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Fusion Protein:AGRN-NOC4L |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: AGRN-NOC4L | FusionPDB ID: 3003 | FusionGDB2.0 ID: 3003 | Hgene | Tgene | Gene symbol | AGRN | NOC4L | Gene ID | 375790 | 79050 |
Gene name | agrin | nucleolar complex associated 4 homolog | |
Synonyms | AGRIN|CMS8|CMSPPD | NET49|NOC4|UTP19 | |
Cytomap | 1p36.33 | 12q24.33 | |
Type of gene | protein-coding | protein-coding | |
Description | agrinagrin proteoglycan | nucleolar complex protein 4 homologNOC4 protein homologNOC4-like proteinnucleolar complex-associated protein 4-like protein | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | O00468 | Q9BVI4 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000477585, ENST00000379370, | ENST00000330579, ENST00000538784, ENST00000535343, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 14 X 7 X 10=980 | 36 X 4 X 20=2880 |
# samples | 18 | 41 | |
** MAII score | log2(18/980*10)=-2.4447848426729 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(41/2880*10)=-2.81237299682423 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: AGRN [Title/Abstract] AND NOC4L [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | AGRN(970704)-NOC4L(132635526), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | AGRN-NOC4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGRN-NOC4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGRN-NOC4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AGRN-NOC4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AGRN | GO:0043113 | receptor clustering | 15340048 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-BH-A0DK-01A | AGRN | chr1 | 970704 | - | NOC4L | chr12 | 132635526 | + |
ChimerDB4 | KIRC | TCGA-B8-A54I-01A | AGRN | chr1 | 957842 | + | NOC4L | chr12 | 132635526 | + |
ChimerDB4 | LUSC | TCGA-39-5029-01A | AGRN | chr1 | 970704 | - | NOC4L | chr12 | 132635526 | + |
ChimerDB4 | STAD | TCGA-CG-5723 | AGRN | chr1 | 970704 | + | NOC4L | chr12 | 132635525 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000379370 | AGRN | chr1 | 970704 | + | ENST00000330579 | NOC4L | chr12 | 132635525 | + | 1251 | 561 | 1192 | 2 | 397 |
ENST00000379370 | AGRN | chr1 | 957842 | + | ENST00000330579 | NOC4L | chr12 | 132635526 | + | 1203 | 513 | 1144 | 2 | 381 |
ENST00000379370 | AGRN | chr1 | 970704 | - | ENST00000330579 | NOC4L | chr12 | 132635526 | + | 1251 | 561 | 1192 | 2 | 397 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000379370 | ENST00000330579 | AGRN | chr1 | 970704 | + | NOC4L | chr12 | 132635525 | + | 0.01224119 | 0.9877588 |
ENST00000379370 | ENST00000330579 | AGRN | chr1 | 957842 | + | NOC4L | chr12 | 132635526 | + | 0.008579757 | 0.99142027 |
ENST00000379370 | ENST00000330579 | AGRN | chr1 | 970704 | - | NOC4L | chr12 | 132635526 | + | 0.01224119 | 0.9877588 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >3003_3003_1_AGRN-NOC4L_AGRN_chr1_957842_ENST00000379370_NOC4L_chr12_132635526_ENST00000330579_length(amino acids)=381AA_BP=1 MGTEFTRPSQQALGWDKLQWHRLGPLLLQVPLKDLVGRELQQWRDADLRHGQGLVDDAGGFGHLRVVVALEGLKLPQGALQGPALGWVLL SRVVGVGVQLRAVWTVHEDPAGRVPAQQVTDERQDHEQGLRGSRQGQAGQPLGEGGHQVGGEVGGGQEEVSQVEEAGAVLDVKDRGVQEA VELPVEVRVLQVVFVNQDEQPVQGQEAEGPPFHTELHLLQVPQGDPHEAGVEHQLVLVGWPQVWGCRVHKEDPGVPSGHLVVTDEGVSKA ADHHLVAAVQQALPGHQVFALQVPPDPNLAGVRVLHRVHVEDLLHRPGEHHVRLLLAPLQRALRACPAGSGQDARGHHKERQQRPQRARV -------------------------------------------------------------- >3003_3003_2_AGRN-NOC4L_AGRN_chr1_970704_ENST00000379370_NOC4L_chr12_132635525_ENST00000330579_length(amino acids)=397AA_BP=1 MGTEFTRPSQQALGWDKLQWHRLGPLLLQVPLKDLVGRELQQWRDADLRHGQGLVDDAGGFGHLRVVVALEGLKLPQGALQGPALGWVLL SRVVGVGVQLRAVWTVHEDPAGRVPAQQVTDERQDHEQGLRGSRQGQAGQPLGEGGHQVGGEVGGGQEEVSQVEEAGAVLDVKDRGVQEA VELPVEVRVLQVVFVNQDEQPVQGQEAEGPPIRRRRRHWSEVGPGFIFHTELHLLQVPQGDPHEAGVEHQLVLVGWPQVWGCRVHKEDPG VPSGHLVVTDEGVSKAADHHLVAAVQQALPGHQVFALQVPPDPNLAGVRVLHRVHVEDLLHRPGEHHVRLLLAPLQRALRACPAGSGQDA -------------------------------------------------------------- >3003_3003_3_AGRN-NOC4L_AGRN_chr1_970704_ENST00000379370_NOC4L_chr12_132635526_ENST00000330579_length(amino acids)=397AA_BP=1 MGTEFTRPSQQALGWDKLQWHRLGPLLLQVPLKDLVGRELQQWRDADLRHGQGLVDDAGGFGHLRVVVALEGLKLPQGALQGPALGWVLL SRVVGVGVQLRAVWTVHEDPAGRVPAQQVTDERQDHEQGLRGSRQGQAGQPLGEGGHQVGGEVGGGQEEVSQVEEAGAVLDVKDRGVQEA VELPVEVRVLQVVFVNQDEQPVQGQEAEGPPIRRRRRHWSEVGPGFIFHTELHLLQVPQGDPHEAGVEHQLVLVGWPQVWGCRVHKEDPG VPSGHLVVTDEGVSKAADHHLVAAVQQALPGHQVFALQVPPDPNLAGVRVLHRVHVEDLLHRPGEHHVRLLLAPLQRALRACPAGSGQDA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:970704/chr12:132635526) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
AGRN | NOC4L |
FUNCTION: [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.; FUNCTION: [Isoform 2]: transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.; FUNCTION: Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.; FUNCTION: Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.; FUNCTION: [Agrin N-terminal 110 kDa subunit]: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:19631309, ECO:0000269|PubMed:21969364}.; FUNCTION: [Agrin C-terminal 22 kDa fragment]: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 30_157 | 154.33333333333334 | 2046.0 | Domain | NtA |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 30_157 | 170.33333333333334 | 2046.0 | Domain | NtA |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 30_157 | 170.33333333333334 | 2046.0 | Domain | NtA |
Tgene | NOC4L | chr1:957842 | chr12:132635526 | ENST00000330579 | 8 | 15 | 347_367 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:957842 | chr12:132635526 | ENST00000330579 | 8 | 15 | 375_395 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:970704 | chr12:132635525 | ENST00000330579 | 8 | 15 | 347_367 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:970704 | chr12:132635525 | ENST00000330579 | 8 | 15 | 375_395 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:970704 | chr12:132635526 | ENST00000330579 | 8 | 15 | 347_367 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:970704 | chr12:132635526 | ENST00000330579 | 8 | 15 | 375_395 | 300.3333333333333 | 517.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1941_2009 | 154.33333333333334 | 2046.0 | Calcium binding | Ontology_term=ECO:0000250 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1941_2009 | 170.33333333333334 | 2046.0 | Calcium binding | Ontology_term=ECO:0000250 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1941_2009 | 170.33333333333334 | 2046.0 | Calcium binding | Ontology_term=ECO:0000250 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1058_1097 | 154.33333333333334 | 2046.0 | Compositional bias | Note=Gly/Ser-rich |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1254_1324 | 154.33333333333334 | 2046.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 671_677 | 154.33333333333334 | 2046.0 | Compositional bias | Note=Gly/Ser-rich |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 974_1099 | 154.33333333333334 | 2046.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1058_1097 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Gly/Ser-rich |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1254_1324 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 671_677 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Gly/Ser-rich |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 974_1099 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1058_1097 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Gly/Ser-rich |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1254_1324 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 671_677 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Gly/Ser-rich |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 974_1099 | 170.33333333333334 | 2046.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1130_1252 | 154.33333333333334 | 2046.0 | Domain | SEA |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1329_1367 | 154.33333333333334 | 2046.0 | Domain | EGF-like 1 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1372_1548 | 154.33333333333334 | 2046.0 | Domain | Laminin G-like 1 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1549_1586 | 154.33333333333334 | 2046.0 | Domain | EGF-like 2 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1588_1625 | 154.33333333333334 | 2046.0 | Domain | EGF-like 3 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1635_1822 | 154.33333333333334 | 2046.0 | Domain | Laminin G-like 2 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1818_1857 | 154.33333333333334 | 2046.0 | Domain | EGF-like 4 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 1868_2065 | 154.33333333333334 | 2046.0 | Domain | Laminin G-like 3 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 191_244 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 1 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 264_319 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 2 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 337_391 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 3 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 408_463 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 4 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 484_536 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 5 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 540_601 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 6 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 607_666 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 7 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 699_752 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 8 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 793_846 | 154.33333333333334 | 2046.0 | Domain | Laminin EGF-like 1 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 847_893 | 154.33333333333334 | 2046.0 | Domain | Laminin EGF-like 2 |
Hgene | AGRN | chr1:957842 | chr12:132635526 | ENST00000379370 | + | 2 | 36 | 917_971 | 154.33333333333334 | 2046.0 | Domain | Kazal-like 9 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1130_1252 | 170.33333333333334 | 2046.0 | Domain | SEA |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1329_1367 | 170.33333333333334 | 2046.0 | Domain | EGF-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1372_1548 | 170.33333333333334 | 2046.0 | Domain | Laminin G-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1549_1586 | 170.33333333333334 | 2046.0 | Domain | EGF-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1588_1625 | 170.33333333333334 | 2046.0 | Domain | EGF-like 3 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1635_1822 | 170.33333333333334 | 2046.0 | Domain | Laminin G-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1818_1857 | 170.33333333333334 | 2046.0 | Domain | EGF-like 4 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 1868_2065 | 170.33333333333334 | 2046.0 | Domain | Laminin G-like 3 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 191_244 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 264_319 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 337_391 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 3 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 408_463 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 4 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 484_536 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 5 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 540_601 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 6 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 607_666 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 7 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 699_752 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 8 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 793_846 | 170.33333333333334 | 2046.0 | Domain | Laminin EGF-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 847_893 | 170.33333333333334 | 2046.0 | Domain | Laminin EGF-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635525 | ENST00000379370 | + | 3 | 36 | 917_971 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 9 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1130_1252 | 170.33333333333334 | 2046.0 | Domain | SEA |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1329_1367 | 170.33333333333334 | 2046.0 | Domain | EGF-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1372_1548 | 170.33333333333334 | 2046.0 | Domain | Laminin G-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1549_1586 | 170.33333333333334 | 2046.0 | Domain | EGF-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1588_1625 | 170.33333333333334 | 2046.0 | Domain | EGF-like 3 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1635_1822 | 170.33333333333334 | 2046.0 | Domain | Laminin G-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1818_1857 | 170.33333333333334 | 2046.0 | Domain | EGF-like 4 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 1868_2065 | 170.33333333333334 | 2046.0 | Domain | Laminin G-like 3 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 191_244 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 264_319 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 337_391 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 3 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 408_463 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 4 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 484_536 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 5 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 540_601 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 6 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 607_666 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 7 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 699_752 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 8 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 793_846 | 170.33333333333334 | 2046.0 | Domain | Laminin EGF-like 1 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 847_893 | 170.33333333333334 | 2046.0 | Domain | Laminin EGF-like 2 |
Hgene | AGRN | chr1:970704 | chr12:132635526 | ENST00000379370 | - | 3 | 36 | 917_971 | 170.33333333333334 | 2046.0 | Domain | Kazal-like 9 |
Tgene | NOC4L | chr1:957842 | chr12:132635526 | ENST00000330579 | 8 | 15 | 297_317 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:970704 | chr12:132635525 | ENST00000330579 | 8 | 15 | 297_317 | 300.3333333333333 | 517.0 | Transmembrane | Helical | |
Tgene | NOC4L | chr1:970704 | chr12:132635526 | ENST00000330579 | 8 | 15 | 297_317 | 300.3333333333333 | 517.0 | Transmembrane | Helical |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>795_AGRN_970704_NOC4L_132635526_ranked_0.pdb | AGRN | 970704 | 970704 | ENST00000330579 | NOC4L | chr12 | 132635526 | + | MGTEFTRPSQQALGWDKLQWHRLGPLLLQVPLKDLVGRELQQWRDADLRHGQGLVDDAGGFGHLRVVVALEGLKLPQGALQGPALGWVLL SRVVGVGVQLRAVWTVHEDPAGRVPAQQVTDERQDHEQGLRGSRQGQAGQPLGEGGHQVGGEVGGGQEEVSQVEEAGAVLDVKDRGVQEA VELPVEVRVLQVVFVNQDEQPVQGQEAEGPPIRRRRRHWSEVGPGFIFHTELHLLQVPQGDPHEAGVEHQLVLVGWPQVWGCRVHKEDPG VPSGHLVVTDEGVSKAADHHLVAAVQQALPGHQVFALQVPPDPNLAGVRVLHRVHVEDLLHRPGEHHVRLLLAPLQRALRACPAGSGQDA | 397 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
AGRN_pLDDT.png![]() |
NOC4L_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
AGRN | |
NOC4L |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to AGRN-NOC4L |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to AGRN-NOC4L |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |