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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABHD12-KIF16B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABHD12-KIF16B
FusionPDB ID: 375
FusionGDB2.0 ID: 375
HgeneTgene
Gene symbol

ABHD12

KIF16B

Gene ID

26090

55614

Gene nameabhydrolase domain containing 12, lysophospholipasekinesin family member 16B
SynonymsABHD12A|BEM46L2|C20orf22|PHARC|dJ965G21.2|hABHD12C20orf23|KISC20ORF|SNX23
Cytomap

20p11.21

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidylserine lipase ABHD122-arachidonoylglycerol hydrolase2-arachidonoylglycerol hydrolase ABHD12abhydrolase domain containing 12abhydrolase domain-containing protein 12monoacylglycerol lipase ABHD12oxidized phosphatidylserine lipase ABHD1kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a
Modification date2020031320200313
UniProtAcc

Q7Z5M8

Q96L93

Ensembl transtripts involved in fusion geneENST idsENST00000339157, ENST00000376542, 
ENST00000481556, 		ENST00000355755, 
ENST00000378003, ENST00000408042, 
ENST00000354981, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 6=5287 X 5 X 6=210
# samples 138
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABHD12 [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABHD12(25282855)-KIF16B(16509085), # samples:1
Anticipated loss of major functional domain due to fusion event.ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABHD12

GO:0006660

phosphatidylserine catabolic process

30643283

HgeneABHD12

GO:0009395

phospholipid catabolic process

30237167

HgeneABHD12

GO:0046464

acylglycerol catabolic process

22969151

HgeneABHD12

GO:0046475

glycerophospholipid catabolic process

25290914

HgeneABHD12

GO:0052651

monoacylglycerol catabolic process

25290914|30237167


check buttonFusion gene breakpoints across ABHD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIF16B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-7142-01AABHD12chr20

25282855

-KIF16Bchr20

16509085

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376542ABHD12chr2025282855-ENST00000354981KIF16Bchr2016509085-6493143719953431714
ENST00000339157ABHD12chr2025282855-ENST00000354981KIF16Bchr2016509085-6486143019253361714

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376542ENST00000354981ABHD12chr2025282855-KIF16Bchr2016509085-0.0018413270.99815863
ENST00000339157ENST00000354981ABHD12chr2025282855-KIF16Bchr2016509085-0.00182530.99817467

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>375_375_1_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000339157_KIF16B_chr20_16509085_ENST00000354981_length(amino acids)=1714AA_BP=412
MGGGGCERRHCGAGQRAPSAAGPVGRGMRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALG
RRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQ
GKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIW
GHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDD
PVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERT
KTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEAS
FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ
AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSL
GGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEA
RVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHC
IFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYN
PGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER
LREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQ
EMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC
LKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE
EQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGS
REQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDL
HRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSR
FREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSS

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>375_375_2_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000376542_KIF16B_chr20_16509085_ENST00000354981_length(amino acids)=1714AA_BP=412
MGGGGCERRHCGAGQRAPSAAGPVGRGMRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALG
RRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQ
GKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIW
GHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDD
PVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERT
KTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEAS
FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ
AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSL
GGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEA
RVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHC
IFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYN
PGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER
LREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQ
EMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC
LKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE
EQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGS
REQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDL
HRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSR
FREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:25282855/chr20:16509085)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABHD12

Q7Z5M8

KIF16B

Q96L93

FUNCTION: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121320_25385.6666666666667399.0Compositional biasNote=Poly-Ser
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121326_29385.6666666666667399.0Compositional biasNote=Poly-Ala
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121320_25385.6666666666667405.0Compositional biasNote=Poly-Ser
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121326_29385.6666666666667405.0Compositional biasNote=Poly-Ala
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-12131_74385.6666666666667399.0Topological domainCytoplasmic
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-12131_74385.6666666666667405.0Topological domainCytoplasmic
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121375_95385.6666666666667399.0TransmembraneHelical
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121375_95385.6666666666667405.0TransmembraneHelical
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026370_42515.6666666666666661318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026595_88215.6666666666666661318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026936_108715.6666666666666661318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025370_42515.6666666666666661288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025595_88215.6666666666666661288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025936_108715.6666666666666661288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023370_42515.6666666666666661393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023595_88215.6666666666666661393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023936_108715.6666666666666661393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026597_107015.6666666666666661318.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025597_107015.6666666666666661288.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023597_107015.6666666666666661393.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003549810261182_129615.6666666666666661318.0DomainPX
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026478_52915.6666666666666661318.0DomainNote=FHA
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003557550251182_129615.6666666666666661288.0DomainPX
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025478_52915.6666666666666661288.0DomainNote=FHA
TgeneKIF16Bchr20:25282855chr20:16509085ENST000004080420231182_129615.6666666666666661393.0DomainPX
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023478_52915.6666666666666661393.0DomainNote=FHA
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026102_10915.6666666666666661318.0Nucleotide bindingATP
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025102_10915.6666666666666661288.0Nucleotide bindingATP
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023102_10915.6666666666666661393.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121396_398385.6666666666667399.0Topological domainExtracellular
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121396_398385.6666666666667405.0Topological domainExtracellular
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003549810263_35815.6666666666666661318.0DomainKinesin motor
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003557550253_35815.6666666666666661288.0DomainKinesin motor
TgeneKIF16Bchr20:25282855chr20:16509085ENST000004080420233_35815.6666666666666661393.0DomainKinesin motor


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABHD12
KIF16B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABHD12-KIF16B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABHD12-KIF16B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource