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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HIPK1-UROD

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HIPK1-UROD
	FusionPDB ID: 36397
	FusionGDB2.0 ID: 36397
		Hgene	Tgene
	Gene symbol	HIPK1	UROD
	Gene ID	204851	7389
	Gene name	homeodomain interacting protein kinase 1	uroporphyrinogen decarboxylase
	Synonyms	Myak\|Nbak2	PCT\|UPD
	Cytomap	1p13.2	1p34.1
	Type of gene	protein-coding	protein-coding
	Description	homeodomain-interacting protein kinase 1homeodomain interacting protein kinase 1-like proteinnuclear body associated kinase 2bnuclear body-associated kinase 2	uroporphyrinogen decarboxylaseuroporphyrinogen III decarboxylase
	Modification date	20200313	20200313
	UniProtAcc	Q86Z02	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000340480, ENST00000369553, ENST00000369554, ENST00000369555, ENST00000369558, ENST00000369561, ENST00000406344, ENST00000426820, ENST00000369559,	ENST00000494399, ENST00000246337,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 2=18	5 X 5 X 1=25
	# samples	3	5
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HIPK1 [Title/Abstract] AND UROD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HIPK1(114515938)-UROD(45480619), # samples:2
Anticipated loss of major functional domain due to fusion event.	HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. HIPK1-UROD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIPK1	GO:0006468	protein phosphorylation	24559171
Hgene	HIPK1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	15701637
Hgene	HIPK1	GO:0072577	endothelial cell apoptotic process	15701637
Hgene	HIPK1	GO:0097191	extrinsic apoptotic signaling pathway	15701637

Fusion gene breakpoints across HIPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UROD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE772547	HIPK1	chr1	114515938	-	UROD	chr1	45480619	+
ChiTaRS5.0	N/A	BE772548	HIPK1	chr1	114515938	-	UROD	chr1	45480619	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369558	HIPK1	chr1	114515938	-	ENST00000246337	UROD	chr1	45480619	+	8162	7864	208	3387	1059
ENST00000369561	HIPK1	chr1	114515938	-	ENST00000246337	UROD	chr1	45480619	+	3782	3484	163	3240	1025
ENST00000340480	HIPK1	chr1	114515938	-	ENST00000246337	UROD	chr1	45480619	+	7002	6704	194	2227	677

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369558	ENST00000246337	HIPK1	chr1	114515938	-	UROD	chr1	45480619	+	0.00027208	0.9997279
ENST00000369561	ENST00000246337	HIPK1	chr1	114515938	-	UROD	chr1	45480619	+	0.003413111	0.9965869
ENST00000340480	ENST00000246337	HIPK1	chr1	114515938	-	UROD	chr1	45480619	+	0.000487512	0.99951243

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36397_36397_1_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000340480_UROD_chr1_45480619_ENST00000246337_length(amino acids)=677AA_BP=
MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCL
DDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ
IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQ
TDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAG
RPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQP
LNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE
EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQAS

--------------------------------------------------------------

>36397_36397_2_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000369558_UROD_chr1_45480619_ENST00000246337_length(amino acids)=1059AA_BP=
MRTRHTGGMASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVE
HIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGE
GDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKN
HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTY
LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTP
EEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHV
KSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA
PVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATL
HPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQ
YSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQP
IIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT

--------------------------------------------------------------

>36397_36397_3_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000369561_UROD_chr1_45480619_ENST00000246337_length(amino acids)=1025AA_BP=
MRTRHTGGMASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVE
HIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGE
GDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKN
HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTY
LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTP
EEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHV
KSCFQNMEICKRRVHMYDTASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCP
PAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVL
QAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQ
QSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSG
LKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVAS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:114515938/chr1:45480619)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIPK1 Q86Z02	.
FUNCTION: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269\|PubMed:12702766, ECO:0000269\|PubMed:12968034, ECO:0000269\|PubMed:15701637, ECO:0000269\|PubMed:16390825, ECO:0000269\|PubMed:19646965, ECO:0000269\|PubMed:24559171}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UROD

chr1:114515938

chr1:45480619

ENST00000246337

37_41

368.0

Region

Note=Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000340480

190_518

837.0

Domain

Protein kinase

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369553

190_518

817.0

Domain

Protein kinase

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369558

190_518

1211.0

Domain

Protein kinase

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369559

190_518

1076.0

Domain

Protein kinase

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000406344

190_518

817.0

Domain

Protein kinase

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000426820

190_518

1211.0

Domain

Protein kinase

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000340480

844_847

837.0

Motif

Nuclear localization signal 1 (NLS1)

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369553

844_847

817.0

Motif

Nuclear localization signal 1 (NLS1)

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369558

844_847

1211.0

Motif

Nuclear localization signal 1 (NLS1)

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369559

844_847

1076.0

Motif

Nuclear localization signal 1 (NLS1)

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000406344

844_847

817.0

Motif

Nuclear localization signal 1 (NLS1)

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000426820

844_847

1211.0

Motif

Nuclear localization signal 1 (NLS1)

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000340480

196_204

837.0

Nucleotide binding

ATP

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369553

196_204

817.0

Nucleotide binding

ATP

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369558

196_204

1211.0

Nucleotide binding

ATP

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369559

196_204

1076.0

Nucleotide binding

ATP

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000406344

196_204

817.0

Nucleotide binding

ATP

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000426820

196_204

1211.0

Nucleotide binding

ATP

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000340480

891_998

837.0

Region

Required for localization to nuclear speckles

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369553

891_998

817.0

Region

Required for localization to nuclear speckles

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369558

891_998

1211.0

Region

Required for localization to nuclear speckles

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000369559

891_998

1076.0

Region

Required for localization to nuclear speckles

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000406344

891_998

817.0

Region

Required for localization to nuclear speckles

Hgene

HIPK1

chr1:114515938

chr1:45480619

ENST00000426820

891_998

1211.0

Region

Required for localization to nuclear speckles

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1836_HIPK1_114515938_UROD_45480619_ranked_0.pdb	HIPK1	114515938	114515938	ENST00000246337	UROD	chr1	45480619	+	MRTRHTGGMASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVE HIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGE GDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKN HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTY LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTP EEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHV KSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA PVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATL HPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQ YSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQP IIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT	1059

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HIPK1_pLDDT.png

UROD_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HIPK1
UROD

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HIPK1	chr1:114515938	chr1:45480619	ENST00000340480	-	1	15	885_1093	0	837.0	TP53
Hgene	HIPK1	chr1:114515938	chr1:45480619	ENST00000369553	-	1	14	885_1093	0	817.0	TP53
Hgene	HIPK1	chr1:114515938	chr1:45480619	ENST00000369558	-	1	16	885_1093	0	1211.0	TP53
Hgene	HIPK1	chr1:114515938	chr1:45480619	ENST00000369559	-	1	15	885_1093	0	1076.0	TP53
Hgene	HIPK1	chr1:114515938	chr1:45480619	ENST00000406344	-	1	13	885_1093	0	817.0	TP53
Hgene	HIPK1	chr1:114515938	chr1:45480619	ENST00000426820	-	1	16	885_1093	0	1211.0	TP53

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Related Drugs to HIPK1-UROD

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HIPK1-UROD

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source