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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GOLPH3-IKZF3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GOLPH3-IKZF3
FusionPDB ID: 33968
FusionGDB2.0 ID: 33968
HgeneTgene
Gene symbol

GOLPH3

IKZF3

Gene ID

64083

22806

Gene namegolgi phosphoprotein 3IKAROS family zinc finger 3
SynonymsGOPP1|GPP34|MIDAS|Vps74AIO|AIOLOS|ZNFN1A3
Cytomap

5p13.3

17q12-q21.1

Type of geneprotein-codingprotein-coding
DescriptionGolgi phosphoprotein 3coat protein GPP34coat-proteingolgi peripheral membrane protein 1, 34 kDagolgi proteingolgi-associated proteinmitochondrial DNA absence factorzinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2020032920200327
UniProtAcc

Q9H4A5

Q9UKT9

Ensembl transtripts involved in fusion geneENST idsENST00000265070, ENST00000512668, 
ENST00000583368, ENST00000346243, 
ENST00000350532, ENST00000351680, 
ENST00000377944, ENST00000377945, 
ENST00000377952, ENST00000377958, 
ENST00000394189, ENST00000439016, 
ENST00000439167, ENST00000467757, 
ENST00000535189, ENST00000346872, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 10 X 7=77034 X 12 X 14=5712
# samples 1649
** MAII scorelog2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(49/5712*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GOLPH3 [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GOLPH3(32173916)-IKZF3(37944627), # samples:3
Anticipated loss of major functional domain due to fusion event.GOLPH3-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
GOLPH3-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOLPH3

GO:0010821

regulation of mitochondrion organization

16263763


check buttonFusion gene breakpoints across GOLPH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IKZF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NI-01AGOLPH3chr5

32173916

-IKZF3chr17

37944627

-
ChimerDB4ESCATCGA-L5-A8NIGOLPH3chr5

32173915

-IKZF3chr17

37922746

-
ChimerDB4ESCATCGA-L5-A8NIGOLPH3chr5

32173915

-IKZF3chr17

37934020

-
ChimerDB4ESCATCGA-L5-A8NIGOLPH3chr5

32173916

-IKZF3chr17

37922746

-
ChimerDB4ESCATCGA-L5-A8NIGOLPH3chr5

32173916

-IKZF3chr17

37934020

-
ChimerDB4ESCATCGA-L5-A8NIGOLPH3chr5

32173916

-IKZF3chr17

37944627

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265070GOLPH3chr532173915-ENST00000346243IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173915-ENST00000350532IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173915-ENST00000351680IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173915-ENST00000467757IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173916-ENST00000346243IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173916-ENST00000350532IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173916-ENST00000351680IKZF3chr1737922746-12455411171244375
ENST00000265070GOLPH3chr532173916-ENST00000467757IKZF3chr1737922746-12455411171244375

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265070ENST00000346243GOLPH3chr532173915-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000350532GOLPH3chr532173915-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000351680GOLPH3chr532173915-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000467757GOLPH3chr532173915-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000346243GOLPH3chr532173916-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000350532GOLPH3chr532173916-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000351680GOLPH3chr532173916-IKZF3chr1737922746-0.0015420170.998458
ENST00000265070ENST00000467757GOLPH3chr532173916-IKZF3chr1737922746-0.0015420170.998458

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33968_33968_1_GOLPH3-IKZF3_GOLPH3_chr5_32173915_ENST00000265070_IKZF3_chr17_37922746_ENST00000346243_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_2_GOLPH3-IKZF3_GOLPH3_chr5_32173915_ENST00000265070_IKZF3_chr17_37922746_ENST00000350532_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_3_GOLPH3-IKZF3_GOLPH3_chr5_32173915_ENST00000265070_IKZF3_chr17_37922746_ENST00000351680_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_4_GOLPH3-IKZF3_GOLPH3_chr5_32173915_ENST00000265070_IKZF3_chr17_37922746_ENST00000467757_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_5_GOLPH3-IKZF3_GOLPH3_chr5_32173916_ENST00000265070_IKZF3_chr17_37922746_ENST00000346243_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_6_GOLPH3-IKZF3_GOLPH3_chr5_32173916_ENST00000265070_IKZF3_chr17_37922746_ENST00000350532_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_7_GOLPH3-IKZF3_GOLPH3_chr5_32173916_ENST00000265070_IKZF3_chr17_37922746_ENST00000351680_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

>33968_33968_8_GOLPH3-IKZF3_GOLPH3_chr5_32173916_ENST00000265070_IKZF3_chr17_37922746_ENST00000467757_length(amino acids)=375AA_BP=89
MPRRRPASPLRPDLFPHDCPRPCCRRTSPRRPDLTRKPGSEAARGGGGRPGRSCDPLGPARRLGGSHDLADPAQLRPGAAAHRGLPQRRR
QGAGGGRRRRQQRGRRAEPPRRAGRRRQGRLQGNAADPDGGSAPAGPQGPRGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISY
LGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQN
HMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:32173916/chr17:37944627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLPH3

Q9H4A5

IKZF3

Q9UKT9

FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}.FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLPH3chr5:32173915chr17:37922746ENST00000265070-1448_5175.0299.0Compositional biasNote=Poly-Asp
HgeneGOLPH3chr5:32173916chr17:37922746ENST00000265070-1448_5175.0299.0Compositional biasNote=Poly-Asp
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034624346202_224197.33333333333334432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034624346452_474197.33333333333334432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034624346480_504197.33333333333334432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034687268452_474275.3333333333333510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034687268480_504275.3333333333333510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035053257452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035053257480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035168057452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035168057480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794446146_168132.33333333333334367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794446174_196132.33333333333334367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794446202_224132.33333333333334367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794446452_474132.33333333333334367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794446480_504132.33333333333334367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794535146_168141.33333333333334376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794535174_196141.33333333333334376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794535202_224141.33333333333334376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794535452_474141.33333333333334376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794535480_504141.33333333333334376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795224118_14054.333333333333336289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795224146_16854.333333333333336289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795224174_19654.333333333333336289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795224202_22454.333333333333336289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795224452_47454.333333333333336289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795224480_50454.333333333333336289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795857202_224188.33333333333334423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795857452_474188.33333333333334423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795857480_504188.33333333333334423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000039418935118_14093.33333333333333328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000039418935146_16893.33333333333333328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000039418935174_19693.33333333333333328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000039418935202_22493.33333333333333328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000039418935452_47493.33333333333333328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000039418935480_50493.33333333333333328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043901646202_224180.33333333333334415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043901646452_474180.33333333333334415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043901646480_504180.33333333333334415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043916746202_224202.33333333333334437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043916746452_474202.33333333333334437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043916746480_504202.33333333333334437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000046775757452_474219.33333333333334454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000046775757480_504219.33333333333334454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000053518957452_474241.33333333333334476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173915chr17:37922746ENST0000053518957480_504241.33333333333334476.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034624346202_224197.33333333333334432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034624346452_474197.33333333333334432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034624346480_504197.33333333333334432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034687268452_474275.3333333333333510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034687268480_504275.3333333333333510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035053257452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035053257480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035168057452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035168057480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794446146_168132.33333333333334367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794446174_196132.33333333333334367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794446202_224132.33333333333334367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794446452_474132.33333333333334367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794446480_504132.33333333333334367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794535146_168141.33333333333334376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794535174_196141.33333333333334376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794535202_224141.33333333333334376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794535452_474141.33333333333334376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794535480_504141.33333333333334376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795224118_14054.333333333333336289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795224146_16854.333333333333336289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795224174_19654.333333333333336289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795224202_22454.333333333333336289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795224452_47454.333333333333336289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795224480_50454.333333333333336289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795857202_224188.33333333333334423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795857452_474188.33333333333334423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795857480_504188.33333333333334423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000039418935118_14093.33333333333333328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000039418935146_16893.33333333333333328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000039418935174_19693.33333333333333328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000039418935202_22493.33333333333333328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000039418935452_47493.33333333333333328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000039418935480_50493.33333333333333328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043901646202_224180.33333333333334415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043901646452_474180.33333333333334415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043901646480_504180.33333333333334415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043916746202_224202.33333333333334437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043916746452_474202.33333333333334437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043916746480_504202.33333333333334437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000046775757452_474219.33333333333334454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000046775757480_504219.33333333333334454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000053518957452_474241.33333333333334476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr5:32173916chr17:37922746ENST0000053518957480_504241.33333333333334476.0Zinc fingerC2H2-type 6%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLPH3chr5:32173915chr17:37922746ENST00000265070-14190_20175.0299.0RegionBeta-hairpin required for oligomerization
HgeneGOLPH3chr5:32173916chr17:37922746ENST00000265070-14190_20175.0299.0RegionBeta-hairpin required for oligomerization
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034624346118_140197.33333333333334432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034624346146_168197.33333333333334432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034624346174_196197.33333333333334432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034687268118_140275.3333333333333510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034687268146_168275.3333333333333510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034687268174_196275.3333333333333510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000034687268202_224275.3333333333333510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035053257118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035053257146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035053257174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035053257202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035168057118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035168057146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035168057174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000035168057202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794446118_140132.33333333333334367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037794535118_140141.33333333333334376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795857118_140188.33333333333334423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795857146_168188.33333333333334423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000037795857174_196188.33333333333334423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043901646118_140180.33333333333334415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043901646146_168180.33333333333334415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043901646174_196180.33333333333334415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043916746118_140202.33333333333334437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043916746146_168202.33333333333334437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000043916746174_196202.33333333333334437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000046775757118_140219.33333333333334454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000046775757146_168219.33333333333334454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000046775757174_196219.33333333333334454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000046775757202_224219.33333333333334454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173915chr17:37922746ENST0000053518957118_140241.33333333333334476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173915chr17:37922746ENST0000053518957146_168241.33333333333334476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173915chr17:37922746ENST0000053518957174_196241.33333333333334476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173915chr17:37922746ENST0000053518957202_224241.33333333333334476.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034624346118_140197.33333333333334432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034624346146_168197.33333333333334432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034624346174_196197.33333333333334432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034687268118_140275.3333333333333510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034687268146_168275.3333333333333510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034687268174_196275.3333333333333510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000034687268202_224275.3333333333333510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035053257118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035053257146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035053257174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035053257202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035168057118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035168057146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035168057174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000035168057202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794446118_140132.33333333333334367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037794535118_140141.33333333333334376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795857118_140188.33333333333334423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795857146_168188.33333333333334423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000037795857174_196188.33333333333334423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043901646118_140180.33333333333334415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043901646146_168180.33333333333334415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043901646174_196180.33333333333334415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043916746118_140202.33333333333334437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043916746146_168202.33333333333334437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000043916746174_196202.33333333333334437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000046775757118_140219.33333333333334454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000046775757146_168219.33333333333334454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000046775757174_196219.33333333333334454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000046775757202_224219.33333333333334454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr5:32173916chr17:37922746ENST0000053518957118_140241.33333333333334476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr5:32173916chr17:37922746ENST0000053518957146_168241.33333333333334476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr5:32173916chr17:37922746ENST0000053518957174_196241.33333333333334476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr5:32173916chr17:37922746ENST0000053518957202_224241.33333333333334476.0Zinc fingerC2H2-type 4%3B atypical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GOLPH3
IKZF3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GOLPH3-IKZF3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GOLPH3-IKZF3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource