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Fusion Protein:AGGF1-RAF1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: AGGF1-RAF1 | FusionPDB ID: 2882 | FusionGDB2.0 ID: 2882 | Hgene | Tgene | Gene symbol | AGGF1 | RAF1 | Gene ID | 55109 | 6037 |
| Gene name | angiogenic factor with G-patch and FHA domains 1 | ribonuclease A family member 3 | |
| Synonyms | GPATC7|GPATCH7|HSU84971|HUS84971|VG5Q | ECP|RAF1|RNS3 | |
| Cytomap | 5q13.3 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | angiogenic factor with G patch and FHA domains 1G patch domain-containing protein 7angiogenic factor VG5Qvasculogenesis gene on 5q protein | eosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8N302 | P04049 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000312916, ENST00000503538, ENST00000506806, | ENST00000251849, ENST00000442415, ENST00000534997, ENST00000542177, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 2 X 3=18 | 19 X 16 X 7=2128 |
| # samples | 3 | 18 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/2128*10)=-3.56342933917152 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: AGGF1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | AGGF1(76335544)-RAF1(12641914), # samples:5 RAF1(12645635)-AGGF1(76342172), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AGGF1 | GO:0001938 | positive regulation of endothelial cell proliferation | 14961121 |
| Hgene | AGGF1 | GO:0007155 | cell adhesion | 14961121 |
| Hgene | AGGF1 | GO:0045766 | positive regulation of angiogenesis | 14961121 |
| Tgene | RAF1 | GO:0002227 | innate immune response in mucosa | 12860195 |
| Tgene | RAF1 | GO:0019731 | antibacterial humoral response | 12860195 |
| Tgene | RAF1 | GO:0043152 | induction of bacterial agglutination | 23992292 |
| Tgene | RAF1 | GO:0045087 | innate immune response | 23992292 |
| Tgene | RAF1 | GO:0050829 | defense response to Gram-negative bacterium | 23992292 |
| Tgene | RAF1 | GO:0050830 | defense response to Gram-positive bacterium | 12860195|23992292 |
| Tgene | RAF1 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12860195 |
| Fusion gene breakpoints across AGGF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RAF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-CH-5737-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ChimerDB4 | THCA | TCGA-BJ-A2N7-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ChimerDB4 | THCA | TCGA-DJ-A2Q4-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ChimerDB4 | THCA | TCGA-EM-A1CS-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000251849 | RAF1 | chr3 | 12641914 | - | 3278 | 1252 | 286 | 2364 | 692 |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000442415 | RAF1 | chr3 | 12641914 | - | 3081 | 1252 | 286 | 2364 | 692 |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000534997 | RAF1 | chr3 | 12641914 | - | 2612 | 1252 | 286 | 2364 | 692 |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000542177 | RAF1 | chr3 | 12641914 | - | 2546 | 1252 | 286 | 2364 | 692 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000312916 | ENST00000251849 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.003556621 | 0.99644333 |
| ENST00000312916 | ENST00000442415 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.005202861 | 0.99479717 |
| ENST00000312916 | ENST00000534997 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.00489195 | 0.99510807 |
| ENST00000312916 | ENST00000542177 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.005396192 | 0.9946038 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >2882_2882_1_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- >2882_2882_2_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- >2882_2882_3_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- >2882_2882_4_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:76335544/chr3:12641914) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGGF1 | RAF1 |
| FUNCTION: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. | FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 18_88 | 290.0 | 715.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 12_15 | 290.0 | 715.0 | Compositional bias | Note=Poly-Pro |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 349_609 | 278.0 | 649.0 | Domain | Protein kinase | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 349_609 | 298.0 | 669.0 | Domain | Protein kinase | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 355_363 | 278.0 | 649.0 | Nucleotide binding | ATP | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 355_363 | 298.0 | 669.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 18_88 | 0 | 177.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 12_15 | 0 | 177.0 | Compositional bias | Note=Poly-Pro |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 434_487 | 290.0 | 715.0 | Domain | FHA |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 619_665 | 290.0 | 715.0 | Domain | G-patch |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 434_487 | 0 | 177.0 | Domain | FHA |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 619_665 | 0 | 177.0 | Domain | G-patch |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 56_131 | 278.0 | 649.0 | Domain | RBD | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 56_131 | 298.0 | 669.0 | Domain | RBD | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 138_184 | 278.0 | 649.0 | Zinc finger | Phorbol-ester/DAG-type | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 138_184 | 298.0 | 669.0 | Zinc finger | Phorbol-ester/DAG-type |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1419_AGGF1_76335544_RAF1_12641914_ranked_0.pdb | AGGF1 | 76335544 | 76335544 | ENST00000542177 | RAF1 | chr3 | 12641914 | - | MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA | 692 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
AGGF1_pLDDT.png  |
RAF1_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| RAF1 | YWHAQ, YWHAG, YWHAZ, Hras, SFN, HRAS, VDAC1, PEBP4, CNKSR1, RASD2, CNKSR2, ERAS, SPRY4, SPRY2, YWHAB, OIP5, PHKA2, CCT3, MYC, AR, MRAS, KRAS, LRPAP1, RRAS2, SHOC2, TSC22D3, STK26, MAPK1, MAPK3, PRKCE, BCL2, BCL2L1, PEBP1, MAP2K1, GRB10, NRAS, MAPK8IP3, AKT1, HSP90AA1, GNG4, GNB2, VAV1, RHEB, RAP1A, SRC, FYN, RB1, RBL2, PRKG1, JAK2, YWHAH, CFLAR, CDC25A, BRAF, MAP3K1, PDGFRB, MAP3K5, MAPK7, PHB, BAG1, PAK1, PRKCZ, RRAS, PRPF6, UBE2D2, YWHAE, NR3C1, LCK, LTK, JAK1, XIAP, BIRC2, BIRC3, STUB1, Arrb2, EEF1A1, HSP82, HSPA8, HSPA5, CALM1, SGK1, NEDD4, SCNN1B, NEDD4L, STK3, BRAP, WDR83, KSR1, LATS1, MAP2K2, Rfxank, RFXANK, PPP1CC, VCP, HSPD1, BAD, BCL6, BIRC7, PIN1, MMS19, PPP2R1A, PPP2R2B, PPP2CA, HSPA4, RAF1, PPP2CB, MAPK8, RBBP8, YY1, PKM, CDK20, HIPK4, TBXA2R, SH3KBP1, ILK, GPRASP2, CDC37, IRS4, FAM96B, HUWE1, Prkab1, RANBP9, TMEM70, PACSIN3, NPLOC4, PRKAR1A, DCAF8, PURA, FYCO1, MYBPC1, COPS7A, MOV10, NXF1, EGFR, CALU, CCT8, DNAJA1, EMD, TIMM50, LOX, ARRB2, AGTR1, CASZ1, MRC2, PDLIM2, HERC2, XPO1, ACOX1, PCDH7, MAD2L1, SYNPO, TMEM63B, EEF1E1, COPS5, SS18L2, Smn1, Cep152, Aldh4a1, Ksr1, NUP133, RPGRIP1L, NCAPG2, NUP107, MSH2, LAS1L, AMER1, NUP160, EIF3D, SPATA7, NPHP4, DYNLL2, DYNLL1, IQCB1, RMDN3, TRIM25, Mapkbp1, EGLN3, RIPK4, MAPK6, CSNK1A1, HERC1, LZTR1, QKI, COPS3, TRIM28, MAEA, NANOG, ITCH, IRF7, PSMB9, MAP2K5, CDK4, CDK6, CDKN2B, FGFR4, MAP2K3, NF2, PDGFRA, TEAD2, RASSF1, ABCB5, BECN1, CBLC, GLIS2, GRM1, HGF, MAP2K6, ARNT, CCND2, CD44, CDKN2A, CDKN2C, EPHA2, ERBB2, KEAP1, LATS2, MET, NF1, TERT, DUSP2, MBP, PAK2, PLEKHA4, CRBN, ARAF, SLC25A3, TUBB4B, TUBB, HSPA6, HSP90AB3P, HSP90AB1, HSPA1A, HSPB1, BAG2, CCT7, DSG1, CCT2, CCT4, CCT6A, TCP1, AKAP8L, ATAD3A, ABCD3, SLC25A22, TMEM33, TUBA4A, HPX, MGST1, TUBB4A, TMEM161A, HSP90AB2P, CCAR2, SLC25A10, FANCD2, TUBB6, HSD17B12, SLC25A11, SLC25A1, ARL1, DNAJA2, DPM1, CCT5, AIFM1, SQSTM1, TUBG2, TUBG1, STK39, GCN1L1, ABCF2, POLD1, NUBP2, TM9SF3, NCLN, SEC61A2, SEC61A1, ALDH1A3, TUBB3, POLR2B, IARS2, TMED1, CIT, AURKB, KIF20A, BRD1, TRIM66, HAX1, CUL4A, ACTR1A, AKAP1, FLOT1, LAMTOR1, LMAN1, RAB2A, RAB4A, STX7, NPAS1, OPALIN, METTL21B, SSSCA1, FAM174A, CRKL, DDB1, DICER1, LDHB, PIK3R1, NONO, DVL2, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| AGGF1 | |
| RAF1 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to AGGF1-RAF1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to AGGF1-RAF1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RAF1 | C0028326 | Noonan Syndrome | 10 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | RAF1 | C0175704 | LEOPARD Syndrome | 7 | CLINGEN;CTD_human;GENOMICS_ENGLAND |
| Tgene | RAF1 | C1969057 | Noonan Syndrome 5 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | RAF1 | C1969056 | LEOPARD SYNDROME 2 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | RAF1 | C0007194 | Hypertrophic Cardiomyopathy | 2 | CTD_human |
| Tgene | RAF1 | C0041409 | Turner Syndrome, Male | 2 | CTD_human |
| Tgene | RAF1 | C1519086 | Pilomyxoid astrocytoma | 2 | ORPHANET |
| Tgene | RAF1 | C1527404 | Female Pseudo-Turner Syndrome | 2 | CTD_human |
| Tgene | RAF1 | C4551472 | Hypertrophic obstructive cardiomyopathy | 2 | CTD_human |
| Tgene | RAF1 | C4551602 | Noonan Syndrome 1 | 2 | CTD_human |
| Tgene | RAF1 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Tgene | RAF1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | RAF1 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
| Tgene | RAF1 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | RAF1 | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | RAF1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | RAF1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | RAF1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | RAF1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| Tgene | RAF1 | C0259783 | mixed gliomas | 1 | CTD_human |
| Tgene | RAF1 | C0340427 | Familial dilated cardiomyopathy | 1 | ORPHANET |
| Tgene | RAF1 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
| Tgene | RAF1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | RAF1 | C0458247 | Allodynia | 1 | CTD_human |
| Tgene | RAF1 | C0555198 | Malignant Glioma | 1 | CTD_human |
| Tgene | RAF1 | C0587248 | Costello syndrome (disorder) | 1 | CLINGEN |
| Tgene | RAF1 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Tgene | RAF1 | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
| Tgene | RAF1 | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
| Tgene | RAF1 | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
| Tgene | RAF1 | C0751213 | Tactile Allodynia | 1 | CTD_human |
| Tgene | RAF1 | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
| Tgene | RAF1 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Tgene | RAF1 | C1275081 | Cardio-facio-cutaneous syndrome | 1 | CLINGEN |
| Tgene | RAF1 | C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | CTD_human |
| Tgene | RAF1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | RAF1 | C2936719 | Mechanical Allodynia | 1 | CTD_human |
| Tgene | RAF1 | C4014656 | CARDIOMYOPATHY, DILATED, 1NN | 1 | CTD_human;UNIPROT |
| Tgene | RAF1 | C4551484 | Leopard Syndrome 1 | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | RAF1 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | RAF1 | C4721610 | Carcinoma, Ovarian Epithelial | 1 | CTD_human |
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