UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:GAPDH-TNC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GAPDH-TNC
FusionPDB ID: 32420
FusionGDB2.0 ID: 32420
HgeneTgene
Gene symbol

GAPDH

TNC

Gene ID

2597

7134

Gene nameglyceraldehyde-3-phosphate dehydrogenasetroponin C1, slow skeletal and cardiac type
SynonymsG3PD|GAPD|HEL-S-162ePCMD1Z|CMH13|TN-C|TNC|TNNC
Cytomap

12p13.31

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionglyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDHtroponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)
Modification date2020032720200313
UniProtAcc

P04406

.
Ensembl transtripts involved in fusion geneENST idsENST00000229239, ENST00000396856, 
ENST00000396858, ENST00000396859, 
ENST00000396861, 		ENST00000481475, 
ENST00000340094, ENST00000341037, 
ENST00000345230, ENST00000346706, 
ENST00000423613, ENST00000535648, 
ENST00000537320, ENST00000542877, 
ENST00000350763, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score45 X 34 X 13=198908 X 8 X 4=256
# samples 5111
** MAII scorelog2(51/19890*10)=-5.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/256*10)=-1.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GAPDH [Title/Abstract] AND TNC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GAPDH(6646176)-TNC(117783546), # samples:1
Anticipated loss of major functional domain due to fusion event.GAPDH-TNC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAPDH-TNC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAPDH-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAPDH-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAPDH-TNC seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GAPDH-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GAPDH-TNC seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAPDH

GO:0010951

negative regulation of endopeptidase activity

22832495

HgeneGAPDH

GO:0017148

negative regulation of translation

23071094

HgeneGAPDH

GO:0031640

killing of cells of other organism

22832495

HgeneGAPDH

GO:0050715

positive regulation of cytokine secretion

22832495

HgeneGAPDH

GO:0050832

defense response to fungus

22832495

HgeneGAPDH

GO:0051873

killing by host of symbiont cells

22832495

HgeneGAPDH

GO:0052501

positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction

22832495

HgeneGAPDH

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

22832495

HgeneGAPDH

GO:0071346

cellular response to interferon-gamma

15479637

TgeneTNC

GO:0006937

regulation of muscle contraction

18092822

TgeneTNC

GO:0060048

cardiac muscle contraction

25771144


check buttonFusion gene breakpoints across GAPDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-6024-01AGAPDHchr12

6646176

+TNCchr9

117783546

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229239GAPDHchr126646176+ENST00000350763TNCchr9117783546-17279934891103204
ENST00000396856GAPDHchr126646176+ENST00000350763TNCchr9117783546-114941592472126
ENST00000396861GAPDHchr126646176+ENST00000350763TNCchr9117783546-1212478121588155
ENST00000396859GAPDHchr126646176+ENST00000350763TNCchr9117783546-114040679516145
ENST00000396858GAPDHchr126646176+ENST00000350763TNCchr9117783546-120046641523160

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229239ENST00000350763GAPDHchr126646176+TNCchr9117783546-0.0071405980.9928595
ENST00000396856ENST00000350763GAPDHchr126646176+TNCchr9117783546-0.57299450.42700556
ENST00000396861ENST00000350763GAPDHchr126646176+TNCchr9117783546-0.0058751890.9941248
ENST00000396859ENST00000350763GAPDHchr126646176+TNCchr9117783546-0.0041730720.9958269
ENST00000396858ENST00000350763GAPDHchr126646176+TNCchr9117783546-0.04841380.9515862

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32420_32420_1_GAPDH-TNC_GAPDH_chr12_6646176_ENST00000229239_TNC_chr9_117783546_ENST00000350763_length(amino acids)=204AA_BP=168
MGWDWLSLAGGGVRVTACRRAPGFYKLSPQPPASLSAPPVRQSAASSFASPAEPHRSDTMGKVKVGVNGFGRIGRLVTRAAFNSGKVDIV
AINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGGVNWFHWKGHEH

--------------------------------------------------------------

>32420_32420_2_GAPDH-TNC_GAPDH_chr12_6646176_ENST00000396856_TNC_chr9_117783546_ENST00000350763_length(amino acids)=126AA_BP=108
MVVLGAWSPGLLLTLVKWILLPSMTPSLTSTTWFTCSNMIPPMANSMAPSRLRTGSLSSMEIPSPSSRSEWKTEWKKCEIPPKSSGAMLA

--------------------------------------------------------------

>32420_32420_3_GAPDH-TNC_GAPDH_chr12_6646176_ENST00000396858_TNC_chr9_117783546_ENST00000350763_length(amino acids)=160AA_BP=142
MPVTNPALLPRWVESRVAGKSGGARLAGPISPPGDAFPRLFSDLVVLGAWSPGLLLTLVKWILLPSMTPSLTSTTWFTCSNMIPPMANSM

--------------------------------------------------------------

>32420_32420_4_GAPDH-TNC_GAPDH_chr12_6646176_ENST00000396859_TNC_chr9_117783546_ENST00000350763_length(amino acids)=145AA_BP=109
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDA

--------------------------------------------------------------

>32420_32420_5_GAPDH-TNC_GAPDH_chr12_6646176_ENST00000396861_TNC_chr9_117783546_ENST00000350763_length(amino acids)=155AA_BP=119
MRAEPHRSDTMGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQER

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6646176/chr9:117783546)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAPDH

P04406

.
FUNCTION: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000250, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:3170585}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAPDHchr12:6646176chr9:117783546ENST00000229239+5913_14109.0336.0Nucleotide bindingNAD
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396858+4813_1467.0294.0Nucleotide bindingNAD
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396859+4813_14109.0336.0Nucleotide bindingNAD
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396861+5913_14109.0336.0Nucleotide bindingNAD
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241802_18881801.01838.0DomainFibronectin type-III 14
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241889_19771801.01838.0DomainFibronectin type-III 15
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241975_21901801.01838.0DomainFibrinogen C-terminal
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211533_16211528.01565.0DomainFibronectin type-III 11
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211622_17111528.01565.0DomainFibronectin type-III 12
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211712_18011528.01565.0DomainFibronectin type-III 13
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211802_18881528.01565.0DomainFibronectin type-III 14
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211889_19771528.01565.0DomainFibronectin type-III 15
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211975_21901528.01565.0DomainFibrinogen C-terminal
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221622_17111619.01656.0DomainFibronectin type-III 12
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221712_18011619.01656.0DomainFibronectin type-III 13
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221802_18881619.01656.0DomainFibronectin type-III 14
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221889_19771619.01656.0DomainFibronectin type-III 15
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221975_21901619.01656.0DomainFibrinogen C-terminal
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231712_18011710.01747.0DomainFibronectin type-III 13
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231802_18881710.01747.0DomainFibronectin type-III 14
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231889_19771710.01747.0DomainFibronectin type-III 15
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231975_21901710.01747.0DomainFibrinogen C-terminal
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201533_16211528.01565.0DomainFibronectin type-III 11
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201622_17111528.01565.0DomainFibronectin type-III 12
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201712_18011528.01565.0DomainFibronectin type-III 13
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201802_18881528.01565.0DomainFibronectin type-III 14
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201889_19771528.01565.0DomainFibronectin type-III 15
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201975_21901528.01565.0DomainFibrinogen C-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAPDHchr12:6646176chr9:117783546ENST00000229239+59245_250109.0336.0Motif[IL]-x-C-x-x-[DE] motif
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396858+48245_25067.0294.0Motif[IL]-x-C-x-x-[DE] motif
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396859+48245_250109.0336.0Motif[IL]-x-C-x-x-[DE] motif
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396861+59245_250109.0336.0Motif[IL]-x-C-x-x-[DE] motif
HgeneGAPDHchr12:6646176chr9:117783546ENST00000229239+59151_153109.0336.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000229239+59211_212109.0336.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396858+48151_15367.0294.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396858+48211_21267.0294.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396859+48151_153109.0336.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396859+48211_212109.0336.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396861+59151_153109.0336.0RegionGlyceraldehyde 3-phosphate binding
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396861+59211_212109.0336.0RegionGlyceraldehyde 3-phosphate binding
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224118_1451801.01838.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921118_1451528.01565.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022118_1451619.01656.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628118_1452165.02202.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123118_1451710.01747.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820118_1451528.01565.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241076_11651801.01838.0DomainFibronectin type-III 6
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241167_12561801.01838.0DomainFibronectin type-III 7
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241258_13501801.01838.0DomainFibronectin type-III 8
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241351_14391801.01838.0DomainFibronectin type-III 9
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241440_15311801.01838.0DomainFibronectin type-III 10
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241533_16211801.01838.0DomainFibronectin type-III 11
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241622_17111801.01838.0DomainFibronectin type-III 12
TgeneTNCchr12:6646176chr9:117783546ENST0000034009422241712_18011801.01838.0DomainFibronectin type-III 13
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224174_1861801.01838.0DomainEGF-like 1%3B incomplete
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224186_2171801.01838.0DomainEGF-like 2
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224217_2481801.01838.0DomainEGF-like 3
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224248_2801801.01838.0DomainEGF-like 4
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224280_3111801.01838.0DomainEGF-like 5
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224311_3421801.01838.0DomainEGF-like 6
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224342_3731801.01838.0DomainEGF-like 7
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224373_4041801.01838.0DomainEGF-like 8
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224404_4351801.01838.0DomainEGF-like 9
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224435_4661801.01838.0DomainEGF-like 10
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224466_4971801.01838.0DomainEGF-like 11
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224497_5281801.01838.0DomainEGF-like 12
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224528_5591801.01838.0DomainEGF-like 13
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224559_5901801.01838.0DomainEGF-like 14
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224590_6211801.01838.0DomainEGF-like 15
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224625_7151801.01838.0DomainFibronectin type-III 1
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224716_8041801.01838.0DomainFibronectin type-III 2
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224805_8941801.01838.0DomainFibronectin type-III 3
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224895_9901801.01838.0DomainFibronectin type-III 4
TgeneTNCchr12:6646176chr9:117783546ENST000003400942224991_10751801.01838.0DomainFibronectin type-III 5
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211076_11651528.01565.0DomainFibronectin type-III 6
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211167_12561528.01565.0DomainFibronectin type-III 7
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211258_13501528.01565.0DomainFibronectin type-III 8
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211351_14391528.01565.0DomainFibronectin type-III 9
TgeneTNCchr12:6646176chr9:117783546ENST0000034523019211440_15311528.01565.0DomainFibronectin type-III 10
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921174_1861528.01565.0DomainEGF-like 1%3B incomplete
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921186_2171528.01565.0DomainEGF-like 2
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921217_2481528.01565.0DomainEGF-like 3
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921248_2801528.01565.0DomainEGF-like 4
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921280_3111528.01565.0DomainEGF-like 5
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921311_3421528.01565.0DomainEGF-like 6
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921342_3731528.01565.0DomainEGF-like 7
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921373_4041528.01565.0DomainEGF-like 8
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921404_4351528.01565.0DomainEGF-like 9
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921435_4661528.01565.0DomainEGF-like 10
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921466_4971528.01565.0DomainEGF-like 11
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921497_5281528.01565.0DomainEGF-like 12
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921528_5591528.01565.0DomainEGF-like 13
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921559_5901528.01565.0DomainEGF-like 14
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921590_6211528.01565.0DomainEGF-like 15
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921625_7151528.01565.0DomainFibronectin type-III 1
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921716_8041528.01565.0DomainFibronectin type-III 2
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921805_8941528.01565.0DomainFibronectin type-III 3
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921895_9901528.01565.0DomainFibronectin type-III 4
TgeneTNCchr12:6646176chr9:117783546ENST000003452301921991_10751528.01565.0DomainFibronectin type-III 5
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221076_11651619.01656.0DomainFibronectin type-III 6
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221167_12561619.01656.0DomainFibronectin type-III 7
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221258_13501619.01656.0DomainFibronectin type-III 8
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221351_14391619.01656.0DomainFibronectin type-III 9
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221440_15311619.01656.0DomainFibronectin type-III 10
TgeneTNCchr12:6646176chr9:117783546ENST0000034670620221533_16211619.01656.0DomainFibronectin type-III 11
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022174_1861619.01656.0DomainEGF-like 1%3B incomplete
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022186_2171619.01656.0DomainEGF-like 2
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022217_2481619.01656.0DomainEGF-like 3
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022248_2801619.01656.0DomainEGF-like 4
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022280_3111619.01656.0DomainEGF-like 5
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022311_3421619.01656.0DomainEGF-like 6
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022342_3731619.01656.0DomainEGF-like 7
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022373_4041619.01656.0DomainEGF-like 8
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022404_4351619.01656.0DomainEGF-like 9
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022435_4661619.01656.0DomainEGF-like 10
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022466_4971619.01656.0DomainEGF-like 11
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022497_5281619.01656.0DomainEGF-like 12
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022528_5591619.01656.0DomainEGF-like 13
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022559_5901619.01656.0DomainEGF-like 14
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022590_6211619.01656.0DomainEGF-like 15
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022625_7151619.01656.0DomainFibronectin type-III 1
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022716_8041619.01656.0DomainFibronectin type-III 2
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022805_8941619.01656.0DomainFibronectin type-III 3
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022895_9901619.01656.0DomainFibronectin type-III 4
TgeneTNCchr12:6646176chr9:117783546ENST000003467062022991_10751619.01656.0DomainFibronectin type-III 5
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281076_11652165.02202.0DomainFibronectin type-III 6
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281167_12562165.02202.0DomainFibronectin type-III 7
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281258_13502165.02202.0DomainFibronectin type-III 8
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281351_14392165.02202.0DomainFibronectin type-III 9
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281440_15312165.02202.0DomainFibronectin type-III 10
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281533_16212165.02202.0DomainFibronectin type-III 11
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281622_17112165.02202.0DomainFibronectin type-III 12
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281712_18012165.02202.0DomainFibronectin type-III 13
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628174_1862165.02202.0DomainEGF-like 1%3B incomplete
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281802_18882165.02202.0DomainFibronectin type-III 14
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628186_2172165.02202.0DomainEGF-like 2
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281889_19772165.02202.0DomainFibronectin type-III 15
TgeneTNCchr12:6646176chr9:117783546ENST0000035076326281975_21902165.02202.0DomainFibrinogen C-terminal
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628217_2482165.02202.0DomainEGF-like 3
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628248_2802165.02202.0DomainEGF-like 4
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628280_3112165.02202.0DomainEGF-like 5
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628311_3422165.02202.0DomainEGF-like 6
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628342_3732165.02202.0DomainEGF-like 7
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628373_4042165.02202.0DomainEGF-like 8
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628404_4352165.02202.0DomainEGF-like 9
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628435_4662165.02202.0DomainEGF-like 10
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628466_4972165.02202.0DomainEGF-like 11
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628497_5282165.02202.0DomainEGF-like 12
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628528_5592165.02202.0DomainEGF-like 13
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628559_5902165.02202.0DomainEGF-like 14
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628590_6212165.02202.0DomainEGF-like 15
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628625_7152165.02202.0DomainFibronectin type-III 1
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628716_8042165.02202.0DomainFibronectin type-III 2
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628805_8942165.02202.0DomainFibronectin type-III 3
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628895_9902165.02202.0DomainFibronectin type-III 4
TgeneTNCchr12:6646176chr9:117783546ENST000003507632628991_10752165.02202.0DomainFibronectin type-III 5
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231076_11651710.01747.0DomainFibronectin type-III 6
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231167_12561710.01747.0DomainFibronectin type-III 7
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231258_13501710.01747.0DomainFibronectin type-III 8
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231351_14391710.01747.0DomainFibronectin type-III 9
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231440_15311710.01747.0DomainFibronectin type-III 10
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231533_16211710.01747.0DomainFibronectin type-III 11
TgeneTNCchr12:6646176chr9:117783546ENST0000053564821231622_17111710.01747.0DomainFibronectin type-III 12
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123174_1861710.01747.0DomainEGF-like 1%3B incomplete
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123186_2171710.01747.0DomainEGF-like 2
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123217_2481710.01747.0DomainEGF-like 3
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123248_2801710.01747.0DomainEGF-like 4
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123280_3111710.01747.0DomainEGF-like 5
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123311_3421710.01747.0DomainEGF-like 6
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123342_3731710.01747.0DomainEGF-like 7
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123373_4041710.01747.0DomainEGF-like 8
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123404_4351710.01747.0DomainEGF-like 9
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123435_4661710.01747.0DomainEGF-like 10
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123466_4971710.01747.0DomainEGF-like 11
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123497_5281710.01747.0DomainEGF-like 12
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123528_5591710.01747.0DomainEGF-like 13
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123559_5901710.01747.0DomainEGF-like 14
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123590_6211710.01747.0DomainEGF-like 15
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123625_7151710.01747.0DomainFibronectin type-III 1
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123716_8041710.01747.0DomainFibronectin type-III 2
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123805_8941710.01747.0DomainFibronectin type-III 3
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123895_9901710.01747.0DomainFibronectin type-III 4
TgeneTNCchr12:6646176chr9:117783546ENST000005356482123991_10751710.01747.0DomainFibronectin type-III 5
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201076_11651528.01565.0DomainFibronectin type-III 6
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201167_12561528.01565.0DomainFibronectin type-III 7
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201258_13501528.01565.0DomainFibronectin type-III 8
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201351_14391528.01565.0DomainFibronectin type-III 9
TgeneTNCchr12:6646176chr9:117783546ENST0000053732018201440_15311528.01565.0DomainFibronectin type-III 10
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820174_1861528.01565.0DomainEGF-like 1%3B incomplete
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820186_2171528.01565.0DomainEGF-like 2
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820217_2481528.01565.0DomainEGF-like 3
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820248_2801528.01565.0DomainEGF-like 4
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820280_3111528.01565.0DomainEGF-like 5
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820311_3421528.01565.0DomainEGF-like 6
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820342_3731528.01565.0DomainEGF-like 7
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820373_4041528.01565.0DomainEGF-like 8
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820404_4351528.01565.0DomainEGF-like 9
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820435_4661528.01565.0DomainEGF-like 10
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820466_4971528.01565.0DomainEGF-like 11
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820497_5281528.01565.0DomainEGF-like 12
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820528_5591528.01565.0DomainEGF-like 13
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820559_5901528.01565.0DomainEGF-like 14
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820590_6211528.01565.0DomainEGF-like 15
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820625_7151528.01565.0DomainFibronectin type-III 1
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820716_8041528.01565.0DomainFibronectin type-III 2
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820805_8941528.01565.0DomainFibronectin type-III 3
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820895_9901528.01565.0DomainFibronectin type-III 4
TgeneTNCchr12:6646176chr9:117783546ENST000005373201820991_10751528.01565.0DomainFibronectin type-III 5


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GAPDH
TNC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGAPDHchr12:6646176chr9:117783546ENST00000229239+592_148109.0336.0WARS1
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396858+482_14867.0294.0WARS1
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396859+482_148109.0336.0WARS1
HgeneGAPDHchr12:6646176chr9:117783546ENST00000396861+592_148109.0336.0WARS1


Top

Related Drugs to GAPDH-TNC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to GAPDH-TNC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource