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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HSD17B12-WT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HSD17B12-WT1
	FusionPDB ID: 37666
	FusionGDB2.0 ID: 37666
		Hgene	Tgene
	Gene symbol	HSD17B12	WT1
	Gene ID	51144	7490
	Gene name	hydroxysteroid 17-beta dehydrogenase 12	WT1 transcription factor
	Synonyms	KAR\|SDR12C1	AWT1\|GUD\|NPHS4\|WAGR\|WIT-2\|WT33
	Cytomap	11p11.2	11p13
	Type of gene	protein-coding	protein-coding
	Description	very-long-chain 3-oxoacyl-CoA reductase17-beta-HSD 1217-beta-hydroxysteroid dehydrogenase 1217beta-HSD type 123-ketoacyl-CoA reductaseestradiol 17-beta-dehydrogenase 12short chain dehydrogenase/reductase family 12C member 1steroid dehydrogenase hom	Wilms tumor proteinWilms tumor 1
	Modification date	20200313	20200320
	UniProtAcc	Q53GQ0	P19544
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000278353, ENST00000395700, ENST00000529261,	ENST00000332351, ENST00000379079, ENST00000448076, ENST00000530998,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 13 X 7=1183	3 X 6 X 5=90
	# samples	14	4
	** MAII score	log2(14/1183*10)=-3.07895134139482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/90*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HSD17B12 [Title/Abstract] AND WT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HSD17B12(43702537)-WT1(32450165), # samples:4
Anticipated loss of major functional domain due to fusion event.	HSD17B12-WT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B12-WT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B12-WT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B12-WT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	WT1	GO:0000122	negative regulation of transcription by RNA polymerase II	7585606
Tgene	WT1	GO:0007530	sex determination	9815658
Tgene	WT1	GO:0008285	negative regulation of cell proliferation	9553041\|9765217
Tgene	WT1	GO:0030308	negative regulation of cell growth	9553041\|9765217
Tgene	WT1	GO:0045892	negative regulation of transcription, DNA-templated	1332065\|7585606\|7720589\|8119964\|12802290\|14701728\|19050011
Tgene	WT1	GO:0045893	positive regulation of transcription, DNA-templated	8132626\|9178767\|9553041\|9765217\|12802290\|14701728\|16467207\|21390327
Tgene	WT1	GO:0045944	positive regulation of transcription by RNA polymerase II	23042785
Tgene	WT1	GO:0071371	cellular response to gonadotropin stimulus	15961562

Fusion gene breakpoints across HSD17B12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KICH	TCGA-KL-8335-01A	HSD17B12	chr11	43702537	-	WT1	chr11	32450165	-
ChimerDB4	KICH	TCGA-KL-8335-01A	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-
ChimerDB4	KICH	TCGA-KL-8335	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000278353	HSD17B12	chr11	43702537	+	ENST00000379079	WT1	chr11	32450165	-	2461	279	119	1177	352
ENST00000278353	HSD17B12	chr11	43702537	+	ENST00000332351	WT1	chr11	32450165	-	2470	279	119	1186	355
ENST00000278353	HSD17B12	chr11	43702537	+	ENST00000530998	WT1	chr11	32450165	-	2416	279	119	1135	338
ENST00000278353	HSD17B12	chr11	43702537	+	ENST00000448076	WT1	chr11	32450165	-	1557	279	119	1177	352
ENST00000395700	HSD17B12	chr11	43702537	+	ENST00000379079	WT1	chr11	32450165	-	2389	207	47	1105	352
ENST00000395700	HSD17B12	chr11	43702537	+	ENST00000332351	WT1	chr11	32450165	-	2398	207	47	1114	355
ENST00000395700	HSD17B12	chr11	43702537	+	ENST00000530998	WT1	chr11	32450165	-	2344	207	47	1063	338
ENST00000395700	HSD17B12	chr11	43702537	+	ENST00000448076	WT1	chr11	32450165	-	1485	207	47	1105	352

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000278353	ENST00000379079	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.015225739	0.98477423
ENST00000278353	ENST00000332351	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.015108737	0.98489124
ENST00000278353	ENST00000530998	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.009088906	0.99091107
ENST00000278353	ENST00000448076	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.11383599	0.88616407
ENST00000395700	ENST00000379079	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.015235038	0.98476493
ENST00000395700	ENST00000332351	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.015001932	0.98499805
ENST00000395700	ENST00000530998	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.008630293	0.9913697
ENST00000395700	ENST00000448076	HSD17B12	chr11	43702537	+	WT1	chr11	32450165	-	0.103710964	0.896289

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37666_37666_1_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000332351_length(amino acids)=355AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------

>37666_37666_2_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000379079_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------

>37666_37666_3_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000448076_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------

>37666_37666_4_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000530998_length(amino acids)=338AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTH
GVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVK

--------------------------------------------------------------

>37666_37666_5_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000332351_length(amino acids)=355AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------

>37666_37666_6_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000379079_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------

>37666_37666_7_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000448076_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------

>37666_37666_8_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000530998_length(amino acids)=338AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTH
GVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:43702537/chr11:32450165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HSD17B12 Q53GQ0	WT1 P19544
FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269\|PubMed:12482854, ECO:0000269\|PubMed:16166196}.	FUNCTION: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269\|PubMed:15520190, ECO:0000269\|PubMed:16934801, ECO:0000269\|PubMed:17716689, ECO:0000269\|PubMed:19123921, ECO:0000269\|PubMed:19416806, ECO:0000269\|PubMed:25258363, ECO:0000269\|PubMed:7862533}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HSD17B12

chr11:43702537

chr11:32450165

ENST00000278353

4_24

53.333333333333336

313.0

Transmembrane

Helical

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000379079

27_83

3.3333333333333335

303.0

Compositional bias

Note=Pro-rich

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000530998

27_83

3.3333333333333335

289.0

Compositional bias

Note=Pro-rich

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000379079

236_244

3.3333333333333335

303.0

Motif

9aaTAD

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000530998

236_244

3.3333333333333335

289.0

Motif

9aaTAD

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000379079

323_347

3.3333333333333335

303.0

Zinc finger

C2H2-type 1

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000379079

353_377

3.3333333333333335

303.0

Zinc finger

C2H2-type 2

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000379079

383_405

3.3333333333333335

303.0

Zinc finger

C2H2-type 3

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000379079

414_438

3.3333333333333335

303.0

Zinc finger

C2H2-type 4

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000530998

323_347

3.3333333333333335

289.0

Zinc finger

C2H2-type 1

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000530998

353_377

3.3333333333333335

289.0

Zinc finger

C2H2-type 2

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000530998

383_405

3.3333333333333335

289.0

Zinc finger

C2H2-type 3

Tgene

WT1

chr11:43702537

chr11:32450165

ENST00000530998

414_438

3.3333333333333335

289.0

Zinc finger

C2H2-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HSD17B12

chr11:43702537

chr11:32450165

ENST00000278353

308_312

53.333333333333336

313.0

Motif

Note=Di-lysine motif

Hgene

HSD17B12

chr11:43702537

chr11:32450165

ENST00000278353

50_79

53.333333333333336

313.0

Nucleotide binding

NADP

Hgene

HSD17B12

chr11:43702537

chr11:32450165

ENST00000278353

182_202

53.333333333333336

313.0

Transmembrane

Helical

Hgene

HSD17B12

chr11:43702537

chr11:32450165

ENST00000278353

271_291

53.333333333333336

313.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>694_HSD17B12_43702537_WT1_32450165_ranked_0.pdb	HSD17B12	43702537	43702537	ENST00000448076	WT1	chr11	32450165	-	MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF	355

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HSD17B12_pLDDT.png

WT1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HSD17B12
WT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to HSD17B12-WT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HSD17B12-WT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	WT1	C0950121	Denys-Drash Syndrome	20	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C0027708	Nephroblastoma	8	CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C3151568	NEPHROTIC SYNDROME, TYPE 4	6	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	WT1	C0950122	Frasier Syndrome	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C1837026	MEACHAM SYNDROME (disorder)	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C0023467	Leukemia, Myelocytic, Acute	2	CGI;CTD_human
Tgene	WT1	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Tgene	WT1	C0345967	Malignant mesothelioma	2	CTD_human;GENOMICS_ENGLAND
Tgene	WT1	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Tgene	WT1	C2930471	Bilateral Wilms Tumor	2	CTD_human
Tgene	WT1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	WT1	C0007102	Malignant tumor of colon	1	CTD_human
Tgene	WT1	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	WT1	C0017636	Glioblastoma	1	CTD_human
Tgene	WT1	C0017658	Glomerulonephritis	1	CTD_human
Tgene	WT1	C0018054	Gonadal Dysgenesis, 46,XY	1	ORPHANET
Tgene	WT1	C0019284	Diaphragmatic Hernia	1	CTD_human
Tgene	WT1	C0023418	leukemia	1	CTD_human
Tgene	WT1	C0023473	Myeloid Leukemia, Chronic	1	CTD_human
Tgene	WT1	C0023487	Acute Promyelocytic Leukemia	1	CTD_human
Tgene	WT1	C0024121	Lung Neoplasms	1	CTD_human
Tgene	WT1	C0027809	Neurilemmoma	1	CTD_human
Tgene	WT1	C0029463	Osteosarcoma	1	CTD_human
Tgene	WT1	C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene	WT1	C0031149	Peritoneal Neoplasms	1	CTD_human
Tgene	WT1	C0085215	Ovarian Failure, Premature	1	CTD_human
Tgene	WT1	C0086367	Gonadotropin-Resistant Ovary Syndrome	1	CTD_human
Tgene	WT1	C0206115	WAGR Syndrome	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	WT1	C0235833	Congenital diaphragmatic hernia	1	CTD_human
Tgene	WT1	C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene	WT1	C0265699	Congenital hernia of foramen of Morgagni	1	CTD_human
Tgene	WT1	C0265700	Congenital hernia of foramen of Bochdalek	1	CTD_human
Tgene	WT1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	WT1	C0346647	Malignant neoplasm of pancreas	1	CTD_human
Tgene	WT1	C0346990	Carcinomatosis of peritoneal cavity	1	CTD_human
Tgene	WT1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	WT1	C0751374	Schwannomatosis, Plexiform	1	CTD_human
Tgene	WT1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	WT1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	WT1	C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene	WT1	C1704377	Bright Disease	1	CTD_human
Tgene	WT1	C1840452	Hyaloideoretinal degeneration of Wagner	1	GENOMICS_ENGLAND
Tgene	WT1	C1868672	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	1	ORPHANET
Tgene	WT1	C2931803	Deletion 11p13	1	ORPHANET
Tgene	WT1	C2936694	Swyer Syndrome	1	ORPHANET
Tgene	WT1	C3494522	Hypergonadotropic Ovarian Failure, X-Linked	1	CTD_human
Tgene	WT1	C4510744	46,XY partial gonadal dysgenesis	1	ORPHANET
Tgene	WT1	C4552079	Premature Ovarian Failure 1	1	CTD_human
Tgene	WT1	C4704874	Mammary Carcinoma, Human	1	CTD_human