	EZH2	GO:0070734	histone H3-K27 methylation	24474760
Hgene	EZH2	GO:0071902	positive regulation of protein serine/threonine kinase activity	20154697
Tgene	ZNF746	GO:0000122	negative regulation of transcription by RNA polymerase II	21376232
Tgene	ZNF746	GO:0045892	negative regulation of transcription, DNA-templated	21376232
Tgene	ZNF746	GO:0045944	positive regulation of transcription by RNA polymerase II	21376232
Tgene	ZNF746	GO:1901216	positive regulation of neuron death	21376232

Fusion gene breakpoints across EZH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF746 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2019	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000460911	EZH2	chr7	148543561	-	ENST00000340622	ZNF746	chr7	149191594	-	3836	335	89	2245	718
ENST00000460911	EZH2	chr7	148543561	-	ENST00000458143	ZNF746	chr7	149191594	-	3837	335	89	2248	719
ENST00000460911	EZH2	chr7	148543561	-	ENST00000461958	ZNF746	chr7	149191594	-	5165	335	89	874	261
ENST00000350995	EZH2	chr7	148543561	-	ENST00000340622	ZNF746	chr7	149191594	-	3839	338	92	2248	718
ENST00000350995	EZH2	chr7	148543561	-	ENST00000458143	ZNF746	chr7	149191594	-	3840	338	92	2251	719
ENST00000350995	EZH2	chr7	148543561	-	ENST00000461958	ZNF746	chr7	149191594	-	5168	338	92	877	261
ENST00000320356	EZH2	chr7	148543561	-	ENST00000340622	ZNF746	chr7	149191594	-	3869	368	122	2278	718
ENST00000320356	EZH2	chr7	148543561	-	ENST00000458143	ZNF746	chr7	149191594	-	3870	368	122	2281	719
ENST00000320356	EZH2	chr7	148543561	-	ENST00000461958	ZNF746	chr7	149191594	-	5198	368	122	907	261

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000460911	ENST00000340622	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.02570787	0.9742921
ENST00000460911	ENST00000458143	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.026625514	0.9733744
ENST00000460911	ENST00000461958	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.010981322	0.9890187
ENST00000350995	ENST00000340622	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.025804026	0.974196
ENST00000350995	ENST00000458143	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.02671212	0.97328794
ENST00000350995	ENST00000461958	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.010944763	0.9890553
ENST00000320356	ENST00000340622	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.025029466	0.97497046
ENST00000320356	ENST00000458143	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.025883798	0.97411627
ENST00000320356	ENST00000461958	EZH2	chr7	148543561	-	ZNF746	chr7	149191594	-	0.010820173	0.98917985

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28107_28107_1_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000340622_length(amino acids)=718AA_BP=563
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIK
TEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQV
SLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDH

--------------------------------------------------------------

>28107_28107_2_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000458143_length(amino acids)=719AA_BP=564
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEADVKIVI
KTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFG
GVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQ
VSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID

--------------------------------------------------------------

>28107_28107_3_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000461958_length(amino acids)=261AA_BP=82
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES

--------------------------------------------------------------

>28107_28107_4_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000340622_length(amino acids)=718AA_BP=563
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIK
TEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQV
SLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDH

--------------------------------------------------------------

>28107_28107_5_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000458143_length(amino acids)=719AA_BP=564
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEADVKIVI
KTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFG
GVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQ
VSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID

--------------------------------------------------------------

>28107_28107_6_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000461958_length(amino acids)=261AA_BP=82
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES

--------------------------------------------------------------

>28107_28107_7_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000340622_length(amino acids)=718AA_BP=563
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIK
TEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQV
SLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDH

--------------------------------------------------------------

>28107_28107_8_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000458143_length(amino acids)=719AA_BP=564
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEADVKIVI
KTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFG
GVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQ
VSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID

--------------------------------------------------------------

>28107_28107_9_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000461958_length(amino acids)=261AA_BP=82
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:148543561/chr7:149191594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EZH2 Q15910	.
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269\|PubMed:14532106, ECO:0000269\|PubMed:15225548, ECO:0000269\|PubMed:15231737, ECO:0000269\|PubMed:15385962, ECO:0000269\|PubMed:16179254, ECO:0000269\|PubMed:16357870, ECO:0000269\|PubMed:16618801, ECO:0000269\|PubMed:16717091, ECO:0000269\|PubMed:16936726, ECO:0000269\|PubMed:17210787, ECO:0000269\|PubMed:17344414, ECO:0000269\|PubMed:18285464, ECO:0000269\|PubMed:19026781, ECO:0000269\|PubMed:20935635, ECO:0000269\|PubMed:22323599, ECO:0000269\|PubMed:23063525, ECO:0000269\|PubMed:24474760, ECO:0000269\|PubMed:30923826}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

16_92

8.0

645.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

16_92

8.0

646.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

476_516

8.0

645.0

Compositional bias

Note=Gly-rich

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

476_516

8.0

646.0

Compositional bias

Note=Gly-rich

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

96_167

8.0

645.0

Domain

KRAB

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

96_167

8.0

646.0

Domain

KRAB

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

453_478

8.0

645.0

Zinc finger

C2H2-type 1%3B degenerate

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

510_532

8.0

645.0

Zinc finger

C2H2-type 2

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

538_560

8.0

645.0

Zinc finger

C2H2-type 3

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000340622

566_588

8.0

645.0

Zinc finger

C2H2-type 4

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

453_478

8.0

646.0

Zinc finger

C2H2-type 1%3B degenerate

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

510_532

8.0

646.0

Zinc finger

C2H2-type 2

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

538_560

8.0

646.0

Zinc finger

C2H2-type 3

Tgene

ZNF746

chr7:148543561

chr7:149191594

ENST00000458143

566_588

8.0

646.0

Zinc finger

C2H2-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000320356

523_605

82.0

752.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000350995

523_605

82.0

708.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000460911

523_605

82.0

747.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000476773

523_605

696.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000478654

523_605

696.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000483967

523_605

738.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000541220

523_605

696.0

Compositional bias

Note=Cys-rich

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000320356

503_605

82.0

752.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000320356

612_727

82.0

752.0

Domain

SET

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000350995

503_605

82.0

708.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000350995

612_727

82.0

708.0

Domain

SET

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000460911

503_605

82.0

747.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000460911

612_727

82.0

747.0

Domain

SET

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000476773

503_605

696.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000476773

612_727

696.0

Domain

SET

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000478654

503_605

696.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000478654

612_727

696.0

Domain

SET

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000483967

503_605

738.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000483967

612_727

738.0

Domain

SET

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000541220

503_605

696.0

Domain

CXC

Hgene

EZH2

chr7:148543561

chr7:149191594

ENST00000541220

612_727

696.0

Domain

SET

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EZH2
ZNF746

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000320356	-	3	20	329_522	82.0	752.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000350995	-	3	19	329_522	82.0	708.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000460911	-	3	20	329_522	82.0	747.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000476773	-	1	19	329_522	0	696.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000478654	-	1	20	329_522	0	696.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000483967	-	1	20	329_522	0	738.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000541220	-	1	19	329_522	0	696.0	CDYL
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000320356	-	3	20	1_340	82.0	752.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000350995	-	3	19	1_340	82.0	708.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000460911	-	3	20	1_340	82.0	747.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000476773	-	1	19	1_340	0	696.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000478654	-	1	20	1_340	0	696.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000483967	-	1	20	1_340	0	738.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000541220	-	1	19	1_340	0	696.0	DNMT1%2C DNMT3A and DNMT3B
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000476773	-	1	19	39_68	0	696.0	EED
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000478654	-	1	20	39_68	0	696.0	EED
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000483967	-	1	20	39_68	0	738.0	EED
Hgene	EZH2	chr7:148543561	chr7:149191594	ENST00000541220	-	1	19	39_68	0	696.0	EED

Top

Related Drugs to EZH2-ZNF746

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EZH2-ZNF746

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source