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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HNRNPUL1-BRSK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HNRNPUL1-BRSK1
FusionPDB ID: 37305
FusionGDB2.0 ID: 37305
HgeneTgene
Gene symbol

HNRNPUL1

BRSK1

Gene ID

11100

84446

Gene nameheterogeneous nuclear ribonucleoprotein U like 1BR serine/threonine kinase 1
SynonymsE1B-AP5|E1BAP5|HNRPUL1hSAD1
Cytomap

19q13.2

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5serine/threonine-protein kinase BRSK1BR serine/threonine-protein kinase 1SAD1 homologSAD1 kinaseSadB kinase short isoformbrain-selective kinase 1brain-specific serine/threonine-protein kinase 1protein kinase SAD1Aserine/threonine-protein kinase SA
Modification date2020032720200313
UniProtAcc

Q9BUJ2

Q8TDC3

Ensembl transtripts involved in fusion geneENST idsENST00000263367, ENST00000352456, 
ENST00000392006, ENST00000593587, 
ENST00000595018, ENST00000602130, 
ENST00000378215, ENST00000594207, 
ENST00000326848, ENST00000588584, 
ENST00000309383, ENST00000585418, 
ENST00000590333, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 14 X 12=30245 X 5 X 4=100
# samples 205
** MAII scorelog2(20/3024*10)=-3.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HNRNPUL1 [Title/Abstract] AND BRSK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HNRNPUL1(41787180)-BRSK1(55795889), # samples:1
Anticipated loss of major functional domain due to fusion event.HNRNPUL1-BRSK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
HNRNPUL1-BRSK1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRSK1

GO:0000086

G2/M transition of mitotic cell cycle

15150265

TgeneBRSK1

GO:0006468

protein phosphorylation

15150265

TgeneBRSK1

GO:0006974

cellular response to DNA damage stimulus

15150265

TgeneBRSK1

GO:0007095

mitotic G2 DNA damage checkpoint

15150265

TgeneBRSK1

GO:0009411

response to UV

15150265

TgeneBRSK1

GO:0010212

response to ionizing radiation

15150265

TgeneBRSK1

GO:0018105

peptidyl-serine phosphorylation

15150265


check buttonFusion gene breakpoints across HNRNPUL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRSK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A907-01AHNRNPUL1chr19

41787180

+BRSK1chr19

55795889

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000352456HNRNPUL1chr1941787180+ENST00000590333BRSK1chr1955795889+35157911130491012
ENST00000595018HNRNPUL1chr1941787180+ENST00000590333BRSK1chr1955795889+3492768453026993
ENST00000392006HNRNPUL1chr1941787180+ENST00000590333BRSK1chr1955795889+389611724434301128
ENST00000602130HNRNPUL1chr1941787180+ENST00000590333BRSK1chr1955795889+377610525333101085
ENST00000593587HNRNPUL1chr1941787180+ENST00000590333BRSK1chr1955795889+3517793943051985
ENST00000263367HNRNPUL1chr1941787180+ENST00000590333BRSK1chr1955795889+365092616131841007

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000352456ENST00000590333HNRNPUL1chr1941787180+BRSK1chr1955795889+0.0021457380.9978543
ENST00000595018ENST00000590333HNRNPUL1chr1941787180+BRSK1chr1955795889+0.0022564640.9977436
ENST00000392006ENST00000590333HNRNPUL1chr1941787180+BRSK1chr1955795889+0.0033780140.99662197
ENST00000602130ENST00000590333HNRNPUL1chr1941787180+BRSK1chr1955795889+0.0032458430.9967541
ENST00000593587ENST00000590333HNRNPUL1chr1941787180+BRSK1chr1955795889+0.0025108660.9974891
ENST00000263367ENST00000590333HNRNPUL1chr1941787180+BRSK1chr1955795889+0.002376960.997623

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37305_37305_1_HNRNPUL1-BRSK1_HNRNPUL1_chr19_41787180_ENST00000263367_BRSK1_chr19_55795889_ENST00000590333_length(amino acids)=1007AA_BP=255
MRKEDPGICRWMRSWAFSYLDAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQF
QSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVC
FEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAHAQYVGPYRLEKTLG
KGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPK
EARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVIL
FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPS
NGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSME
VLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQ
PPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSS
LTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSE
GPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRR

--------------------------------------------------------------

>37305_37305_2_HNRNPUL1-BRSK1_HNRNPUL1_chr19_41787180_ENST00000352456_BRSK1_chr19_55795889_ENST00000590333_length(amino acids)=1012AA_BP=260
MGGERERGSRTWARGGVSGLEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKP
DRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVR
RGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAHAQYVGPYRL
EKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKG
RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWS
CGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAM
RSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPE
RKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGG
GAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTA
EEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVD
ISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELS

--------------------------------------------------------------

>37305_37305_3_HNRNPUL1-BRSK1_HNRNPUL1_chr19_41787180_ENST00000392006_BRSK1_chr19_55795889_ENST00000590333_length(amino acids)=1128AA_BP=376
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFAHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVY
ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETS
CGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQ
KHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLP
PRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPG
AGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWR
SRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLS
QTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKN

--------------------------------------------------------------

>37305_37305_4_HNRNPUL1-BRSK1_HNRNPUL1_chr19_41787180_ENST00000593587_BRSK1_chr19_55795889_ENST00000590333_length(amino acids)=985AA_BP=233
MDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDR
RGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPH
VVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIK
IVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSIC
HRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKV
KRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRE
RLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEM
AQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSG
GTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLD
KEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFT

--------------------------------------------------------------

>37305_37305_5_HNRNPUL1-BRSK1_HNRNPUL1_chr19_41787180_ENST00000595018_BRSK1_chr19_55795889_ENST00000590333_length(amino acids)=993AA_BP=241
MEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRG
YFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHL
PSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAHAQYVGPYRLEKTLGKGQTGLVKLGVHCI
TGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALD
FCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDN
LRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMAS
LGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPV
PTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGP
PGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSW
FGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSGGG
GIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGT

--------------------------------------------------------------

>37305_37305_6_HNRNPUL1-BRSK1_HNRNPUL1_chr19_41787180_ENST00000602130_BRSK1_chr19_55795889_ENST00000590333_length(amino acids)=1085AA_BP=333
MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVK
HLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAHAQYVGPYRLEKTLGKGQTGLVKLGVH
CITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSA
LDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDD
DNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESM
ASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGS
PVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLP
GPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKR
SWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSG
GGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41787180/chr19:55795889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL1

Q9BUJ2

BRSK1

Q8TDC3

FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+7153_37333.0857.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+7153_37233.0757.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+7153_37233.0757.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+7153_37333.0805.0DomainSAP
TgeneBRSK1chr19:41787180chr19:55795889ENST00000309383019492_5400779.0Compositional biasNote=Pro-rich
TgeneBRSK1chr19:41787180chr19:55795889ENST00000585418010492_5400344.0Compositional biasNote=Pro-rich
TgeneBRSK1chr19:41787180chr19:55795889ENST00000590333121492_54042.0795.0Compositional biasNote=Pro-rich
TgeneBRSK1chr19:41787180chr19:55795889ENST00000309383019314_3560779.0DomainUBA
TgeneBRSK1chr19:41787180chr19:55795889ENST0000030938301934_2850779.0DomainProtein kinase
TgeneBRSK1chr19:41787180chr19:55795889ENST00000585418010314_3560344.0DomainUBA
TgeneBRSK1chr19:41787180chr19:55795889ENST0000058541801034_2850344.0DomainProtein kinase
TgeneBRSK1chr19:41787180chr19:55795889ENST00000590333121314_35642.0795.0DomainUBA
TgeneBRSK1chr19:41787180chr19:55795889ENST0000030938301940_480779.0Nucleotide bindingATP
TgeneBRSK1chr19:41787180chr19:55795889ENST0000058541801040_480344.0Nucleotide bindingATP
TgeneBRSK1chr19:41787180chr19:55795889ENST0000059033312140_4842.0795.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114613_6660753.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114670_6890753.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114692_8110753.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114757_8450753.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114806_8320753.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715613_666333.0857.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715670_689333.0857.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715692_811333.0857.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715757_845333.0857.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715806_832333.0857.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715613_666233.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715670_689233.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715692_811233.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715757_845233.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715806_832233.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715613_666233.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715670_689233.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715692_811233.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715757_845233.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715806_832233.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715613_666333.0805.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715670_689333.0805.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715692_811333.0805.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715757_845333.0805.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715806_832333.0805.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114191_3880753.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+1143_370753.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715191_388333.0857.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715191_388233.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715191_388233.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715191_388333.0805.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114612_6580753.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715612_658333.0857.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715612_658233.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715612_658233.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715612_658333.0805.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114612_6140753.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114620_6220753.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114639_6410753.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114645_6470753.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000378215+114656_6580753.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715612_614333.0857.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715620_622333.0857.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715639_641333.0857.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715645_647333.0857.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000392006+715656_658333.0857.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715612_614233.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715620_622233.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715639_641233.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715645_647233.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000593587+715656_658233.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715612_614233.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715620_622233.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715639_641233.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715645_647233.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000595018+715656_658233.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715612_614333.0805.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715620_622333.0805.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715639_641333.0805.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715645_647333.0805.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:55795889ENST00000602130+715656_658333.0805.0RepeatNote=1-5
TgeneBRSK1chr19:41787180chr19:55795889ENST0000059033312134_28542.0795.0DomainProtein kinase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HNRNPUL1
BRSK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HNRNPUL1-BRSK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HNRNPUL1-BRSK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource