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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FDFT1-TNKS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FDFT1-TNKS
	FusionPDB ID: 30051
	FusionGDB2.0 ID: 30051
		Hgene	Tgene
	Gene symbol	FDFT1	TNKS
	Gene ID	2222	8658
	Gene name	farnesyl-diphosphate farnesyltransferase 1	tankyrase
	Synonyms	DGPT\|ERG9\|SQS\|SQSD\|SS	ARTD5\|PARP-5a\|PARP5A\|PARPL\|TIN1\|TINF1\|TNKS1\|pART5
	Cytomap	8p23.1	8p23.1
	Type of gene	protein-coding	protein-coding
	Description	squalene synthaseFPP:FPP farnesyltransferasepresqualene-di-diphosphate synthasesqualene synthetase	poly [ADP-ribose] polymerase tankyrase-1ADP-ribosyltransferase diphtheria toxin-like 5TANK1TNKS-1TRF1-interacting ankyrin-related ADP-ribose polymerase 1poly [ADP-ribose] polymerase 5Aprotein poly-ADP-ribosyltransferase tankyrase-1tankyrase Itanky
	Modification date	20200320	20200313
	UniProtAcc	P37268	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000220584, ENST00000443614, ENST00000446331, ENST00000525777, ENST00000525900, ENST00000528643, ENST00000528812, ENST00000530664, ENST00000538689,	ENST00000518027, ENST00000522110, ENST00000310430, ENST00000518281, ENST00000520408,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 12 X 9=1728	8 X 9 X 6=432
	# samples	20	9
	** MAII score	log2(20/1728*10)=-3.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FDFT1 [Title/Abstract] AND TNKS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FDFT1(11660440)-TNKS(9562173), # samples:2
Anticipated loss of major functional domain due to fusion event.	FDFT1-TNKS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FDFT1-TNKS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FDFT1-TNKS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FDFT1-TNKS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TNKS	GO:0000209	protein polyubiquitination	19759537\|21478859
Tgene	TNKS	GO:0006471	protein ADP-ribosylation	9822378\|15133513\|21270334
Tgene	TNKS	GO:0018105	peptidyl-serine phosphorylation	17026964
Tgene	TNKS	GO:0018107	peptidyl-threonine phosphorylation	17026964
Tgene	TNKS	GO:0032212	positive regulation of telomere maintenance via telomerase	12782650\|18221737
Tgene	TNKS	GO:0045944	positive regulation of transcription by RNA polymerase II	19245366
Tgene	TNKS	GO:0051973	positive regulation of telomerase activity	12782650
Tgene	TNKS	GO:0070212	protein poly-ADP-ribosylation	9822378\|16076287\|25043379
Tgene	TNKS	GO:0070213	protein auto-ADP-ribosylation	9822378\|15133513\|19759537\|21478859
Tgene	TNKS	GO:1904355	positive regulation of telomere capping	21531765
Tgene	TNKS	GO:1904743	negative regulation of telomeric DNA binding	9822378

Fusion gene breakpoints across FDFT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TNKS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GC-A4ZW-01A	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000220584	FDFT1	chr8	11660440	+	ENST00000520408	TNKS	chr8	9562173	+	1152	321	222	1067	281
ENST00000220584	FDFT1	chr8	11660440	+	ENST00000310430	TNKS	chr8	9562173	+	8808	321	222	3197	991
ENST00000220584	FDFT1	chr8	11660440	+	ENST00000518281	TNKS	chr8	9562173	+	3391	321	222	3197	991
ENST00000443614	FDFT1	chr8	11660440	+	ENST00000520408	TNKS	chr8	9562173	+	1024	193	94	939	281
ENST00000443614	FDFT1	chr8	11660440	+	ENST00000310430	TNKS	chr8	9562173	+	8680	193	94	3069	991
ENST00000443614	FDFT1	chr8	11660440	+	ENST00000518281	TNKS	chr8	9562173	+	3263	193	94	3069	991

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000220584	ENST00000520408	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+	0.003045551	0.99695444
ENST00000220584	ENST00000310430	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+	0.000251723	0.9997483
ENST00000220584	ENST00000518281	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+	0.002204993	0.997795
ENST00000443614	ENST00000520408	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+	0.001958652	0.9980413
ENST00000443614	ENST00000310430	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+	0.000208535	0.99979144
ENST00000443614	ENST00000518281	FDFT1	chr8	11660440	+	TNKS	chr8	9562173	+	0.001738184	0.99826187

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30051_30051_1_FDFT1-TNKS_FDFT1_chr8_11660440_ENST00000220584_TNKS_chr8_9562173_ENST00000310430_length(amino acids)=991AA_BP=317
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA
CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF
KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT
CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNR
VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP
LDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN
AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFK
PQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDV
LADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYN
VIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPT
HKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQK

--------------------------------------------------------------

>30051_30051_2_FDFT1-TNKS_FDFT1_chr8_11660440_ENST00000220584_TNKS_chr8_9562173_ENST00000518281_length(amino acids)=991AA_BP=317
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA
CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF
KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT
CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNR
VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP
LDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN
AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFK
PQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDV
LADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYN
VIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPT
HKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQK

--------------------------------------------------------------

>30051_30051_3_FDFT1-TNKS_FDFT1_chr8_11660440_ENST00000220584_TNKS_chr8_9562173_ENST00000520408_length(amino acids)=281AA_BP=33
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA
CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF
KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKVRHTPEQSARLSTEQPAALNTAS

--------------------------------------------------------------

>30051_30051_4_FDFT1-TNKS_FDFT1_chr8_11660440_ENST00000443614_TNKS_chr8_9562173_ENST00000310430_length(amino acids)=991AA_BP=317
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA
CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF
KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT
CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNR
VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP
LDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN
AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFK
PQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDV
LADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYN
VIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPT
HKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQK

--------------------------------------------------------------

>30051_30051_5_FDFT1-TNKS_FDFT1_chr8_11660440_ENST00000443614_TNKS_chr8_9562173_ENST00000518281_length(amino acids)=991AA_BP=317
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA
CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF
KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT
CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNR
VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP
LDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN
AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFK
PQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDV
LADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYN
VIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPT
HKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQK

--------------------------------------------------------------

>30051_30051_6_FDFT1-TNKS_FDFT1_chr8_11660440_ENST00000443614_TNKS_chr8_9562173_ENST00000520408_length(amino acids)=281AA_BP=33
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA
CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF
KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKVRHTPEQSARLSTEQPAALNTAS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11660440/chr8:9562173)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FDFT1 P37268	.
FUNCTION: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. {ECO:0000269\|PubMed:10896663, ECO:0000269\|PubMed:24531458}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

1030_1089

369.0

1328.0

Domain

SAM

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

1112_1317

369.0

1328.0

Domain

PARP catalytic

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

368_397

369.0

1328.0

Repeat

ANK 6

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

401_430

369.0

1328.0

Repeat

ANK 7

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

434_463

369.0

1328.0

Repeat

ANK 8

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

521_553

369.0

1328.0

Repeat

ANK 9

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

557_586

369.0

1328.0

Repeat

ANK 10

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

590_619

369.0

1328.0

Repeat

ANK 11

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

621_647

369.0

1328.0

Repeat

ANK 12

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

649_679

369.0

1328.0

Repeat

ANK 13

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

683_712

369.0

1328.0

Repeat

ANK 14

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

716_745

369.0

1328.0

Repeat

ANK 15

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

749_778

369.0

1328.0

Repeat

ANK 16

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

782_810

369.0

1328.0

Repeat

ANK 17

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

836_865

369.0

1328.0

Repeat

ANK 18

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

869_898

369.0

1328.0

Repeat

ANK 19

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

902_931

369.0

1328.0

Repeat

ANK 20

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

935_964

369.0

1328.0

Repeat

ANK 21

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FDFT1

chr8:11660440

chr8:9562173

ENST00000220584

284_304

33.0

418.0

Transmembrane

Helical

Hgene

FDFT1

chr8:11660440

chr8:9562173

ENST00000220584

384_404

33.0

418.0

Transmembrane

Helical

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

109_161

369.0

1328.0

Compositional bias

Ser-rich

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

20_83

369.0

1328.0

Compositional bias

Pro-rich

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

9_14

369.0

1328.0

Compositional bias

Poly-His

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

181_209

369.0

1328.0

Repeat

ANK 1

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

215_244

369.0

1328.0

Repeat

ANK 2

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

248_277

369.0

1328.0

Repeat

ANK 3

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

281_310

369.0

1328.0

Repeat

ANK 4

Tgene

TNKS

chr8:11660440

chr8:9562173

ENST00000310430

335_364

369.0

1328.0

Repeat

ANK 5

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FDFT1
TNKS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FDFT1-TNKS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FDFT1-TNKS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source