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Fusion Protein:FOS-MAST2 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: FOS-MAST2 | FusionPDB ID: 31036 | FusionGDB2.0 ID: 31036 | Hgene | Tgene | Gene symbol | FOS | MAST2 | Gene ID | 2353 | 23139 |
Gene name | Fos proto-oncogene, AP-1 transcription factor subunit | microtubule associated serine/threonine kinase 2 | |
Synonyms | AP-1|C-FOS|p55 | MAST205|MTSSK | |
Cytomap | 14q24.3 | 1p34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | proto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular o | microtubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinase | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P15408 | Q6P0Q8 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000303562, ENST00000535987, ENST00000555347, ENST00000555686, ENST00000554617, ENST00000555242, ENST00000556324, | ENST00000477968, ENST00000361297, ENST00000372009, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 9 X 1=54 | 14 X 16 X 10=2240 |
# samples | 9 | 17 | |
** MAII score | log2(9/54*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(17/2240*10)=-3.71989208080727 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: FOS [Title/Abstract] AND MAST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FOS(75747698)-MAST2(46496700), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | FOS-MAST2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FOS-MAST2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FOS-MAST2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FOS-MAST2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FOS-MAST2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. FOS-MAST2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FOS-MAST2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FOS | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9732876 |
Hgene | FOS | GO:0034614 | cellular response to reactive oxygen species | 17217916 |
Hgene | FOS | GO:0045893 | positive regulation of transcription, DNA-templated | 9732876 |
Hgene | FOS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10508860 |
Hgene | FOS | GO:0060395 | SMAD protein signal transduction | 9732876 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | BF904848 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000303562 | FOS | chr14 | 75747698 | + | ENST00000372009 | MAST2 | chr1 | 46496700 | + | 4252 | 1945 | 1939 | 4251 | 771 |
ENST00000303562 | FOS | chr14 | 75747698 | + | ENST00000361297 | MAST2 | chr1 | 46496700 | + | 4670 | 1945 | 1939 | 4611 | 890 |
ENST00000535987 | FOS | chr14 | 75747698 | + | ENST00000372009 | MAST2 | chr1 | 46496700 | + | 3496 | 1189 | 1228 | 3495 | 756 |
ENST00000535987 | FOS | chr14 | 75747698 | + | ENST00000361297 | MAST2 | chr1 | 46496700 | + | 3914 | 1189 | 1228 | 3855 | 875 |
ENST00000555686 | FOS | chr14 | 75747698 | + | ENST00000372009 | MAST2 | chr1 | 46496700 | + | 3590 | 1283 | 1322 | 3589 | 756 |
ENST00000555686 | FOS | chr14 | 75747698 | + | ENST00000361297 | MAST2 | chr1 | 46496700 | + | 4008 | 1283 | 1322 | 3949 | 875 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000303562 | ENST00000372009 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + | 0.0285393 | 0.9714607 |
ENST00000303562 | ENST00000361297 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + | 0.04074297 | 0.95925707 |
ENST00000535987 | ENST00000372009 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + | 0.06127257 | 0.93872744 |
ENST00000535987 | ENST00000361297 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + | 0.035141822 | 0.9648582 |
ENST00000555686 | ENST00000372009 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + | 0.049851764 | 0.9501482 |
ENST00000555686 | ENST00000361297 | FOS | chr14 | 75747698 | + | MAST2 | chr1 | 46496700 | + | 0.031540196 | 0.9684598 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >31036_31036_1_FOS-MAST2_FOS_chr14_75747698_ENST00000303562_MAST2_chr1_46496700_ENST00000361297_length(amino acids)=890AA_BP=2 MRSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPA METRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDS SPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELIL KSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHS HSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTAS PQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSP LEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGA GESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALT ALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSY -------------------------------------------------------------- >31036_31036_2_FOS-MAST2_FOS_chr14_75747698_ENST00000303562_MAST2_chr1_46496700_ENST00000372009_length(amino acids)=771AA_BP=2 MRSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPA METRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDS SPYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPA RKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSEL SRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRAL GTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITL GPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSW KSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPD -------------------------------------------------------------- >31036_31036_3_FOS-MAST2_FOS_chr14_75747698_ENST00000535987_MAST2_chr1_46496700_ENST00000361297_length(amino acids)=875AA_BP= MTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGA TAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRP PIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLEN TSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVT PDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQA FPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGA LPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPR SLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSC SPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQ -------------------------------------------------------------- >31036_31036_4_FOS-MAST2_FOS_chr14_75747698_ENST00000535987_MAST2_chr1_46496700_ENST00000372009_length(amino acids)=756AA_BP= MTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGA TAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPYGFTLRAIRVYMG DSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSKR SRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSELSRPKSAEPPRSPLLK RVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQ KQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPHRRL GSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRK ATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCP -------------------------------------------------------------- >31036_31036_5_FOS-MAST2_FOS_chr14_75747698_ENST00000555686_MAST2_chr1_46496700_ENST00000361297_length(amino acids)=875AA_BP= MTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGA TAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRP PIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLEN TSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVT PDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQA FPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGA LPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPR SLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSC SPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQ -------------------------------------------------------------- >31036_31036_6_FOS-MAST2_FOS_chr14_75747698_ENST00000555686_MAST2_chr1_46496700_ENST00000372009_length(amino acids)=756AA_BP= MTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGA TAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPYGFTLRAIRVYMG DSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSKR SRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSELSRPKSAEPPRSPLLK RVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQ KQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPHRRL GSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRK ATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:75747698/chr1:46496700) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
FOS | MAST2 |
FUNCTION: Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}. | FUNCTION: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MAST2 | chr14:75747698 | chr1:46496700 | ENST00000361297 | 0 | 29 | 1104_1192 | 0 | 1799.0 | Domain | PDZ | |
Tgene | MAST2 | chr14:75747698 | chr1:46496700 | ENST00000361297 | 0 | 29 | 512_785 | 0 | 1799.0 | Domain | Protein kinase | |
Tgene | MAST2 | chr14:75747698 | chr1:46496700 | ENST00000361297 | 0 | 29 | 786_854 | 0 | 1799.0 | Domain | AGC-kinase C-terminal | |
Tgene | MAST2 | chr14:75747698 | chr1:46496700 | ENST00000361297 | 0 | 29 | 518_526 | 0 | 1799.0 | Nucleotide binding | ATP |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | FOS | chr14:75747698 | chr1:46496700 | ENST00000303562 | + | 1 | 4 | 137_200 | 0 | 381.0 | Domain | bZIP |
Hgene | FOS | chr14:75747698 | chr1:46496700 | ENST00000303562 | + | 1 | 4 | 139_159 | 0 | 381.0 | Region | Note=Basic motif%3B required for the activation of phospholipid synthesis%2C but not for CDS1-binding |
Hgene | FOS | chr14:75747698 | chr1:46496700 | ENST00000303562 | + | 1 | 4 | 165_193 | 0 | 381.0 | Region | Leucine-zipper |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
FOS | |
MAST2 | ![]() |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to FOS-MAST2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to FOS-MAST2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |