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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GNAS-GAPDH

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GNAS-GAPDH
FusionPDB ID: 33624
FusionGDB2.0 ID: 33624
HgeneTgene
Gene symbol

GNAS

GAPDH

Gene ID

2778

2597

Gene nameGNAS complex locusglyceraldehyde-3-phosphate dehydrogenase
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVIG3PD|GAPD|HEL-S-162eP
Cytomap

20q13.32

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH
Modification date2020032920200327
UniProtAcc

P63092

P04406

Ensembl transtripts involved in fusion geneENST idsENST00000313949, ENST00000371075, 
ENST00000464624, ENST00000265620, 
ENST00000306090, ENST00000354359, 
ENST00000371085, ENST00000371095, 
ENST00000371100, ENST00000371102, 
ENST00000306120, ENST00000371081, 
ENST00000371098, ENST00000371099, 
ENST00000229239, ENST00000396856, 
ENST00000396858, ENST00000396859, 
ENST00000396861, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 25 X 16=1760027 X 29 X 8=6264
# samples 5131
** MAII scorelog2(51/17600*10)=-5.10893437155316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/6264*10)=-4.3367440920168
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GNAS [Title/Abstract] AND GAPDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GNAS(57478846)-GAPDH(6647267), # samples:1
Anticipated loss of major functional domain due to fusion event.GNAS-GAPDH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-GAPDH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-GAPDH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-GAPDH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-GAPDH seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNAS-GAPDH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GNAS-GAPDH seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNAS-GAPDH seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAPDH

GO:0010951

negative regulation of endopeptidase activity

22832495

TgeneGAPDH

GO:0017148

negative regulation of translation

23071094

TgeneGAPDH

GO:0031640

killing of cells of other organism

22832495

TgeneGAPDH

GO:0050715

positive regulation of cytokine secretion

22832495

TgeneGAPDH

GO:0050832

defense response to fungus

22832495

TgeneGAPDH

GO:0051873

killing by host of symbiont cells

22832495

TgeneGAPDH

GO:0052501

positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction

22832495

TgeneGAPDH

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

22832495

TgeneGAPDH

GO:0071346

cellular response to interferon-gamma

15479637


check buttonFusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GAPDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-IR-A3LI-01AGNASchr20

57478846

+GAPDHchr12

6647267

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371100GNASchr2057478846+ENST00000229239GAPDHchr126647267+318429135312918795
ENST00000371100GNASchr2057478846+ENST00000396861GAPDHchr126647267+317229135312918795
ENST00000371102GNASchr2057478846+ENST00000229239GAPDHchr126647267+2593232232327774
ENST00000371102GNASchr2057478846+ENST00000396861GAPDHchr126647267+2581232232327774
ENST00000371095GNASchr2057478846+ENST00000229239GAPDHchr126647267+10868158232274
ENST00000371095GNASchr2057478846+ENST00000396861GAPDHchr126647267+10748158232274
ENST00000371085GNASchr2057478846+ENST00000229239GAPDHchr126647267+11278568641288
ENST00000371085GNASchr2057478846+ENST00000396861GAPDHchr126647267+11158568641288
ENST00000354359GNASchr2057478846+ENST00000229239GAPDHchr126647267+11308598671289
ENST00000354359GNASchr2057478846+ENST00000396861GAPDHchr126647267+11188598671289
ENST00000265620GNASchr2057478846+ENST00000229239GAPDHchr126647267+10217507580253
ENST00000265620GNASchr2057478846+ENST00000396861GAPDHchr126647267+10097507580253
ENST00000306090GNASchr2057478846+ENST00000229239GAPDHchr126647267+8035325401180
ENST00000306090GNASchr2057478846+ENST00000396861GAPDHchr126647267+7915325401180

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371100ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.010681280.9893188
ENST00000371100ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0106351930.98936486
ENST00000371102ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.0166917850.9833082
ENST00000371102ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0165814960.9834185
ENST00000371095ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.0086829080.99131715
ENST00000371095ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0086675130.9913325
ENST00000371085ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.0052518070.9947482
ENST00000371085ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0052877480.99471223
ENST00000354359ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.0048715630.9951284
ENST00000354359ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0051171990.9948828
ENST00000265620ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.0088992550.9911007
ENST00000265620ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0093807260.9906193
ENST00000306090ENST00000229239GNASchr2057478846+GAPDHchr126647267+0.0102528840.98974717
ENST00000306090ENST00000396861GNASchr2057478846+GAPDHchr126647267+0.0104198380.9895802

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33624_33624_1_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000265620_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=253AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLISIKPINMQDPHLLHNGAFTRFSSTQQQQ
AVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAGR

--------------------------------------------------------------

>33624_33624_2_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000265620_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=253AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLISIKPINMQDPHLLHNGAFTRFSSTQQQQ
AVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAGR

--------------------------------------------------------------

>33624_33624_3_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000306090_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=180AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTVSIKPINMQDPHLLHNGAFTRFSSTQQQ
QAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAA

--------------------------------------------------------------

>33624_33624_4_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000306090_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=180AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTVSIKPINMQDPHLLHNGAFTRFSSTQQQ
QAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAA

--------------------------------------------------------------

>33624_33624_5_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000354359_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=289AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTAIAVAPCSLRVLFAALSIKPINMQDPHL
LHNGAFTRFSSTQQQQAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGR
AGRARARLLGKERAGRTAGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPR

--------------------------------------------------------------

>33624_33624_6_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000354359_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=289AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTAIAVAPCSLRVLFAALSIKPINMQDPHL
LHNGAFTRFSSTQQQQAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGR
AGRARARLLGKERAGRTAGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPR

--------------------------------------------------------------

>33624_33624_7_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371085_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=288AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTIAVAPCSLRVLFAALSIKPINMQDPHLL
HNGAFTRFSSTQQQQAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRA
GRARARLLGKERAGRTAGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPRA

--------------------------------------------------------------

>33624_33624_8_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371085_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=288AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTIAVAPCSLRVLFAALSIKPINMQDPHLL
HNGAFTRFSSTQQQQAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRA
GRARARLLGKERAGRTAGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPRA

--------------------------------------------------------------

>33624_33624_9_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371095_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=274AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTVSIKPINMQDPHLLHNGAFTRFSSTQQQ
QAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAG
RTAGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPRAKSAAAGGGRRGEEE

--------------------------------------------------------------

>33624_33624_10_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371095_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=274AA_BP=
MSYGREVKVRHVHHTQDVVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTVSIKPINMQDPHLLHNGAFTRFSSTQQQ
QAVRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAG
RTAGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPRAKSAAAGGGRRGEEE

--------------------------------------------------------------

>33624_33624_11_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371100_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=795AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG

--------------------------------------------------------------

>33624_33624_12_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371100_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=795AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG

--------------------------------------------------------------

>33624_33624_13_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371102_GAPDH_chr12_6647267_ENST00000229239_length(amino acids)=774AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK

--------------------------------------------------------------

>33624_33624_14_GNAS-GAPDH_GNAS_chr20_57478846_ENST00000371102_GAPDH_chr12_6647267_ENST00000396861_length(amino acids)=774AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:57478846/chr12:6647267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAS

P63092

GAPDH

P04406

FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:21488135, ECO:0000269|PubMed:26206488, ECO:0000269|PubMed:8702665}.FUNCTION: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000250, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:3170585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513641_667787.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513730_756787.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412641_667773.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412730_756773.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57478846chr12:6647267ENST00000313949+51378_142357.666666666666726.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57478846chr12:6647267ENST00000371075+51378_142358.666666666666736.333333333333336Compositional biasGlu-rich
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513358_522787.01038.0Compositional biasAla-rich
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412358_522773.01024.0Compositional biasAla-rich
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+41247_55129.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+51347_55130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+51347_55145.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+51347_55144.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+41247_55130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513690_698787.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412690_698773.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+41242_55129.0380.0RegionG1 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+51342_55130.0381.0RegionG1 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+51342_55145.0396.0RegionG1 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+51342_55144.0395.0RegionG1 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+41242_55130.0381.0RegionG1 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513685_698787.01038.0RegionG1 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412685_698773.01024.0RegionG1 motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57478846chr12:6647267ENST00000306120+11238_4760.0626.0Compositional biasPro-rich
HgeneGNASchr20:57478846chr12:6647267ENST00000371098+1478_142020.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+41239_394129.0380.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+51339_394130.0381.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+51339_394145.0396.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+51339_394144.0395.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+41239_394130.0381.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513682_1037787.01038.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412682_1037773.01024.0DomainG-alpha
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412197_204129.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412223_227129.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412292_295129.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513197_204130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513223_227130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513292_295130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513197_204145.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513223_227145.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513292_295145.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513197_204144.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513223_227144.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513292_295144.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412197_204130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412223_227130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412292_295130.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513840_847787.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513866_870787.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513935_938787.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412840_847773.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412866_870773.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412935_938773.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412196_204129.0380.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412219_228129.0380.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412288_295129.0380.0RegionG4 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000265620+412364_369129.0380.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513196_204130.0381.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513219_228130.0381.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513288_295130.0381.0RegionG4 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000306090+513364_369130.0381.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513196_204145.0396.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513219_228145.0396.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513288_295145.0396.0RegionG4 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000354359+513364_369145.0396.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513196_204144.0395.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513219_228144.0395.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513288_295144.0395.0RegionG4 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371085+513364_369144.0395.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412196_204130.0381.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412219_228130.0381.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412288_295130.0381.0RegionG4 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371095+412364_369130.0381.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+5131007_1012787.01038.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513839_847787.01038.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513862_871787.01038.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371100+513931_938787.01038.0RegionG4 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+4121007_1012773.01024.0RegionG5 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412839_847773.01024.0RegionG2 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412862_871773.01024.0RegionG3 motif
HgeneGNASchr20:57478846chr12:6647267ENST00000371102+412931_938773.01024.0RegionG4 motif
TgeneGAPDHchr20:57478846chr12:6647267ENST0000022923979245_250312.6666666666667336.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039685868245_250270.6666666666667294.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039685968245_250312.6666666666667336.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039686179245_250312.6666666666667336.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr20:57478846chr12:6647267ENST000002292397913_14312.6666666666667336.0Nucleotide bindingNAD
TgeneGAPDHchr20:57478846chr12:6647267ENST000003968586813_14270.6666666666667294.0Nucleotide bindingNAD
TgeneGAPDHchr20:57478846chr12:6647267ENST000003968596813_14312.6666666666667336.0Nucleotide bindingNAD
TgeneGAPDHchr20:57478846chr12:6647267ENST000003968617913_14312.6666666666667336.0Nucleotide bindingNAD
TgeneGAPDHchr20:57478846chr12:6647267ENST0000022923979151_153312.6666666666667336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000022923979211_212312.6666666666667336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039685868151_153270.6666666666667294.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039685868211_212270.6666666666667294.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039685968151_153312.6666666666667336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039685968211_212312.6666666666667336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039686179151_153312.6666666666667336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr20:57478846chr12:6647267ENST0000039686179211_212312.6666666666667336.0RegionGlyceraldehyde 3-phosphate binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GNAS
GAPDH


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGAPDHchr20:57478846chr12:6647267ENST00000229239792_148312.6666666666667336.0WARS1
TgeneGAPDHchr20:57478846chr12:6647267ENST00000396858682_148270.6666666666667294.0WARS1
TgeneGAPDHchr20:57478846chr12:6647267ENST00000396859682_148312.6666666666667336.0WARS1
TgeneGAPDHchr20:57478846chr12:6647267ENST00000396861792_148312.6666666666667336.0WARS1


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Related Drugs to GNAS-GAPDH


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GNAS-GAPDH


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource