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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HIVEP3-LRP8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HIVEP3-LRP8
FusionPDB ID: 36558
FusionGDB2.0 ID: 36558
HgeneTgene
Gene symbol

HIVEP3

LRP8

Gene ID

59269

7804

Gene nameHIVEP zinc finger 3LDL receptor related protein 8
SynonymsKBP-1|KBP1|KRC|SHN3|Schnurri-3|ZAS3|ZNF40CAPOER2|HSZ75190|LRP-8|MCI1
Cytomap

1p34.2

1p32.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor HIVEP3ZAS family, member 3human immunodeficiency virus type I enhancer binding protein 3kappa-B and V(D)J recombination signal sequences-binding proteinkappa-binding protein 1zinc finger protein ZAS3low-density lipoprotein receptor-related protein 8ApoE receptor 2low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Modification date2020031320200313
UniProtAcc

Q5T1R4

Q14114

Ensembl transtripts involved in fusion geneENST idsENST00000247584, ENST00000372583, 
ENST00000372584, ENST00000429157, 
ENST00000460604, 		ENST00000347547, 
ENST00000354412, ENST00000465675, 
ENST00000460214, ENST00000306052, 
ENST00000371454, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 18 X 10=37804 X 3 X 4=48
# samples 254
** MAII scorelog2(25/3780*10)=-3.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HIVEP3 [Title/Abstract] AND LRP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HIVEP3(42041214)-LRP8(53792664), # samples:1
Anticipated loss of major functional domain due to fusion event.HIVEP3-LRP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-LRP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-LRP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-LRP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-LRP8 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
HIVEP3-LRP8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIVEP3

GO:0045893

positive regulation of transcription, DNA-templated

15790681

TgeneLRP8

GO:0006897

endocytosis

8626535


check buttonFusion gene breakpoints across HIVEP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A51DHIVEP3chr1

42041214

-LRP8chr1

53792664

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372583HIVEP3chr142041214-ENST00000306052LRP8chr153792664-10334609388661801764
ENST00000372583HIVEP3chr142041214-ENST00000371454LRP8chr153792664-9149609388661801764

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372583ENST00000306052HIVEP3chr142041214-LRP8chr153792664-0.0050302970.99496967
ENST00000372583ENST00000371454HIVEP3chr142041214-LRP8chr153792664-0.0077619390.9922381

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36558_36558_1_HIVEP3-LRP8_HIVEP3_chr1_42041214_ENST00000372583_LRP8_chr1_53792664_ENST00000306052_length(amino acids)=1764AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE

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>36558_36558_2_HIVEP3-LRP8_HIVEP3_chr1_42041214_ENST00000372583_LRP8_chr1_53792664_ENST00000371454_length(amino acids)=1764AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:42041214/chr1:53792664)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIVEP3

Q5T1R4

LRP8

Q14114

FUNCTION: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.FUNCTION: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity). {ECO:0000250|UniProtKB:Q924X6, ECO:0000269|PubMed:12807892, ECO:0000269|PubMed:12899622, ECO:0000269|PubMed:12950167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481442_14661735.66666666666672407.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591442_14661735.66666666666672407.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481442_14661735.66666666666672406.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481442_14661735.66666666666672406.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48308_3341735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48378_4141735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48797_8191735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48844_8801735.66666666666672407.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48916_9481735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59308_3341735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59378_4141735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59797_8191735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59844_8801735.66666666666672407.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59916_9481735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48308_3341735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48378_4141735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48797_8191735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48844_8801735.66666666666672406.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48916_9481735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48308_3341735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48378_4141735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48797_8191735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48844_8801735.66666666666672406.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48916_9481735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48903_9091735.66666666666672407.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59903_9091735.66666666666672407.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48903_9091735.66666666666672406.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48903_9091735.66666666666672406.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48192_2421735.66666666666672407.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48211_10741735.66666666666672407.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48264_2871735.66666666666672407.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48862_8831735.66666666666672407.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59192_2421735.66666666666672407.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59211_10741735.66666666666672407.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59264_2871735.66666666666672407.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59862_8831735.66666666666672407.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48192_2421735.66666666666672406.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48211_10741735.66666666666672406.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48264_2871735.66666666666672406.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48862_8831735.66666666666672406.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48192_2421735.66666666666672406.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48211_10741735.66666666666672406.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48264_2871735.66666666666672406.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48862_8831735.66666666666672406.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48192_2141735.66666666666672407.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48220_2421735.66666666666672407.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-48640_6701735.66666666666672407.0Zinc fingerCCHC HIVEP-type
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59192_2141735.66666666666672407.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59220_2421735.66666666666672407.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-59640_6701735.66666666666672407.0Zinc fingerCCHC HIVEP-type
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48192_2141735.66666666666672406.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48220_2421735.66666666666672406.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-48640_6701735.66666666666672406.0Zinc fingerCCHC HIVEP-type
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48192_2141735.66666666666672406.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48220_2421735.66666666666672406.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-48640_6701735.66666666666672406.0Zinc fingerCCHC HIVEP-type
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019126_16441.333333333333336964.0DomainLDL-receptor class A 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019166_20241.333333333333336964.0DomainLDL-receptor class A 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019205_24641.333333333333336964.0DomainLDL-receptor class A 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019258_29541.333333333333336964.0DomainLDL-receptor class A 6
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019298_33441.333333333333336964.0DomainLDL-receptor class A 7
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019336_37541.333333333333336964.0DomainEGF-like 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019376_41541.333333333333336964.0DomainEGF-like 2%3B calcium-binding
TgeneLRP8chr1:42041214chr1:53792664ENST0000030605201946_8241.333333333333336964.0DomainLDL-receptor class A 1
TgeneLRP8chr1:42041214chr1:53792664ENST0000030605201985_12341.333333333333336964.0DomainLDL-receptor class A 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017126_16441.333333333333336794.0DomainLDL-receptor class A 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017166_20241.333333333333336794.0DomainLDL-receptor class A 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017205_24641.333333333333336794.0DomainLDL-receptor class A 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017258_29541.333333333333336794.0DomainLDL-receptor class A 6
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017298_33441.333333333333336794.0DomainLDL-receptor class A 7
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017336_37541.333333333333336794.0DomainEGF-like 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017376_41541.333333333333336794.0DomainEGF-like 2%3B calcium-binding
TgeneLRP8chr1:42041214chr1:53792664ENST0000034754701746_8241.333333333333336794.0DomainLDL-receptor class A 1
TgeneLRP8chr1:42041214chr1:53792664ENST0000034754701785_12341.333333333333336794.0DomainLDL-receptor class A 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016126_16441.333333333333336701.0DomainLDL-receptor class A 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016166_20241.333333333333336701.0DomainLDL-receptor class A 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016205_24641.333333333333336701.0DomainLDL-receptor class A 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016258_29541.333333333333336701.0DomainLDL-receptor class A 6
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016298_33441.333333333333336701.0DomainLDL-receptor class A 7
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016336_37541.333333333333336701.0DomainEGF-like 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016376_41541.333333333333336701.0DomainEGF-like 2%3B calcium-binding
TgeneLRP8chr1:42041214chr1:53792664ENST0000035441201646_8241.333333333333336701.0DomainLDL-receptor class A 1
TgeneLRP8chr1:42041214chr1:53792664ENST0000035441201685_12341.333333333333336701.0DomainLDL-receptor class A 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018126_16441.333333333333336905.0DomainLDL-receptor class A 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018166_20241.333333333333336905.0DomainLDL-receptor class A 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018205_24641.333333333333336905.0DomainLDL-receptor class A 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018258_29541.333333333333336905.0DomainLDL-receptor class A 6
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018298_33441.333333333333336905.0DomainLDL-receptor class A 7
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018336_37541.333333333333336905.0DomainEGF-like 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018376_41541.333333333333336905.0DomainEGF-like 2%3B calcium-binding
TgeneLRP8chr1:42041214chr1:53792664ENST0000037145401846_8241.333333333333336905.0DomainLDL-receptor class A 1
TgeneLRP8chr1:42041214chr1:53792664ENST0000037145401885_12341.333333333333336905.0DomainLDL-receptor class A 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019740_79841.333333333333336964.0RegionNote=Clustered O-linked oligosaccharides
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017740_79841.333333333333336794.0RegionNote=Clustered O-linked oligosaccharides
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016740_79841.333333333333336701.0RegionNote=Clustered O-linked oligosaccharides
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018740_79841.333333333333336905.0RegionNote=Clustered O-linked oligosaccharides
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019462_50841.333333333333336964.0RepeatNote=LDL-receptor class B 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019509_55141.333333333333336964.0RepeatNote=LDL-receptor class B 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019552_59541.333333333333336964.0RepeatNote=LDL-receptor class B 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019596_63941.333333333333336964.0RepeatNote=LDL-receptor class B 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019640_68141.333333333333336964.0RepeatNote=LDL-receptor class B 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017462_50841.333333333333336794.0RepeatNote=LDL-receptor class B 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017509_55141.333333333333336794.0RepeatNote=LDL-receptor class B 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017552_59541.333333333333336794.0RepeatNote=LDL-receptor class B 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017596_63941.333333333333336794.0RepeatNote=LDL-receptor class B 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017640_68141.333333333333336794.0RepeatNote=LDL-receptor class B 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016462_50841.333333333333336701.0RepeatNote=LDL-receptor class B 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016509_55141.333333333333336701.0RepeatNote=LDL-receptor class B 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016552_59541.333333333333336701.0RepeatNote=LDL-receptor class B 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016596_63941.333333333333336701.0RepeatNote=LDL-receptor class B 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016640_68141.333333333333336701.0RepeatNote=LDL-receptor class B 5
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018462_50841.333333333333336905.0RepeatNote=LDL-receptor class B 1
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018509_55141.333333333333336905.0RepeatNote=LDL-receptor class B 2
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018552_59541.333333333333336905.0RepeatNote=LDL-receptor class B 3
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018596_63941.333333333333336905.0RepeatNote=LDL-receptor class B 4
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018640_68141.333333333333336905.0RepeatNote=LDL-receptor class B 5
TgeneLRP8chr1:42041214chr1:53792664ENST0000030605201942_82641.333333333333336964.0Topological domainExtracellular
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019848_96341.333333333333336964.0Topological domainCytoplasmic
TgeneLRP8chr1:42041214chr1:53792664ENST0000034754701742_82641.333333333333336794.0Topological domainExtracellular
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017848_96341.333333333333336794.0Topological domainCytoplasmic
TgeneLRP8chr1:42041214chr1:53792664ENST0000035441201642_82641.333333333333336701.0Topological domainExtracellular
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016848_96341.333333333333336701.0Topological domainCytoplasmic
TgeneLRP8chr1:42041214chr1:53792664ENST0000037145401842_82641.333333333333336905.0Topological domainExtracellular
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018848_96341.333333333333336905.0Topological domainCytoplasmic
TgeneLRP8chr1:42041214chr1:53792664ENST00000306052019827_84741.333333333333336964.0TransmembraneHelical
TgeneLRP8chr1:42041214chr1:53792664ENST00000347547017827_84741.333333333333336794.0TransmembraneHelical
TgeneLRP8chr1:42041214chr1:53792664ENST00000354412016827_84741.333333333333336701.0TransmembraneHelical
TgeneLRP8chr1:42041214chr1:53792664ENST00000371454018827_84741.333333333333336905.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481907_19361735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591907_19361735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481907_19361735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481907_19361735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481754_18061735.66666666666672407.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481817_18721735.66666666666672407.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-482053_21481735.66666666666672407.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591754_18061735.66666666666672407.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591817_18721735.66666666666672407.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-592053_21481735.66666666666672407.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481754_18061735.66666666666672406.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481817_18721735.66666666666672406.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-482053_21481735.66666666666672406.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481754_18061735.66666666666672406.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481817_18721735.66666666666672406.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-482053_21481735.66666666666672406.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481964_19671735.66666666666672407.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481970_19731735.66666666666672407.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481993_19961735.66666666666672407.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481998_20011735.66666666666672407.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-482067_20701735.66666666666672407.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-482079_20821735.66666666666672407.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591964_19671735.66666666666672407.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591970_19731735.66666666666672407.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591993_19961735.66666666666672407.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591998_20011735.66666666666672407.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-592067_20701735.66666666666672407.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-592079_20821735.66666666666672407.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481964_19671735.66666666666672406.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481970_19731735.66666666666672406.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481993_19961735.66666666666672406.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481998_20011735.66666666666672406.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-482067_20701735.66666666666672406.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-482079_20821735.66666666666672406.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481964_19671735.66666666666672406.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481970_19731735.66666666666672406.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481993_19961735.66666666666672406.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481998_20011735.66666666666672406.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-482067_20701735.66666666666672406.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-482079_20821735.66666666666672406.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481754_17761735.66666666666672407.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000247584-481782_18061735.66666666666672407.0Zinc fingerC2H2-type 4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591754_17761735.66666666666672407.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372583-591782_18061735.66666666666672407.0Zinc fingerC2H2-type 4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481754_17761735.66666666666672406.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000372584-481782_18061735.66666666666672406.0Zinc fingerC2H2-type 4
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481754_17761735.66666666666672406.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr1:53792664ENST00000429157-481782_18061735.66666666666672406.0Zinc fingerC2H2-type 4


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HIVEP3
LRP8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HIVEP3-LRP8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HIVEP3-LRP8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource