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Fusion Protein:FBXW7-ARFIP1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: FBXW7-ARFIP1 | FusionPDB ID: 29912 | FusionGDB2.0 ID: 29912 | Hgene | Tgene | Gene symbol | FBXW7 | ARFIP1 | Gene ID | 55294 | 27236 |
| Gene name | F-box and WD repeat domain containing 7 | ADP ribosylation factor interacting protein 1 | |
| Synonyms | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 | HSU52521 | |
| Cytomap | 4q31.3 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of | arfaptin-1 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q969H0 | P53367 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000263981, ENST00000281708, ENST00000296555, ENST00000393956, ENST00000603548, ENST00000603841, ENST00000604095, ENST00000604872, | ENST00000511289, ENST00000353617, ENST00000356064, ENST00000405727, ENST00000451320, ENST00000429148, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 15 X 9 X 10=1350 | 10 X 10 X 11=1100 |
| # samples | 17 | 19 | |
| ** MAII score | log2(17/1350*10)=-2.98935275580049 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/1100*10)=-2.53343220008107 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: FBXW7 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ARFIP1(153701378)-FBXW7(153271276), # samples:1 FBXW7(153268082)-ARFIP1(153831216), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBXW7 | GO:0016567 | protein ubiquitination | 12354302|15103331 |
| Hgene | FBXW7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331|17434132 |
| Hgene | FBXW7 | GO:0031398 | positive regulation of protein ubiquitination | 12628165 |
| Hgene | FBXW7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 20208556 |
| Hgene | FBXW7 | GO:0050821 | protein stabilization | 20208556 |
| Hgene | FBXW7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 12628165 |
| Hgene | FBXW7 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 23858059 |
| Hgene | FBXW7 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 23858059 |
| Hgene | FBXW7 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20208556 |
| Tgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
| Tgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
| Fusion gene breakpoints across FBXW7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ARFIP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | ERR315398 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000281708 | FBXW7 | chr4 | 153268082 | - | ENST00000451320 | ARFIP1 | chr4 | 153831216 | + | 4250 | 1956 | 1002 | 2111 | 369 |
| ENST00000603548 | FBXW7 | chr4 | 153268082 | - | ENST00000429148 | ARFIP1 | chr4 | 153831216 | + | 1917 | 906 | 81 | 1061 | 326 |
| ENST00000296555 | FBXW7 | chr4 | 153268082 | - | ENST00000429148 | ARFIP1 | chr4 | 153831216 | + | 1563 | 552 | 180 | 707 | 175 |
| ENST00000263981 | FBXW7 | chr4 | 153268082 | - | ENST00000429148 | ARFIP1 | chr4 | 153831216 | + | 1738 | 727 | 229 | 882 | 217 |
| ENST00000393956 | FBXW7 | chr4 | 153268082 | - | ENST00000429148 | ARFIP1 | chr4 | 153831216 | + | 1286 | 275 | 71 | 430 | 119 |
| ENST00000603841 | FBXW7 | chr4 | 153268082 | - | ENST00000429148 | ARFIP1 | chr4 | 153831216 | + | 1812 | 801 | 0 | 956 | 318 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000281708 | ENST00000451320 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + | 0.000240156 | 0.99975985 |
| ENST00000603548 | ENST00000429148 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + | 0.000352483 | 0.9996475 |
| ENST00000296555 | ENST00000429148 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + | 0.021627951 | 0.97837204 |
| ENST00000263981 | ENST00000429148 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + | 0.030787995 | 0.96921194 |
| ENST00000393956 | ENST00000429148 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + | 0.12897725 | 0.8710227 |
| ENST00000603841 | ENST00000429148 | FBXW7 | chr4 | 153268082 | - | ARFIP1 | chr4 | 153831216 | + | 0.000388017 | 0.99961203 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >29912_29912_1_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000263981_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=217AA_BP=165 MHVCMCVPRSGLILSCICLYCGVLLPVLLPNLPFLTCLSMSTLESVTYLPEKGLYCQRLPSSRTHGGTESLKGKNTENMGFYGTLKMIFY KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKVLHNQLVLFHNA -------------------------------------------------------------- >29912_29912_2_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000281708_ARFIP1_chr4_153831216_ENST00000451320_length(amino acids)=369AA_BP=317 MAARKRPGLPPGLATRAPLLPQYRAGAFRSCRFSPKEEGNQPTFSAPRLFSKSNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRR TGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEH AGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYT STTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGV -------------------------------------------------------------- >29912_29912_3_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000296555_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=175AA_BP=123 MSKPGKPTLNHGLVPVDLKSAKEPLPHQTVMKIFSISIIAQGLPFCRRRMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTT -------------------------------------------------------------- >29912_29912_4_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000393956_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=119AA_BP=67 MLMLFFKCISLLLIWLIPGQSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKVLHNQLVLFHNAIAAYFAGN -------------------------------------------------------------- >29912_29912_5_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000603548_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=326AA_BP=274 MPEVELLGQRNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNG EVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSS SIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEW -------------------------------------------------------------- >29912_29912_6_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000603841_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=318AA_BP=266 LQNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPR PGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVH QLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKV -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:153701378/chr4:153271276) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXW7 | ARFIP1 |
| FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}. | FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 278_324 | 162.0 | 628.0 | Domain | F-box |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 278_324 | 242.0 | 708.0 | Domain | F-box |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 278_324 | 124.0 | 590.0 | Domain | F-box |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 278_324 | 242.0 | 708.0 | Domain | F-box |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 278_324 | 242.0 | 708.0 | Domain | F-box |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 378_418 | 162.0 | 628.0 | Repeat | Note=WD 1 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 420_456 | 162.0 | 628.0 | Repeat | Note=WD 2 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 459_498 | 162.0 | 628.0 | Repeat | Note=WD 3 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 500_536 | 162.0 | 628.0 | Repeat | Note=WD 4 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 539_578 | 162.0 | 628.0 | Repeat | Note=WD 5 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 580_618 | 162.0 | 628.0 | Repeat | Note=WD 6 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000263981 | - | 3 | 11 | 622_659 | 162.0 | 628.0 | Repeat | Note=WD 7 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 378_418 | 242.0 | 708.0 | Repeat | Note=WD 1 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 420_456 | 242.0 | 708.0 | Repeat | Note=WD 2 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 459_498 | 242.0 | 708.0 | Repeat | Note=WD 3 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 500_536 | 242.0 | 708.0 | Repeat | Note=WD 4 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 539_578 | 242.0 | 708.0 | Repeat | Note=WD 5 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 580_618 | 242.0 | 708.0 | Repeat | Note=WD 6 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000281708 | - | 4 | 12 | 622_659 | 242.0 | 708.0 | Repeat | Note=WD 7 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 378_418 | 124.0 | 590.0 | Repeat | Note=WD 1 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 420_456 | 124.0 | 590.0 | Repeat | Note=WD 2 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 459_498 | 124.0 | 590.0 | Repeat | Note=WD 3 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 500_536 | 124.0 | 590.0 | Repeat | Note=WD 4 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 539_578 | 124.0 | 590.0 | Repeat | Note=WD 5 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 580_618 | 124.0 | 590.0 | Repeat | Note=WD 6 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000296555 | - | 3 | 11 | 622_659 | 124.0 | 590.0 | Repeat | Note=WD 7 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 378_418 | 242.0 | 708.0 | Repeat | Note=WD 1 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 420_456 | 242.0 | 708.0 | Repeat | Note=WD 2 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 459_498 | 242.0 | 708.0 | Repeat | Note=WD 3 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 500_536 | 242.0 | 708.0 | Repeat | Note=WD 4 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 539_578 | 242.0 | 708.0 | Repeat | Note=WD 5 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 580_618 | 242.0 | 708.0 | Repeat | Note=WD 6 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603548 | - | 5 | 13 | 622_659 | 242.0 | 708.0 | Repeat | Note=WD 7 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 378_418 | 242.0 | 708.0 | Repeat | Note=WD 1 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 420_456 | 242.0 | 708.0 | Repeat | Note=WD 2 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 459_498 | 242.0 | 708.0 | Repeat | Note=WD 3 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 500_536 | 242.0 | 708.0 | Repeat | Note=WD 4 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 539_578 | 242.0 | 708.0 | Repeat | Note=WD 5 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 580_618 | 242.0 | 708.0 | Repeat | Note=WD 6 |
| Hgene | FBXW7 | chr4:153268082 | chr4:153831216 | ENST00000603841 | - | 3 | 11 | 622_659 | 242.0 | 708.0 | Repeat | Note=WD 7 |
| Tgene | ARFIP1 | chr4:153268082 | chr4:153831216 | ENST00000353617 | 7 | 9 | 153_353 | 322.0 | 374.0 | Domain | AH | |
| Tgene | ARFIP1 | chr4:153268082 | chr4:153831216 | ENST00000356064 | 6 | 8 | 153_353 | 290.0 | 342.0 | Domain | AH | |
| Tgene | ARFIP1 | chr4:153268082 | chr4:153831216 | ENST00000405727 | 6 | 8 | 153_353 | 290.0 | 342.0 | Domain | AH | |
| Tgene | ARFIP1 | chr4:153268082 | chr4:153831216 | ENST00000451320 | 7 | 9 | 153_353 | 322.0 | 374.0 | Domain | AH |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| ARFIP1 | ARF3, ARF1, ARF5, SLC2A4, ATP6V1C1, TBC1D15, TSNAX, YAP1, DNM1L, HIST1H4A, IDE, LUC7L2, PRMT3, PSMG3, SEC24A, SHMT2, STAT3, ARFIP2, PICK1, AACS, AKR1A1, ADSS, DPYSL2, G6PD, GART, HSD17B8, MVB12A, PFKM, PFKP, PPP3CA, PROSC, SARS, SEC24D, SHMT1, TSTA3, TXNDC9, USP14, ATOX1, ECH1, FLNB, LYPLA1, PAFAH1B2, PDCD6, PGM2L1, QDPR, STIP1, TBCA, DYNLT1, TMEM17, TMEM216, CDC5L, CDH1, CLPB, HSPA8, HSPBP1, RECQL4, TGOLN2, BET1, SCAMP1, DESI2, SYNGR3, KRT33B, SMPD2, BSND, CMTM5, KRT27, AFF1, TNFRSF10D, RPRM, MAGEA6, SFT2D1, SMIM5, ORF7b, nsp4, KIF14, Rnf183, HSPA1L, ACTB, ARF6, B3GAT1, EBAG9, ELOVL5, GJD3, LAMP2, LAMP3, LAMTOR1, MARCKS, METTL7A, PEX14, PFN1, RAB11A, RAB2A, RAB35, RAB3B, RAB4A, RAB5A, RAB5C, RAB9A, RHOB, STX7, ZFPL1, UBQLN2, NAA40, SMAD4, BAG2, HSPA1A, TFDP2, TUSC2, GIMAP2, DNAJB6, MRPL42, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| FBXW7 | |
| ARFIP1 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to FBXW7-ARFIP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to FBXW7-ARFIP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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