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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IL20RB-NR4A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IL20RB-NR4A1
FusionPDB ID: 39508
FusionGDB2.0 ID: 39508
HgeneTgene
Gene symbol

IL20RB

NR4A1

Gene ID

53833

3164

Gene nameinterleukin 20 receptor subunit betanuclear receptor subfamily 4 group A member 1
SynonymsDIRS1|FNDC6|IL-20R2GFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3
Cytomap

3q22.3

12q13.13

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-20 receptor subunit betaIL-20 receptor subunit betaIL-20R-betaIL-20RBfibronectin type III domain containing 6interleukin 20 receptor beta subunitinterleukin-20 receptor IInuclear receptor subfamily 4 group A member 1ST-59TR3 orphan receptorearly response protein NAK1growth factor-inducible nuclear protein N10hormone receptornerve growth factor IB nuclear receptor variant 1nuclear hormone receptor NUR/77orphan nucle
Modification date2020031320200329
UniProtAcc

Q6UXL0

P22736

Ensembl transtripts involved in fusion geneENST idsENST00000484501, ENST00000329582, 
ENST00000309741, 		ENST00000360284, 
ENST00000545748, ENST00000550082, 
ENST00000547206, ENST00000243050, 
ENST00000394824, ENST00000394825, 
ENST00000548232, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 3 X 3=4515 X 14 X 4=840
# samples 516
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/840*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IL20RB [Title/Abstract] AND NR4A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NR4A1(52435713)-IL20RB(136699308), # samples:3
IL20RB(136677043)-NR4A1(52448111), # samples:1
Anticipated loss of major functional domain due to fusion event.IL20RB-NR4A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IL20RB-NR4A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IL20RB-NR4A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IL20RB-NR4A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR4A1

GO:0002042

cell migration involved in sprouting angiogenesis

18059339

TgeneNR4A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22427340


check buttonFusion gene breakpoints across IL20RB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NR4A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6871-01AIL20RBchr3

136677043

-NR4A1chr12

52448111

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000329582IL20RBchr3136677043-ENST00000360284NR4A1chr1252448111+22413372492135628
ENST00000329582IL20RBchr3136677043-ENST00000545748NR4A1chr1252448111+26933372492135628
ENST00000329582IL20RBchr3136677043-ENST00000550082NR4A1chr1252448111+22413372492135628

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000329582ENST00000360284IL20RBchr3136677043-NR4A1chr1252448111+0.079385720.9206143
ENST00000329582ENST00000545748IL20RBchr3136677043-NR4A1chr1252448111+0.0362582360.9637418
ENST00000329582ENST00000550082IL20RBchr3136677043-NR4A1chr1252448111+0.079385720.9206143

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39508_39508_1_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000360284_length(amino acids)=628AA_BP=29
MQTFTMVLEEIWTSLFMWFFYALIPCLLTEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQ
LSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV
GMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV

--------------------------------------------------------------

>39508_39508_2_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000545748_length(amino acids)=628AA_BP=29
MQTFTMVLEEIWTSLFMWFFYALIPCLLTEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQ
LSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV
GMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV

--------------------------------------------------------------

>39508_39508_3_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000550082_length(amino acids)=628AA_BP=29
MQTFTMVLEEIWTSLFMWFFYALIPCLLTEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQ
LSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV
GMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52435713/chr12:136699308)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL20RB

Q6UXL0

NR4A1

P22736

FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.FUNCTION: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12813, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000002430501882_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418583_58612.333333333333334612.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000003602841882_9212.333333333333334612.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000003948241882_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000003948250782_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202583_5860326.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000005482320282_920326.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207583_58612.333333333333334612.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000005500820782_9212.333333333333334612.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418264_33912.333333333333334612.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202264_3390326.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207264_33912.333333333333334612.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018360_5950599.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418360_59512.333333333333334612.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418360_5950599.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507360_5950599.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202360_5950326.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207360_59512.333333333333334612.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418171_46612.333333333333334612.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202171_4660326.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207171_46612.333333333333334612.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418267_28712.333333333333334612.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418303_32712.333333333333334612.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202267_2870326.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202303_3270326.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207267_28712.333333333333334612.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207303_32712.333333333333334612.0Zinc fingerNR C4-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-17144_22829.333333333333332312.0DomainFibronectin type-III 2
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-1737_13629.333333333333332312.0DomainFibronectin type-III 1
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-17255_31129.333333333333332312.0Topological domainCytoplasmic
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-1730_23329.333333333333332312.0Topological domainExtracellular
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-17234_25429.333333333333332312.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IL20RB
NR4A1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IL20RB-NR4A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IL20RB-NR4A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource